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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

The rediscovery of Strix butleri(Hume,1878)in Oman and Iran,with molecular resolution of the identity of Strix omanensis Robb,van den Berg and Constantine,2013

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Chinese Birds 2016年第2期7卷 85-94页

作者： Magnus S.Robb George Sangster Mansour Aliabadian Arnoud B.van den Berg Mark Constantine Martin Irestedt Ali Khani Seyed Babak Musavi joao M.G.Nunes Maia Sarrouf Willson Alyn j.walsh The Sound Approach Department of Bioinformatics and Genetics Swedish Museum of Natural History Department of Zoology Stockholm University Department of Biology Faculty of ScienceFerdowsi University of Mashhad Research Department of Zoological Innovations Institute of Applied ZoologyFaculty of ScienceFerdowsi University of Mashhad Khorasan-e Razavi Provincial Office of the Department of the environment Khucheh Gochin Parque ecológico do Funchal environment Society of Oman Wildfowl Reserve

Background:Many species of owls(Strigidae) represent cryptic species and their taxonomic study is in *** recent years,two new species of owls of the genus Strix have been described from the Middle east by different research *** has been suggested that one of these species,***,is not a valid species but taxonomic compari?sons have been hampered by the lack of voucher specimens of ***,and the poor state of the holotype of ***:Here we use new DNA sequence data to clarify the taxonomy and nomenclature of the *** *** also report the capture of a single *** sensu stricto in Mashhad,***:A cytochrome b sequence of *** was found to be identical to that of the holotype of ***,indicating that the name *** is best regarded as a junior synonym of *** identity of the *** captured in Mashhad,Iran,was confirmed using DNA sequence *** represents a major(1300 km) range exten?sion of this ***:The population discovered in Oman in 2013 and originally named ‘***' actually represents the rediscovery of ***,which was known from a single specimen and had not been recorded since *** range of *** extends into northeast *** study augments the body of evidence for the recognition of *** and *** as separate species and highlights the importance of using multiple evidence to study cryptic owl species.

关键词： Molecular identification Nomenclature Phylogenetics Strigidae Strix Taxonomy

Sensitivities of Numerical Model Forecasts of extreme Cyclone events

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Advances in Atmospheric Sciences 1991年第1期8卷 51-66页

作者： A. C. Yih j. e. walsh Department of Atmospheric Sciences University of Illinois Urbana IL 61801Department of Atmospheric Sciences University of Illinois Urbana IL 61801

A global forecast model is used to examine various sensitivities of numerical predictions of three extreme winter storms that occurred near the eastern continental margin of North America: the Ohio Valley blizzard of january 1978, the New england blizzard of February 1978, and the Mid-Atlantic cyclone of February 1979. While medium-resolution simulations capture much of the intensification, the forecasts of the precise timing and intensity levels suffer from various degrees of error. The coastal cyclones show a 5-10 hPa dependence on the western North Atlantic sea surface temperature, which is varied within a range (± 2.5℃) compatible with interannual fluctuations. The associated vertical velocities and precipitation rates show proportionately stronger dependences on the ocean temperature perturbations. The Ohio Valley blizzard, which intensified along a track 700-800 km from the coast, shows little sensitivity to ocean temperature. The effect of a shift of - 10?latitude in the position of the snow boundary is negligible in each case. The forecasts depend strongly on the model resolution, and the coarse-resolution forecasts are consistently inferior to the medium-resolution forecasts. Studies of the corresponding sensitivities of extreme cyclonic events over eastern Asia are encouraged in order to identify characteristics that are common to numerical forecasts for the two regions.

