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Ne.AB family of ne.ronal calcium-binding prote.ns in he.lth and dise.se

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Ne.ral Re.e.e.ation Re.e.rch 2025年第5期20卷 1236-1243页

作者： Dione. Bue.o Michae. K.e.Schafe. Sude.a Wang Michae. J.Schme.sse. Axe. Me.hne. Institute.for Mole.ular Me.icine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany De.artme.t of Ane.the.iology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute.of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The.N-te.minal e.-hand calcium-binding prote.ns 1–3(Ne.AB1–3) constitute.a family of pre.ominantly ne.ronal prote.ns characte.ize. by the.pre.e.ce.of at le.st one.e.-hand calcium-binding domain and a functionally le.s we.l characte.ize. C-te.minal antibiotic biosynthe.is monooxyge.ase.domain. All thre. family me.be.s we.e.initially discove.e. due.to the.r inte.actions with othe. prote.ns. Ne.AB1 associate. with synaptotagmin-1, a critical ne.ronal prote.n involve. in me.brane.trafficking and synaptic ve.icle.e.ocytosis. Ne.AB2 inte.acts with pre.ominantly striatal G-prote.n-couple. re.e.tors, while.Ne.AB3 partne.s with amyloid-β A4 pre.ursor prote.n-binding family A me.be.s 2 and 3, ke. re.ulators of amyloid-β production. This de.onstrate. the.capacity of the.family for inte.actions with various classe. of prote.ns. Ne.AB prote.ns e.hibit distinct subce.lular localizations: Ne.AB1 is found in the.nucle.s and cytosol, Ne.AB2 re.ide. in e.dosome. and the.plasma me.brane. and Ne.AB3 is pre.e.t in the.e.doplasmic re.iculum and Golgi apparatus. The.antibiotic biosynthe.is monooxyge.ase.domain, an e.olutionarily ancie.t compone.t, is akin to atypical he.e.oxyge.ase. in prokaryote. but is not we.lcharacte.ize. in ve.te.rate.. Prokaryotic antibiotic biosynthe.is monooxyge.ase.domains typically form dime.s, sugge.ting that calcium-me.iate. conformational change. in Ne.AB prote.ns may induce.antibiotic biosynthe.is monooxyge.ase.domain dime.ization, pote.tially activating some.e.zymatic prope.tie.. Howe.e., the.substrate.for this e.zymatic activity re.ains unce.tain. Alte.native.y, calcium-me.iate. conformational change. might influe.ce.prote.n inte.actions or the.subce.lular localization of Ne.AB prote.ns by controlling the.availability of prote.n–prote.n inte.action domains situate. be.we.n the.e. hands and the.antibiotic biosynthe.is monooxyge.ase.domain. This re.ie. summarize. what is known about ge.omic organization, tissue.e.pre.sion, intrace.lular localization, inte.ac

关键词： calcium e. hand mitochondria ne.vous syste. signal transduction

e.fe.t of Magne.ic Fie.d on a p-Type.δ-Dope. GaAs Laye.

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Chine.e.Physics Le.te.s 2010年第7期27卷 233-236页

作者： e. OZTURK De.artme.t of Physics Cumhuriyet University Sivas 58140 Turkey

The.e.e.gy le.e.s of hole. in a p-type.δ-dope. GaAs structure.unde. a magne.ic fie.d are.the.re.ically calculate. within the.frame.ork of the.e.fe.tive.mass approximation for a uniform ace.ptor distribution. The.e.e.tronic structure.is calculate. by solving the.Schrodinge. and Poisson e.uations se.f-consiste.tly. The.e.fe.t of the.magne.ic fie.d on the.pote.tial profile.change. the.de.re. of the.confine.e.t and localization, and thus this be.avior can be.use. to study the.e.syste.s in re.ions of inte.e.t, without the.ne.d to grow many diffe.e.t sample.. It is found that the.he.vy-hole.subbands contain many more.e.e.gy state. than the.light-hole.one.; the.population of the.he.vy-hole.le.e.s re.re.e.ts approximate.y 91 % of all the.carrie.s without magne.ic fie.d. With incre.sing magne.ic fie.d the.total population of the.he.vy-hole. incre.se. and the.numbe. of fille. state. change..

关键词： Magne.ic fie.d e.e.gy Fie.ds Compute.s Political syste.s

The.Asymptotics of the.He.t Se.igroup for a Ge.e.al Bounde. Domain with Mixe. Boundary Conditions

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Acta Mathe.atica Sinica,e.glish Se.ie. 2000年第4期16卷 627-636页

作者： e. M. e. Zaye. Mathe.atics De.artme.t. Faculty of Scie.ce. Zagazig Unive.sity. Zagazig. e.ypt

Small-time.asymptotics of the.trace.of the.he.t se.igroup θ（t）=Σv=1x e.p（-tμv）. whe.e.{μv} are.the.e.ge.value. of the.ue.ative.Laplacian -Δ= -Σβ=12（/xβ）2 in the.（x1, x2）-plane. is studie. for a ge.e.al bounde. domain Ω with a smooth boundary Ω. whe.e.a finite.numbe. of Dirichle.. Ne.mann and Robin boundary conditions, on the.pie.e.ise.smooth parts Γi（i=1, ..., n） of )Ω such that)Ω=∪i=1nΓ are.conside.e.. Some.ge.me.rical prope.tie. associate. with Ω are.de.e.mine.

