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Asian Journal of Andrology 2011年第4期13卷 620-621页

作者： douglas T Carrell Andrology and IVF Laboratories Departments of Surgery （Urology） Obstetrics and Gynecology and Physiology University of Utah School of Medicine Salt Lake City UT 84108 USA

Human sperm chromatin, and the sperm of most mammals, undergoes extensive remodeling during spermiogenesis during which 85%-95% of the histones are removed and replaced with protamines. The replacement of most histones with protamines facilitates a tighter packaging of the chromatin that is necessary for normal sperm function, and may help protect sperm DNA from damage during transport.

关键词： Epigenetic fertilization

Characterising populations living close to intensive farming and composting facilities in England

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 97-109页

作者： Philippa douglas Daniela Fecht Deborah Jarvis National Heart and Lung Institute MRC Centre for Environment and HealthImperial College LondonLondonSW36LZUK Centre for Radiation Chemical and Environmental HazardsPublic Health EnglandHarwell CampusDidcotOxfordshireOX 11 ORQUK UK Small Area Health Statistics Unit MRC Centre for Environment and HealthSchool of Public HealthImperial College LondonLondonW2 IPGUK

Bioaerosol exposure has been linked to adverse respiratory *** farming and composting facilities are important anthropogenic sources of *** aimed to characterise populations living close to intensive farming and composting *** also infer whether the public are becoming more concerned about anthropogenic bioaerosol emissions,using reports of air pollution related incidents attributed to *** mapped the location of 1,257 intensive farming and 310 composting facilities in England in relation to the resident population and its characteristics(sex and age),area characteristics(deprivation proxy and rural/urban classification)and school locations stratified by pre-defined distance bands from these bioaerosol *** also calculated the average number of air pollution related incidents per year per *** found that more than 16%of the population and 15%of schools are located within 4,828 m of an intensive farming facility or 4,000 m of a composting facility;few people(0.01%)live very close to these sites and tend to be older *** to composting facilities,populations are more likely to be urban and more *** number of incidents were attributed to a small proportion of facilities;population characteristics around these facilities were *** indicate that populations living near composting facilities(particularly>250 to≤4,000 m)are mostly located in ur6an areas(80188%of the population),which supports the need for more community health studies to be *** could also be used to inform risk management strategies at facilities with higher numbers of incidents.

关键词： Composting Intensive farming Bioaerosol Population characteristics Public health

Key quality indicators in colonoscopy

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Gastroenterology Report 2023年第1期11卷 49-59页

作者： douglas K.Rex Division of Gastroenterology/Hepatology Indiana University School of MedicineIndianapolisINUSA

Many quality indicators have been proposed for colonoscopy,but most colonoscopists and endoscopy groups focus on measuring the adenoma detection rate and the cecal intubation *** of proper screening and surveillance intervals is another accepted key indicator but it is seldom evaluated in clinical *** preparation efficacy and polyp resection skills are areas that are emerging as potential key or priority *** review summarizes and provides an update on key performance indicators for colonoscopy quality.

关键词： colonoscopy quality adenoma detection rate polypectomy post-polypectomy surveillance

Adjacent strong edge colorings and total colorings of regular graphs

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Science China Mathematics 2009年第5期52卷 973-980页

作者： WOODALL douglas R School of Mathematical Sciences University of NottinghamNottinghamNG7 2RDUK

It is conjectured that X as ′ (G) = X t (G) for every k-regular graph G with no C 5 component (k ? 2). This conjecture is shown to be true for many classes of graphs, including: graphs of type 1; 2-regular, 3-regular and (|V(G)| - 2)-regular graphs; bipartite graphs; balanced complete multipartite graphs; k-cubes; and joins of two matchings or cycles.

关键词： graph total coloring adjacent strong edge coloring 05C15 68R10

Texture-based latent space disentanglement for enhancement of a training dataset for ANN-based classification of fruit and vegetables

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Information Processing in Agriculture 2023年第1期10卷 85-105页

作者： Khurram Hameed douglas Chai Alexander Rassau School of Engineering Edith Cowan University270 Joondalup DriveJoondalup WA 6027PerthAustralia

The capability of Convolutional Neural Networks(CNNs)for sparse representation has significant application to complex tasks like Representation Learning(RL).However,labelled datasets of sufficient size for learning this representation are not easily *** unsupervised learning capability of Variational Autoencoders(VAEs)and Generative Adversarial Networks(GANs)provide a promising solution to this issue through their capacity to learn representations for novel data samples and classification *** this research,a texture-based latent space disentanglement technique is proposed to enhance learning of representations for novel data samples.A comparison is performed among different VAEs and GANs with the proposed approach for synthesis of new data *** different VAE architectures are considered,a single layer dense VAE and a convolution based VAE,to compare the effectiveness of different architectures for learning of the *** GANs are selected based on the distance metric for disjoint distribution divergence estimation of complex representation learning *** proposed texture-based disentanglement has been shown to provide a significant improvement for disentangling the process of representation learning by conditioning the random noise and synthesising texture rich images of fruit and vegetables。

关键词： Information Maximisation(IM) Fruit and vegetables classification Representation Learning(RL) Variational Autoencoder(VAE) Generative Adversarial Network (GAN) Latent space disentanglement

Powering brain power: GLUT1 and the era of structure based human transporter biology

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National Science Review 2015年第1期2卷 3-4页

