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Cell-specific mineralocorticoid receptors:future therapeutic targets for stroke?

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Neural Regeneration Research 2016年第8期11卷 1230-1231页

作者： Quynh N.Dinh Grant R.drummond Christopher G.Sobey Sophocles Chrissobolis Vascular Biology & Immunopharmacology Group Cardiovascular Disease Program and Department of PharmacologyBiomedicine Discovery InstituteMonash University Department of Pharmaceutical and Biomedical Sciences Raabe College of PharmacyOhio Northern University

The mineralocorticoid receptor（MR）,well known to be expressed in renal epithelial cells where it is important in fluid and electrolyte homeostasis,has aldosterone as one of its main *** research in the last 10–15 years indicates that MRs are also expressed outside of the kidney,including in the brain,vasculature and heart,where they contribute to the pathophysiology of disease（Dinh et al.,2012;]aisser and Farman, 2016）.

关键词： aldosterone homeostasis electrolyte outside inflammation deletion neurological protective infarct remodeling

Diagnostic and treatment utility of echocardiography in the management of the cardiac patient

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World Journal of Cardiology 2020年第6期12卷 262-268页

作者： Ariella Khalili Jennifer drummond Neiman Ramjattan Roman Zeltser Amgad N Makaryus North Shore Hebrew Academy Great NeckNY 11020United States Department of Internal Medicine Tufts Medical CenterBostonMA 10211United States Department of Cardiology Nassau University Medical CenterEast MeadowNY 11554United States Department of Cardiology Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11549United States

BACKGROUND Echocardiograms are an incredibly useful diagnostic tool due to their lack of harmful radiation,the relative ease and speed with which they can be performed,and their almost ubiquitous ***,the advantages that support the use of echocardiography can also lead to the overuse of this *** sought to evaluate the physician perceived impact echocardiography has on patient *** To evaluate the physician perceived impact echocardiography has on patient *** Surveys were distributed to the ordering physician for echocardiograms performed at our institution over a 10-wk *** transthoracic echocardiograms performed on the inpatient service were *** were distributed to either the attending physician or the resident physician listed on the echocardiogram *** information requested in the survey focused on the indication for the study and the perceived importance and effect of the *** statistical analysis was performed on all of the answers from the collected *** A total of 103 surveys were obtained and *** internal medicine(57%)and cardiology(37%)specialties ordered the most *** most common reason for ordering an echocardiogram was to rule out a diagnosis(38.2%).Only 27.5%of physicians reported that the echocardiogram significantly affected patient care,with 18.6%reporting a moderate effect,and 30.4%reporting a mild effect.A total of 19.6%of physicians stated that there was no effect on patient ***,43.1%of physicians reported that they made changes in patient management due to no change having occurred in the disease,11.8%reported that changes in management were based on the recommendation of a specialist,and only 9.8%reported that further imaging was ordered due to the results of the *** majority of physicians(67.6%)considered an echocardiogram to be“somewhat essential”in the management of adult inpat

关键词： Echocardiogram Utilization Cardiology Inpatient Survey Management

Epidemio-toxicological profile of suicide cases:analysis from a forensic unit in Brazil

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Forensic Sciences Research 2022年第4期7卷 643-649页

作者： Carolina de Castro Martins Yara Viera Lemos Maycoln Leoni Martins Teodoro Ana Paula drummond-Lage Department of Phsycology Universidade Federal de Minas GeraisBelo HorizonteMGBrazil Department of Forensic Anthropology Polícia Civil de Minas GeraisBelo HorizonteMGBrazil School of Medicine Faculdade de Ciências Médicas de Minas GeraisBelo HorizonteMGBrazil Post-Graduation Department Faculdade de Ciências Médicas de Minas GeraisBelo HorizonteMGBrazil

The suicide phenomenon involves complex interactions between psychological,biological,cultural and socio-environmental *** study aimed to assess the epidemiological and toxicological profiles of officially confirmed suicide *** study was performed using autopsy reports,forensic anthropology examinations and police summaries of all suicide cases that underwent toxicological analysis at an Official Forensic Laboratory(Minas Gerais,Brazil)in 1 *** sample set was composed of 351 suicide victims,predominantly men(70.32%),most of them were adults between 31 and 64 years old(62.11%),with mixed skin colour(48.89%)and low educational level(66.44%).The most common suicide method was hanging(57.79%),followed by intoxication(30.45%).Most victims presented positive toxicological results(56.41%),especially for the presence of medicines(37.6%),illicit drugs(36.3%)and pesticides(26.1%).Our study corroborated previous data that most suicide victims have low educational *** most common toxicological findings were medicines,especially prescription drugs,followed by illicit drugs and *** hope this study contributes to reflections and planning of preventive suicide programmes,considering the described profiles of victims.