关键词： Sensitivities of Numerical Model Forecasts of extreme Cyclone events SST

Tranexamic acid for major trauma patients in Ireland

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World journal of emergency Medicine 2022年第1期13卷 11-17页

作者： Kieran walsh Francis O’Keeff e Louise Brent Biswadev Mitra National Trauma Research Institute the Alfred HospitalMelbourne 3004Australia Critical Care Research School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia emergency&Trauma Centre Alfred HealthMelbourne 3004Australia emergency Department Mater Misericordiae University HospitalDublin D07 R2WYIreland National Offi ce for Clinical Audit Ardilaun HouseDublin D02 VN51Ireland

BACKGROUND:The Clinical Randomisation of an Anti-fibrinolytic in Significant Hemorrhage-2(CRASH-2)is the largest randomized control trial(RCT)examining circulatory resuscitation for trauma patients to date and concluded a statistically significant reduction in all-cause mortality in patients administered tranexamic acid(TXA)within 3 hours of *** the publication of CRASH-2,significant geographical variance in the use of TXA for trauma patients *** study aims to assess TXA use for major trauma patients with hemorrhagic shock in Ireland after the publication of ***:A retrospective cohort study was conducted using data derived from the Trauma Audit and Research Network(TARN).All injured patients in Ireland between january 2013 and December 2018 who had evidence of hemorrhagic shock on presentation(as defined by systolic blood pressure[SBP]ere eligible for *** at hospital discharge was the primary ***:During the study period,a total of 234 patients met the inclusion *** injured patients presenting with hemorrhagic shock,133(56.8%;95%confidence interval[CI]50.2%–63.3%)received *** patients that received TXA,a higher proportion of patients presented with shock index>1(70.68%vs.57.43%)and higher Injury Severity Score(ISS>25;49.62%vs.23.76%).Administration of TXA was not associated with mortality at hospital discharge(odds ratio[OR]0.86,95%CI 0.31–2.38).CONCLUSIONS:Among injured Irish patients presenting with hemorrhagic shock,TXA was administered to 56.8%of *** administered with TXA were on average more severely ***,a mortality benefit could not be demonstrated.

关键词： Tranexamic acid Shock Ireland Hemorrhage

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“宙斯盾”武器系统的支援方案

上海航天 1989年第5期6卷 28-30页

作者： edward j.walsh 黄浩英

计划装在“霍恩”导弹巡洋舰(CG-30)上的AN-48e型对空搜索雷达本月交付美国海军使用,从而使美海军的一项长期发展计划又朝前迈进了一大步,此计划旨在提高海面舰艇对敌方高空反舰巡航导弹的防御能力.跟踪距离达370km的SPS-48e雷达属于海... 详细信息

计划装在“霍恩”导弹巡洋舰(CG-30)上的AN-48e型对空搜索雷达本月交付美国海军使用,从而使美海军的一项长期发展计划又朝前迈进了一大步,此计划旨在提高海面舰艇对敌方高空反舰巡航导弹的防御能力.跟踪距离达370km的SPS-48e雷达属于海军的新威胁对抗系统(NTU)的一个重要组成部分.NTU是专为29艘配备有“鞑靼人”、“小猎犬”反空袭作战(AAW)火控系统的巡洋舰和驱逐舰所研制的一种整体式防空系统.“霍恩”舰将是配备NTU的第12艘战舰.

关键词：武器系统防空武器

Comparison of five video-assisted intubation devices by novice and expert laryngoscopists for use in the aeromedical evacuation environment

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Military Medical Research 2017年第2期4卷 61-69页

作者： Matthew C.Wallace SSgt Tyler Britton Robbie Meek Sharon walsh-Hart Col Todd e.Carter Steven j.Lisco University of Cincinnati Medical Center Department of Anesthesiology

