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曲美他嗪对猪心脏再灌注性心律失常的治疗作用

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中华心血管病杂志 1994年第3期22卷 216-218页

作者：肖传实 M.M.koning P.D.Verdouw 太原山西医学院第二附属医院心内科荷兰鹿特丹ＥＲＡＳＭＵＳ医学院附属医院

为研究曲美他嗪（ｔｒｉｍｅｔａｚｉｄｉｎｅ）对猪心脏再灌注性心律失常的治疗作用，我们采用两组在体猪心脏（对照组ｎ＝９，用药组ｎ＝１０）左冠状动脉前降支（ＬＤＡＣＡ）完全阻断１０分钟，再灌５分钟，重复３次。结果显示：对... 详细信息

为研究曲美他嗪（ｔｒｉｍｅｔａｚｉｄｉｎｅ）对猪心脏再灌注性心律失常的治疗作用，我们采用两组在体猪心脏（对照组ｎ＝９，用药组ｎ＝１０）左冠状动脉前降支（ＬＤＡＣＡ）完全阻断１０分钟，再灌５分钟，重复３次。结果显示：对照组心室纤颤（ＶＦ）发生率三次分别为８９％、６７％、３０％（Ｐ＜０．０１），ＶＦ潜伏期分别为１４．５±１．４ｓ、１１９．８±１３．８ｓ、４８±１２．５ｓ（Ｐ＜０．０１）。用药组ＶＦ发生率三次分别为４０％、３０％、３０％、（Ｐ＞０．０５），ＶＦ潜伏期分别为１５．２±６．４ｓ，１２６．５±１８．６ｓ，９７±２３．４ｓ（Ｐ＜０．０１）。曲美他嗪对猪心脏再灌性ＶＦ有一定的减少作用。

关键词：曲美他嗪再灌流损伤心律失常

Iterative Bayesian Monte Carlo for nuclear data evaluation

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Nuclear Science and Techniques 2022年第4期33卷 105-135页

作者： Erwin Alhassan Dimitri Rochman Alexander Vasiliev Mathieu Hursin Arjan Jkoning Hakim Ferroukhi Laboratory for Reactor Physics and Thermal-Hydraulics Paul Scherrer Institute5232 VilligenSwitzerland Division Large Research Facilities(GFA) Paul Scherrer InstituteVilligenSwitzerland Ecole Polytechnique Federale de Lausanne LausanneSwitzerland Nuclear Data Section International Atomic Energy Commission(IAEA)ViennaAustria Division of Applied Nuclear Physics Department of Physics and AstronomyUppsala UniversityUppsalaSweden

In this work,we explore the use of an iterative Bayesian Monte Carlo(iBMC)method for nuclear data evaluation within a TALYS Evaluated Nuclear Data Library(TENDL)*** goal is to probe the model and parameter space of the TALYS code system to find the optimal model and parameter sets that reproduces selected experimental *** method involves the simultaneous variation of many nuclear reaction models as well as their parameters included in the TALYS ***‘best’model set with its parameter set was obtained by comparing model calculations with selected experimental *** experimental data types were used:(1)reaction cross sections,(2)residual production cross sections,and(3)the elastic angular *** improve our fit to experimental data,we update our‘best’parameter set—the file that maximizes the likelihood function—in an iterative *** was determined by monitoring the evolution of the maximum likelihood estimate(MLE)values and was considered reached when the relative change in the MLE for the last two iterations was within 5%.Once the final‘best’file is identified,we infer parameter uncertainties and covariance information to this file by varying model parameters around this *** this way,we ensured that the parameter distributions are centered on our *** proposed method was applied to the evaluation of p+^(59)Co between 1 and 100 ***,the adjusted files were compared with experimental data from the EXFOR database as well as with evaluations from the TENDL-2019,JENDL/He-2007 and JENDL-4.0/HE nuclear data libraries.

