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Analytical description of shape transition in nuclear alternating parity bands

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Chinese Physics C 2018年第12期42卷 112-122页

作者： e.v.Mardyban T.M.Shneidman e.A.Kolganova R.v.Jolos S.-G.Zhou Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear ResearchDubna 141980Russia Dubna State University Dubna 141980Russia Kazan Federal University Kazan 420008Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion AcceleratorLanzhou 730000China Synergetic Innovation Center for Quantum effects and Application Hunan Normal UniversityChangsha 410081China

The angular momentum dependencies parity bands of heavy nuclei have been analyzed of parity splitting and electric dipole transitions in the alternating It is shown that these dependencies can be treated in a universal manner with a single critical angular momentum parameter, which characterizes phase transition from octupole vibrations to the stable octupole deformation. Using the simple but useful model of axially-symmetric reflection- asymmetric mode, the analytical expressions for parity splitting and electric dipole transitional moment have been obtained. The findings are in good agreement with the experimental data for various isotopes of Ra, Th, U, and Pu.

关键词： octupole deformation phase transition angular momentum

SIMAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Nekisa Zakeri Konstantinos Koilias Rosemary e Faulkes Rachel Brown Owen Cain M Thamara P R Perera Keith J Roberts Rebeca Sanabria-Mateos David C Bartlett Yuk Ting Ma Shivan Sivakumar Shishir Shetty Tahir Shah Bobby v M Dasari Department of HBP and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Department of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Recurrence of hepatocellular carcinoma(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting time,as that could influence the recurrence despite strict listing *** This study aims to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-mingham between July 2011 and February *** and multivariate analyses were performed to identify recurrence predictors,based on which the novel SIMAP500(satellite nodules,increase in size,microvascular invasion,AFP>500,poor differentiation)risk score was *** 234 LTs for HCC were performed with a median follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,ReTReAT score>3,α-fetoprotein(AFP)at listing 100-500 and>500,bridging,increased tumour size between imaging at the listing time and explant histology,increase in the size of viable tumour between listing and explant,presence of satellite nodules,micro-and macrovascular invasion on explant and poor differentiation of tumours were significantly associated with recurrence,based on which,the SIMAP500 risk score is *** SIMAP500 demonstrated an excellent predictive ability(c-index=0.803)and outper-formed the ReTReAT score(c-index=0.73).SIMAP500 is indicative of the time to disease *** SIMAP500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recommended.

关键词： Liver transplantation Hepatocellular carcinoma Recurrence Survival

effects of small additions of Zn on the microstructure, mechanical properties and corrosion resistance of We43B Mg alloys

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International Journal of Minerals,Metallurgy and Materials 2019年第7期26卷 858-868页

作者： A.v. Koltygin v.e. Bazhenov R.S. Khasenova A.A. Komissarov A.I. Bazlov v.A. Bautin Foundry Department National University of Science and Technology “MISiS” Moscow 119049 Russia Laboratory of Hybrid Nanostructured Materials National University of Science and Technology “MISiS” Moscow 119049 Russia Laboratory of Advanced Green Materials National University of Science and Technology “MISiS” Moscow 119049 Russia Department of Metallurgy Steel New Production Technologies and Protection of Metals National University of Science and Technology “MISiS” Moscow 119049 Russia

Zn is a commonly used alloying element for Mg alloys owing to its beneficial effects on mechanical properties. To improve the mechanical and corrosion properties of We43B Mg alloys, the effects of 0–0.7wt% Zn addition on the microstructure and properties of sample alloys were investigated. Addition of Zn to as-cast We43B alloy promoted the formation of the Mg12Nd phase;by contrast, after T6 heat treatment, the phase composition of We43B alloys with and without Zn addition remained mostly the same. A long-period stacking ordered phase was predicted by CALPHAD calculation, but this phase was not observed in either the as-cast or heat-treated Zn-containing We43B alloys. The optimum temperature and duration of T6 heat treatment were obtained using CALPHAD calculations and hardness measurements. Addition of Zn resulted in a slight reduction in the average grain size of the as-cast and T6 heat-treated We43B alloys and endowed them with increased corrosion resistance with little effect on their mechanical properties.

关键词： magnesium alloys corrosion resistance mechanical properties Zn addition

Unilateral rNurr1-v5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes escobedo Minerva Maldonado-Berny Me Gutierrez-Castillo Armando J.espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais e.valenzuela-Arzeta Claudia Luna-Herrera Francisco e.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la educación y Desarrollo y la Investigación Científica de Iztacala(Red MeDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-v5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-v5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-v5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Adiponectin,the past two decades

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分子细胞生物学报:英文版 2016年第2期8卷 93-100页

作者： Zhao v.Wang Philipp e.Scherer Division of Cardiology Department of Internal MedicineUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd.DallasTX 75390USA Touchstone Diabetes Center Department of Internal MedicineUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd.DallasTX 75390USA Department of Cell Biology University of Texas Southwestern Medical Center5323 Harry Hines Blvd.DallasTX 75390USA

Adiponectin is an adipocyte-specific factor,first described in *** the past two decades,numerous studies have elucidated the physiological functions of adiponectin in obesity,diabetes,inflammation,atherosclerosis,and cardiovascular ***,elicited through cognate receptors,suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle,which together contribute to a beneficial metabolic action in whole body energy *** its role in metabolism,adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent ***,as a fat-derived hormone,therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs.A better understanding of adiponectin actions,including the pros and cons,will advance our insights into basic mechanisms of metabolism and inflammation,and potentially pave theway toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes,atherosclerosis,and cardiometabolic disease.

