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Antihyperglycemic Activity of Moringa oleifera Lam Leaf Functional Tea in Rat Models and Human Subjects

Food and Nutrition Sciences 2016年第11期7卷 1021-1032页

作者： edith N. Fombang Romuald Willy Saa Department of Food Science and Nutrition National School of Agro-Industrial Sciences (ENSAI) University of Ngaoundere Ngaoundere Cameroon

Maintenance of glycemic control is important in preventing diabetes and its associated complications. Considering the current recommended approach for the use of functional foods and their bioactive components in the prevention and management of diabetes, the aim of this study was to determine the antihyperglycemic effect of Moringa oleifera functional tea in rat models and in normoglycemic human volunteers using the oral glucose tolerance test (OGTT). Moringa tea prepared by extracting Moringa leaf powder in distilled water (1:20 mg/ml) at 97°C for 30 min was administered at different doses to male Wistar rats and human volunteers prior to glucose loading. Blood glucose was measured at intervals of 30 min for 150 min. Consumption of Moringa tea prior to glucose loading suppressed the elevation in blood glucose in all cases compared to controls that did not receive the tea initially. The degree and pattern of decrease however, were dose dependent. In rats, intermediate doses of 20 ml/kg BW were more effective in reducing blood glucose overall (18.2%) vs 13.3% and 6% at doses of 10 and 30 ml/kg BW respectively. In humans, the final decrease in blood glucose was not significantly different for high 400 ml (19%) and low 200 ml (17%) doses. Of interest here was the pattern of decrease, being significantly higher (p < 0.05) at 30 min with 200 ml (22.8%) than with 400 ml (17.9%). It is suggested that low doses exert their antihyperglycemic effect more at intestinal level by inhibiting glucose absorption, whereas high doses exert their effect more in circulation. We conclude that Moringa oleifera tea has potential as a functional food in the management of hyperglycemia.

关键词： Moringa oleifera Functional Tea Antihyperglycemic Activity Phenolic Compounds Antioxidant Activity Humans Rats

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Calcineurin B-like interacting protein kinase OsCIPK23 functions in pollination and drought stress responses in rice (Oryza sativa L.)

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Journal of Genetics and Genomics 2008年第9期35卷 531-543页

作者： Wenqiang Yang Zhaosheng Kong edith Omo-Ikerodah Wenying Xu Qun Li Yongbiao Xue Institute of Genetics and Developmental Biology Chinese Academy of Sciences National Centre for Plant Gene Research Beijing 100190 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

Drought is very harmful to grain yield due to its adverse effect on reproduction, especially on pollination process in rice. However, the molecular basis of such an effect still remains largely unknown. Here, we report the role of a member of CBL （Calcineurin B-Like） Interacting Protein Kinase （CIPK） family, OsCIPK23, in pollination and stress responses in rice. Molecular analyses revealed that it is mainly expressed in pistil and anther but up-regulated by pollination, as well as by treatments of various abiotic stresses and phytohormones. RNA interference-mediated suppression of OsCIPK23 expression significantly reduced seed set and conferred a hypersensitive response to drought stress, indicating its possible roles in pollination and drought stress. In consistent, overexpression of OsCIPK23 induced the expression of several drought tolerance related genes. Taken together, these results indicate that OsCIPK23 is a multistress induced gene and likely mediates a signaling pathway commonly shared by both pollination and drought stress responses in rice.

关键词： OsCIPK23 water pollination drought rice (Oryza sativa L.)

