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An Integrative Meta-analysis of MicroRNAs in Hepatocellular Carcinoma

Genomics, Proteomics & Bioinformatics 2013年第6期11卷 354-367页

作者： Mahmoud ElHefnawi Bangli soliman Nourhan Abu-Shahba Marwa Amer Centre of Excellence for Advanced Sciences Informatics and Systems DepartmentNational Research Centre Stem Cells Research Group Centre of Excellence for Advanced SciencesMedical Molecular Genetics DepartmentNational Research Centre Biology Department American University in Cairo (AUC) Faculty of Biotechnology Misr University for Science and Technology (MUST)

We aimed to shed new light on the roles of microRNAs （miRNAs） in liver cancer using an integrative in silico bioinformatics analysis. A new protocol for target prediction and functional analysis is presented and applied to the 26 highly differentially deregulated miRNAs in hepatocellular carcinoma. This framework comprises：（1） the overlap of prediction results by four out of five target prediction tools, including TargetScan, PicTar, miRanda, DIANA-microT and miRDB （combining machine-learning, alignment, interaction energy and statistical tests in order to minimize false positives）, （2） evidence from previous microarray analysis on the expression of these targets, （3） gene ontology （GO） and pathway enrichment analysis of the miRNA targets and their pathways and （4） linking these results to oncogenesis and cancer hallmarks. This yielded new insights into the roles of miRNAs in cancer hallmarks. Here we presented several key targets and hundreds of new targets that are significantly enriched in many new cancer-related hallmarks. In addition, we also revealed some known and new oncogenic pathways for liver cancer. These included the famous MAPK, TGFβ and cell cycle pathways. New insights were also provided into Wnt signaling, prostate cancer, axon guidance and oocyte meiosis pathways. These signaling and developmental pathways crosstalk to regulate stem cell transformation and implicate a role of miRNAs in hepatic stem cell deregulation and cancer development. By analyzing their complete interactome, we proposed new categorization for some of these miRNAs as either tumor-suppressors or oncomiRs with dual roles. Therefore some of these miRNAs may be addressed as therapeutic targets or used as therapeutic agents. Such dual roles thus expand the view of miRNAs as active maintainers of cellular homeostasis.

关键词： Hepatocellular carcinoma miRNA Target prediction Integrative bioinformatics Cancer hallmarks

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Estimation of the novel antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects of silymarin in Albino rats and mice

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Asian Pacific Journal of Tropical Biomedicine 2015年第8期5卷 605-609页

作者： Mohamed Mahmoud Amin Mahmoud soliman Arbid Department of Pharmacology Medical Division National Research Centre

Objective: To evaluate the other pharmacological actions of silymarin in Albino rats and mice such as antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects. Methods: Rats were injected intramuscularly with pyrogenic dose of brewer's yeast for the antipyretic test of silymarin. Another group of rats injected with 0.1 mL of 1% carrageenan solution in saline at the subplanter area of the right hind paw for the anti-inflammatory test of silymarin. Another group of mice tested by hot plate method for determination of antinociceptive effect of silymarin. Hyperlipidemia was induced using high fat diet for 2 months to estimate the antihyperlipidemic activity of silymarin. Results: Silymarin showed a significant antipyretic effect of both doses(50 and 100 mg/kg) compared with control untreated group. Moreover, silymarin elucidated a significant anti-inflammatory effect of both doses reflected on the decrease of the rat paw edema every hour interval for 4 h after administration in comparison with control positive group. By the same taken, both doses of silymarine revealed a significant antinociceptive action in hot plate method at 30 and 60 min post administration. Besides, it lowered significantly the serum levels of prostaglandin E2, tumor necrosis factor alpha and interleukin 1 beta after 2 h of silymarin administration in carrageenan induced rat paw edema besides the significant decrease of total cholesterol, triglycerides, low density lipoprotein and significantly elevated high density lipoprotein after 2 weeks of silymarin administration. Conclusions: These outcomes delivered a new vision into the possible pharmacological mechanisms by which silymarin advances antipyretic, anti-inflammatory, antinociceptive and antihyperlipidemic effects.

