估测卵泡期早期卵泡刺激素(FSH)水平增高的患者卵泡发育终末期初始化的FSH阈值

作     者：De Koning C.H. Schoemaker J. Lambalk C.B. 石磊 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第2期

页      面：28-29页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：卵泡发育 FSH 卵泡刺激素 卵泡数目 黄体中期 小卵泡 大卵泡 高阈 激动剂 试点研究 

摘      要：To test the hypothesis that the folli cle -stimulating hor-mone(FSH)threshold in patients with elevated FSH levels in the early follicular phase(EFP)is higher than in *** *** *** patients with elevated EFP FSH(10IU /L)and ***-ment with a GnRH agonist in the midlut eal phase before IV administration of recombinant FSH w as started in an ul-tra -low -dose step -up *** FSH threshold was determined by the mean of FSH levels o f the above threshold value and the below thresh old *** -stimulating hormone threshold,FSH screening value,E 2,number of *** FSH threshold in the elevated EFP FSH group was 6.75IU /L and was significantly higher than the FSH threshold of the controls(4.65IU /L).The FSH screening value on day 3was 12.0I U /L in the pa-tient group and 5.0IU /L in the contro *** significantly lower on the day that t he largest follicle was 18mm in the elevated EFP FSH group compared with controls(277vs.491pmol /L,respectively)-.On the day of hCG administration,the number of sm aller(10-13mm)follicles was equal but the number of larger(14mm)follicles was higher in the control g roup compared with the elevated FSH *** the contro l group,the basal FSH levels correlated highly with th e FSH threshold levels(r =0.8),but in the patients with elevated EFP FSH this correlation was *** normal wo men,basal FSH day 3values represent the ovarian thresh old for *** womenwith elevated day 3FSH,the FSH threshold is higher but not as high as basal FSH *** postulate that the FSH threshold in patients with elevated EFP FSH is higher be-cause of intraovarian *** l FSH overshoots the threshold,probably because of the l imited feedback by the ovary.