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Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study

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World Journal of Gastroenterology 2013年第35期19卷 5837-5847页

作者： Greetje J Tack Jolanda MW van de Water Maaike J Bruins Engelina MC Kooy-Winkelaar Jeroen van Bergen Petra Bonnet Anita CE Vreugdenhil Ilma Korponay-Szabo Luppo Edens B Mary E von Blomberg Marco WJ Schreurs Chris J Mulder Frits koning Department of Gastroenterology and Hepatology VU University Medical Centre DSM Biotechnology Centre Department of Immunohematology and Blood Transfusion Leiden University Medical Centre Department of Pathology VU University Medical Centre Department of Paediatrics University Hospital Maastricht Department of Paediatrics University of Debrecen Paediatric Research Centre University of Tampere

AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease(AN-PEP)to mitigate the im-munogenic effects of gluten in celiac ***:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet(GFD)resulting in normalised antibodies and mucosal healing classified as Marsh 0 orⅠwere *** a randomised double-blind placebo-controlled pilot study,patients consumed toast(approximately 7 g/d gluten)with AN-PEP for 2 wk(safety phase).After a 2-wk washout period with adherence of the usual GFD,14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk(efficacy phase).Measurements at baseline included complaints,quality-of-life,serum antibodies,immunophenotyping of T-cells and duodenal mucosa ***,serum and quality of life questionnaires were collected during and after the safety,washout and efficacy *** biopsies were collected after the safety phase and after the efficacy phase.A change in histological evaluation according to the modified Marsh classification was the primary ***:In total,16 adults were enrolled in the *** serious adverse events occurred during the trial and no patients withdrew during the *** mean score for the gastrointestinal subcategory of the celiac disease quality(CDQ)was relatively high throughout the study,indicating that AN-PEP was well *** the efficacy phase,the CDQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were *** the efficacy phase,neither the placebo nor the AN-PEP group developed significant antibody *** IgA-EM concentrations remained negative in both *** patients were excluded from entering the efficacy phase as their mucosa showed an increase oftwo Marsh steps a

关键词： Celiac disease Gluten Enzyme Prolyl endoprotease Aspergillus niger prolyl endoprotease Treatment Adverse events efficacy IgA-tTG intestinal deposits

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责任金融:将原则付诸实践

西部金融 2013年第1期 30-39页

作者： Katharine McKee Estelle Lahaye Antonique koning

小额金融早期的开拓者们抱着改善穷人生活的愿望建立了小额金融这一部门。当时金融服务方面存在大块的“空白”，低收人家庭几乎无法获得正式的金融服务。因此，要应付这一挑战，需要有一个能够为穷人提供充分的金融服务的可持续、可扩... 详细信息

小额金融早期的开拓者们抱着改善穷人生活的愿望建立了小额金融这一部门。当时金融服务方面存在大块的“空白”，低收人家庭几乎无法获得正式的金融服务。因此，要应付这一挑战，需要有一个能够为穷人提供充分的金融服务的可持续、可扩展的模式。

关键词：金融服务实践责任低收人家庭 “空白” 开拓者穷人

一种从冠状动脉X线造影生成最佳投照角度的新方法

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中华放射学杂志 2011年第2期45卷 195-198页

作者：涂圣贤魏向龙宋旭东郝培远黄铮 koning Gerhard Reiber Johan HC 2300 RC Leiden Department of Radiology LeidenUniversity Medical Center 南方医科大学珠江医院心内科广州510282 南方医科大学南方医院心内科

虽然冠状动脉介入治疗是治疗冠心病最主要的方法之一，但其一定比例的再狭窄率以及由再狭窄和支架内血栓所导致的高病死率和高致残率仍限制着该方法的进一步应用。

关键词：冠状动脉介入治疗最佳投照角度 x线造影再狭窄率支架内血栓冠心病致残率病死率

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在Ka波段上全波段参差增益耿效应放大

微纳电子技术 1976年第5期 60-63页

作者： J.G.De koning 李继国

使用参差增益放大方法已经证明了在 Ka 波段上全波段低噪声瞬时放大的可能性。利用对这两级放大器总增益变化的简化分析计算了满足最大允许波纹所需的最小隔离电平。用这个方法,已经得到26.6～39.4千兆赫、10±2.2分贝增益。