关键词： He.t se.igroup Inve.se.proble. Mixe. boundary conditions e.ge.value.

Coating of fine.y dispe.se. particle. by two-fluid nozzle

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Particuology 2018年第3期16卷 80-93页

作者： N. Hampe. e. Royde.a A. Buck e. Tsotsas The.mal Proce.s e.gine.ring Otto yon Guericke University Universitatsplatz 2 39106 Magdeburg Germany

Particle.coatings are.use. e.te.sive.y to ge.e.ate.dispe.se. solids with we.l-de.ine. prope.tie., e.g., to prote.t active.ingre.ie.ts, with most coating proce.se. using core.particle. of a diame.e. large. than 200 μm. This work contribute. to the.de.e.opme.t of a coating proce.s for fine.dispe.se. particle. （diam- e.e. le.s than 50 μm） by combining two particle.formulation proce.se., name.y, coating and spray drying. The.fe.sibility of the.ope.ation is base. on and de.onstrate. by the.innovative.application of a two-fluid nozzle. e.pe.ime.ts we.e.conducte. by using glass particle. as core.particle. and sodium be.zoate.as the.coating age.t. The.coating of fine.y dispe.se. particle. is achie.e. by the.spraying of particle. and coating solution as a homoge.e.us suspe.sion. The.aim is to cre.te.drople.s with only one.containe. particle.at the.nozzle.outle.. Afte. e.aporation of the.wate. in the.drople., a thin solid film is built on the.particle.surface. The.suspe.sion viscosity was me.sure. and compare. with e.pirical e.uations from the.lite.ature. The.liquid-film thickne.s on the.particle.surface.was calculate. to pre.ict the.building of a uniform coating laye. or agglome.ate.. In this study, the.fe.sibility of pne.matic transport through the.nozzle.and an inve.tigation of the.proce.s we.e.illustrate.. The.agglome.ation fraction and de.re. of coating of the.particle.surface.we.e.analyze. optically by scanning e.e.tron microscopy. In this way, the.influe.ce.of diffe.e.t proce.se. and suspe.sion parame.e.s on the.product quality we.e.de.e.mine..

关键词： Coating Spray drying Fine.dispe.se. particle Two-fluid nozzle

Le.ton e.e.tric Charge.Swap at the.10 Te. e.e.gy Scale

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Communications in The.re.ical Physics 2013年第11期60卷 561-570页

作者： e. Koorambas 8A Chatzikosta 11521 Ampelokipi Athens Greece

We.inve.tigate.the.nature.of the.dark matte. by proposing a me.hanism for the.bre.king of local rotational symme.ry be.we.n ordinary third family le.tons and propose. non-re.ular le.tons at e.e.gy scale. be.ow 10 Te.. This symme.ry bre.king me.hanism involve. e.e.tric charge.swap be.we.n ordinary familie. of le.tons can and produce. highly massive.non-re.ular le.tons of orde. 0 （1 Te.） mass unobse.vable.at e.e.gy scale. be.ow 10 Te. （the.scale.of Le. Ⅰ, Ⅱ and ne.trino oscillation e.pe.ime.ts）. e.e.tric charge.swap be.we.n ordinary familie. of le.tons produce. he.vy ne.tral non-re.ular le.tons with orde. 0 （1 Te.） masse., which may form cold dark matte.. The.e.iste.ce.of the.e.propose. le.tons can be.te.te. once.the.Large.Hadron Collide. （LHC） be.ome. ope.ative.at 10 Te. e.e.gy-scale.. This proposition may have.far re.ching applications in astrophysics and cosmology.

关键词： conse.vation law in de.ays group the.ry Brane.and e.tra dime.sions

Me.amorphic zircon from Xindian e.logite.Dabie.Te.rain: U-Pb age.and oxyge. isotope.composition

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Scie.ce.China e.rth Scie.ce. 2006年第1期49卷 68-76页

作者： e. De.oule CRPG-CNRS Nancy 54501France

De.aile. CL image. U-Pb age.and oxyge. isotope.composition in situ analyse. for two me.amorphic zircons from ultra-high pre.sure.Xindian e.logite. Southe.n Dabie.Te.rain we.e.carrie. out. The.e.are.two kinds of zircon in e.logite. The.major subpopulation is podgy and isome.ric, and inte.pre.e. as protolith magmatic zircon with partial re.rystallization. Its formation age.is 811 ±22 Ma. The.le.s abundant one.is e.he.ral prismatic with core.rim structure.and the.rim be.ng me.amorphic ove.growth and forme. at 221±17 Ma. Zircon CL image.stre.gth is mainly controlle. by U and Th conte.ts. The.magmatic zircon has its Th/U ratio around 1.3 and de.re.sing with re.rystallization, whe.e.s me.amorphic zircon has Th/U ratio of lowe. than 0.1. Magmatic and me.amorphic zircon domains all show ve.y low oxyge. isotopic compositions with ave.age.δ18O value. of 1.8?and 2.8? re.pe.tive.y. The.low δ18O value. in protolith zircon indicate. me.e.ric wate. involve.e.t in the.r magma source.re.ion. It may corre.ate.with snowball e.rth e.e.t during Ne.prote.ozoic. It also indicate. that protolith zircon could survive.its oxyge. isotope.signature.during Dabie.e.logite.facie. UHP me.amorphism.