关键词： Silymarin Antipyretic Anti-inflammatory Antinociceptive Antihyperlipidemic PGE2 TNF-α IL-1β

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Vertical Pod Autoscaling in Kubernetes for Elastic Container Collaborative Framework

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Computers, Materials & Continua 2023年第1期74卷 591-606页

作者： Mushtaq Niazi Sagheer Abbas Abdel-Hamid soliman Tahir Alyas Shazia Asif Tauqeer Faiz School of Computer Science National College of Business Administration and EconomicsLahore54000Pakistan School of Digital Technologies and ArtStaffordshire UniversityST42DFUK Department of Computer Science Lahore Garrison UniversityLahore54000Pakistan Higher Colleges of Technology Abu DhabiUAE Department of Enterprise Computing Skyline University CollegeSharjahUAE

Kubernetes is an open-source container management tool which automates container deployment,container load balancing and container(de)scaling,including Horizontal Pod Autoscaler(HPA),Vertical Pod Autoscaler(VPA).HPA enables flawless operation,interactively scaling the number of resource units,or pods,without *** Resource Metrics,such as CPU and memory use of host machines and pods,are monitored by *** Computing has emerged as a platform for individuals beside the corporate *** provides cost-effective infrastructure,platform and software services in a shared *** the other hand,the emergence of industry 4.0 brought new challenges for the adaptability and infusion of cloud *** the global work environment is adapting constituents of industry 4.0 in terms of robotics,artificial intelligence and IoT devices,it is becoming eminent that one emerging challenge is collaborative *** of such autonomous mechanism that can develop,manage and operationalize digital resources like CoBots to perform tasks in a distributed and collaborative cloud environment for optimized utilization of resources,ensuring schedule *** schematics are also linked with Bigdata management produced by large scale industry 4.0 *** use cases and simulation results showed a significant improvement in Pod CPU utilization,latency,and throughput over Kubernetes environment.

关键词： Autoscaling query optimization pods kubernetes container orchestration

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2,5-Furandicarboxylic acid production via catalytic oxidation of 5-hydroxymethylfurfural:Catalysts,processes and reaction mechanism

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Journal of Energy Chemistry 2021年第3期30卷 528-554页

作者： Chunlin Chen Lingchen Wang Bin Zhu Zhenqiang Zhou soliman I.El-Hout Jie Yang Jian Zhang Ningbo Institute of Materials Technology&Engineering CAS1219 Zhongguan West RoadNingbo 315201ZhejiangChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Ningbo 315201ZhejiangChina Nano Science and Technology Institute University of Science and Technology of China166 Renai RoadSuzhou 215123JiangsuChina Nanomaterials and Nanotechnology Department Advanced Materials DivisionCentral Metallurgical Research and Development Institute CMRDIHelwan 11421Egypt

Biomass conversion to value-added chemicals has received tremendous attention for solving global warming issues and fossil fuel depletion.5-Hydroxymethylfurfural(HMF)is a key bio-based platform molecule to produce many useful organic chemicals by oxidation,hydrogenation,polymerization,and ring-opening *** all derivatives,the oxidation product 2,5-furandicarboxylic acid(FDCA)is a promising alternative to petroleum-based terephthalic acid for the synthesis of biodegradable *** review analytically discusses the recent progress in the thermocatalytic,electrocatalytic,and photocatalytic oxidation of HMF into FDCA,including catalyst screening,synthesis processes,and reaction *** fundamental advances may be possible in non-precious metal and metal-free catalysts that are highly efficient under the base-free conditions,and external field-assisted processes like electrochemical or photoelectrochemical cells.

关键词： 5-Hydroxymethylfurfural 2,5-Furandicarboxylic acid Catalytic oxidation Mechanism

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Effect of single subconjunctival injection of bevacizumab on primary pterygium:clinical,histopathological and immunohistochemical study

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 797-801页

作者： Tarek A Mohamed Wael soliman Ahmed M.Fathalla Abeer El Refaie Department of Ophthalmology Assiut University Hospital Department of Pathology Faculty of MedicineAssiut University

