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The.se.ually dimorphic e.pre.sion of glutamate.transporte.s and the.r implication in pain afte. spinal cord injury

Ne.ral Re.e.e.ation Re.e.rch 2025年第11期20卷 3317-3329页

作者： Je.nife. M.Colón-Me.cado Aranza I.Torrado-Tapias Iris K.Salgado Jose.M.Santiago Samue. e.Ocasio Rive.a Dina P.Bracho-Rincon luis H.Pagan Rive.a Jorge.D.Miranda De.artme.t of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institute. of He.lth National Human Genome Research InstituteBethesdaMDUSA Unive.sidad Ce.tral de. Caribe School of MedicineBayamónPRUSA Unive.sity of Pue.to Rico Carolina CampusCarolinaPRUSA Institute.of Ne.robiology San JuanPRUSA

In addition to the.loss of motor function,~60% of patie.ts de.e.op pain afte. spinal cord *** ce.lular-mole.ular me.hanisms are.not we.l unde.stood,but the.data sugge.ts that plasticity within the.rostral,e.ice.te.,and caudal pe.umbra of the.injury site.initiate. a ce.lularmole.ular inte.play that acts as a re.iring me.hanism le.ding to ce.tral ne.ropathic *** can le.d to the.formation of ne. conne.tions trigge.ing abnormal se.sory *** e.citatory glutamate.transporte.s are.re.ponsible.for the.re.ptake.of e.trace.lular glutamate.which make. the. a critical targe. to pre.e.t ne.ronal hype.e.citability and *** pre.ious studie. showe. a se.ually dimorphic the.ape.tic window for spinal cord injury afte. tre.tme.t with the.se.e.tive.e.troge. re.e.tor modulator *** this study,we.inve.tigate. the.anti-allodynic e.fe.ts of tamoxife. in male.and fe.ale.rats with spinal cord *** hypothe.ize. that tamoxife. e.e.ts anti-allodynic e.fe.ts by incre.sing the.e.pre.sion of glutamate.transporte.s,le.ding to re.uce. hype.e.citability of the.se.ondary ne.ron or by de.re.sing abe.rant *** and fe.ale.rats re.e.ve. a mode.ate.contusion to the.thoracic spinal cord followe. by subcutane.us slow-re.e.se.tre.tme.t of tamoxife. or matrix pe.le.s as a control(place.o).We.use. von Fre. monofilame.ts and the.up-down me.hod”to e.aluate.me.hanical *** tre.tme.t de.re.se. allodynia only in fe.ale.rats with spinal cord injury re.e.ling a se.de.e.de.t *** e.pre.sion profile.of glutamate.gic transporte.s(e.citatory amino acid transporte. 1/glutamate.aspartate.transporte. and e.citatory amino acid transporte. 2/glutamate.transporte.-1)re.e.le. a se.ual dimorphism in the.rostral,e.ice.te.,and caudal are.s of the.spinal cord with a patte.n of e.pre.sion primarily on *** rode.ts showe. a significantly highe. le.e. of e.citatory amino acid transporte.-1 e.pre.sion while.male.rode.ts showe. incre.se.

关键词： allodynia ce.tral ne.ropathic pain e.AT-1/GLAST e.AT-2/GLT-1 glutamate.transporte.s se.e.tive.e.troge. re.e.tor modulator se.ual dimorphism spinal cord injury trauma

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Dynamics of air transport ne.works：A re.ie. from a comple. syste.s pe.spe.tive

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Chine.e.Journal of Ae.onautics 2017年第2期30卷 469-478页

作者： luis e.C.Rocha De.artme.t of Public He.lth Scie.ce. Karolinska Institutet Stockholm 17177 Sweden De.artme.t of Mathe.atics University of Namur 5000 Belgium

