Utilization of bromine azide to access vicinal-azidobromides from arylidene malononitrile

作     者：Hanan A.Soliman Tamer K.Khatab Farouk M.E.Abdel-Megeid 

作者机构：Photochemistry Department National Research Centre Organometallic and Organometalloid Chemistry Department National Research Centre 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第9期

页      面：1515-1518页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Azidobromination Tetrachlorosilane Arylidene malononitrile Sodium azide N Bromosuccinimide 

摘      要：An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN3 from azidochlorosilane and N-bromosuccinimide in acetonitrile as solvent at ambient temperature is achieved. This catalytic process represents a highly regioselective and high yielding method for the synthesis of 1,2- bromoazides. Thiamine pyrophosphate （TPP） riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Molecular docking studies are conducted to understand the orientation and the interaction of each synthesized molecules with TPP riboswitches, 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academv of Medical Sciences.