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Role of systemic inflammation in cirrhosis:From pathogenesis to prognosis

World journal of Hepatology 2015年第16期7卷 1974-1981页

作者： Melisa Dirchwolf Andres eduardo Ruf Hepatopatias Infecciosas Hospital Francisco J Muniz Fundacion para la Docencia e Investigacion de las Enfermedades del Higado (FUNDIEH) Liver Transplant Unit British Hospital of Buenos Aires

The natural history of cirrhosis can be divided into an initial stage, known as compensated cirrhosis, and an advanced stage which encompasses both decompensated cirrhosis and acute-on-chronic liver failure(ACLF). The latter syndrome has been recently described as an acute deterioration of liver function in patients with cirrhosis, which is usually triggered by a precipitating event and results in the failure of one or more organs and high short-term mortality rates. Each stage is characterized by distinctive clinical manifestations and prognoses. One of the key elements involved in cirrhosis physiopathology is systemic inflammation, recently described as one of the components in the cirrhosis-associated immune dysfunction syndrome. This syndrome refers to the combination of immune deficiency and exacerbated inflammation that coexist during the course of cirrhosis and relates to the appearance of clinical complications. Since systemic inflammation is often difficult to assess in cirrhosis patients, new objective, reproducible and readily-available markers are needed in order to optimize prognosis and lengthen survival. Thus, surrogate serum markers and clinical parameters of systemic inflammation have been sought to improve disease follow-up and management, especially in decompensated cirrhosis and ACLF. Leukocyte counts(evaluated as total leukocytes, total eosinophils or neutrophil:lymphocyte ratio) and plasma levels of procalcitonin or C-reactive protein have been proposed as prognostic markers, each with advantages and shortcomings. Research and prospective randomized studies that validate these and other markers are clearly warranted.

关键词： Immune dysfunction Cirrhosis Acute-onchronic liver failure Prognosis Systemic inflammation

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Investigation of Galactic open cluster remnants： the case of NGC 7193

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Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de Souza Angelo joao Francisco Coelho dos Santos jr Wagner jose Barbosa Corradi Francisco Ferreira de Souza Maia Andres eduardo Piatti Departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil Observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （OCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （OCR）. This study is devoted to assessing the real physical nature of the OCR candidate NGC 7193. GMOS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （j - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （j - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. Our results indi- cate that NGC 7193 is a genuine OCR, of a once very populous OC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（B-V） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the OCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

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Catalytic Performance of La0.6Ca0.4Fe1-xNixO3Perovskites in DME Oxidation

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Modern Research in Catalysis 2015年第4期4卷 97-106页

作者： Gina Pecchi Ruddy Morales Daniela Salinas eduardo j. Delgado josé Luis García Fierro Facultad Ciencias Químicas Universidad de Concepción Concepción Chile Instituo Catálisisy Petroleoquímica CSIC Cantoblanco Madrid Spain

Substituted La0.6Ca0.4Fe1-xNixO3 (0.0 ≤ x ≤ 1.0) perovskite-type oxides prepared by the amorphous citrate method have been investigated as catalysts in the dimethyl ether (DME) oxidation reaction. The samples with an x ≤ 0.3 composition show an orthorhombic structure, while the intermediate compositions with 0.5 ≤ x ≤ 0.9 show a less crystalline orthorhombic perovskite structure with segregated phases that increase upon increasing the Ni content. The progressive substitution of Fe3+ by Ni2+ in La0.6Ca0.4FeO3 entails the progressive formation of oxygen vacancies and Fe4+ species for Ni substitution degrees of x ≤ 0.5. For larger degrees of substitution with x > 0.7, segregated phases and a progressive loss of the perovskite structure are detected. The highest catalytic performance for the total combustion of DME is obtained from equimolar substitution in the B-site position (Fe0.5Ni0.5), in which a large extent of Fe4+ species and oxygen vacancies are present.