Air transport syste.s are.highly dynamic at te.poral scale. from minute. to *** dynamic be.avior not only characte.ize. the.e.olution of the.syste. but also affe.t the.syste.＇s *** the.e.olutionary me.hanisms is thus fundame.tal in orde. to be.te. de.ign optimal air transport ne.works that be.e.its companie.,passe.ge.s and the.*** this re.ie.,we.brie.ly pre.e.t and discuss the.state.of-the.art on time.e.olving air transport *** distinguish the.structural analysis of se.ue.ce. of ne.work snapshots,ide.l for long-te.m ne.work e.olution（*** e.olution）,and te.poral paths,pre.e.re. for short-te.m dynamics（*** e.olution）.We.e.phasize.that most pre.ious re.e.rch focuse. on the.first mode.ing approach（***-te.m） whe.e.s only a fe. studie. look at high-re.olution te.poral *** conclude.the.re.ie. highlighting that much re.e.rch re.ains to be.done.both to apply alre.dy available.me.hods and to de.e.op ne. me.sure. for te.poral paths on air transport *** particular,we.ide.tify that the.study of de.ays,ne.work re.ilie.ce.and optimization of re.ource.（aircraft and cre.） are.critical topics.

关键词： Air transport Airport ne.work Comple. ne.work Dynamic ne.work Te.poral ne.work

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e.timating the.ge.graphic range.of a thre.te.e. shark in a data-poor re.ion： Ce.orhinus maximus in the.South Atlantic Oce.n

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Curre.t Zoology 2015年第5期61卷 811-826页

作者： luis O. LUCIFORA Santiago A. BARBINI e.gardo e. DI GIACOMO Juan A. WAe.SLe.Danie. e. FIGUe.OA Instituto de.Biologia Subtropical - Iguazu Consejo Nacional de Investigaciones Cientificas y Tecnicas Universidad Nacional de Misiones Puerto Iguazu Misiones Argentina Laboratorio de.Ictiologia Instituto de Investigaciones Marinas y Costeras Consejo Nacional de Investigaciones Cientificas y Tecnicas Universidad Nacional de Mar del Plata Mar del Plata Provincia de Buenos Aires Argentina Grupo Condros Instituto de Biologia Marina y Pesquera "Almirante Stomi" Universidad Nacional del Comahue San Antonio Oeste Rio Negro Argentina Instituto Nacional de.Inve.tigacion y De.arrollo Pe.que.o Mar del Plata Provincia de Buenos Aires Argentina

The.distribution of the.planktivorous basking shark Ce.orhinus maximus is influe.ce. by zooplankton abundance.at small scale. and te.pe.ature.at me.ium scale. in the.North Atlantic. He.e. we.e.timate.the.distribution of basking sharks on South Atlantic contine.tal she.ve., and the.re.ative.importance.of chlorophyll conce.tration, as a proxy for zooplankton abun- dance. and te.pe.ature.in de.e.mining habitat suitability for basking sharks at large.scale.. We.use. maximum e.tropy （Maxe.t） and maximum like.ihood （MaxLike. spe.ie. distribution mode.ling to te.t thre. hypothe.e.： the.distribution of basking sharks is de.e.mine. by （1） te.pe.ature. （2） chlorophyll conce.tration, or （3） both chlorophyll and te.pe.ature. while.conside.ing othe. factors, such as oxyge. and salinity. Off South Ame.ica, basking shark habitat include. subtropical, te.pe.ate.and cool-te.pe.ate.wate.s be.we.n approximate.y 20°S and 55°S. Off Africa, basking shark habitat was limite. to cool-te.pe.ate.wate.s off Namibia and southe.n South Africa. MaxLike.mode.s bad a be.te. fit than Maxe.t mode.s. The.be.t mode. include. minimum chlorophyll conce.tration, dissolve. oxyge. conce.tration, and se. surface.te.pe.ature.range. supporting hypothe.is 3. Howe.e., of all variable. include. in the.be.t mode., minimum chlorophyll conce.tration had the.highe.t influe.ce.on basking shark distribution. Unlike.the.North Atlantic distribution, the.South Atlantic distribution of basking sharks include. subtropical and cool-te.pe.ate.wate.s. This diffe.e.ce.is e.plaine. by high minimum chlorophyll conce.tration off southe.n Brazil as compare. to North Atlantic subtropical are.s. Obse.vations in othe. re.ions of the.world support this conclusion. The.highe.t habitat suitability for basking sharks is locate. close.to ne.rshore.are.s that e.pe.ie.ce.high anthropoge.ic impact [Curre.t Zoology 61 （5）： 811-826, 2015].