AIM：To evaluate the effect（clinically,histopathologically and immunohistochemically） and safety of a single intrapterygium injection of ***：Prospective interventional study comprised 40 eyes of 40 patients with primary fleshy pterygia who attended the Outpatient Clinic of Department of Ophthalmology,Assiut University Hospitals,Egypt from May 2015 to May *** were randomly classified into 2 groups：the first group received a single intralesional injection of bevacizumab（Avastin;Genentech,San Francisco,CA,USA）;the second group comprised patients who did not receive subconjunctival *** of pterygium and conjunctival auto graft was done in both *** excised pterygium tissues were subjected to histopathological and immunohistochemical ***：The study comprised 40 eyes of 40 patients（33 men,7 women） of age range from 31-58 *** study group included 22 *** control group included 18 eyes.A decrease in the vascularity of the pterygium was noted in all injected *** mean vessel count was higher in non-injected pterygia than that in injected pterygia and the difference was statistically significant（P=0.001）.Also,the mean vessel count in both groups was significantly higher than normal conjunctive（P=0.005 and 0.001）.A statistically significant difference in vascular endothelial growth factor（VEGF） expression between injected and non-injected cases was detected in the epithelial,stromal and endothelial cells（P=0.0001,0.016,0.014）.No serious intraoperative complications occurred in both ***：The use of single intra lesional injection of Avastin in pterygium decreased vascularity and decreased VEGF expression in injected pterygium after one *** study proved the effect of single intra lesional injection of Avastin on *** studies may enable limiting the need for surgery and improve quality of life for patients with pterygia.

关键词： pterygiurn vascularity bevacizumab vessel count

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Evaluation of phosphorus bioavailability in El Mex Bay and Lake Mariut sediments

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International Journal of Sediment Research 2017年第3期32卷 432-441页

作者： Naglaa F.soliman Gehan M.El Zokm Mohamed A.Okbah Department of Environmental Studies Institute of Graduate Studies and Research University of Alexandria National Institute of Oceanography and Fisheries

Phosphorus(P) fractions and their bioavailability in the sediments from El Mex Bay and Lake Mariut in Egypt were investigated using different chemical extraction methods. Sodium bicarbonate(NaHC03)extractable P(Olsen-P) was the largest fraction(14.42%), followed by algal available P(AAP)(3.56%),water soluble P(WSP)(0.79%), and readily desorbable P(RDP)(0.06%) for El Mex Bay. While AAP contributed 9.94% to total P in sediments from Lake Mariut, Olsen-P 8.53%, WSP 4.11%, and RDP 0.92%.Summation of the bioavailable P fractions didn’t exceed the sediment quality guidelines, and, therefore, P doesn’t represent a danger to marine organisms. Correlation coefficients showed that no apparent relations between total P(TP) and iron(Fe), aluminum(Al), and calcium(Ca) in the sediments. Furthermore, Fe:P ratio was less than 15 indicting that there was not enough Fe in surface sediments to bind to P at most of the sampling sites. The positive correlation between TP and organic matter(OM) for Lake Mariut and El Mex Bay sediments indicated that the organic matter content of the sediment was a useful predictor of the total phosphorus content. Data from this study constitute a baseline of phosphorus bioavailability in sediments from El Mex Bay and Lake Mariut and could be used as a reference for future studies on the changes of bioavailable and residual phosphorus fractions over time.

关键词： Phosphorus bioavailability Sediments El Mex Bay Lake Mariut

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A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry

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Bio-Design and Manufacturing 2018年第3期1卷 161-170页

作者： Erfan soliman Sarujan Ranjan Tianyou Xu Carol Gee Aidan Harker Alvaro Barrera John Geddes Department of Engineering Sciences Institute of BiomedicalEngineering Old Road Campus Research BuildingUniversity of Oxford Oxford OX3 7DQ UK Warneford Hospital Oxford Health NHS Foundation Trust Warneford Ln Oxford OX3 7JX UK Department of Psychiatry University of Oxford Warneford Hospital Warneford Ln Oxford OX3 7JX UK

There are 12 billion injections given worldwide every year. For many injections, the intramuscular route is favoured over the subcutaneous route due to the increased vascularity of muscle tissue and the corresponding increase in the bioavailability of drugs when administered intramuscularly. This paper is a review of the variables that affect the success of intramuscular injections and the implications that these success rates have in psychiatry and general medicine. Studies have shown that the success rates of intended intramuscular injections vary between 32 and 52%, with the rest potentially resulting in inadvertent subcutaneous drug deposition. These rates are found to be even lower for certain at-risk populations, such as obese patients and those on antipsychotic medications. The variables associated with an increased risk of injection failure include female sex, obesity, site of injection, and subcutaneous fat depth. New guidelines and methods are needed in order to address this challenge and ensure that patients receive optimum care. Looking forward, the best way to improve the delivery of intramuscular injections worldwide is to develop uniform algorithms or innovative medical devices to confirm or guarantee successful delivery at the bedside.