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Baossi–Warack monogenetic volcanoes, Adamawa Plateau,Cameroon: petrography, mineralogy and geochemistry

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Acta Geochimica 2019年第1期38卷 40-67页

作者： Anicet Feudjio Tiabou Robert Temdjim Pierre Wandji Jacques-Marie Bardintzeff Vivian Bih Che edith Ekatah Bate Tibang Caroline Neh Ngwa Fran?ois Xavier Onana Mebara Remote Sensing Unit Faculty of Science Department of Geology University of Buea Department of Earth Sciences Faculty of Science University of Yaoundé 1 Laboratoire de Géologie Ecole Normale Supérieure de Yaoundé Univ.Paris-Sud Sciences de la Terre VolcanologiePlanétologie UMR CNRS 8148 GEOPS Bat.504 Université Paris-Saclay Higher Teacher Training College Department of GeologyUniversity of Bamenda Institute for Geological and Mining Research (IRGM) Institute for Geological and Mining Research (IRGM) Branch of Volcanologic and Geophysics Research (ARGV)

Three monogenetic cones in the Baossi–Warack area, Ngaoundéré, Adamawa Plateau forming part of the Cameroon Volcanic Line(CVL) are documented in this study. Basaltic lavas(<1 km^3) scattered around these vents and restricted volcaniclastic deposits were emplaced by Hawaiian and mild strombolian style eruptions. The lavas are porphyritic, mainly composed of olivine(chrysolite) and clinopyroxene(diopside and augite) phenocrysts and plagioclase(andesine) microphenocrysts. Accessory minerals include titano-magnetite and titano-hematite, nepheline,apatite and amphibole xenocrysts. Sanidine occurs in some samples and sodi-potassic albite in others. Some olivines and clinopyroxenes exhibit resorbed margins and thin reaction rims while plagioclase displays oscillatory zoning, and sieved textures as a result of magma mixing. Whole-rock geochemistry data indicates that the lavas are silica-undersaturated, composed of basanites and basalts, showing little compositional variations(SiO_2: 39.20 wt.%–48.01 wt.%,MgO: 5.29 wt.%–9.70 wt.%). Trace elements patterns of these lavas suggest they are enriched in LILE including Pb,probably due to crustal contamination. REE patterns suggest cogenetic magmas below Baossi 1 and Baossi 2 volcanoes,and distinct sources below Warack volcano and nearby *** lavas studied show affinity to high-μ(HIMU), enriched type Ⅰ(EM1) and Oceanic Island Basalt(OIB)-like mantle signatures and thus indicate a heterogeneous mantle source underneath the vents as noted at other monogenetic and polygenetic volcanoes along the CVL. Primary melts derived from low degrees of partial melting(0.5%–2%) and encountered low rates of fractionation, and crustal contamination coupled with magma mixing. These melts evolved independently through structural weaknesses in the basement.

关键词： Cameroon volcanic line Adamawa Plateau Volcanic field Monogenetic volcano Magma mixing Petrogenesis

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LSD1 is required for euchromatic origin firing and replication timing

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1703-1718页

作者： Yue Wang Yunchao Huang edith Cheng Xinhua Liu Yu Zhang Jianguo Yang Jordan T.F.Young Grant W.Brown Xiaohan Yang Yongfeng Shang Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesHangzhou Normal UniversityHangzhou 311121China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Biochemistry and Donnelly Centre University of TorontoTorontoON M5S 1A8Canada Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital600 University Ave.TorontoON M5G 1×5Canada

The chromatin-based rule governing the selection and activation of replication origins remains to be *** is believed that DNA replication initiates from open chromatin domains;thus,replication origins reside in open and active ***,we report here that lysine-specific demethylase 1(LSD1),which biochemically catalyzes H3K4me1/2 demethylation favoring chromatin condensation,interacts with the DNA replication machinery in human *** find that LSD1 level peaks in early S phase.

关键词： origin LSD1 replication

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白消安、依托泊苷和环磷酰胺与大剂量马法兰作为多发性骨髓瘤患者自体造血干细胞移植预处理方案的疗效比较

白消安、依托泊苷和环磷酰胺与大剂量马法兰作为多发性骨髓瘤患者...

