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neCAB family of neuronal calcium-binding proteins in health and disease

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neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Me.icine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(neCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. neCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic ve.icle exocytosis. neCAB2 interacts with predominantly striatal G-protein-coupled receptors, while neCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. neCAB proteins exhibit distinct subcellular localizations: neCAB1 is found in the nucleus and cytosol, neCAB2 resides in endosomes and the plasma membrane, and neCAB3 is present in the endoplasmic re.iculum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in neCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of neCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

estimating costs of salvage logging for large-scale burned forest lands: A case study on Turkey's Mediterranean coast

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Journal of Forestry Research 2021年第5期32卷 1899-1909页

作者： neşe Gülci Faculty of Forestry Kahramanmaras Sutcu Imam University46100 KahramanmarasTurkey

Different forest fires causing different degrees of effects occur in fire-sensitive forests due to various reasons such as climate *** as well as harmful aspects of forest fires are a multi-disciplinary research *** information systems(GIS)and remote sensing(RS)methods offer a number of benefits for researchers and operators in the field of forest fire *** present study analyses timber pricing based on forest contractor demands of post-salvage logging *** effect of timber obtained from compartment units on producers’pricing policy was *** forest fire area(2500 ha)located in Antalya in Turkey was selected as the main study *** parameters(aspect,slope and slope position),stand types(diameter class and crown closure),and burn severity were analyzed together using GIS and R software packages.A multi-linear regression model(R^(2)=0.752)demonstrated that factors that had the most impact on pricing were slope position,aspect,stand age,crown closure and burn *** model can be used to estimate salvage logging prices in Calabrian pine(Pinus brutia Ten.)stands with similar *** administrators and contractors may readily address the unit price of timber by estimating approximate costs in a given forest area for which they are going to *** will help reduce operational planning times of harvesting procedures in burned stands.

关键词： Timber extraction Forest fires Stumpage sale Cost estimation Sustainability Crown fire

effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transge.ic mice

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neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Gene.ics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Me.icine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i neurons)and studied TAU in neurons in the hippocampus of mice transge.ic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transge.ic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transge.ic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

ellipticity-dependent ionization yield for noble atoms

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Chinese Physics B 2019年第8期28卷 73-78页

作者： Hristina Deliba?ic Violeta Petrovi Faculty of Science University of Kragujevac

The photoionization in the frame of the Ammosov-Delone-krainov theory has been theore.ically examined for noble gases,argon,krypton,and xenon,in an elliptically polarized laser *** consider the intermediate range of the keldysh parameter,γ~1,and analyze the influence of shifted ionization potential and temporal profile to eliminate disagreement between theore.ical and experimental *** including these effects in the ionization rates,we solve rate equations in order to determine an expression for the ionization *** use of modified ionization potential shows that the ionization yields will actually decrease below the values pre.icted by original(uncorrected)*** paper will discuss the causes of this discrepancy.

关键词： elliptical polarization ponderomotive potential Stark effect Gaussian laser pulse

Antioxidant,hepatoprotective and hypolipide.ic effects of methanolic root extract of Cassia singueana in rats following acute and chronic carbon tetrachloride intoxication

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Asian Pacific Journal of Tropical Me.icine 2013年第8期6卷 126-132页

作者： Ottu OJ Atawodi se Onyike e Department of Biochemistry Ahmadu Bello UniversityZariaNigeria

Objective:To evaluate in vivo antioxidant and hepatoprotective activities of the methanolic extract of the root of Cassia singueana in rats following acute and chronic carbon tetrachloride ***:Malondialdehyde（MDA）,aspartate aminotransferase（AST）,alanine aminotransferase（ALT） and bilirubin as indices of liver damage and lipid peroxidation were detected in rats after intraperitoneal administration of extract（5 mg/kg）.Results:The liver, kidney and heart showed significant reduction（Pe levels of MDA from（0.18±0.04）,（0.23±0.07） and（0.26±0.10） nmol/mg respectively in the CCl4 control to（0.15±0.03）,（0.17±0.04） and（0.17±0.07） nmol/mg protein in groups pre-treated with the extract for three days at 5 mg/kg(.Similarly, compared to the CCl4 control,significant reduction（Pserum AST,ALT and bilirubin as well as in level of total cholesterol and MDA with concomitant increase in HDL cholesterol, superoxide dismutase and catalase levels when CCl4-intoxicated rats were treated with Cassia singueana root extract for two ***:These results suggest that methanolic extract of Cassia singueana contain potent antioxidant compounds that can offer significant protection against hepatic and oxidative injuries.