关键词： Iterative Bayesian Monte Carlo(iBMC) Nuclear reaction models Model parameters Adjustments Bayesian calibration Nuclear data TALYS

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责任金融：将原则付诸实践

科学决策 2013年第11期 24-42页

作者： Mekee,Lahaye koning CGAP(Consultative Groupto Assistthe Poor)

小额金融具有双重底线的特征,近年来爆发的信贷危机凸显双重底线之间存在的矛盾冲突。基于此,有必要对双重底线进行重新平衡,而出路就是实施责任金融战略。文章首先界定了责任金融的内涵;随后从行业自我监管、政府监管、消费者能力提高... 详细信息

小额金融具有双重底线的特征,近年来爆发的信贷危机凸显双重底线之间存在的矛盾冲突。基于此,有必要对双重底线进行重新平衡,而出路就是实施责任金融战略。文章首先界定了责任金融的内涵;随后从行业自我监管、政府监管、消费者能力提高三个方面探讨了责任金融对客户保护的三个战略;最后结合实践发展现状提出了推动责任金融发展的建议。

关键词：责任金融双重底线客户保护

SuperSAGE digital expression analysis of differential growth rate in a European sea bass population

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Aquaculture and Fisheries 2019年第1期4卷 17-26页

作者： Bruno Louro Rute S.T.Martins Patricia I.S.Pinto Richard Reinhardt Dirk-Jan de koning Adelino V.M.Canario Deborah M.Power CCMAR-Centre of Marine Sciences University of AlgarveCampus de GambelasFaro 8005-139Portugal Max Planck Genome Centre Carl-von-Linne-Weg 10Köln 50829Germany The Roslin Institute and R(D)SVS University of EdinburghEaster BushMidlothian EH259RGScotland UK Department of Animal Breeding and Genetics Swedish University of Agricultural SciencesBox 7023Uppsala 75007Sweden

One of the goals of the aquaculture industry is to understand and control growth associated traits through selective *** the present study the molecular basis of growth heterogeneity in the European sea bass(Dicentrarchus labrax)was *** establish growth heterogeneity in a group of hatchery bred sea bass individuals were tagged and their specific growth rates(SGR)determined at monthly *** expression in the brain,liver and white muscle from fish with the most divergent sustained SGR(6 individuals of the first and last quartile)was assessed using SuperSAGE(Serial Analysis Gene Expression)combined with next generation SOLiD4 sequencing.A total of approx.11 million edited tags(26 bp),on average 2 million tags per SAGE library,that represented 47.071 unique transcripts were *** of transcripts in fish with high and low SGR yielded 344,698 and 601 differently expressed tags(0.01%false discovery rate and 4-fold change)in brain,liver and muscle,*** tags were mapped onto the sea bass genome and approximately one third of the tags could be assigned to annotated *** enrichment analysis revealed in liver,muscle and brain intricate gene expression changes in endocrine regulatory pathways involved in growth,metabolic and the stress axis,underlying divergent SGR in sea bass.

关键词： European sea bass Specific growth rate Gene expression SuperSAGE Pathways

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3-氯丙二醇测定新法

实验与分析 2013年第3期 30-31页

作者： Sjaak De koning Leco公司欧洲生命科学与化学分析中心(LSCA)

食用植物油中普遍存在3-氯丙二醇（3-MCPD）．该物质对人体健康的危害性至今尚无定论。然而，对它的鉴定分析已成为食品安全的热点之一。本文介绍了将大体积进样（LVI）与二维气相-飞行时间质谱（GC×GC—TOF-MS）相结合的方式．

关键词：氯丙二醇测定飞行时间质谱食用植物油大体积进样人体健康食品安全

Multiple Comprehensive Chromatography in edible and mineral oil analysis:LC×GC-,GC×GC-and LC×GC×GC-ToF-MS

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Multiple Comprehensive Chromatography in edible and mineral ...