关键词： Intramuscular injection Gluteal Subcutaneous Ultrasound Computed tomography Antipsychotic

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Optimizing the Preparation Parameters of Nanocrystalline Zirconia for Catalytic Applications

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Acta Metallurgica Sinica(English Letters) 2013年第5期26卷 565-573页

作者： M.M.Abd El-Latif M.S.Showman A.M.Ibrahim M.M.soliman Fabrication Technology Department Advanced Technology and New Materials Research Institute(ATNMRI) City of Scientific Research and Technological Applications (SRTA-City) Dharyya Colleges for Science and Atrs Qassim University Surface Chemistry and Catalysis Laboratory Physical Chemistry Department National Research Center Department of Materials Science Institute of Graduate Studies and Research Alexandria University

Nanocrystalline zirconia powder with high surface area and high tetragonal phase percentage is prepared by the precipitation method using ammonium hydroxide as a precipitating agent. The pH of precipitation, preparation temperature and calcinations＇ temperature are *** size, specific surface area, tetragonal phase percentage and the thermal stability of the prepared samples are identified by diferent characterization tools such as X-ray difraction（XRD）, thermo gravimetric analysis（TGA）, diferential scanning calorimetry（DSC）, BET surface area, scanning electron microscopy（SEM） and transmission electron microscopy（TEM）. The optimum preparation parameters for obtaining nanocrystalline zirconia with high percentage of tetragonal phase and high surface area are pH 9, preparation temperature of 80℃ and calcinations＇ temperature of 400℃. The sample prepared under optimized conditions showed a high specific surface area of 179.2 m2/g, high tetragonal phase percentage of 81% and high catalytic activity（60%） for synthesis of butyl acetate ester.

关键词： Tetragonal zirconia Nanocrystalline zirconia Precipitation synthesis Catalytic properties of zirconia Esterification with zirconia

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Utilization of bromine azide to access vicinal-azidobromides from arylidene malononitrile

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Chinese Chemical Letters 2016年第9期27卷 1515-1518页

作者： Hanan A.soliman Tamer K.Khatab Farouk M.E.Abdel-Megeid Photochemistry Department National Research Centre Organometallic and Organometalloid Chemistry Department National Research Centre

An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN3 from azidochlorosilane and N-bromosuccinimide in acetonitrile as solvent at ambient temperature is achieved. This catalytic process represents a highly regioselective and high yielding method for the synthesis of 1,2- bromoazides. Thiamine pyrophosphate （TPP） riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Molecular docking studies are conducted to understand the orientation and the interaction of each synthesized molecules with TPP riboswitches, 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academv of Medical Sciences.

关键词： Azidobromination Tetrachlorosilane Arylidene malononitrile Sodium azide N-Bromosuccinimide

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Simulation of ion beam extraction and focusing system

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Chinese Physics C 2011年第1期35卷 83-87页

作者： B.A.soliman M.M.Abdelrahman A.G.Helal F.W.Abdelsalam Accelerators & Ion Sources Department Nuclear Research CenterEgyptian Atomic Energy Authority P.O.Box:13759 InchasAtomic EnergyCairoEgypt

The characteristics of ion beam extraction and focused to a volume as small as possible were investigated with the aid of computer code SIMION 3D version 7. This has been used to evaluate the extraction characteristics （accel-decel system） to generate an ion beam with low beam emittance and high brightness. The simulation process can provide a good study for optimizing the extraction and focusing system of the ion beam without any losses and transported to the required target. Also, a study of a simulation model for the extraction system of the ion source was used to describe the possible plasma boundary curvatures during the ion extraction that may be affected by the change in an extraction potential with a constant plasma density meniscus.

关键词： ion beam emittance plasma meniscus space charge argon ion trajectories

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