关键词：全波段环行器频带反射型高频段低频段频程 Ka 放大器电路

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腰围或腰臀比增加与心血管事件风险增加相关

英国医学杂志中文版 2008年第2期11卷 110-111页

作者： de koning L Merchant AT Pogue J 朱瑶(译) Waist circumference and waist-to-hip ratio as predictors of cardiovascular events : metaregression analysis of prospective studies. Eur Heart J 2007 不详

问题：腰围或腰臀比（WHR）与心血管疾病（CVD）有什么联系？方法资料来源：Medline（1966年至2006年11月），EMBASE／医学文摘（Excerpta Medica）（1980年至2006年第45周），Cochrane图书馆（至2006年），相关研究及作者的文献。

关键词：腰臀比心血管事件 Cochrane图书馆腰围风险心血管疾病

心肌缺血性应激力对再灌注性心律失常的保护作用

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山西医药杂志 1993年第4期22卷 255-256页

作者：肖传实刘晓玲周毅 MM koning PD Verdouw 山西医学院第二附属医院大同市第三人民医院荷兰鹿特丹Erasmus大学附属医院

为研究缺血性应激力（ＩｓｃｈｅｍｉｃＰｒｅｃｏｎｄｉｔｉｏｎｉｎｇＩＰＣ）对猪心再灌注（ＲｅｐｅｒｆｕｓｉｏｎＲｅＰ）性心律失常的影响，二组载体猪心（对照组ｎ＝９，治疗组ｎ＝１０）的左冠状动脉前降支完全阻断１０分钟／... 详细信息

为研究缺血性应激力（ＩｓｃｈｅｍｉｃＰｒｅｃｏｎｄｉｔｉｏｎｉｎｇＩＰＣ）对猪心再灌注（ＲｅｐｅｒｆｕｓｉｏｎＲｅＰ）性心律失常的影响，二组载体猪心（对照组ｎ＝９，治疗组ｎ＝１０）的左冠状动脉前降支完全阻断１０分钟／ＲｅＰ５分钟，重复３次。对照组：室颤（ＶＦ）发生率为８９％、６７％、３０％，Ｐ＜０．０１，发生时间（秒）１４．５±１．４，１１９．８±１３．８，４８±１２．５，Ｐ＜０．０１。治疗组：ＶＦ发生率为４０％，３０％，３０％，发生时间（秒）１５．２±６．４，１２６．５±１８．６，９７±２３．４，Ｐ＜０．０１。心肌缺血性应激力对猪心ＲｅＰ性心律失常具有保护作用。

关键词：再灌注心肌缺血应激力心律失常

估测卵泡期早期卵泡刺激素(FSH)水平增高的患者卵泡发育终末期初始化的FSH阈值

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 28-29页

作者： De koning C.H. Schoemaker J. Lambalk C.B. 石磊

To test the hypothesis that the folli cle -stimulating hor-mone(FSH)threshold in patients with elevated FSH levels in the early follicular phase(EFP)is higher than in *** *** *** patients with elevated EFP FSH(>10IU /L)and ***-ment with a GnRH agonist in the midlut eal phase before IV administration of recombinant FSH w as started in an ul-tra -low -dose step -up *** FSH threshold was determined by the mean of FSH levels o f the above threshold value and the below thresh old *** -stimulating hormone threshold,FSH screening value,E 2,number of *** FSH threshold in the elevated EFP FSH group was 6.75IU /L and was significantly higher than the FSH threshold of the controls(4.65IU /L).The FSH screening value on day 3was 12.0I U /L in the pa-tient group and 5.0IU /L in the contro *** significantly lower on the day that t he largest follicle was 18mm in the elevated EFP FSH group compared with controls(277vs.491pmol /L,respectively)-.On the day of hCG administration,the number of sm aller(10-13mm)follicles was equal but the number of larger(>14mm)follicles was higher in the control g roup compared with the elevated FSH *** the contro l group,the basal FSH levels correlated highly with th e FSH threshold levels(r =0.8),but in the patients with elevated EFP FSH this correlation was *** normal wo men,basal FSH day 3values represent the ovarian thresh old for *** womenwith elevated day 3FSH,the FSH threshold is higher but not as high as basal FSH *** postulate that the FSH threshold in patients with elevated EFP FSH is higher be-cause of intraovarian *** l FSH overshoots the threshold,probably because of the l imited feedback by the ovary.

