Adiponectin,the past two decades

作     者：Zhao V.Wang Philipp E.Scherer 

作者机构：Division of CardiologyDepartment of Internal MedicineUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd.DallasTX 75390USA Touchstone Diabetes CenterDepartment of Internal MedicineUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd.DallasTX 75390USA Department of Cell BiologyUniversity of Texas Southwestern Medical Center5323 Harry Hines Blvd.DallasTX 75390USA 

出 版 物：《分子细胞生物学报:英文版》 (Journal of Molecular Cell Biology)

年 卷 期：2016年第8卷第2期

页      面：93-100页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by a Scientist Development Grant (14SDG18440002)from the American Heart Association (Z.V.W.) National Institutes of Health grants R01-DK55758,R01-DK099110,and P01-DK088761 (P.E.S.) 

主　　题：adiponectin diabetes obesity metabolic syndrome 

摘      要：Adiponectin is an adipocyte-specific factor,first described in *** the past two decades,numerous studies have elucidated the physiological functions of adiponectin in obesity,diabetes,inflammation,atherosclerosis,and cardiovascular ***,elicited through cognate receptors,suppresses glucose production in the liver and enhances fatty acid oxidation in skeletal muscle,which together contribute to a beneficial metabolic action in whole body energy *** its role in metabolism,adiponectin also protects cells from apoptosis and reduces inflammation in various cell types via receptor-dependent ***,as a fat-derived hormone,therefore fulfills a critical role as an important messenger to communicate between adipose tissue and other organs.A better understanding of adiponectin actions,including the pros and cons,will advance our insights into basic mechanisms of metabolism and inflammation,and potentially pave theway toward novel means of pharmacological intervention to address pathophysiological changes associated with diabetes,atherosclerosis,and cardiometabolic disease.