关键词： Forensic sciences forensic toxicology forensic medicine forensic anthropology suicide

Reflections on the Green Economy(Redemption of the Principles of Mill and Pigou):A View of a Brazilian Environmentalist

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Journal of Environmental Protection 2014年第12期5卷 1153-1168页

作者： Joao Batista drummond Camara Centro Universitario de Brasília UniCeub/ICPDBrasíliaBrazil

The current context of global efforts in the pursuit of sustainable development can be characterized by the perception of the scientific-technological losses of ecosystems and ecosystem services and their consequences for the survival of humanity in the face of threats of imbalances in the basic conditions for survival such as food production, the environmental quality, natural control of pests and diseases, loses of biodiversity and climate changes. Some recent initiatives at global, regional and local level are pointed and some conceptual trends and deployment strategies advance towards the consolidation of the principles of sustainable development, despite several difficulties for effectively reaching its goals. The trend of gradual changes in the models of developing nations and in the patterns of production and consumption is portrayed objectively, seeking to correlate with principles of environmental economics and green economy, since Cecil Pigou and Stuart Mill principles to recent researches as Kenneth Boulding, Herman Daly, Nicholas Georgescu-Rogen, Franz Capra, Ignacy Sachs, Edgar Morin, beyond others. The ability of the United Nations and governments to intervene in neoliberal logic aiming wider benefit to society and the reduction of the negative effects of market distortions, as striking on the global stage, represents a true redemption of the principles advocated by Cecil Pigou, at the beginning of the last century, both for the global economy and for their effects on environmental and social conflicts, social exclusion resulting from the current economic systems which are not necessary new strategies, principles, or economic formulas, but decision making to tackle the market with seriousness to promote equity, social justice and environmental sustainability, without sacrificing progress and development, as evident in the current discussion of social inclusion and the convergence of individual and collective interests, so far in the development model b

关键词： Principles of Environmental Economics Green Economy Sustainable Development Productions and Consumption Patterns Environmental Services Anthropogenic Footprint

In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum

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Journal of Integrative Medicine 2018年第6期16卷 404-410页

作者： Bruno Jose Martins Da Silva Sandro Wilson Gomes Pereira Ana Paula drummond Rodrigues Jose Luiz Martins Do Nascimento Edilene Oliveira Silva Laboratory of Structural Biology Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging(INCT-INBEB) Rio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil Laboratory of Molecular and Cellular Neurochemistry Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Neuroimmunomodulation(INCT-NIM) Rio de Janeiro 21040-360Brazil

Objective： In the present study, we evaluated the effects of the aqueous extract of Physalis angulata root （AEPa） on Leishmania infanturn proliferation, morphology, and the driving mechanism in leishmanicidal activity and modulatory action on macrophages. Methods： I., infantum promastigotes were treated with 50 and 100 μg/mL AEPa for 72 h and then antipro- mastigote assay was performed by counts in a Newbauer chamber, morphological changes were analyzed by transmission electron microscopy and the mechanism of the leishmanicidal activity was detected. In addition, macrophages were infected with L. infantum and were used to evaluate anti-amastigote activity of AEPa and effects of AEPa on cytokine secretion after 72-hour treatment. Results： Treatment with AEPa reduced the numbers ofL infantum promastigotes （50% inhibitory concen- tration （ICso） = 65.9μg/mL; selectivity index （SI）= 22.1） and amastigotes （ICso = 37.9 μg/mL; SI = 38.5） compared with the untreated control. Amphotericin B reduced 100% of the promastigote numbers after 72 h of treatment （IC50 = 0.2μg/mL）. AEPa induced several morphological changes and increased the production of reactive oxygen species and apoptotic death in promastigotes after treating for 72 h. AEPa （100 μg/mL） promoted tumor necrosis factor-α secretion in macrophages infected with L. infantum after 72 h of treatment, but did not induce an increase in this cytokine in noninfected macrophages. In addition, AEPa showed no cytotoxic effect on J774-A1 cells （50% cytotoxic concentration 〉1000μg/mL）. Conclusion： AEPa presented antileishmanial activity against the promastigotes and amastigotes of I.. infantum without macrophage cytotoxicity; these results show that natural products such as P. angulata have leishmanicidal potential and in the future may be an alternative treatment for leishmaniasis.

关键词： Leishmanicidal activity Leishmania infantum Reactive oxygen species Apoptosis Physalis angulata

Carbon dioxide insufflation during colonoscopy in deeply sedated patients

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World Journal of Gastroenterology 2012年第25期18卷 3250-3253页

作者： Rajvinder Singh Eu Nice Neo Nazree Nordeen Ganesananthan Shanmuganathan Angelie Ashby Sharon drummond Garry Nind Elizabeth Murphy Andrew Luck Graeme Tucker William Tam Division of Gastroenterology Department of MedicineLyell McEwin HospitalSouth Australia 5070Australia Department of Medicine University of AdelaideSouth Australia 5070Australia Colorectal Unit Department of SurgeryLyell McEwin HospitalSouth Australia 5070Australia Pantai Hospital Kuala Lumpur 50000Malaysia Health Statistics Unit South Australia Health CenterSouth Australia 5000Australia

AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing ***:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the *** the colonoscopist and patient were blinded to the type of gas *** the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were *** level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar *** during and after the procedure were ***:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 *** age between the two study groups were *** time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two *** intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air *** were no complications in both ***:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation *** discomfort and bloating were significantly less with CO2 insufflation.