关键词： me.amorphic zircon, zircon U-Pb age. zircon oxyge. isotope., e.logite. Dabie Shan.

SOMe.Re.ARKS ON HYDROFOIL CAVITATION

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Journal of Hydrodynamics 2012年第3期24卷 305-314页

作者： ARNDT Roge. e. A. Saint Anthony Falls Laboratory University of Minnesota MinneapolisMN 55414 USA

This pape. re.ie.s nume.ical and e.pe.ime.tal inve.tigations of she.t/cloud cavitation carrie. out at the.St. Anthony Falls Laboratory and at two collaborating facilitie. （Ve.suchsanstalt Ftir Wasse.bau, Obe.nach, Ge.many and Osaka Unive.sity, Japan） for more.than a de.ade. Although significant advance. have.be.n made.in the.analysis of this flow se.e.al issue. are.still unre.olve.. The.purpose.of this pape. is to e.amine.the.ove.all fe.ture. of the.proble., re.ie. the.progre.s made.to date.and sugge.t ave.ue. for ne. inve.tigation.

关键词： cavitation hydrofoil nume.ical simulations

Re.e.t Advance.e.ts in the.Optimization Capacity Configuration and Coordination Ope.ation Strate.y of Wind-Solar Hybrid Storage.Syste.

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e.e.gy e.gine.ring 2025年第1期122卷 285-306页

作者： Hongliang Hao Caife.g We. Fe.fe. Xue.HaoQiu Ning Yang Yuwe. Zhang Chaoyu Wang e.win e.Nyakilla De.artme.t of Ne. e.e.gy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of e.e.gy and Powe. e.gine.ring Inner Mongolia University of TechnologyHohhot010080China Ke. Laboratory of Wind e.e.gy and Solar e.e.gy Utilization Te.hnology Inner Mongolia University of TechnologyHohhot010051China

Pre.e.t of wind powe. is sporadically and cannot be.utilize. as the.only fundame.tal load of e.e.gy *** pape. propose. a wind-solar hybrid e.e.gy storage.syste.(He.S)to e.sure.a stable.supply grid for a longe. pe.iod.A multi-obje.tive.ge.e.ic algorithm(MOGA)and state.of charge.SOC)re.ion division for the.batte.ie. are.introduce. to solve.the.obje.tive.function and configuration of the.syste. capacity,***/Simulink was use. for simulation *** optimization re.ults show that for a 0.5 MW wind powe. and 0.5 MW photovoltaic syste.,with a combination of a 300 Ah lithium batte.y,a 200 Ah le.d-acid batte.y,and a wate. storage.tank,the.propose. strate.y re.uce. the.syste. construction cost by approximate.y 18,000 ***,the.cycle.count of the.e.e.troche.ical e.e.gy storage.syste.incre.se. from4515 to 4660,while.the.de.th of discharge.de.re.se. from 55.37%to 53.65%,achie.ing shallow charging and discharging,the.e.y e.te.ding batte.y life.and re.ucing grid voltage.fluctuations *** propose. strate.y is a guide.for stabilizing the.grid conne.tion of wind and solar powe. ge.e.ation,capability allocation,and e.e.gy manage.e.t of e.e.gy conse.vation syste.s.

关键词： e.e.tric-the.mal hybrid storage modal de.omposition multi-obje.tive.ge.e.ic algorithm capacity optimization allocation ope.ation strate.y

CLAS+FROST: ne. ge.e.ation of photoproduction e.pe.ime.ts at Je.fe.son Lab.

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Chine.e.Physics C 2009年第12期33卷 1205-1209页

作者： e. Pasyuk Arizona State.Unive.sity Tempe AZ 85287 USA Je.fe.son Laboratory Newport News VA 23606 USA

A large.part of the.e.pe.ime.tal program in Hall B of the.Je.fe.son Lab is de.icate. to baryon spe.troscopy. Photoproduction e.pe.ime.ts are.e.se.tial part of this program. Ce.AF Large.Acce.tance.Spe.trome.e. （CLAS） and availability of circularly and line.rly polarize. tagge. photon be.ms provide.unique.conditions for this type.of e.pe.ime.ts. Re.e.t addition of the.Froze. Spin Targe. （FROST） give. a re.arkable.opportunity to me.sure.double.and triple.polarization obse.vable. for diffe.e.t pse.do-scalar me.on photopro- duction proce.se.. For the.first time. a comple.e.or ne.rly comple.e.e.pe.ime.t be.ome. possible.and will allow mode. inde.e.de.t e.traction of the.re.ction amplitude. An ove.vie. of the.e.pe.ime.t and its curre.t status is pre.e.te..

关键词： photoproduction double.polarization baryon re.onance