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岩土力学 2022年第6期43卷 1617-1634页

作者： FERRO edgar OSS Andrea SIMEONI Lucia Department of Civil Environmental and Mechanical Engineering University of TrentoTrentoItaly SWS Engineering S.p.A. TrentoItaly

In engineering practice simplified methods are essential to the seismic design of embedded earth retaining walls,as fullydynamic numerical analyses are costly,time-consuming and require specific *** developed pseudostatic methods provide earth stresses and internal forces,even in those cases in which the strength of the soil surrounding the structure is not entirely *** correlations or Newmark sliding block method provide an estimate of earthquake-induced permanent ***,the use of these methods is hindered by uncertainties in the evaluation of a few input parameters,affecting the reliability of the *** study uses 1 D site response analyses and 2 D fully-dynamic finite element analyses to show that simplified methods can provide a reasonable estimate of the maximum bending moment and permanent displacements for stiff cantilever walls embedded in uniform sand,providing that a few input parameters are evaluated through semiempirical correlations and a simple 1 D site response analysis.

关键词： embedded retaining wall seismic design finite elements pseudostatic methods Newmark permanent displacement

Venopulmonary ECMO Improved Hypoxemia and Supported the Right Ventricle in a Patient with Decompensated Eisenmenger Syndrome

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World Journal of Cardiovascular Surgery 2024年第1期14卷 7-19页

作者： Daniel Manzur-Sandoval Gian Manuel Jiménez-Rodríguez edgar García-Cruz Ramón Espinosa-Soto Erika Yamali Ramirez-Marcano Yessenia Máyory Téllez-López José Luis Elizalde-Silva Gustavo Rojas-Velasco Cardiovascular Critical Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adult Congenital Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiology Department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

Mechanical circulatory and/or respiratory assistance with extracorporeal membrane oxygenation (ECMO) has become a standard of care for patients with circulatory (venoarterial) and/or respiratory (venovenous) failure refractory to standard therapies. Adult patients with congenital heart disease are an increasingly recognized and growing population and include various groups, such as undiagnosed cases in childhood and palliated and/or corrected cases, which require subsequent care because of residual lesions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these patients are prone to developing pathologies that are typical of adulthood with a generally increased risk of morbidity and mortality because of their low reserves and organic damage associated with the underlying heart disease, which makes them candidates for ECMO. These patients represent an additional challenge in this therapy because malformations and the presence of a shunt can generally affect the usual cannulation methods and hemodynamic and oximetry monitoring. Thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannulation method, venopulmonary artery ECMO, which provides hemodynamic and respiratory support, and may be ideal for patients with shunts and/or right ventricular dysfunction. To our knowledge, this is the first report of this configuration in patients with congenital heart diseases.

关键词： Eisenmenger Syndrome Venopulmonary Artery ECMO Refractory Hypoxemia Right Ventricular Dysfunction

Single-cell transcriptome profiling of human HSCs during development:new insights into HSC ontogeny

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Signal Transduction and Targeted Therapy 2023年第3期8卷 877-878页

作者： edgar Grinstein Csaba Mahotka Department of Hematology Oncology and Clinical ImmunologyMedical FacultyHeinrich Heine UniversityDüsseldorfGermany Institute of Pathology Medical FacultyHeinrich Heine UniversityDüsseldorfGermany

A study recently published in Nature reported a single-cell transcriptome map of human hematopoietic stem cells(HSCs)and a gene expression signature that distinguishes nascent HSCs from non-HSCs during prenatal development.1 This transcriptome map provides an important tool for further elucidation of human HSC ontogeny and could also serve as a guide for generation of transplantable HSCs ex vivo,1 to widen the therapeutic application of HSCs.