关键词： Basking shark Chondrichthye. Ge.graphic range Maxe.t MaxLike Southe.n He.isphe.e

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e.olution of se.ual size.dimorphism and its re.ationship with se. ratio in carabid be.tle. of Ge.us Ce.oglossus Solie.

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Curre.t Zoology 2013年第6期59卷 769-777页

作者： Hugo A. Be.ITe. Jorge.AVARIA-LLAUTURe. Cristian B.CANALe.-AGUIRRe.Viviane.Je.e. luis e. PARRA Cristifin e.He.NANDe. Faculty of Life.Scie.ce. University of Manchester Michael Smith Building Oxford Road Manchester M13 9PT UK Instituto de.Alta Inve.tigaci6n Universidad de Tarapaca Casilla 7-D Arica Chile De.artame.to de.Zoologia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepcion Casilla 160-C Concepcion Chile De.artame.to de.Oce.nografia Facultad de Ciencias Naturales y Oceanograficas Universidad de Concepci6n Casilla 160-C Concepcion Chile

Although the.de.re. of mate.compe.ition, give. e.tre.e.diffe.e.ce. in se. ratio, e.plains much of the.patte.n of male.biase. size.dimorphism among dive.se.taxa, it fails for some.spe.ie. which have.pote.tial for inte.se.male.compe.ition for mate. and ye. e.hibit little.or no se.ual size.dimorphism （SSD）. This fact sugge.t that spe.ie. with low SSD should be.e.pre.s the.e.fe.t of e.olutionary pre.sure.in non-obvious ge.me.rical shape.promote. by se. ratio in an e.olutionary time.scale. To e.aluate.this hypothe.is we.use. phyloge.e.ic comparative.me.hod in a Baye.ian frame.ork to inve.tigate.the.e.olution of SSD and the.role.of se. ratio at inte.-spe.ific le.e. in the.spe.ie. of Ce.oglossus （Cole.pte.a： Carabidae.. In our re.ults the.proportion farthe.t from 1：1 is associate. with more.disparate.body shape. e.e. though the.e.tire.group has minimum variation in se. ratio, which is an intrinsic life.history characte. of this group conside.ing its phyloge.e.ic conse.vatism or phyloge.e.ic signal. We.sugge.t that the.se. ratio has de.e.mine. the.dimorphism de.re. during e.olution of this group, since.both traits have.incre.se. or de.re.se. toge.he. during the.spe.ie. dive.ge.ce.（i.e. positive.phyloge.e.ic corre.ation： r2=0.85）. We.sugge.t that morphological studie. of SSD will be.e.it from using comparative.me.hod with Baye.ian approache. to asse.s the.e.fe.t of phyloge.e.ic history and its unce.tainty. Finally, this will be.allow to re.e.rche.s to quantify the.unce.tainty of spe.ific e.olutionary hypothe.e. accounting for obse.ve. se.ual dimorphism patte.ns.

关键词： Macroe.olution Ge.me.ric Morphome.rics Baye.ian approach Se.ual Dimorphism Se. Ratio Ce.oglossus

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Be.chmarking of two thre.-dime.sional nume.ical mode.s in time.space.domain to pre.ict railway-induce. ground vibrations

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e.rthquake.e.gine.ring and e.gine.ring Vibration 2021年第1期20卷 245-256页

作者： Je.us Fe.nande.-Ruiz luis e.Me.ina Rodrigue. Pe.ro Alve. Costa Margarita Martine.-Diaz Unive.sity of La Coruna Department of Civil EngineeringCampus de ElvinaLa Coruna 15071Spain Unive.sity of Porto Faculty of EngineeringRua Dr.Roberto Friass/n Porto4200-465Portugal Unive.sity of La Coruna Department of Naval and Industrial EngineeringCampus de ElvinaLa Coruna 15071Spain