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作者： edith Henry Kimambo 山东大学

学位级别：硕士

研究背景:大剂量马法兰（high-dose melphalan,HDM）是多发性骨髓瘤（multiple myeloma,MM）自体造血干细胞移植（autologous hematopoietic stem cell transplantation,autoHSCT）前的标准预处理方案。尽管患者的反应率和存活率有所提高,但复发率和与方案相关的安全性仍然是一个挑战。目的:本研究主要目的是比较接受白消安、环磷酰胺和依托泊苷（BVC）和HDM作为自体造血干细胞移植预处理方案的MM患者的疗效和预处理毒副作用的差异。方法:对2015年8月至2020年12月期间来自山东省3个主要移植中心（山东大学齐鲁医院、山东省立医院和山东省千佛山医院）的29-65岁（中位年龄52岁）接受自体造血干细胞的78例MM患者进行回顾性分析。37名患者接受BVC预处理方案,而41名患者接受HDM预处理方案。多发性骨髓瘤的诊断使用IMWG标准进行,并使用国际分期系统进行分期。纳入标准包括肌酐低于***/dL、无活动性感染或经肺功能检查确定的严重阻塞性和/或限制性肺疾病（即DLCO＜50%和/或FEV1＜50%和/或FVC＜50%）且心脏射血分数（EF）大于40%的成人（年龄在18-65岁之间）。患者首先接受若干个周期的诱导化疗（通常为3-6个周期）,对疗效达部分缓解以上的患者进行干细胞动员和收集。自体外周血造血干细胞（PBHSCs）用作自体干细胞移植细胞。76例患者接受大剂量环磷酰胺联合粒细胞集落刺激因子（G-CSF）化疗动员采集外周血造血干细胞。2名患者使用plerixafor联合G-CSF稳态动员采集干细胞。CD34+细胞平均采集量为4.61 × 106/kg。CD34+细胞最小采集量为2×1 06个/kg。37名MM患者接受BVC预处理方案:白消安在-7天、-6天和-5天以0.8mg/kg/天静脉注射。依托泊苷在-5天和-4天以400mg/m2/天静脉给药,环磷酰胺在-3天和-2天以50mg/m2/天静脉内给药。41名MM患者接受HDM预处理方案:马法兰总剂量为200mg/m2,分成-3天和-2天静脉注射,然后进行自身HSCT。预处理方案对待评估的移植受者中发生的毒副作用毒性的影响如下:a.方案相关的毒性;包括血液学毒性和非血液学毒性。b.中性粒细胞和血小板植入的时间。c.住院时间。要分析的结果包括:a.移植后疾病的反应状态。b.移植1年时复发率。c.移植后100天内的移植相关死亡率。d.移植 1 年时无进展生存期（progression-free survival,PFS）。e.移植1年时的总生存期（overall survival,OS）。使用SPSS版本26对两组之间的数据进行分析和比较。描述性统计用于报告结果,包括人口统计学,疾病相关因素和移植相关因素。使用Kaplan-Meier方法估计PFS和OS的概率,并使用Log-rank检验对组进行比较。使用Cox比例风险回归模型对OS,PFS和累积复发发生率进行多变量分析,该模型用于估计与HDM相比BVC的风险比（HR）。结果:本研究共纳入MM患者78例,其中37名患者在接受BVC 预处理方案后接受autoHSCT,而41名患者在接受HDM预处理方案后接受autoHSCT。两组的总缓解率（ORR）、PFS、OS和复发率在统计学上相似。BVC组的中位随访时间为540天,HDM组为436天。HDM组肺毒性发生率显著增加（BVC为36.6%对5.4%,P=0.002）。BVC组患者的住院时间明显长于HDM组（中位数20天,范围:BVC为18-27;与中位18天范围:HDM为13-27,P＜0.0001）。BVC组（7天,范围:4-12）中性粒细胞减少的中位持续时间明显长于HDM组(6天,范围:（2-12）;P=0.002。有两例TRM病例,每组一例。在多变量亚组分析中,BVC调理在PFS、OS和复发方面与HDM调理有统计学相似。但是,低风险疾病分期显示可以预测PFS和复发的累积发生率,ISSⅠ和ISSⅡ疾病阶段的患者PFS明显更长;（ISS Ⅰ:HR=0.186,P=0.006,ISS Ⅱ:HR=0.240,P=0.022）;并延迟复发时间;（ISSⅠ:HR=0.220,P=0.013,ISS Ⅱ:HR=0.262,P=0.036）。β-2 微球蛋白预测 OS,β-2微球蛋白水平升高显示显著恶化OS（HR=1.356,P=0.041）。年龄,性别,MM亚型,KPS,移植前使用的化疗方案/周期数或移植时的疾病状况与两组的PFS,OS或复发率无关。结论:尽管两种方案的反应率和生存率似乎相似,但与HDM方案相比,BVC方案在非血液学毒性（肺毒性）方面似乎更优越,但在血液学毒性（血细胞减少）方面较差。本研究显示BV