关键词： HSCs transcriptome hematopoietic

Efficient Graph-based Genetic Programming Representation with Multiple Outputs

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International Journal of Automation and computing 2008年第1期5卷 81-89页

作者： edgar Galvan-Lopez Department of Computer Science University of EssexColchester CO4 3SQUK

In this work, we explore and study the implication of having more than one output on a genetic programming （GP） graph-representation. This approach, called multiple interactive outputs in a single tree （MIOST）, is based on two ideas. First, we defined an approach, called interactivity within an individual （IWI）, which is based on a graph-GP representation. Second, we add to the individuals created with the IWI approach multiple outputs in their structures and as a result of this, we have MIOST. As a first step, we analyze the effects of IWI by using only mutations and analyze its implications （i.e., presence of neutrality）. Then, we continue testing the effectiveness of IWI by allowing mutations and the standard GP crossover in the evolutionary process. Finally, we tested the effectiveness of MIOST by using mutations and crossover and conducted extensive empirical results on different evolvable problems of different complexity taken from the literature. The results reported in this paper indicate that the proposed approach has a better overall performance in terms of consistency reaching feasible solutions.

关键词： Interactivity within an individual (IWI) multiple interactive outputs in a single tree (MIOST) neutrality evolvable hardware genetic programming (GP)

Co-Morbidities Associated with Prematurity in Two Referral Hospitals in Cameroon

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Open Journal of Pediatrics 2024年第4期14卷 738-753页

作者： Diomede Noukeu Njinkui Dominique Enyama Yolande Djike Fokam Cyrelle O. Mefotse Saha Beatrice Moudze Kaptue Charlotte Eposse Koube Annick A. Tchouamo Sime Christophe Akazong Adjahoung Marthe E. Barla edgar Mandeng Ma Linwa Seraphin Nguefack Faculty of Medicine and Pharmaceutical Sciences of the University of Dschang Dschang Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Health Sciences University of Mountains Bangangte Cameroon Douala Laquintinie Hospital Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Douala General Hospital Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Yaound I Yaound Cameroon

Introduction: Prematurity is the leading cause of neonatal death in Africa. More than a million children die each year due to co-morbidities related to prematurity. In addition to being one of the causes of neonatal deaths, the health problems associated with prematurity can also lead to severe lifelong impairment in those who survive. Objectives: This paper aims to determine the epidemiology and identify co-morbidities of prematurity in the neonatology units of the Douala General Hospital (DGH) and the Laquintinie Hospital of Douala (LHD). Patients and Methodology: We conducted an analytical retrospective cohort study from January 2015 to January 2018 in the neonatology department of the GDH and the LHD, which are considered reference hospitals for the management of preterm babies in Cameroon. We included all newborns aged less than 37 weeks admitted to the neonatology units of the GDH and the LHD. The descriptive component was based on the analysis of quantitative variables using measures of central tendency. The analytical component was evaluated using Spearman correlations and the Chi-square and Fisher tests. Simple and multiple logistic regressions measured factors predictive of mortality. The Kaplan Meier survival curve used the Log Rank test and significance at p ≤ 0.05. Results: We recorded 908 preterm newborns in neonatal service and 1,124 preterm deliveries in maternity, representing an incidence of 32.5% in neonatal unit and 10.6% in maternity. 51% of whom were girls, given a sex ratio M/F of 0.9. Hypertension was the main prenatal pathology (9.1%), while premature rupture of membranes: PROM (35.5%) and eclampsia/pre-eclampsia (18.6%) were the most common obstetrical pathologies. 75.9% of deliveries were vaginal with 65.2% being performed in our referral hospitals. Gestational age ranged from 22 to 36 weeks, with a mean of 32.4 weeks. Late preterm birth rate was 53.7%, and birth weight varied between 590 and 3200 g with an average of 1747 ± 479 g. The per

关键词： Epidemiology Co-Morbidities Prematurity Douala

Shortening filtrations

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Science China Mathematics 2012年第4期55卷 687-693页

作者： ENOCHS edgar E. Department of Mathematics University of Kentucky

Let C be a set of modules. We argue that there is an ordinal d such that if a module has a filtration by modules in g, then it has a filtration of length k by direct sums of modules in C. As an application we give ano... 详细信息

关键词： Hill classes filtrations precovering

Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease?A discussion of data from the culture dish to the clinic

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Neural Regeneration Research 2022年第7期17卷 1462-1467页

作者： James A.Conway edgar R.Kramer Institute of Translational and Stratified Medicine Peninsula Medical SchoolFaculty of HealthUniversity of PlymouthDevonUK