关键词： Antioxidant effect Hepatoprotective effect Disease chemoprevention Me.icinal plant Oxidative stress Cassia singueana

Power characteristics of multiple inductively coupled RF discharges inside a metallic chamber

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Plasma Science and Technology 2022年第1期24卷 70-76页

作者： dane LOJeN Rok ZAPLOTNIk Miran MOZe.ic Alenka VeseL Gregor PRIMC Department of Surface engineering Jozef Stefan InstituteJamova cesta 391000 LjubljanaSlovenia Jozef Stefan International Postgraduate School Jamova cesta 391000 LjubljanaSlovenia Plasmadis Ltd. Teslova ulica 301000 LjubljanaSloven

The characteristics of an innovative configuration of multiple radiofrequency(RF)coils immersed in a large metallic chamber are ***-cooled copper coils were mounted within the slits of double-walled glass tubes,which were immersed into a stainless-steel *** coils were connected in parallel to a gamma-type matching network,powered by an RF generator operating at industrial *** leads enabled optimisation of the line impedances and thus uniformly distributed RF power across the four *** from e-to H-mode and vice versa were measured for all coils at various oxygen pressures between 5 and 25 Pa.A uniform plasma was sustained in H-mode at the absorbed power threshold,which increased monotonously with increasing pressure in the metallic *** coils exhibit the same e-to H-mode transition hysteresis and need the same amount of power for transitioning from e-to *** setup enables maintaining uniform plasma in virtually any number of coils at high power without the risk of arcing and without the dead volume typical for a classical configuration with coils mounted outside the metallic chamber.

关键词： inductively coupled plasma large-area plasma e-to H-mode transition high power

Formally Analyzing expected Time Complexity of Algorithms Using Theorem Proving

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Journal of Computer Science & Technology 2010年第6期25卷 1305-1320页

作者： Osman Hasan Sofiène Tahar Department of electrical and Computer engineering Concordia University

Probabilistic techniques are widely used in the analysis of algorithms to estimate the computational complexity of algorithms or a computational ***,such analyses are performed using paper-and-pencil proofs and the results are sometimes validated using simulation *** techniques are informal and thus may result in an inaccurate *** this paper,we propose a formal technique for analyzing the expected time complexity of algorithms using higher-order-logic theorem *** approach calls for mathematically modeling the algorithm along with its inputs,using indicator random variables,in higher-order *** model is then used to formally reason about the expected time complexity of the underlying algorithm in a theorem *** paper includes the higher-order-logic formalization of indicator random variables,which are fundamental to the proposed *** order to illustrate the practical effiectiveness and utilization of the proposed infrastructure,the paper also includes the analysis of algorithms for three well-known problems,i.e.,the hat-check problem,the birthday paradox and the hiring problem.

关键词： formal method higher-order logic probability theory theorem proving birthday paradox hat-check problem hiring problem

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris k.Salgado Jose M.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,e.icenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,e.icenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

A Proposed Method for evaluating Management Feasibility When Determining Weed Control Priorities after Major Fires and Floods

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Research in ecology 2023年第2期5卷 28-39页

作者： F.dane Panetta School of Agriculture and Food Sustainability The University of QueenslandGattonQueensland4343Australia

Major fires and floods have enormous impacts on natural ecosystems and are pre.icted to increase in frequency with global *** managers need to make decisions on the prioritisation of weeds for control in post-disturbance landscapes,but little is available in the way of guidance to support timely decision ***-quantitative models(e.g.,scoring systems)have been employed routinely in weed risk assessment,which considers the potential impacts posed by weeds,as well as the likelihood of these impacts being *** progress has been made in the development of similar models addressing the topic of weed risk *** conditions prevailing after major disturbances,changes(both positive and negative)can be expected in the multiple factors that determine weed management feasibility,relative to pre-disturbance conditions.A semi-quantitative model is proposed that is based on the key factors that contribute to weed management feasibility in post-disturbance environments,along with annotated modules that could be used by land managers in both post-fire and post-flood *** fundamental challenge for weed management in these scenarios lies in the identification of differences between weeds and native species in relation to(1)patterns of seedling emergence;and(2)detectability relative to the growth *** two factors will determine the timing of control actions that are designed to address the trade-off between weed control and off-target damage during the period when both types of plants are recovering from a major disturbance *** model is intuitively sound,but field testing is required to determine both its practical value and any necessary improvement.

关键词： Maintenance control Natural ecosystems semi-quantitative models Weed risk management