关键词： Colonoscopy Carbon dioxide Air Insuffla-tions, Patient tolerance Safety, Efficacy

Land-Cover Change Monitoring in Obuasi, Ghana： An Integration of Earth Observation, Geoinformation Systems and Stochastic Modelling

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Journal of Earth Science and Engineering 2012年第7期2卷 430-443页

作者： Isaac Adu-Poku Jane drummond Zhenhong Li College of Engineering Kwame Nkrumah University of Science and Technology PMB Kumasi Ghana College of Science and Engineering University of Glasgow Glasgow G 1 2 8QQ UK

For over twenty years, Obuasi Municipality, Ghana, has experienced land-cover change arising from gold mining and urbanisation. This project quantified the land-cover changes that have taken place and projected likely future land-cover. An integration of EO （earth observation）, GIS （geographical information science） and Stochastic Modelling was examined. Post-classification Change Detection employed Landsat TM or ETM＋ images in 1986, 2002 and 2008. Subsequently, Markov Chain Analysis projected the land-cover distribution for 2020. Seven broad land-use and land-cover classes were identified and mapped, namely： built-up areas, mine sites tailing ponds barren land forestland farmland and rangeland. The results obtained for the 2008 to 2020 projection revealed a continuous expansion of built-up areas （1.63%）, mine sites （0.89%） and farmland （3.4%）, and a reduction of forestland （4.17%） and rangeland （2.59%）. Despite the advent of very high resolution satellite imagery, this use of EO and GIS technology focussed on low-cost and lower resolution satellite imagery, coupled with Markov Modelling and was found to be beneficial in describing and analysing land-cover change processes in the study area, and was hence potentially useful for strategic planning purposes.

关键词： Ghana TM ETM+ GIS change detection tailing ponds gold mining.

Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo

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Protein & Cell 2011年第4期2卷 333-346页

作者： Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann drummond Evan R.Simpson Jun-Ping Liu Department of Immunology Central Eastern Clinical SchoolMonash UniversityVictoria 3800Australia Prince Henry’s Institute of Medical Research Clayton VIC 3168Australia Current address:Research Services M459The University of Western Australia35 Stirling HighwayCRAWLEY WA 6009Australia Current address:Murdoch Children’s Research Institute Royal Children’s HospitalParkvilleVic 3052Australia

Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully *** we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific *** inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of *** expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen *** replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four *** data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in *** deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling.

关键词： estrogen telomerase reverse transcriptase(TERT) telomeres ovary mice

Identification of victims of the collapse of a mine tailing dam in Brumadinho

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Forensic Sciences Research 2022年第4期7卷 580-589页

作者： Ricardo Moreira Araújo Yara Vieira Lemos Erlon Dias do Nascimento Anna Helena Silva Paraizo Alberto Julius Alves Wainstein Ana Paula drummond-Lage Faculty of Medical Sciences of Minas Gerais Belo HorizonteBrazil Instituto Médico Legal AndréRoquette Belo HorizonteBrazil Corpo de Bombeiros Militar de Minas Gerais Juiz de ForaBrazil

The collapse of the B1 Dam of VALESAmining company in Brumadinho,Minas Gerais,Brazil was the largest humanitarian disaster and occupational accident in the country’s history,and it posed challenges regarding the management and identification of multiple *** evaluated the impact of the iron ore tailings on the victims’*** examined the scientific identification of the victims and the dynamics of the disaster over the 1st year after it *** also determined the socio-demographic profiles of the *** this retrospective,cross-sectional study,we investigated the expert reports of the victims’biological remains from 25 January 2019 to 25 January *** analysed the socio-demographic data,identification methods,identification status,identification time,and necroscopic *** the study period,259 of 270 victims were identified,and 603 biological materials were analysed;among them,86.2%were body parts and 13.8%were whole *** the total cases registered that year,476(78.9%)were submitted during the first 10 weeks after the *** ridge analysis accounted for 67.9%of primary identifications and DNAanalysis did so for 91.6%of re-identification *** dismemberment was 3.4 times greater among mine workers than among community *** males accounted for the greatest number of victims(P<0.001).Polytraumatic injury was the prevalent single cause of *** examination revealed the occurrence of asphyxia in 7%of *** higher number of fatalities and greater dismemberment among employees than with community residents underlines the occupational dangers in the mining industry and clarifies the dynamics of the *** the initial weeks after the dam collapsed,friction ridge analysis was the most appropriate method for ***,DNAanalysis became the most-used technique for identification and re-identification owing to the great volume of body parts and decomposed biological ***

关键词： Disasters victim identification tailings mining legal medicine developing countries man-made disasters traumatic amputation