关键词： DME Perovskites Oxidation Iron Nickel

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LIV-4:A novel model for predicting transplant-free survival in critically ill cirrhotics

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World journal of Hepatology 2020年第6期12卷 298-311页

作者： Christina C Lindenmeyer Gianina Flocco Vedha Sanghi Rocio Lopez Ahyoung j Kim Fadi Niyazi Neal A Mehta Aanchal Kapoor William D Carey eduardo Mireles-Cabodevila Carlos Romero-Marrero Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences Cleveland ClinicClevelandOH 44106United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Critically ill patients with cirrhosis,particularly those with acute decompensation,have higher mortality rates in the intensive care unit(ICU)than patients without chronic liver *** of short-term mortality is important in order to identify patients at highest risk of *** of the currently available prognostic models have been widely accepted for use in cirrhotic patients in the ICU,perhaps due to complexity of calculation,or lack of universal variables readily available for these *** believe a survival model meeting these requirements can be developed,to guide therapeutic decision-making and contribute to cost-effective healthcare resource *** To identify markers that best identify likelihood of survival and to determine the performance of existing survival *** Consecutive cirrhotic patients admitted to a United States quaternary care center ICU between 2008-2014 were included and comprised the training *** data and clinical laboratory test collected on admission to ICU were *** under the curve receiver operator characteristics(AUROC)analysis was performed to assess the value of various scores in predicting inhospital mortality.A new predictive model,the LIV-4 score,was developed using logistic regression analysis and validated in a cohort of patients admitted to the same institution between *** Of 436 patients,119(27.3%)died in the *** multivariate analysis,a combination of the natural logarithm of the bilirubin,prothrombin time,white blood cell count,and mean arterial pressure was found to most accurately predict in-hospital *** from the regression coefficients of the independent variables,a novel model to predict inpatient mortality was developed(the LIV-4 score)and performed with an AUROC of 0.86,compared to the Model for End-Stage Liver Disease,Chronic Liver Failure-Sequential Organ Failure Assessment,and Royal Free Hospital Score,wh

关键词： Risk stratification Resource allocation Intensive care unit Acute-on-chronic liver failure Modeling Mortality

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利用沉积记录精确约束印度-亚洲大陆碰撞时间与过程

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中国科学：地球科学 2017年第3期47卷 261-283页

作者：胡修棉王建刚安慰 eduardo GARZANTI 李娟南京大学内生金属矿床成矿机制研究国家重点实验室南京大学地球科学与工程学院南京210023 中国科学院地质与地球物理研究所北京100029 合肥工业大学资源与环境工程学院合肥230009 Department of Earth and Environmental Sciences Universita di Milano-BicoccaMilano 20126Italy

精确约束印度-亚洲初始碰撞时间对于认识喜马拉雅造山过程、青藏高原隆升机制及其对环境、气候和生物的效应具有重要的意义.本文基于对西藏雅鲁藏布缝合带两侧沉积记录的研究,对印度-亚洲大陆初始碰撞时间研究进行了总结和评述,探讨了印... 详细信息

精确约束印度-亚洲初始碰撞时间对于认识喜马拉雅造山过程、青藏高原隆升机制及其对环境、气候和生物的效应具有重要的意义.本文基于对西藏雅鲁藏布缝合带两侧沉积记录的研究,对印度-亚洲大陆初始碰撞时间研究进行了总结和评述,探讨了印度-亚洲大陆初始碰撞的穿时性,重建了大陆碰撞的沉积演化.在接受以大陆间洋壳消失、陆壳-陆壳初始接触作为初始碰撞定义的前提下,利用两种方法:(1)缝合带附近深水浊积岩物源区由印度物源向亚洲物源转变的时间,(2)喜马拉雅欠充填前陆盆地启动在缝合带两侧造成的沉积环境突变或不整合的时间,精确限定印度-亚洲大陆初始碰撞时间为古新世中期((5 9±1)Ma).从喜马拉雅造山带来看,真正的初始碰撞时间比正常海相沉积结束要早20~25Ma,而磨拉石出现比初始碰撞要晚30~40Ma.基于特提斯喜马拉雅古近系沉积记录,印度-亚洲大陆初始碰撞在喜马拉雅中部和西部不存在明显的穿时性.本文从喜马拉雅地区的沉积记录角度出发,将喜马拉雅造山作用划分为四个阶段:(1)始喜马拉雅初始阶段,古新世中期-早始新世(59~52Ma),初始碰撞发生,同碰撞盆地存在深海环境,印度大陆一侧发育碳酸盐缓坡;(2)始喜马拉雅早期阶段,始新世早-中期(52~41Ma或35Ma),以发育残留的浅海沉积为特征,新特提斯海湾自西向东逐渐消亡;(3)始喜马拉雅晚期阶段,始新世末期-渐新世(41~26Ma),整个喜马拉雅和藏南地区缺乏沉积作用;(4)新喜马拉雅早期阶段,渐新世末期-早中新世(2 6~17Ma),喜马拉雅隆升,陆相磨拉石快速堆积,沿缝合带东西向发育雅鲁藏布江和印度斯河.

