Hepatocellular carcinoma,human immunodeficiency virus and viral hepatitis in the HAART era

作     者：Douglas C Macdonald Mark Nelson Mark Bower Thomas Powles 

作者机构：Chelsea and Westminster hospitalLondonUnited Kingdom St Bartholomew’s HospitalLondonUnited Kingdom 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第11期

页      面：1657-1663页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100214[医学-肿瘤学] 10[医学] 

主　　题：肝细胞癌 人类免疫缺陷病毒 肝炎 乙肝病毒 

摘      要：The incidence of hepatocellular carcinoma(HCC)in patients with human immunodeficiency virus(HIV) is *** in HIV almost invariably occurs in the context of hepatitis C virus(HCV)or hepatitis B virus (HBV)co-infection and,on account of shared modes of transmission,this occurs in more than 33% and 10% of patients with HIV worldwide *** has yet to be clearly established whether HIV directly accelerates HCC pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy(HAART)era,wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to *** this question will have implications for HCC surveillance and the timing of HCV/HBV therapy,which in HIV co-infection presents unique *** HCC develops,there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies,including liver transplantation.