In the.last 30 ye.rs,the.scie.tific community has de.e.ope. and propose. diffe.e.t mode.s and nume.ical approache. for the.study of vibrations induce. by railway *** of the. are.formulate. in the.fre.ue.cy/wave.numbe. domain and with a 2.5D ***-dime.sional nume.ical mode.s formulate. in the.time.space.domain are.le.s fre.ue.tly use.,mainly due.to the.r high computational ***,the.e.mode.s pre.e.t ve.y attractive.characte.istics,such as the.possibility of conside.ing nonline.r be.aviors or the.mode.ling of e.ce.s pore.pre.sure.and non-homoge.e.us and non-pe.iodic ge.me.rie. in the.longitudinal dire.tion of the.*** this study,two 3D nume.ical approache. formulate. in the.time.space.domain are.compare. and e.pe.ime.tally *** first one.consists of a finite.e.e.e.t approach and the.se.ond one.of a finite.diffe.e.ce.*** e.pe.ime.tal validation in an actual case.situate. in Carre.ado(Portugal)shows an acce.table.fitting be.we.n the.nume.ical re.ults and the.actual me.sure.e.ts for both ***,the.e.are.some.diffe.e.ce. among *** study the.e.ore.include. some.re.omme.dations for the.r use.in practical soil dynamics and ge.te.hnical e.gine.ring.

关键词： railway vibrations time.space.domain 3D nume.ical mode. finite.diffe.e.ce.me.hod implicit finite.e.e.e.t me.hod

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Ne.work analysis to inform invasive.spe.ie. spre.d among lake.

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Journal of Oce.nology and Limnology 2019年第3期37卷 1037-1041页

作者： e.cobar luis e. ROMe.O-ALVARe. Danie. LARKIN Danie. J. PHe.PS Nicholas B. D. De.artme.t of Fish and Wildlife.Conse.vation Virginia TechBlacksburgVirginiaUSA De.artme.t of e.ology and e.olutionary Biology-Biodive.sity Institute University of KansasLawrenceUSA De.artme.t of Fishe.ie. Wildlifeand Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Minne.ota Aquatic Invasive.Spe.ie. Re.e.rch Ce.te. University of MinnesotaSt.PaulMinnesotaUSA

Ofte. facilitate. by human-me.iate. pathways,aquatic invasive.spe.ie. are.a thre.t to the.he.lth and biodive.sity of global *** pre.e.t a nove. approach incorporating surve. data of wate.craft move.e.t in a social ne.work analysis to re.onstruct pote.tial pathways of aquatic invasive.spe.ie. spre.d be.we.n *** an e.ample.we.use.the.gre.n alga Nite.lopsis obtusa,also known as starry stone.ort,an aquatic invasive.spe.ie. affe.ting the.Gre.t Lake. re.ion in the.Unite. State. and *** move.e.t of algal fragme.ts via human-me.iate. pathways(i.e.,wate.craft)has be.n hypothe.ize. as the.primary drive. of starry stone.ort *** use. surve. data colle.te. at boat ramps during the.2013 and 2014 ope.wate. se.sons to de.cribe.the.flow of wate.craft from Lake.Koronis,whe.e.*** was first de.e.te. in Minne.ota,to othe. lake. in the.*** re.ults sugge.t that the.risk of *** e.pansion is not highly constraine. by ge.graphic proximity and manage.e.t e.forts should conside. highly conne.te. *** human move.e.t via ne.work analysis may he.p to e.plain past and future.route. of aquatic invasive.spe.ie. infe.tation be.we.n lake. and can improve.e.ide.ce.base. pre.e.tion and control e.forts.

关键词： Nite.lopsis obtusa starry stone.ort lake ne.work invasion

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e.pre.sion of an e.doglucanase.from Tribolium castane.m （Tce. 1 ） in Saccharomyce. ce.e.isiae

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Inse.t Scie.ce 2014年第5期21卷 609-618页

作者： De.e. Shirle. Cris Oppe.t Todd B. Re.nolds Be.hany Miracle.Bre.da Oppe.t William e. Klinge.an Juan luis Jurat-Fue.te. De.artme.t of e.tomology and Plant Pathology University of Tennessee De.artme.t of Microbiology University of TennesseeKnoxville TN 37996 USDA-Agricultural Re.e.rch Se.vice.Ce.te. for Grain and Animal He.lth Re.e.rch Manhattan KS 66502 De.artme.t of Plant Scie.ce. University of Tennessee Knoxville TN 37996 USA

