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The Use of Triancinolone for the Treatment of Keloid Scars

Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 270-275页

作者： José Humberto Cardoso Resende Luís Otávio Torres Anderson Alves Brandão Delma dos Santos Assis Mercadante Jessyka Oliveira Barbosa Batista William Felix de Oliveira Pacheco Elisangelo Aparecido Costa Da Silva douglas Henrique Farias de Oliveira Nébia Maria Almeida de Figueiredo UNIFAN-Centro Universitrio Alfredo Nasser Aparecida de Goinia Brazil UNIRIO Rio de Janeiro Brazil

Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.

关键词： Keloid Scar Hypertrophy Collagen Affection

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Fragment analysis in forensic anthropology

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Forensic Sciences Research 2020年第4期5卷 260-265页

作者： douglas H.Ubelaker Yaohan Wu National Museum of Natural History Smithsonian InstitutionWashingtonDCUSA

Anthropological analysis of fragmentary evidence can be challenging but diverse methods allow substantial information to be *** electron microscopy/energy dispersive X-ray spectroscopy enables determination if bone and/or tooth tissue is *** radioimmunoassay or DNA analysis can establish the species *** analysis can assist in species determination and reveal information about thermal *** analysis with special reference to the modern bomb-curve can clarify the post-mortem *** should also be aware that DNA analysis not only can enable positive identification but assist in the evaluation of sex and age at death.

关键词： Forensic sciences forensic anthropology fragments radiocarbon

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Michael David Kaulana Ing, Why Confucius Wept： A Review of The Dysfunction of Ritual in Early Confucianism （reviewed by douglas L. Berger）

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Frontiers of Philosophy in China 2015年第2期10卷 311-314页

作者： douglas L. Berger Southern Illinois University

Michael David Kaulana Ing, Why Confucius Wept： A Review of The Dysfunction of Ritual in Early Confucianism. New York, NJ： Oxford University Press, 2012, xii ＋ 304 pp., ISBN： *** the centrality of ritual and its relation to ethical conduct in Confucian thought, it is rather remarkable that, apart from Song dynasty-inspired fascination with the Zhongyong （中庸） and Daxue （大学） chapters, very little modern philosophical attention has been paid to the entire corpus of Liji （礼记）, Record of Rights. In addition to this lacuna, it is only very recently that scholars of Religious Studies who focus on ritual have turned their attention to early Confucian conceptions of rites with an eye to incorporating these conceptions into alternative theoretical frameworks. While Michael Ing＇s truly outstanding and powerfully argued Dysfunction of Ritual--grounded both in classical Chinese and modern English-language commentary---does extrapolate a ＂tragic theory of ritual＂ which broadens discussions in current Religious Studies debates, this review will focus on the degree to which this ＂tragic theory＂ can deepen our estimation of early Confucian thought.

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The moral imperative to continue gene editing research on human embryos

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Protein & Cell 2015年第7期6卷 476-479页

作者： Julian Savulescu Jonathan Pugh Thomas douglas Christopher Gyngell Uehiro Centre for Practical Ethics University of Oxford Oxford OX1 1PT UK Queensland University of Technology St Lucia Brisbane QLD 4072 Australia

The publication of the first study to use gene editing tech-niques in human embryos （Liang et al., 2015） has drawn outrage from many in the scientific community. The presti-gious scientific journals Nature and Science have published commentaries which call for this research to be strongly discouraged or halted all together （Lanphier et al., 2015; Baltimore et al., 2015）. We believe this should be ques- tioned. There is a moral imperative to continue this research.

关键词： Moral Status Human Embryo Gene Editing Reproductive Purpose hESC Research

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Light history modulates growth and photosynthetic responses of a diatom to ocean acidification and UV radiation

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Marine Life Science & Technology 2023年第1期5卷 116-125页

作者： Wei Li Tifeng Wang douglas A.Campbell Kunshan Gao State Key Laboratory of Marine Environmental Science&College of Ocean and Earth Science Xiamen UniversityXiamen361005China College of Life and Environmental Sciences Huangshan UniversityHuangshan245041China Co-innovation Center of Jiangsu Marine Bio-industry Technology Jiangsu Ocean UniversityLianyungang222005China Biology Department Mount Allison UniversitySackvilleNBE4L 1G7Canada

