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补肾解毒方联合耳穴压豆对晚期结直肠癌患者癌性疼痛及生活质量的影响

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实用临床医药杂志 2024年第7期28卷 41-44页

作者：石建娜周新东孙科石海波陈霞江苏省无锡市锡山区中医医院肿瘤科江苏无锡214194

目的探讨补肾解毒方联合耳穴压豆对晚期结直肠癌患者癌性疼痛及生活质量的影响。方法将2019年6月—2023年5月本院收治的120例晚期结直肠癌患者纳入本研究,并将其随机分为2组。对照组(60例)行常规护理和“三阶梯”镇痛法干预疼痛,观察组... 详细信息

目的探讨补肾解毒方联合耳穴压豆对晚期结直肠癌患者癌性疼痛及生活质量的影响。方法将2019年6月—2023年5月本院收治的120例晚期结直肠癌患者纳入本研究,并将其随机分为2组。对照组(60例)行常规护理和“三阶梯”镇痛法干预疼痛,观察组(60例)在对照组基础上行补肾解毒方联合耳穴压豆治疗,2组均持续治疗1个月。比较2组患者治疗前后数字评分量表(NRS)评分、治疗效果、生活质量量表(QOL)评分、不良反应发生情况,检测血清中P物质(SP)、β内啡肽(β-eP)、前列腺素e_(2)(PGe_(2))水平。结果治疗后,观察组NRS评分以及SP、β-eP和PGe_(2)水平分别为(2.23±0.64)分、(11.51±2.64)ng/mL、(78.64±9.46)ng/L、(41.90±6.32)ng/L,分别低于对照组的(2.87±1.25)分、(15.64±2.42)ng/mL、(101.29±11.26)ng/L、(78.63±10.17)ng/L,差异有统计学意义(P0.05)。结论补肾解毒方联合耳穴压豆可明显改善晚期结直肠癌患者的癌性疼痛,提高生活质量,且安全性较好。

关键词：补肾解毒方耳穴压豆晚期结直肠癌癌性疼痛生活质量

男性性激素与抗米勒管激素水平对体外受精-胚胎移植胚胎发育的影响

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中国性科学 2024年第3期33卷 32-36页

作者：石绒寇卉马勤利马琳枝张洲西北妇女儿童医院生殖中心西安710004

目的探讨男性性激素与抗米勒管激素(AMH)水平对体外受精-胚胎移植(IVF-eT)胚胎发育的影响。方法回顾性分析2015年5月至2021年8月于西北妇女儿童医院接受体外受精(IVF)/卵胞质内单精子注射(ICSI)助孕的189例男性患者的临床资料,根据受精... 详细信息

目的探讨男性性激素与抗米勒管激素(AMH)水平对体外受精-胚胎移植(IVF-eT)胚胎发育的影响。方法回顾性分析2015年5月至2021年8月于西北妇女儿童医院接受体外受精(IVF)/卵胞质内单精子注射(ICSI)助孕的189例男性患者的临床资料,根据受精卵受精72h后是否有优质胚胎将其分为优质胚胎组和无优胚胎组。对比两组临床资料,通过LASSO和Logistic回归模型探讨影响优质胚胎形成的相关因素,采用受试者工作特征(ROC)曲线评价及性激素水平对胚胎发育情况的预测价值,构建列线图模型并进行评价。结果无优胚胎组的睾酮(T)、雌二醇(e_(2))、AMH、精子密度、精子活动率、精子速度试验结果、生育力指数、活动力指数低于优质胚胎组(Pe_(2)、T、AMH水平及精子速度试验结果、生育力指数均为患者胚胎发育的独立影响因素(Pe_(2)、T及AMH单独预测相比,三者联合的预测效能明显较高。构建的列线图模型具有较高的区分度、准确性和临床适用性。结论血清e_(2)、T、AMH水平异常变化与男性不育症患者无优胚胎形成密切相关,三者联合对IVF-eT胚胎发育具有较高的预测价值,可作为临床筛选高危人群的敏感指标。

关键词：抗米勒管激素性激素体外受精胚胎移植胚胎发育

Novel polyzwitterion shell with adaptable surface chemistry engineered to enhance anti-fouling and intracellular imaging of detonation nanodiamonds under tumor pHe

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Frontiers of Materials Science 2020年第4期14卷 402-412页

作者： Biyu zhou Junbo LI Binzhong LU Wenlan WU Leitao ZHANG Ju LIANG Junpeng YI Xin LI School of Chemical engineering&Pharmaceutics Henan University of Science&TechnologyLuoyang 471023China School of Medicine Henan University of Science&TechnologyLuoyang 471023China College of Food and Bioengineering Henan University of Science&TechnologyLuoyang 471023China