关键词： adiponectin diabetes obesity metabolic syndrome

Ultrasensitive detection of DNA and protein markers in cancer cells

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Cancer Biology & Medicine 2015年第3期12卷 143-149页

作者： Irina v.Smolina Natalia e.Broude Department of Biomedical engineering Boston University

Cancer cells differ from normal cells in various parameters, and these differences are caused by genomic mutations and consequential altered gene expression. The genetic and functional heterogeneity of tumor cells is a major challenge in cancer research, detection, and effective treatment. As such, the use of diagnostic methods is important to reveal this heterogeneity at the single-cell level. Droplet microfluidic devices are effective tools that provide exceptional sensitivity for analyzing single cells and molecules. In this review, we highlight two novel methods that employ droplet microfluidics for ultrasensitive detection of nucleic acids and protein markers in cancer cells. We also discuss the future practical applications of these methods.

关键词： Microfluidic droplets rolling circle amplification (RCA) peptide nucleic acids (PNA) cell-surface protein marker

Influence of the safety factor profile on the particle and heat transport in the Globus-M spherical tokamak

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Plasma Science and Technology 2019年第11期21卷 1-6页

作者： A YU TeLNOvA G S KURSKIev e O KISeLev N N BAKHARev v K GUSev N A KHROMOv S YU MeDveDev v B MIINAev I v MIROSHNIKOv M I PATROv Yu v PeTROv N v SAKHAROv A D SLADKOMeDOvA P B SHCHeGOLev v v SOLOKHA v A TOKARev S YU TOLSTYAKOv e A TUKHMeNevA Ioffe Institute Saint-Petersburg 194021Russia Keldysh Institute Russian Academy of SciencesMoscow 125047Russia NRC'Kurchatov Institute’ Moscow 123098Russia

The advanced tokamak scenario is a promising operation scenario for ITeR and fusion neutron *** this scenario the minimum value of the safety factor in the center of the plasma exceeds *** the compact spherical tokamak Globus-M,the formation of such conditions is possible with neutral beam injection at the current ramp-up *** to the slower diffusion of current inside the plasma,a zone is formed with reduced heat and particle transport across the magnetic field,which affects the temperature and density profiles of the *** leads to the peaked density profile formation and improvement of the energy confinement *** achieve a high fraction of the bootstrap current,it is necessary to increase the plasma *** the same time,the maximum allowable pressure is limited to the normalized beta limit.

关键词： advanced tokamak mode transport analysis internal transport barriers

Influence of anodization conditions on deposition of Hydroxyapatite on α/β Ti alloys for Osseointegration: Atomic Force Microscopy Analysis

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Transactions of Nonferrous Metals Society of China 2024年

作者： Rania e.Hammam engie M.Safwat Soha A.Abdel-Gawad Madiha Shoeib Shimaa el-Hadad Faculty of engineering， Modern University for Technology and Information (MTI) Restorative and Dental Materials Department， National Research Centre Giza Chemistry Department， Faculty of Science， Cairo University Central Metallurgical Research and Development Institute P.O.87

Integrating titanium-based implants with the surrounding bone tissue remains challenging. This study aims to explore the impact of different anodization voltages （20-80v） on the surface topography of two-phase （α/β） Ti alloys and to produce TiO2films with enhanced bone formation abilities. Scanning electron microscopy coupled with energy dispersive spectroscopy （SeM-eDS） and atomic force microscopy （AFM） were applied to investigate the morphological， chemical， and surface topography of the prepared alloys and to confirm the growth of hydroxyapatite （HA） on their surfaces. Results disclosed that the surface roughness of TiO2films formed on Ti-6Al-7Nb alloys was superior to that of Ti–6Al–4v alloys. Ti-6Al-7Nb alloy anodized at 80 v had the highest yields of HA after immersion in SBF with enhanced HA surface coverage. The developed HA layer had a mean thickness of 128.38 ± 18.13 μm， suggesting its potential use as an orthopedic implantable material due to its promising bone integration and， hence， remarkable stability inside the human body.

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ＣＯＭＰＬＥＸＩＴＹＯＦＬＡＲＧＥＴＩＭＥＢＥＨＡＶＩＯＵＲＯＦＥＶＯＬＵＴＩＯＮＥＱＵＡＴＩＯＮＳＷＩＴＨＢＯＵＮＤＥＤＤＡＴＡ

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Chinese Annals of Mathematics,Series B 2002年第2期23卷 293-310页

作者： J.L.vZQUeZ e.ZUAZUA Departamento de Matematicas Universidad AutonomaDepartamento de Matematica AplicadaUniversidadComplutense 28049MadridSpain28040 M

The authors study the asymptotic behaviour of solutions of the heat equation and a number of evolution equations using scaling techniques. It is proved that in the framework of bounded data stabilization need not occur and the general asymptotic behaviour is complex. This behaviour reflects for large times, even on compact sets, the complexity of the initial data at infinity.

关键词： Asymptotic behaviour Scaling Omega-limit Heat equation Hyperbolic conservation laws