关键词：印度-亚洲大陆碰撞初始碰撞时间喜马拉雅造山带西藏喜马拉雅沉积记录

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Endoscopic retrograde cholangiopancreatography drainage for palliation of malignant hilar biliary obstruction——stent-in-stent or side-by-side?A systematic review and meta-analysis

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World journal of Hepatology 2021年第5期13卷 595-610页

作者： Gabriel Mayo Vieira de Souza Igor Braga Ribeiro Mateus Pereira Funari Diogo Turiani Hourneaux de Moura Maria Vitória Cury Vieira Scatimburgo joão Remíde Freitas júnior Sergio A Sánchez-Luna Renato Baracat eduardo Turiani Hourneaux de Moura Wanderley Marques Bernardo eduardo Guimarães Hourneaux de Moura Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Division of Gastroenterology Hepatology and NutritionCenter for Advanced Therapeutic EndoscopyAllegheny Health NetworkPittsburghPA 15212United States Division of Gastroenterology and Hepatology Department of Internal MedicineBasil I.Hirschowitz Endoscopic Center of ExcellenceBirminghamAL 35294United States

BACKGROUND Biliary drainage,either by the stent-in-stent(SIS)or side-by-side(SBS)technique,is often required when treating a malignant hilar biliary obstruction(MHBO).Both methods differ from each other and have distinct *** To compare both techniques regarding their efficacy and safety in achieving drainage of *** A comprehensive search of multiple electronic databases(MEDLINE,Embase,LILACS,BIREME,Cochrane)was conducted and grey literature from their inception until December 2020 with no restrictions regarding the year of publication or language,since there was at least an abstract in *** included studies compared SIS and SBS techniques through endoscopic retrograde *** analyzed included technical and clinical success,early and late adverse events(AEs),stent patency,reintervention,and procedure-related *** Four cohort studies and one randomized controlled trial evaluating a total of 250 patients(127 in the SIS group and 123 in the SBS group)were included in this *** were no statistically significant differences between the two groups concerning the evaluated outcomes,except for stent patency,which was higher in the SIS compared with the SBS technique[mean difference(d)=33.31;95%confidence interval:9.73 to 56.90,I2=45%,P=0.006].CONCLUSION The SIS method showed superior stent patency when compared to SBS for achieving bilateral drainage in *** techniques are equivalent in terms of technical success,clinical success,rates of both early and late AEs,reintervention,and procedure-related mortality.

关键词： Endoscopic retrograde cholangiopancreatography Biliary tract neoplasms Biliary Hilar Stenting Drainage

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Effectiveness of BNT162b2 and CoronaVac vaccines against omicron in children aged 5 to 11 years

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World journal of Pediatrics 2023年第10期19卷 949-960页

作者： eduardo A.Oliveira Maria Christina L.Oliveira Ana Cristina Simões e Silva Enrico A.Colosimo Robert H.Mak Mariana A.Vasconcelos Ludmila R.Silva Daniella B.Martelli Clara C.Pinhati Hercílio Martelli-júnior Department of Pediatrics Health Sciences Postgraduate ProgramSchool of MedicineFederal University of Minas Gerais(UFMG)R.Engenheiro Amaro Lanari 389/501Belo HorizonteMG30130-100Brazil Department of Statistics Federal University of Minas GeraisBelo HorizonteMGBrazil Department of Pediatrics Rady Children’s HospitalUniversity of CaliforniaLa JollaSan DiegoCAUSA Health Science/Postgraduate Program in Nursing.School of Nursing Federal University of Minas Gerais(UFMG)Belo HorizonteMG30130-100Brazil Health Science/Primary Care Postgraduate Program State University of Montes Claros(Unimontes)Montes ClarosMG39401-089Brazil