To examine the synergetic effects of ocean acidification(OA)and light intensity on the photosynthetic performance of marine diatoms,the marine centric diatom Thalassiosira weissflogii was cultured under ambient low CO_(2)(LC,390μatm)and elevated high CO_(2)(HC,1000μatm)levels under low-light(LL,60μmol m^(-2)s^(-1))or high-light(HL,220μmol m^(-2)s^(-1))conditions for over 20 *** stimulated the growth rate by 128 and 99%but decreased cell size by 9 and 7%under LC and HC conditions,***,HC did not change the growth rate under LL but decreased it by 9%under *** combined with HC decreased both maximum quantum yield(FV/FM)and effective quantum yield(ΦPSII),measured under either low or high actinic *** exposed to UV radiation(UVR),LL-grown cells were more prone to UVA exposure,with higher UVA and UVR inducing inhibition ofΦPSII compared with HL-grown *** use efficiency(α)and maximum relative electron transport rate(rETRmax)were inhibited more in the HC-grown cells when UVR(UVA and UVB)was present,particularly under *** results indicate that the growth light history influences the cell growth and photosynthetic responses to OA and UVR.

关键词： Chlorophyll fluorescence Growth Light intensity Ocean acidification Pigmentations UV radiation

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Hepatocellular carcinoma,human immunodeficiency virus and viral hepatitis in the HAART era

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World Journal of Gastroenterology 2008年第11期14卷 1657-1663页

作者： douglas C Macdonald Mark Nelson Mark Bower Thomas Powles Chelsea and Westminster hospital LondonUnited Kingdom St Bartholomew’s Hospital LondonUnited Kingdom

The incidence of hepatocellular carcinoma(HCC)in patients with human immunodeficiency virus(HIV) is *** in HIV almost invariably occurs in the context of hepatitis C virus(HCV)or hepatitis B virus (HBV)co-infection and,on account of shared modes of transmission,this occurs in more than 33% and 10% of patients with HIV worldwide *** has yet to be clearly established whether HIV directly accelerates HCC pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy(HAART)era,wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to *** this question will have implications for HCC surveillance and the timing of HCV/HBV therapy,which in HIV co-infection presents unique *** HCC develops,there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies,including liver transplantation.

关键词： Hepatocellular carcinoma Human immunodeficiency virus hepatitis Hepatitis B virus Hepatitis C virus Co-infection Incidence Transplant Pathogenesis

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The Electrode Process of Titanium Subchlorides and Electrodeposition of Titanium in LiCl-KCl Fused Salts

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Rare Metals 1989年第4期9卷 6-11页

作者： douglas Inman Imperial College of Science and Technology U.K.

The electrochemical behaviour of Ti(Ⅲ) and Ti(Ⅱ) in LiCl-KCl eutectic system has been studied by cyclic voltammetry and *** cathodic reduction of Ti(Ⅲ) and Ti(Ⅱ) has been found to be stepwise:Ti(Ⅲ)+e=Ti(Ⅱ),Ti(Ⅱ)+2e =*** reductions are diffusion *** an equilibrium between Ti subchlorides and excess metallic Ti was estab- lished by reaction 2TiCl_3+Ti=3TiCl_2 in LiCl-KCl melt at 475℃,then the average valence of Ti is less than *** this system the diffusion coefficient for Ti(Ⅱ) ion was calculated as D=2.5×10^(-5)cm^2·s^(-1).The chronoamperometric studies showed that the initial nucleation stage and growth of nuclei were observed when Ti ions were electrodeposited on low carbon steel substrate. The investigation of nucleation of metal may provide the method for obtaining smooth,coherent and adherent deposits of titanium.