关键词：自体干细胞移植预处理方案多发性骨髓瘤生存期毒副作用

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矿业出口对莱索托经济增长的影响

矿业出口对莱索托经济增长的影响

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作者： Motena edith Matala 江西财经大学

学位级别：硕士

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Metabolic complications in liver transplant recipients

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World Journal of Gastroenterology 2016年第28期22卷 6416-6423页

作者： Miguel Jiménez-Pérez Rocío González-Grande edith Omonte Guzmán Víctor Amo Trillo Juan Miguel Rodrigo López UGC de Aparato Digestivo Unidad de Hepatología-Trasplante Hepático Hospital Universitario Regional de Málaga

The metabolic syndrome(MS), which includes obesity,dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease(CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1.78. On the other hand, non-alcoholic fatty liver disease(NAFLD), considered as the manifestation of the MS in the liver, is now the second leading reason for liver transplantation in the United States after hepatitis C and alcohol. NAFLD has a high rate of recurrence in the liver graft and a direct relation with the worsening of other metabolic disorders, such as insulin resistance or diabetes mellitus. Consequently, it is vitally important to identify and treat as soon as possible such modifiable factors as hypertension, overweight, hyperlipidaemia or diabetes in transplanted patients to thus minimise the impact on patient survival. Additionally, steroid-free regimens are favoured, with minimal immunosuppression to limit the possible effects on the development of the MS.

关键词： Metabolic syndrome Liver transplantation Immunosuppressions Risk factors Non-alcoholic fatty liver disease

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Perinatal Outcome of Inadvertent Immunization with the Measles-Rubella Vaccine in Pregnant Mexican Women during the Campaign for the Eradication of Congenital Rubella in 2008

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World Journal of Vaccines 2011年第1期1卷 1-4页

作者： Reyna Jesus Herbas Ilse Gómez Misael Vidal Patricia Richardson Vesta Cruz edith Cruz edith National Center for the Health of the Childhood and the Adolescence Ministery of Health Mexico

Objective: To investigate maternal and neonatal complications resulting from inadvertent immunization against rubella-measles during the first trimester of pregnancy. Methods: A prospective and descriptive study was carried out, including a total of 1,924 pregnant women, 175 (9.1%) of which were classified as non responding to infection by the rubella virus. They underwent clinical and ultrasonographic follow-up to dismiss maternal or fetal complications and complications at the time of delivery. The infant was checked to determine demographic, anthropometric, serological and clinical features at the time of birth. Results: No women had complications during the pregnancy, including exanthematic symptoms. 174/175 newborns were studied;one pregnancy was interrupted based on non-medical arguments. The findings in terms of the analyzed patients suggest a benign evolution after inadvertently immunizing the pregnant women, which support studies with similar results. No complications during the course of the pregnancy or phenotypic alterations of the infant at the time of birth are suggested.