Background This study aimed to estimate vaccine effectiveness(VE)against omicron variant infection and severe corona virus disease 2019(COVID-19)in children aged 5–11 years hospitalized with acute respiratory *** A test-negative,case–control analysis was conducted from February 2022 to june *** enrolled 6950 eligible children,including 1102 cases and 5848 *** was calculated after immunization with one and two doses of BNT162b2 or *** outcomes were hospitalization with acute respiratory symptoms and detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and severe *** adjusted odds ratio for the association of prior vaccination and outcomes was used to estimate *** For fully vaccinated children,the overall estimated VE against hospitalization with SARS-CoV-2 infection was 42%[95%confidence interval(CI)26 to 54].VE peaked at 29–42 days(67%,95%CI 40%to 82%)and then declined to 19%(95%CI,−20%to 45%)at 57–120 days after the second *** BNT162b2 vaccine had a similar VE against hospitalization with SARS-CoV-2 infection(45%,95%CI,20 to 61)compared to the CoronaVac vaccine(40%,95%CI,17%to 56%).Among cases,56(5%)children died;53(94.6%)were not fully *** cases,the two-dose schedule effectiveness against ICU admission,need for invasive ventilation,severe illness,and death were 10%(95%CI,−54%–45%),22%(95%CI−70%–68%),12%(95%CI,−62%–52%),and 16%(95%CI,−77%–75%),*** For hospitalized children aged 5–11 years during the omicron-predominant period in Brazil,two doses of both vaccines had moderate effectiveness against hospitalization with acute respiratory symptoms and SARS-CoV-2 infection and offered limited protection against endpoints of COVID-19 severity.

关键词： Children COVID-19 Effectiveness Omicron Vaccine

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国际卫生机构的停滞与变革:基于制度理论的效应分析

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中国卫生政策研究 2014年第2期7卷 24-31页

作者： eduardo j. Gómez 美国罗格斯大学公共政策与管理系

近期人们普遍关注国际卫生机构适应全球卫生环境变化和各国需求的能力,但很少研究采用路径依赖和制度变迁等制度理论来分析世界卫生组织与抗击艾滋病、结核病和疟疾的全球基金为何没有很好地适应这一变化,而世界银行和联合国艾滋病规划... 详细信息

近期人们普遍关注国际卫生机构适应全球卫生环境变化和各国需求的能力,但很少研究采用路径依赖和制度变迁等制度理论来分析世界卫生组织与抗击艾滋病、结核病和疟疾的全球基金为何没有很好地适应这一变化,而世界银行和联合国艾滋病规划署却可以很好地完成转变。本文认为这些制度理论可以帮助我们更好地理解国际卫生机构在适应国际环境变化方面存在的差异,同时提出了当前政策研究和分析的一些新领域。

关键词：制度理论国际卫生机构机构与卫生政策改革

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Wavelets and Entropy for Power Quality Assessment

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American journal of Computational Mathematics 2017年第3期7卷 276-290页

作者： eduardo Antonio Cano-Plata Armando j. Ustariz-Farfán jorge H. Estrada-Estrada Department of Electrical Electronic and Computer Engineering Universidad Nacional de Colombia Manizales Colombia

In this paper, wavelet transform and entropy are evaluated using the mathematical analysis concepts of reflexibility, regularity and series obtention, these concepts remark the reason to make a selective reference framework for power quality applications. With this idea the paper used the same treatment for the two algorithms (Multiresolution and Multiscale Entropy). The wavelet is denoted to have the most power full consistence to the light off the reflexibility, regularity and series obtention. The paper proposes a power quality technique namely MpqAT.

关键词： Wavelets Entropy Reflexibility Regularity Multiresolution Multiscale

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Paroxysmal atrial fibrillation ablation:Achieving permanent pulmonary vein isolation by point-by-point radiofrequency lesions

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World journal of Cardiology 2017年第3期9卷 230-240页

作者： Alonso Pedrote juan Acosta Beatriz jáuregui-Garrido Manuel Frutos-López eduardo Arana-Rueda Arrhythmia Section Cardiology DepartmentVirgen del Rocío University Hospital41013 SevilleSpain

Pulmonary vein isolation by point-by-point radiofrequency catheter ablation constitutes the cornerstone of catheter ablation strategies for the treatment of atrial fibrillation. However, despite advances in pulmonary vein isolation ablation strategies, long-term success rates after ablation remain suboptimal, which highlights the need to develop techniques to achieve more durable lesions. Strategies proposed to improve the durability of pulmonary vein isolation can be divided into two groups: Those addressed to improving the quality of the lesion and those that optimize the detection of acute PV reconnection during the ablation procedure. This manuscript reviews the role and potential benefits of these techniques according to current clinical evidence.

关键词： Atrial fibrillation Pulmonary vein isolation Lesion durability Contact force Pulmonary vein reconnection

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