第十五次全国色谱学术报告会

作者： Hans-Gerd Janssen Sjaak de koning Udo A.Th.Brinkman Unilever Research and Development Advanced Measurement and Imaging P．O．Box 1143130 AC Vlaardingenthe Netherlands LECO instruments Separation Science Group Marie-Bernays-Ring 31 41199 MngengladbachGermany Free University of Amsterdam De Boelelaan 1083 1081HV Amsterdamthe Netherlands

＜正＞Introduction Comprehensive chromatography （CC） is an excellent separation method for the analysis of extremely complex samples. The most widely employed mode of CC is comprehensive GC×GC. In comprehensive GC×GC both dimensions offer an excellent separation efficiency, but the difference in selectivity between the two dimensions is

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全自动化挤奶系统发展历程

中国奶牛 2012年第17期 50-55页

作者： Keesde koning 肖智毅荷兰瓦格宁根畜牧研究所利拉伐(上海)乳业机械有限公司上海200331

10奶牛流向进入挤奶系统后，奶牛应由通道进入饲喂区。在“强迫式流向”系统中，奶牛必须在进入了挤奶系统后才能进入饲喂区。在“受控式流向”系统中。具有奶牛识别和容量选择功能的单向门将限制奶牛直接走向饲喂区，只有在最后一次挤... 详细信息

10奶牛流向进入挤奶系统后，奶牛应由通道进入饲喂区。在“强迫式流向”系统中，奶牛必须在进入了挤奶系统后才能进入饲喂区。在“受控式流向”系统中。具有奶牛识别和容量选择功能的单向门将限制奶牛直接走向饲喂区，只有在最后一次挤奶超出了预设的最低值时才能走向饲喂区。

关键词：挤奶系统全自动化容量选择奶牛饲喂强迫式最低值

Assessing the quality of life of children with mental disorders using a computer-based self-reported generic instrument (KidIQoL)—Quality of life of children with mental disorders

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Open Journal of Psychiatry 2011年第1期1卷 8-14页

作者： Melanie White-koning Martine Gayral-Taminh Valérie Lauwers-Cancès Hélène Grandjean Jean-Philippe Raynaud 不详

OBJECTIVE: To assess the self-reported quality of life (Qol) of children with various mental disorders and compare the scores in this population with those in children without such problems. METHODS: Self- reported Qol was assessed using KidiQoL, a generic computer-based tool with 44 items exploring four domains (Physical and psychological health, Family life, School life and Social and physical environment). The study group consisted of 139 children (111 boys and 28 girls) aged between 6 and 12 years (mean age 9.1 years) referred to an outpatient mental health unit for mental disorders, 29 of whom completed the questionnaire about 2 weeks later in order to assess test-retest reliability. The comparison group consisted of 130 children from the general population, aged 6 to 12 years (mean age 9.0 years) and attending main- stream schools in the same geographical area. RE- SULTS: The test-retest reliability of the instrument was very good with an intraclass correlation coefficient of 0.97 for the total score and above 0.90 in all domains. No significant differences in domain and total scores were observed according to gender or developmental age. Children with developmental disorders or schizophrenia reported significantly lower QoL in the Health domain than children with other types of mental disorders. In all domains and for the total score, the children with mental disorders re- ported significantly lower QoL than the children from the general population;CONCLUSION: KidIQoL has been found suitable and psychometrically valid in children with mental disorders. Its use could help the assessment and adaptation of psychiatric care.

关键词： Quality of Life Mental Disorder Children

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全自动化挤奶系统发展历程

中国奶牛 2012年第16期 44-47页

作者： Kees de koning 肖智毅荷兰瓦格宁根畜牧研究所利拉伐(上海)乳业机械有限公司上海200331

本文概述了全自动化挤奶系统的发展历程,并讨论了此系统当前所面临的形势、可能存在的挑战以及未来的发展机遇。

关键词：全自动化挤奶系统发展机遇