关键词： Congenital Rubella Pregnancy Perinatal Repercussion

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莱索托的社会救助——制度效果及改善对策研究

莱索托的社会救助——制度效果及改善对策研究

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作者： Teboho edith Rabale（艾静）南昌大学

学位级别：硕士

社会援助已成为抗击贫困和脆弱性的新范式,这使社会援助成为当前最重要的反贫困政策手段之一。社会援助计划旨在根据年龄和公民身份原则,为生活在贫困或脆弱境况中的人们提供收入或实物支持,而没有固有的条件限制。社会援助是福利国家... 详细信息

社会援助已成为抗击贫困和脆弱性的新范式,这使社会援助成为当前最重要的反贫困政策手段之一。社会援助计划旨在根据年龄和公民身份原则,为生活在贫困或脆弱境况中的人们提供收入或实物支持,而没有固有的条件限制。社会援助是福利国家的重要组成部分。每个国家都有一些社会援助,但是其结构、资格标准和阻碍其有效性方面可能会有所不同。社会援助是必不可少的公共服务,是任何市场经济的核心要素。各国政府有责任确保其公民,特别是最弱势群体的福祉,因此莱索托政府已经意识到这一点并采取了适当措施,以促进社会中处境不利群体的机会均等,并使他们充分参与所有领域公共生活。莱索托政府的社会支持系统拥有悠久历史,并已成为撒哈拉以南非洲正式社会援助计划的先驱。尽管莱索托政府取得了一定的成就,但当前的社会救助体系仍然存在许多问题,如排斥/缺乏全面支持的问题。也就是说,由于该计划覆盖面较低,仍有一些弱势群体得不到社会救助服务。与此同时,莱索托的山区和难以到达的地形对社区来说,即使是最近的社会援助设施也构成了严峻的挑战、一些人不明白自己是否有资格被纳入莱索托。莱索托继续在制定各种辅助性社会援助程序方面保持高度创新,并努力协调和协调所有现有的核心社会援助方案(儿童补助金、OVC补助金、养老金和公共援助)。本研究基于对莱索托现有社会援助计划,其发展方式和有效性的描述性分析,分析了影响社会救助体系有效性的问题,包括系统本身的设计不足、社会救助组织的不合理建设以及系统外部的整合压力(政治、国际外部力量和腐败)。然后,本文讨论了提高莱索托社会援助有效性的对策,并就如何改善其现有系统提供了见解。

关键词：社会救助政策有效性体制改革莱索托

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Recharge and Groundwater Quality of an Alluvial Aquifer： Case of the City of N＇djamena （Chad）

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Journal of Environmental Science and Engineering(B) 2017年第10期6卷 493-505页

作者： edith Kadjangaba Frederic Huneau Yves Travi Daira Djoret . Laboratory of Water and Environment Faculty of Exact and Applied Sciences University of N'djamena N'djamena 1027 Chad Laboratory of Hydrogeology University of Corsica Pascal PaolL Grimadi Campus Corte 52 F-20250 France Laboratory of Hydrogeology University of Avignon and the Countries of Vaucluse Jean Henry FABRE Campus Baruch de Spinoza 31239 84916 France

Isotopic tracers and water quality indicators （TDS （Total Dissolved Solid）, Cl^- and NO3^-contents） were used to characterize the recharge and control of the quality of groundwater in the alluvial aquifer beneath of the N＇djamena city. For this study, a total of 92 waters samples were taken and this included 67 wells, 21 pumps and 4 surface waters. Some groundwater has 6180 and 62H values close to those of the city of N＇djamena and/or the Chad river rains. However, all sampled points are below the Global Meteoric Water Line reflecting their evaporated characters. The interpretation of the isotopic tracers highlights that the recharge of the analyzed ground waters may result from two major mechanisms：（1） direct infiltration of local precipitation; （2） lateral inflow of river waters. The upper aquifer is the most vulnerable to pollution, especially during the recharge period. This pollution is due to the leaching of soils during the rainy season and the rise of the groundwater level which accompanies the overflowing of the Chad and causes the leaching of the polluted horizons of the unsaturated zone. In contrast, the lower aquifer has acceptable concentrations of solutes.

关键词： Groundwater stable isotope water quality recharge N'djamena city.

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