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国际医学放射学杂志 2023年第1期46卷 112-113页

作者： S.P.Bhatt S.Bodduluri A.Nakhmani Y.Kim J.M.Reinhardt e.a.hoffman 张颖

摘要女性慢性阻塞性肺疾病(COPD)的发病率正快速接近男性,并且女性症状更严重。虽然肺气肿的性别差异已有报道,气道的性别差异尚未见系统研究。目的评估气道是

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吸烟者合并或不合并慢性阻塞性肺疾病的肺气肿及空气滞留CT影像的5年进展：来自COPDGene研究的结果

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国际医学放射学杂志 2020年第3期 366-367页

作者： e.Pompe M.Strand e.M.van Rikxoort e.a.hoffman R.G.Barr J.P.Charbonnier 张嘉凝 Department of Radiology University Medical Center Utrecht

摘要 CT被用来量化可能患有慢性阻塞性肺疾病(COPD)的吸烟者的肺实质异常变化,但有关吸烟者呼气后气体滞留进展的研究很少。目的评价吸烟者1秒用力呼气

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Glucagon-like peptide (GLP)-1 regulation of lipid and lipoprotein metabolism

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Medical Review 2024年第4期4卷 301-311页

作者： Simon hoffman Khosrow Adeli Molecular Medicine Research InstituteThe Hospital for Sick ChildrenUniversity of TorontoTorontoONCanada Cardiovascular&Metabolic Disease Merck Research LaboratoriesSouth San FranciscoCAUSA Molecular Medicine Research InstituteThe Hospital for Sick ChildrenUniversity of Toronto555 University Avenue M5G 1X8TorontoONCanada

Metabolic health is highly dependent on intestinal and hepatic handling of dietary and endogenous lipids and *** of lipid and lipoprotein metabolism are commonly observed in patients with insulin resistant states such as obesity,metabolic syndrome,and type 2 ***-idence from both animal models and human studies indicates that a major underlying factor in metabolic or diabetic dysli-pidemia is the overproduction of hepatic and intestinal apoli-poprotein(apo)B-containing lipoprotein *** particles are catabolized down into highly proatherogenic remnants,which can be taken up into the arterial intima and promote plaque *** gut-derived peptides have been identiﬁed as key regulators of energy metabolism;one such peptide is the incretin hormone glucagon-like peptide(GLP)-*** laboratory has previously demonstrated that GLP-1 can signal both centrally and peripherally to reduce postprandial and fasting lipoprotein ***,we have demonstrated that GLP-1 receptor(GLP-1R)agonists can ameliorate diet-induced ***,we published evidence for a novel vagal neuroendocrine signalling pathway by which native GLP-1 may exert its anti-lipemic eﬀ***,we demonstrated a novel role for other gut-derived peptides in regulating intestinal lipoprotein ***,ample evidence supports a key role for GLP-1R on the portal vein aﬀerent neurons and nodose ganglion in modulating intestinal fat absorption and lipoprotein produc-tion and identiﬁes other gut-derived peptides as novel regula-tors of postprandial *** from these data may support identiﬁcation of potential drug targets and the development of new therapeutics targeting treatment of dia-betic dyslipidemia.

关键词： glucagon-like peptide-1 lipid lipoprotein intes-tine neuroendocrine

不吸烟者肺膨胀水平对超极化3He表观扩散系数测量的影响

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国际医学放射学杂志 2013年第5期 486-487页

作者： A.F.Halaweish e.a.hoffman D.R.Thedens M.K.Fuld J.P.Sieren e.J.R.van Beek 王霁朏 Department of Radiology Division of Physiological ImagingCarver College of MedicineUniversity of Iowa Hospitals and Clinics

摘要目的评价肺容积的改变对肺各解剖区域表观扩散系数(ADC)测量的影响。肺容积通过不同程度屏气并经各实验对象的肺容积大小差异或个体肺活量(VC)的差异校正后计算获得。材料与方法该研究经当地伦理委员会批准,符合HIPAA规定,并获得所... 详细信息

摘要目的评价肺容积的改变对肺各解剖区域表观扩散系数(ADC)测量的影响。肺容积通过不同程度屏气并经各实验对象的肺容积大小差异或个体肺活量(VC)的差异校正后计算获得。材料与方法该研究经当地伦理委员会批准,符合HIPAA规定,并获得所有实验对象的知情同意。MR成像符合食品与药物管理局关于医生研究用新药应用的规定。24名健康不吸烟者3种肺容积(20%、60%和100%VC)状态下评估ADC的变化。3种肺容积是基于实验对象肺容量测量数

关键词：肺膨胀表观扩散系数超极化吸烟者

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月经周期影响定量CT肺结构测量

国际医学放射学杂志 2022年第4期 487-487页

作者： J.C.Sieren K.e.Schoreder J.F.Guo K.Asosingh S.erzurum e.a.hoffman 高丽娟

摘要目的为了解肺部疾病风险、进展、恶化和治疗反应，定量CT(q CT)正越来越多地用于学术研究和临床试验。人们已认识到肺功能因月经周期而变化，但月经周期对于

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Decision and Coordination of an e-commerce Supply Chain Considering Returns and Network externalities