关键词：卵泡发育 FSH 卵泡刺激素卵泡数目黄体中期小卵泡大卵泡高阈激动剂试点研究

荷兰全科门诊1987年和2001年脓疱病的发病率和治疗——2项国家调查结果

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 19-20页

作者： koning S. Mohammedamin R.S.A. Van Der Wouden J.C. 王琼 Department of General Practice Erasmus MC University Medical Centre Rotterdam PO Box 1738 3000 DR Rotterdam Netherlands

Background: Impetigo is a common skin infection in children. The epidemiology is relatively unknown, and the choice of treatment is subject to debate. Objective: The objective of our study was to determine the incidence and treatment of impetigo in Dutch general practice, and to assess trends between 1987 and 2001. Methods: We used data from the first (1987) and second (2001) Dutch national surveys of general practice. All diagnoses, prescriptions and referrals were registered by the participating general practitioners (GPs), 161 and 195, respectively. Results: The incidence rate of impetigo increased from 16.5 (1987) to 20.6 (2001) per 1000 person years under 18 years old (P < 0.01). In both years, the incidence was significantly higher in summer, in rural areas and in the southern region of the Netherlands, compared with winter, urban areas and northern region, respectively. Socioeconomic status was not associated with the incidence rate. From 1987 to 2001, there was a trend towards treatment with a topical antibiotic (from 43%to 64%), especially fusidic acid cream and mupirocin cream. Treatment with oral antibiotics (from 31%to 14%) and antiseptics (from 11%to 3%) was prescribed less often. Conclusions: We have shown an increased incidence of impetigo in the past decade, which may be the result of an increased tendency to seek help, or increased antibiotic resistance and virulence of Staphylococcus aureus. Further microbiological research on the marked regional difference in incidence may contribute to understanding the factors that determine the spread of impetigo. Trends in prescribing for impetigo generally follow evidencebased knowledge on the effectiveness of different therapies, rather than the national practice guideline.

关键词：治疗情况全科门诊发病率脓疱病荷兰调查结果莫匹罗星软膏 18岁以下人群金黄色葡萄球菌口服抗生素

肛门失禁女性患者的排便造影异常与症状及肛门超声内镜影像的关系

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 58-59页

作者： Savoye- Collet C. Savoye G. koning E. Dacher J.- N. 程欣 Radiology Department Rouen Univ. Hospital Charles NiColle 1 Rue de Germont FR- 76031 Rouen France Dr.

Objective. The need for a defecography in incontinent women is still debatabl e. We prospectively evaluated the prevalence of defecographic abnormalities in i ncontinent women in order to determine whether any symptom or endosonographic fi ndings could be associated with a particular defecographic pattern. Material and methods. Fifty incontinent women (aged 30- 87 years) underwent defecography an d anal endosonography to look for pelvic floor descent, rectocele, intussuscepti on, enterocele and the presence of anal sphincter defects. Other symptoms, i.e. straining at stools and pelvic pressure, were recorded. Results. Twenty- five c ases of external sphincter defect (12 associated with an internal defect) and 4 cases of isolated internal defect were identified. Defecography identified 25 pa tients with perineal descent at rest, 28 with perineal descent at straining, 30 with rectocele, 30 with intussusception and 14 with enterocele. Three defecograp hies were normal. In the 29 women with sphincter defects, the prevalence of defe cographic abnormalities did not differ from that observed in the 21 women withou t sphincter defects. In women complaining of straining at stools (n = 26) or idiopathic p elvic pressure (n = 32), the prevalence of defecographic abnormalities did not d iffer from that observed in women who did not have these symptoms. Conclusions. The prevalence of pelvic floor disorders in incontinent women was similar whethe r associated symptoms or anal sphincter defects were present or not. When defeco graphy has to be performed to investigate female anal incontinence, neither clin ical nor endosonographic features can predict a higher diagnostic efficiency.

关键词：肛门失禁排便造影超声内镜内括约肌直肠膨出肠疝诊断效率