作者： douglas C.Rees Chemistry and Chemical Engineering Howard Hughes Medical InstituteCalifornia Institute of Technology

Every student of biochemistry quickly appreciates the central role of glycolysis in cellular *** is not usually addressed in an introductory course is how glucose gets inside a cell in the irst *** integral membrane p... 详细信息

关键词： GLUT1 and the era of structure based human transporter biology Powering brain power

The unregulated commercialization of stem cell treatments:a global perspective

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Frontiers of Medicine 2011年第4期5卷 348-355页

作者： douglas Sipp Research Unit for Science Policy and Ethics Studies RIKEN Center for Developmental Biology2-2-3 Minatojima MinamimachiChuo-kuKobe 650-0047Japan

Research into the biological properties and clinical potential of stem cells has spurred strong public investment,industry development,media coverage,and patient interest in recent *** date,however,few clinical applications of demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stem cells in the treatment of diseases of the blood and immune *** lack of an evidence basis notwithstanding,hundreds of companies and private clinics around the world now sell putative stem cell treatments for an enormously broad range of medical and quality-of-life *** represents a major challenge for legitimate scientists working in the field,for authorities seeking to protect their constituencies,and for patients and consumers targeted by such companies’marketing *** this review,I provide an overview of the global industry in pseudomedical stem cell treatments,with an investigation of claims in a single disease area(amyotrophic lateral sclerosis),and make recommendations for the introduction and enforcement of appropriate regulatory responses to this problem.

关键词： stem cell tourism medical ethics stem cell policy and regulation alternative medicine

Oxygen and carbon isotope composition from the UHP Shuanghe marbles, Dabie Mountains, China

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Science China Earth Sciences 1999年第1期42卷 88-96页

作者：王清晨 douglas Rumble Geophysical Laboratory Carnegie Institution of Washington 5241 Broad Road N. W. Washington DC 20015-1305 U. S. A.

Investigations on the oxygen and carbon isotope compositions from the ultrahigh-pressure (UHP)-metamorphosed Shuanghe marbles, that occur as a member of a UHP slab, show that the δ18 O values range from +11.1% to+20.5% SMOW, and δ13 C from+1.0% to+5.7% PDB, respectively. The variations in isotope compositions show a centimeter scale of homogeneity and a heterogeneity of regional scale larger than 1 meter.In contrast to the eclogite marbles from Norway, the Shuanghe marbles have inherited the carbon isotope compositions from their sedimentary precursor. The δ13C shows positive correlation to the content of dolomite. The depletion in18O, compared with the pmtolithic carbonate strata, might result from three possible geological processes: 1) exchanging oxygen isotope with meteoric water before the UHP metamorphism, 2) decarbonation during the UHP metamorphism, and 3) exchanging oxygen isotope with country gneiss at local scale during retrograde metamorphism.It seems that the advection of fluid in the orogenic belt was very limited during subduction and exhumation of UHP rocks.

关键词： oxygen and carbon isotope UHP metamorphism Shuanghe marble Dabie Mountains of China.

Molecular mechanisms of insulin resistance in chronic hepatitis C

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World Journal of Gastroenterology 2009年第35期15卷 4356-4364页

作者： Mark W douglas Jacob George Storr Liver Unit Westmead Millennium InstituteUniversity of Sydney at Westmead Hospita

It is now widely recognized that chronic hepatitis C (CHC)is associated with insulin resistance(IR)and type 2 diabetes,so can be considered a metabolic *** is most strongly associated with hepatitis C virus(HCV)genotype 1,in contrast to hepatic steatosis, which is associated with genotype 3 *** from the well-described complications of diabetes,IR in CHC predicts faster progression to fibrosis and cirrhosis that may culminate in liver failure and hepatocellular *** recently,it has been recognized that IR in CHC predicts a poor response to antiviral therapy. The molecular mechanisms for the association between IR and HCV infection are not well *** review will elaborate on the clinical associations between CHC and IR and summarize current knowledge regarding the molecular mechanisms that potentially mediate HCV-associated IR.

关键词： Hepatitis C virus Insulin resistance Treatment response Interferon

Hermitian geometry on the resolvent set(Ⅱ)

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Science China Mathematics 2021年第2期64卷 385-398页

作者： Ronald G.douglas Rongwei Yang Department of Mathematics Texas A&M UniversityCollege StationTX 77843USA School of Mathematical Sciences Tianjin Normal UniversityTianjin 300387China Department of Mathematics and Statistics State University of New York at AlbanyAlbanyNY 12222USA

For an element A in a unital C^(*)-algebra B,the operator-valued 1-formωA(z)=(z-A)^(-1) dz is analytic on the resolvent setρ(A),which plays an important role in the functional calculus of *** paper defines a class of Hermitian metrics onρ(A)through the coupling of the operator-valued(1,1)-formΩA=-ωA^(*)∧ωA with tracial and vector *** main goal is to study the connection between A and the properties of the metric concerning curvature,arc length,completeness and singularity.A particular example is when A is quasi-nilpotent,in which case the metric lives on the punctured complex plane C\{0}.The notion of the power set is defined to gauge the"blow-up"rate of the metric at 0,and examples are given to indicate a likely link with A’s hyper-invariant subspaces.

关键词： C^(*)-algebra Hermitian metric curvature arc length Fuglede-Kadison determinant quasi-nilpotent operator power set