Background: The critically ill or injured patient undergoing military medical evacuation may require emergent intubation. Intubation may be life-saving, but it carries *** novice or infrequent laryngoscopist has a distinct disadvantage because experience is critical for the rapid and safe establishment of a secured airway. This challenge is compounded by the austere environment of the back of an aircraft under blackout conditions. This study determined which of five different video-assisted intubation devices(VAIDs) was best suited for in-flight use by U.S. Air Force Critical Care Air Transport Teams by comparing time to successful intubation between novice and expert laryngoscopists under three conditions, Normal Airway Lights on(NAL), Difficult Airway Lights on(DAL) and Difficult Airway Blackout(DAB), using manikins on a standard military transport stanchion and the floor with a minimal amount of setup time and extraneous light ***: A convenience sample size of 40 participants(24 novices and 16 experts) attempted intubation with each of the 5 different video laryngoscopic devices on high-fidelity airway manikins. Time to tracheal intubation and number of optimization maneuvers used were recorded. Kruskal-Wallis testing determined significant differences between the VAIDs in time to intubation for each particular scenario. Devices with significant differences underwent pair-wise comparison testing using rank-sum analysis to further clarify the difference. Device assembly times, startup times and the amount of light emitted were recorded. Perceived ease of use was surveyed. Results: Novices were fastest with the Pentax AWS in all difficult airway scenarios. experts recorded the shortest median times consistently using 3 of the 5 devices. The AWS was superior overall in 4 of the 6 scenarios tested. experts and novices subjectively judged the Glide Scope Ranger as easiest to use. The light emitted by all the devices was less than the USAF-issued hea

关键词： simulation difficult airway novice expert military video laryngoscopy light emission

Hybrid silicon modulators

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Chinese Optics Letters 2009年第4期7卷 280-285页

作者： j.e.Bowers Department of electrical and Computer engineering University of California Santa Barbara

A number of active elements have been demonstrated using the hybrid silicon evanescent platform, including lasers, amplifiers, and detectors. In this letter, two types of hybrid silicon modulators, flflfilling the building blocks in optical communication on this platform, are presented. A hybrid silicon electroabsorp- tion modulator, suitable for high speed interconnects, with 10-dB extinction ratio at -5 V and 16-GHz modulation bandwidth is demonstrated. In addition, a hybrid silicon Mach-Zehnder modulator utilizing carrier depletion in multiple quantum wells is proved with 2 *** voltage-length product, 150-nm optical bandwidth, and a large signal modulation up to 10 Gb/s.

关键词： Bandwidth electroabsorption modulators Modulation Modulators Optical communication Quantum well lasers Semiconducting indium compounds Semiconductor quantum wells Silicon Silicon detectors

Approximate ballistics formulas for spherical pellets in free flight

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Defence Technology（防务技术） 2018年第1期14卷 1-11页

作者： e.j.Allen Department of Mathematics and Statistics Texas Tech University

The ballistics equations for spherical pellets in free flight are simplified through appropriate scaling of the pellet velocity and pellet distance. Two different drag coefficient curves are averaged to yield a single curve applicable to shot pellets and round balls. The resulting S-shaped drag coefficient curve is approximated by three straight-line segments. The scaled ballistics equations are then solved exactly and simple formulas are found for the velocity and flight time with respect to trajectory distance. The formulas are applicable to spherical shot pellets and round balls of any composition under any atmospheric conditions. The formulas are amenable to quick and easy computation and may also serve as an aid in understanding and comparing black-box ballistics calculators. For shotshell ballistics, an important assumption in the present investigation is that the pellets are moving as single, free spheres and not as a dense cloud or in a shot column, in particular, the pellets are not interacting during flight. Therefore, the formulas are most appropriate for single round balls, for large shot sizes, and for pellets of small shot size fired from open chokes. The formulas are clear and accessible, and can be implemented by military or law enforcement personnel as well as hunters and shooters. This work differs from previous investigations in that accurate ballistics formulas are derived for spherical projectiles of shotguns and muzzleloaders using realistic drag coefficients.

关键词： Ballistics Sphere Drag Shotgun Muzzleloader Nondimensionalization

Are hydrides under high-pressure-high-temperature superconductors?

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National Science Review 2024年第7期11卷 9-12页

作者： j.e.Hirsch Department of Physics University of California

Contrary to the current consensus, I argue that the existing evidence for high-temperature superconductivity in hydrides under high pressure is not compelling. I suggest that the focus of the field should urgently shift to establish unequivocally experimentally whether or not superconductivity in pressurized hydrides exists, instead of continuing to search for new materials that might show elusive signals of unproven superconductivity at ever higher temperatures. The implications of a negative finding for the theoretical understanding of superconductivity are discussed.

关键词： Hydrides