In this work,zwitterionic polymer(polyzwitterion)coated nanodiamonds(ND)with tumorous pH responsiveness were prepared for efficient application of commercial NDS in tumor cells ***(carboxybetaine methacrylate)was firstly grafted on the pristine NDS(PCBMA-@-NDs)by surface-initiated reversible addition-fragmentation chain transfer(RAFT)*** achieve pH responsiveness and activated interaction with tumor cells,PCBMA-@-NDs were subsequently modified with benzene sulfonamide(PCBSA-@-NDs)via one step carbodiimide *** surface polymer functionalization was characterized by FTIR,1H NMR and TGA,and PCBMA-@-NDs and PCBSA-@-NDs showed great dispersibility,enhanced fluorescence intensity and excellent antifouling property in contrast to pristine ***,PCBSA-@-NDs was able to switch zwitterionic surface(at pH 7.4)reversibly into positive charge(at pH 6.5)via protonated or deprotonated *** expected,PCBSA-@-NDS demonstrated higher cell affinity and better imaging performance than those of zwitterionic NDS at tumor slight acid environment,proven by fluorescence microscopy and flow ***,we provide a feasible and valuable strategy to construct smart NDS,thus encouraging the application of cost-effective fluorescence nanomater-ials in biomedical fields.

关键词： zwitterionic polymer surface coating pH-responsive charge-reversal cell imaging

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非饱和土本构模型中应力变量选择研究

岩石力学与工程学报 2009年第6期28卷 1200-1207页

作者：周建浙江大学岩土工程研究所浙江杭州310058 浙江大学软弱土与环境土工教育部重点实验室浙江杭州310058

应力变量是本构模型的基本要素之一,非饱和土本构模型中应力变量的选择目前仍有较大争议,各模型中应力变量的选择非常混乱,严重阻碍了理论研究的进一步发展。Bishop有效应力或其修正的应力形式,以及新提出的吸应力等,虽然可以较好地表... 详细信息

应力变量是本构模型的基本要素之一,非饱和土本构模型中应力变量的选择目前仍有较大争议,各模型中应力变量的选择非常混乱,严重阻碍了理论研究的进一步发展。Bishop有效应力或其修正的应力形式,以及新提出的吸应力等,虽然可以较好地表示非饱和土强度,但不能模拟非饱和土浸湿后体积膨胀和坍塌现象。双应力变量目前应用较多,有考虑非饱和土中孔隙水对土体力学性质影响的骨架应力和毛细应力,有用得最多的净应力和吸力,或者两个应力变量一个是应力的函数,另一个是吸力(或饱和度)的函数等多种形式,可以较好地反映非饱和土的强度和变形特性,但目前双应力变量选择有很大的随意性,没有确凿的理论依据。重点指出建立本构模型时土体的应力变量不能随意选用,应满足Houlsby功率方程,同时还要注意与应力变量对应的应变变量的选择。旨在澄清目前的混淆概念,为非饱和土本构模型建立提出合理的应力变量。

关键词：土力学非饱和土单应力变量双应力变量功率方程

正交异性钢桥面板焊接接头疲劳性能提升方法及其评估

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绍兴文理学院学报 2024年第8期44卷 1-9页

作者：何余良周忠仁应森源娄凯伦绍兴文理学院土木工程学院浙江绍兴312000 浙江中清大建筑工业有限公司浙江绍兴312000

为研究顶板厚度、熔透率和焊缝尺寸三种措施对接头疲劳性能是否有所提升,基于ANSYS-FRANC3D联合仿真方法,考虑不同荷载形式和不同裂纹扩展阶段的影响,从而综合评估三种措施对焊接接头疲劳性能的提升效果。研究得知:竖向荷载作用时,仅增... 详细信息

为研究顶板厚度、熔透率和焊缝尺寸三种措施对接头疲劳性能是否有所提升,基于ANSYS-FRANC3D联合仿真方法,考虑不同荷载形式和不同裂纹扩展阶段的影响,从而综合评估三种措施对焊接接头疲劳性能的提升效果。研究得知:竖向荷载作用时,仅增加顶板厚度可以改善焊根处开裂情况,短裂纹阶段和长裂纹阶段随着顶板厚增加应力强度因子降幅分别可达30.57%和28.54%,同时也可改善多失效模式下焊根处疲劳开裂情况;水平荷载作用时,仅增加熔透率可改善焊根处疲劳开裂情况;相较于单一失效模式,短裂纹阶段和长裂纹阶段裂纹在多失效模式下,裂纹开裂机率分别提升7.58%和8.93%。

关键词：桥梁工程正交异性钢桥面板焊根疲劳裂纹扩展多失效模式

Time-division phase modulated single-photon interference in a Sagnac interferometer

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Chinese Science Bulletin 2003年第16期48卷 1704-1708页

作者： WU Guang, zhou Chunyuan & ZeNG Heping Key Laboratory of Optical and Magnetic Resonance Spectroscopy and Department of Physics, east China Normal University, Shanghai 200062, China Correspondence should be addressed to Zeng Heping (e-mail: hpzeng @***) Key Laboratory of Optical and Magnetic Resonance Spectroscopy andDepartment of Physics East China Normal University Shanghai China

We introduce a stable, long-distance single- photon Sagnac interferometer, which has a balanced con-figuration to efficiently compensate phase drift caused by change of the fiber-optic path. By using time-division phase modulation, single-photon interference was realized at 1550 nm in a 5-km-long as well as 27-km-long Sagnac fiber loops, with a fringe visibility higher than 90% and long-term sta-bility. The stable performance of the single-photon interfer-ence indicated that the time-division phase-modulated Sag- nac interferometer might readily lead to practical applica-tions in single-photon routing and quantum cryptography.