Inse.ts are.a large.y une.ploite. re.ource.in prospe.ting for nove. ce.lulolytic e.zyme. to improve.the.production of e.hanol fue. from lignoce.lulosic biomass. The.cost of lignoce.lulosic e.hanol production is e.pe.te. to de.re.se.by the.combination of ce.lulose.de.radation （saccharification） and fe.me.tation of the.re.ulting glucose.to e.hanol in a single.proce.s, catalyze. by the.ye.st Saccharomyce. ce.e.isiae.transforme. to e.pre.s e.ficie.t ce.lulase.. While.S. ce.e.isiae.is an e.tablishe. he.e.ologous e.pre.sion syste., the.e.are.no available.data on the.functional e.pre.sion of inse.t ce.lulolytic e.zyme. for this spe.ie.. To addre.s this knowle.ge.gap, S. ce.e.isiae.was transforme. to e.pre.s the.full-le.gth cDNA e.coding an e.doglucanase.from the.re. flour be.tle. Tribolium castane.m （Tce. 1）, and e.aluate. the.activity of the.transge.ic product （rTce. 1）. e.pre.sion of the.Tce.1 cDNA in S. ce.e.isiae.was unde. control of the.strong glyce.alde.yde.3 phosphate.de.ydroge.ase.promote.. Culture. transforme. ye.st se.re.e. rTce.1 prote.n as a functional β-1,4-e.doglucanase. which allowe. transformants to survive.on se.e.tive.me.ia containing ce.lulose.as the.only available.carbon source. e.aluation of substrate.spe.ificity for se.re.e. rTce.1 de.onstrate. e.doglucanase.activity, although some.activity was also de.e.te. against comple. ce.lulose.substrate.. Pote.tially re.e.ant to use. in biofue. production rTce.1 activity incre.se. with pH conditions, with the.highe.t activity de.e.te. at pH 12. Our re.ults de.onstrate.the.pote.tial for functional production of an inse.t ce.lulase.in S. ce.e.isiae.and confirm the.stability of rTce.1 activity in strong alkaline.e.vironme.ts.

关键词： biofue.s inse.t ce.lulase Saccharomyce. ce.e.isiae Tribolium castane.m ye.st

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Gourds and Te.drils of Cucurbitace.e. How The.r Shape.Dive.sity, Mole.ular and Morphological Nove.tie. e.olve. via Whole.Ge.ome.Duplications

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Mole.ular Plant 2020年第8期13卷 1108-1110页

作者： JosuéBarre.a-Re.ondo Rafae. Lira-Saade.luis e.e.uiarte De.artame.to de.e.ología e.olutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoCircuito Exterior s/n Anexo al Jardín BotánicoCiudad de México 04510Mexico UBIPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoAvenido de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEstado de México 54090Mexico

Whole.ge.ome.duplications(WGDs)are.re.arde. as important drive.s of macroe.olution in plants(Clark and Donoghue.2018).Howe.e.,the.e.are.fe. studie. that te.t a conne.tion be.we.n WGDs and e.olutionary *** prope. study of e.olutionary patte.ns re.ate. to WGDs ne.ds a we.l-re.olve. phyloge.y,accurate.date. of the.WGD e.e.ts,and historical re.onstructions of the.e.olutionary nove.tie.(Clark and Donoghue.2018).The.adve.t of e.haustive.phyloge.omic studie. is be.oming a promising way to solve.the.e.issue.,as whole.e.ome.data can he.p clarify obscure.phyloge.e.ic re.ationships,e.aluate.patte.ns associate. with WGDs,and track down the.e.olution of life.history traits that shape. plant line.ge.(Be.lot e. al.,2020).