The neurotrophic signaling of glial cell line-derived neurotrophic factor(GDNF)with its canonical receptor,the receptor tyrosine kinase RET,coupled together with the GDNF family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal *** prompted the idea to try GDNF/RET signaling as a therapeutic approach to treat Parkinson’s disease with the hallmark of dopaminergic cell death in the substantia nigra of the *** several clinical trials with GDNF in Parkinson’s disease patients,which mainly focused on optimizing the GDNF delivery technique,benefits were only seen in a few *** general,the endpoints did not show significant *** suggests that it will be helpful to learn more about the basic biology of this fascinating but complicated GDNF/RET signaling system in the dopaminergic midbrain and about recent developments in the field to facilitate its use in the *** we will refer to the latest publications and point out important open questions in the field.

关键词： α-synuclein clinical trials dopaminergic neurons glial cell line-derived neurotrophic factor GFRα1 gut-brain axis Nedd4 Parkin Parkinson’s disease RET

Effector-Decoy Pairs： Another Countermeasure Emerging during Host-Microbe Co-evolutionary Arms Races？

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Molecular Plant 2017年第5期10卷 662-664页

作者： Michael Cummins edgar Huitema Wellcome Trust PhD Programme School of Life Sciences University of Dundee Dow Street Dundee DD1 5EH UK Division of Plant Science School of Life Sciences University of Dundee at the James Hutton Institute (JHI) Invergowrie Dundee DD2 5DA UK Dundee Effector Consortium JHI Invergowrie Dundee DD2 5DA UK

Plant pathogenic microbes pose a significant threat to food production, collectively affecting all cultivated crops. Given the impact of these pathogens on food security, there continues to be an urgent need to understand and exploit the biology of pathogenesis, plant susceptibility, and immunity in crop systems. Consequently, intense research efforts have helped define the molecular and evolutionary events that underpin plant-microbe interactions.

关键词： Effector-Decoy Pairs Another Countermeasure Emerging

The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system

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Neural Regeneration Research 2015年第11期10卷 1752-1753页

作者： edgar R.Kramer Development and Maintenance of the Nervous System Center for Molecular Neurobiology University Medical Center Hamburg-Eppendorf

Parkinson＇s disease（PD）is the second most common neurodegenerative disease after Alzheimer＇s *** etiology of PD is still not completely understood,but the degeneration of dopaminergic（DA）neurons in the substantia nigra pars compacta（SNpc）,loss of DA innervation of the striatum,and protein aggregates in the form of Lewy bodies and neurites are its established hallmarks. In addition to α-synuclein accumu- lation in Lewy bodies and neurites, genetic mutations in the genes encoding parkin, PINK, DJ-1, LRRK2 and other proteins are associated with the inherited form of PD. An association study linked also the receptor tyrosine kinase Ret to PD （Meka et al., 2015）. Currently there are only symptomatic treatments available for PD but no cure. Consequently much effort is being made to find neurotrophic and other factors able to stimulate SNpc DA neuron protection and regeneration.

关键词： GDNF The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system

Frequency Stability of Power System with Large Share of Wind Power Under Storm Conditions

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 219-228页

作者： Kaushik Das Feng Guo edgar Nuno Nicolaos A.Cutululis the Department of Wind Energy Technical University of Denmark(DTU)RiseDenmark Suzlon Energy Limited RostockGermany

The operation of transmission systems with large share of wind power is specially challenging under storm *** the stormy wind speed conditions,wind turbine protection system is designed to shut down the turbine to avoid excessive mechanical *** sudden loss of wind power from large offshore plants is difficult to forecast accurately,which results in a large amount of power *** severity of such a wind power imbalance towards frequency stability needs to be studied for the future power *** addition,the overhead transmission lines can also be affected during storms,thereby increasing their probability of failure in the operation of power system under the islanded *** paper investigates how the stormy weather can threaten the frequency stability of future Danish power system with large share of wind power and how to avoid the frequency instability through proper control and defence strategies such as high-voltage direct current(HVDC)control and load *** studies are performed for ramp rates of HVDC control,load shedding strategies,inertia of the system with different volumes of disturbances to understand their impact on frequency stability.

关键词： Emergency control frequency stability storm security wind power