Single-cell transcriptome profiling of human HSCs during development:new insights into HSC ontogeny

作     者：Edgar Grinstein Csaba Mahotka Edgar Grinstein;Csaba Mahotka

作者机构：Department of HematologyOncology and Clinical ImmunologyMedical FacultyHeinrich Heine UniversityDüsseldorfGermany Institute of PathologyMedical FacultyHeinrich Heine UniversityDüsseldorfGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第3期

页      面：877-878页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：The work was supported by grants from the Forschungskommission of the Medical Faculty of the Heinrich Heine University of Düsseldorf and the Leukämie Lymphom Liga e.V.to E.Grinstein.Acknowledged is furthermore grant support from Deutsche Forschungsgemeinschaft to E.Grinstein 

主　　题：HSCs transcriptome hematopoietic 

摘      要：A study recently published in Nature reported a single-cell transcriptome map of human hematopoietic stem cells(HSCs)and a gene expression signature that distinguishes nascent HSCs from non-HSCs during prenatal development.1 This transcriptome map provides an important tool for further elucidation of human HSC ontogeny and could also serve as a guide for generation of transplantable HSCs ex vivo,1 to widen the therapeutic application of HSCs.