关键词： The Electrode Process of Titanium Subchlorides and Electrodeposition of Titanium in LiCl-KCl Fused Salts Ti

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Effects of overburden characteristics on dynamic failure in underground coal mining

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International Journal of Mining Science and Technology 2017年第1期27卷 121-129页

作者： Lawson Heather E. Tesarik douglas Larson Mark K Abraham Habte NIOSH Office of Mine Safety and Health ResearchGround Control BranchSpokane WA 99207USA

Dynamic failures, or ‘‘bumps", remain an imperative safety concern in underground coal mining, despite significant advancements in engineering controls. The presence of spatially discrete, stiff roof units are one feature that has been linked to these events. However, an empirical stratigraphic review indicates that no significant difference exists in the relative commonality of discrete units between bumping and non-bumping deposits. Instead an apparent relationship exists between reportable bumping and the overall stiffness of the host rock. However, this initial study is too simplistic to be conclusive; to weight the relative impact of changes in a single variable, such as the thickness or location of sandstone members, it must be examined in isolation—i.e., in a setting where all other variables are held *** modelling provides this setting, and the effects of variability in a stiff discrete member in a hypothetical longwall mining scenario are investigated within the context of three stratigraphic ‘‘types",Compliant, Intermediate and Stiff. A modelling experiment examines changes in rupture potential in stiff roof units for each stratigraphic type as discrete unit thickness and location are manipulated through a range of values. Results suggest that the stiff-to-compliant ratio of the host rock has an impact on the relative stress-inducing effects of discrete stiff members. In other words, it is necessary to consider both the thickness and the distance to the seam, within the context of the host rock, to accurately anticipate areas of elevated rupture-induced hazard; acknowledging the presence of a discrete unit within the overburden in general terms is an insufficient indicator of risk. This finding helps to refine our understanding of the role of individual stiff, strong roof members in bumping phenomena, and suggests that a holistic view of overburden lithology and site-specific numerical modelling may be necessary to improve miner safety.

关键词： Dynamic failure Coal mining Bumps Bounces

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Modeling regional landslide susceptibility using dynamic soil moisture profiles

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Journal of Mountain Science 2018年第8期15卷 1807-1824页

作者： RAY Ram L JACOBS Jennifer M douglas Ellen M Cooperative Agricultural Research Center College of Agriculture and Human Sciences Prairie View A&M University Department of Civil Engineering University of New Hampshire Environmental Earth and Ocean Sciences Department University of Massachusetts Boston

A landslide susceptibility mapping study was performed using dynamic hillslope hydrology. The modified infinite slope stability model that directly includes vadose zone soil moisture(SM) was applied at Cleveland Corral, California, US and Krishnabhir, Dhading, Nepal. The variable infiltration capacity(VIC-3L) model simulated vadose zone soil moisture and the wetness index hydrologic model simulated groundwater(GW). The GW model predictions had a 75% NASH-Sutcliffe efficiency when compared to California's in-situ GW measurements. The model performed best during the wet season. Using predicted GW and VIC-3L vadose zone SM, the developed landslide susceptibility maps showed very good agreement with mapped landslides at each study region. Previous quasi-dynamic model predictions of Nepal's hazardous areas during extreme rainfall events were enhanced to improve the spatial characterization and provide the timing of hazardous conditions.

关键词： Landslide susceptibility Vadose zone Soil moisture Infiltration eapacity VIC-3L Groundwater

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Bridging larger gaps in peripheral nerves using neural prosthetics and physical therapeutic agents

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Neural Regeneration Research 2019年第7期14卷 1109-1115页

作者： Muhammad Sana Ullah Sahar Matthew Barton Geoffrey douglas Tansley School of Engineering and Built Environment Griffith University Clem Jones Centre for Neurobiology and Stem Cell Therapies Griffith University

Peripheral nerve injuries are relatively common and can be caused by a variety of traumatic events such as motor vehicle *** can lead to long-term disability,pain,and financial burden,and contribute to poor quality of *** this review,we systematically analyze the contemporary literature on peripheral nerve gap management using nerve prostheses in conjunction with physical therapeutic *** use of nerve prostheses to assist nerve regeneration across large gaps(> 30 mm) has revolutionized neural *** materials used for nerve prostheses have been greatly refined,making them suitable for repairing large nerve ***,research on peripheral nerve gap management using nerve prostheses reports inconsistent functional outcomes,especially when prostheses are integrated with physical therapeutic agents,and thus warrants careful *** review explores the effectiveness of nerve prostheses for bridging large nerve gaps and then addresses their use in combination with physical therapeutic agents.

关键词： nerve repair nerve conduits nerve prosthesis physical therapeutic agents electric stimulation nerve gap axonal growth nerve regeneration

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