关键词：单光子干涉干涉仪基本结构相位补偿时分相位调制稳定性量子密码

Momentum dependence of pion-inducedφmeson production on nuclei near threshold

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Chinese Physics C 2018年第8期42卷 108-120页

作者： e.Ya.Paryev Institute for Nuclear Research Russian Academy of SciencesMoscow 117312Russia Institute for Theoretical and experimental Physics Moscow 117218Russia

We study the near-threshold pion-induced production ofφmesons off nuclei in the kinematical conditions of the HADeS experiment,recently performed at *** calculations have been performed within a collision model based on the nuclear spectral *** model accounts for both the primaryπ^-meson–protonπ^-p→φn and the secondary pion–nucleonπN→φNφproduction processes as well as the effects of the nuclearφand nucleon mean-field *** find that the primary reaction channelπ^-p→φn dominates in theφproduction off 12C and^（184）W target nuclei in the HADeS acceptance window at incident pion momentum of 1.7 Ge V/*** calculate the momentum dependence of the absolute and relative（transparency ratio）φmeson yields from the above direct *** calculations have been performed for this initial pion momentum allowing for different options for theφN absorption cross sectionσ（φN ）and different scenarios for the in-medium mass shifts of theφmeson and secondary neutron,produced together withφin this *** demonstrate that the transparency ratio for theφmesons has,contrary to the absolute cross sections,an insignificant sensitivity to theφmeson and secondary neutron in-medium mass shifts atφmomenta studied in the HADeS *** the other hand,we show that there are measurable changes in the transparency ratio due to theφN absorption cross section,which means that such a relative observable can be useful to help determine this cross section from the data taken in the HADeS experiment.

关键词： in-medium effects φ absorption pion-nucleus reactions

Forecasting vulnerability of deep extraction level excavations to drawinduced cave loads

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Journal of Rock Mechanics and Geotechnical engineering 2019年第3期11卷 527-534页

作者： Matthew e.Pierce Pierce engineering

Block and panel caving methods are increasingly used for mining of large and strong orebodies at large depths below the ground surface (>1 km). This paper focuses on the production phase of caving when the extraction level is fully developed and subjected to the weight of overlying caved material. A limit equilibrium solution for estimation of cave loads is critically reviewed and combined with existing empirical tools in order to forecast extraction level performance under cave loading. The analysis results, presented in nomogram form, suggest that the risk of severe squeezing of extraction level tunnels does not increase with cave depths below 500-1000 m due to the beneficial effects of arching. Under normal extraction ratios (eR = ~50%), severe squeezing experienced from cave loads in deep mines appears to be unlikely in all but the weakest rock masses (σcm ere σcm is the rock mass global strength), even with poor draw control or low drawpoint availability. The likelihood of severe squeezing is greater when large draw areas (HR = 50-75 m, where HR is the hydraulic radius) are combined with low drawpoint availability or poor draw control and locally higher extraction ratios (eR = ~75%), even in better quality rock (σcm = 5-10 MPa). The analysis results are back-analyzed with the extraction level performance before and after a doubling production of rate and draw area at the deep ore zone (DOZ) mine in Indonesia. The extraction level conditions predicted by the nomograms correlate well with the experience at the DOZ, in which extraction level damage increases significantly over the production rampup, accompanied by a significant drop in drawpoint availability.

关键词： Block caving Panel caving extraction level Draw control Squeezing

Pricing Decision of e-Commerce Supply Chains with Return and Online Review of Product Quality

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Journal of Systems Science and Information 2023年第4期11卷 405-426页

作者： Yuyan WANG Luping DING T.C.e.CHeNG Dexia WANG School of Management Science and engineering Shandong University of Finance and EconomicsJinan 250014China Poly U Business School The Hong Kong Polytechnic UniversityHong Kong 999077China

The online review function helps consumers grasp more real product information and reduce the possibility of returning, but it may also damage firms’ reputations or profits. However, few studies considered the relationship between online reviews and consumer returns. Based on this, we develop an e-commerce supply chain(e-SC) game model consisting of a single manufacturer and a single e-platform, aiming to explore the relationship between consumer returns and online reviews and to analyze the impact on both the decision-making of e-SC members and their profits. We find that there is a negative relationship between consumer returns and online reviews of product quality, and consumer returns make the pricing decisions in the two scenarios of yes/no online reviews move toward two different directions. Only when the online review is positive and higher than a certain threshold will it have a positive impact on sales and e-SC members’ profits. Finally, we design a new “commission joint returns and quality improvement costs sharing” contract to optimize the decentralized model with online reviews, and we find that the higher the accuracy of product information, the less conducive the contract applied to e-SC.

关键词： e-commerce supply chains pricing decision consumer returns online review