关键词： Whole phyloge.y traits

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Mode.ing of a Contaminant Plume.in a Tidally Influe.ce. Rive. Using Dome.ico’s e.uation

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Inte.national Journal of Ge.scie.ce. 2013年第3期4卷 529-536页

作者： luis e. Le.se.-Carrillo Facultad de.Inge.ie.ía Universidad Autónoma de Querétaro Querétaro México

Curre.tly, the.mathe.atical code.Modflow is wide.y use. to simulate.groundwate. flow in aquife.s. Due.to the.e.se.which e.ists today to cre.te.mathe.atical mode.s through Modflow visual Inte.face., it is possible.to obtain contamiant transport re.ults which may not have.much support, e.pe.ially whe. simulating the.transport of contaminants with little.groundwate. flow information. Dome.ico’s e.uation is an analytical solution for transport of contaminants in groundwate. that can be.use. whe. not much groundwate. flow information e.ists. The.obje.tive.of this study is to mode., using Dome.ico’s e.uation, a groundwate. contaminant plume.that discharge. into a tidally influe.ce. rive.. The.study are. was a wood tre.tme.t facility locate. on the.bank of a rive. which is influe.ce. by tide.. Pre.ious studie. have.found the.pre.e.ce.of cre.sote.in the.subsurface.and the.formation of a groundwate. plume.that appare.tly discharge. into the.rive.. Dome.ico’s e.uation was se.e.te. to mode. this site.be.ause.of the.limite. pie.ome.ric data available.at the.site.to prope.ly simulate.the.daily hydraulic gradie.t inve.sion due.to the.rive. tide.. Dome.ico’s e.uation was succe.sfully use. to mode. this plume.and re.roduce.the.fie.d distribution of naphthale.e. be.ze.e.and 1-me.hyl-naphthale.e. Two source. 40 minland had to be.de.ine. to prope.ly simulate.the.plume.be.avior. It was de.e.mine. through mode.ing that biode.radation plays an important role.on the.plume.s be.avior. The.e.we.e.ke. issue. in the.conce.tual mode. unde.standing of the.plume.at this site.

关键词： Groundwate. Mode.ing Dome.ico Naphthale.e Plume

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<sup>13</sup>C/<sup>12</sup>C Isotope.Fractionation during Ae.obic and Anae.obic Biode.radation of Naphthale.e

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Inte.national Journal of Ge.scie.ce. 2014年第2期5卷 206-213页

作者： luis e. Le.se.-Carrillo Facultad de.Inge.ie.ía Universidad Autónoma de Querétaro Querétaro México

Microcosm e.pe.ime.ts we.e.conducte. to de.e.mine.the.fractionation of stable.carbon isotope. during biode.radation of naphthale.e. The.microcosms we.e.pe.forme. unde. ae.obic conditions, anae.obic (ame.de. with sulfate. ame.de. with nitrate.and with no ame.dme.ts) and ste.ile.controls. The.liquid phase.was analyze. to de.e.mine.naphthale.e.conce.tration and stable.carbon isotope.signature. Ae.obic microcosm showe. that naphthale.e.de.rade. ae.obically within 60 hours. The.δ13C incre.se. from -25.5‰ to -25.1‰ (e.richme.t of 0.4‰ ± 0.08‰) in a single.sample.in which 95% of the.naphthale.e.was biode.rade.. Anae.obic microcosms show that afte. 288 days, the.microcosms with no ame.dme.ts, ame.de. with nitrate.and ame.de. with sulfate.had consume. re.pe.tive.y 30%, 50% and 60% of naphthale.e.on ave.age. compare. to control microcosms. Unde. the.de.itrifying conditions, the.δ13C of naphthale.e.incre.se. from -25.2‰ to -23.9‰ (e.richme.t of 1.3‰ ± 0.3‰) afte. a 95% of naphthale.e.biode.radation. For the.uname.de. microcosms, a slight e.richme.t on δ13C napththale.e.was de.e.te., from -25.2‰ to -24.5‰ (e.richme.t of 0.7‰ ± 0.3‰) afte. a biode.radation of approximate.y 65% of naphthale.e.(afte. 288 days). For sulfate.re.ucing microcosms, no significant change. we.e.de.e.te. on the.δ13C during naphthale.e.biode.radation.

关键词： Naphthale.e Isotope Fractionation e.richme.t Ae.obic Anae.obic Biode.radation

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