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Journal of Systems Science and Systems engineering 2024年第5期33卷 552-575页

作者： Liang Shen Fei Lin Yuyan Wang Luping Ding T.C.e.Cheng Dexia Wang School of Public Finance and Taxation Shandong University of Finance and Economicsjinan 250014China bschool of Management Science and engineering Shandong University of Finance and EconomicsJinan 250014China PolyU Business School The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

Considering the large number of returns in online sales and the network externalities of e-platforms,we develop a decentralized model and a centralized model to explore the impacts of returns and network externalities on e-commerce supply chain(eCSC)*** show that in the decentralized model,the service level,price,market demand,and eCSC members’profits increase with the network externality ***,the service level and price increase,while the market demand and eCSC members’profits decrease with the product return *** centralized model is the optimal operating mode when it is properly *** design the“commission and return cost-sharing”contract to optimize eCSC,in which the proportion of the e-platform’s sharing of the return handling cost is exactly equal to the proportion of the system profit after *** on the decentralized model,we develop two extended models in which we endogenize the impacts of the service level and return rate on the network externality *** comparisons between the extended and decentralized models,we show that high-quality service can improve eCSC’s profitability,while a high return rate hurts its economic performance.

关键词： e-commerce supply chain coordination mechanism network externalities return products

Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil engineering 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Zehra N.KUTLU İsmail e.KILIÇ Department of Civil engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

CLASSIFICATIONS OF DUPIN HYPeRSURFACeS IN LIe SPHeRe GeOMeTRY

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Acta Mathematica Scientia 2024年第1期44卷 1-36页

作者： Thomas e.CeCIL Department of Mathematics and Computer Science College of the Holy CrossWorcesterMA01610USA

This is a survey of local and global classification results concerning Dupin hypersurfaces in S^(n)(or R^(n))that have been obtained in the context of Lie sphere *** emphasis is on results that relate Dupin hypersurfaces to isoparametric hypersurfaces in *** with these classification results,many important concepts from Lie sphere geometry,such as curvature spheres,Lie curvatures,and Legendre lifts of submanifolds of S^(n)(or R^(n)),are described in *** paper also contains several important constructions of Dupin hypersurfaces with certain special properties.

关键词： Dupin hypersurfaces isoparametric hypersurfaces Lie sphere geometry Lie sphere transformations Lie curvatures

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Investigating the impact of the universal function of the nuclear proximity potential in heavy-ion fusion cross sections

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Communications in Theoretical Physics 2024年第5期76卷 86-93页

作者： R Gharaei e Sarvari Department of Physics Sciences FacultyHakim Sabzevari UniversityPO Box 397SabzevarIran Department of Physics Faculty of ScienceFerdowsi University of MashhadPO Box 91775-1436MashhadIran Science Faculty Department of PhysicsTarbiat Modares UniversityTehranIran

The fusion barriers and cross sections of 15 colliding systems with 320≤Z_(1)Z_(2)≤1512 are investigated in detail to understand the influence of the universal function of proximity potential formalism in the heavy-ion fusion *** realize this goal,we select three versions of the phenomenological proximity potentials,including Prox.77,Zhang 2013,and Guo 2013,to calculate the nucleus-nucleus *** experimental fusion cross sections for the selected reactions are analyzed using the standard coupled-channel calculations,including couplings to the low-lying 2^(+)and 3^(-)states in the target and *** calculated results show that the universal functions of the Guo 2013 and Prox.77 models provide the lowest and highest fusion barriers,*** addition,it is found that the height of the fusion barriers is enhanced by increasing the mass number of the projectile from light to heavy *** highest sensitivity to the mass number of the projectile belongs to the results of Prox.77.A discussion is also presented on the influence of the universal function on the radial behavior of the interaction potential in the allowed region for overlapping *** results reveal that the best fit to the experimental data of the fusion cross sections for the reactions involving light and medium nuclei is obtained using the universal function of the Zhang 2013 *** the heavier systems,the results of the Guo 2013 model at sub-barrier energies provide a good description of the available data.

关键词： fusion reactions proximity-type potentials universal function coupled-channel calculations

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Are hydrides under high-pressure-high-temperature superconductors?

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National Science Review 2024年第7期11卷 9-12页

作者： J.e.Hirsch Department of Physics University of California

Contrary to the current consensus, I argue that the existing evidence for high-temperature superconductivity in hydrides under high pressure is not compelling. I suggest that the focus of the field should urgently shift to establish unequivocally experimentally whether or not superconductivity in pressurized hydrides exists, instead of continuing to search for new materials that might show elusive signals of unproven superconductivity at ever higher temperatures. The implications of a negative finding for the theoretical understanding of superconductivity are discussed.

关键词： Hydrides