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Cubic multi-ions-doped Na_(2)TiO_(3) nanorod-like coatings:Structure-stable,highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition

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Bioactive Materials 2022年第12期7卷 72-90页

作者： dongmei yu Bo Li Meng yu Shuo Guo Zheng Guo Yong Han a State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049ShaanxiChina Department of Orthopaedics Tangdu HospitalFourth Military Medical UniversityXi’an710038ShaanxiChina

The dissolution-derived release of bioactive ions from ceramic coatings on metallic implants,despite improving osseointegration,renders a concern on the interfacial breakdown of the metal/coating/bone system during longterm service.Consequently,persistent efforts to seek alternative strategies instead of dissolution-derived activation are pressingly carrying out.Inspired by bone mineral containing ions as Ca2+,Mg2+,Sr2+and Zn2+,here we hydrothermally grew the quadruple ions co-doped Na2TiO3 nanorod-like coatings.The co-doped ions partially substitute Na+in Na2TiO3,and can be efficiently released from cubic lattice via exchange with Na+in fluid rather than dissolution,endowing the coatings superior long-term stability of structure and bond strength.Regulated by the coatings-conditioned extracellular ions,TLR4-NFκB signalling is enhanced to act primarily in macrophages(MΦs)at 6 h while CaSR-PI3K-Akt1 signalling is potentiated to act predominately since 24 h,triggering MΦs in a M1 response early and then in a M2 response to sequentially secrete diverse cytokines.Acting on endothelial and mesenchymal stem cells with the released ions and cytokines,the immunomodulatory coatings greatly promote Type-H(CD31hiEmcnhi)angiogenesis and osteogenesis in vitro and in vivo,providing new insights into orchestrating insoluble ceramics-coated implants for early vascularized osseointegration in combination with long-term fixation to bone.

关键词： Nanorod-like coating Ion doping Sodium titanate Immunomodulation Angiogenesis Osseointegration

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Immunomodulation and osseointegration activities of Na_(2)TiO_(3) nanorods-arrayed coatings doped with different Sr content

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Bioactive Materials 2022年第4期7卷 323-334页

作者： dongmei yu Shuo Guo Meng yu Wenwen Liu Xiaokang Li Dafu Chen Bo Li Zheng Guo Yong Han State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049ShaanxiChina Department of Orthopaedics Tangdu HospitalFourth Military Medical UniversityXi’an710038ShaanxiChina Department of Biomedical Engineering Fourth Military Medical UniversityXi’an710032ShaanxiChina Laboratory of Bone Tissue Engineering Beijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing100035China

To endow Ti-based orthopedic implants immunomodulatory capability and thus enhanced osseointegration,different amounts of Sr are doped in Na_(2)TiO_(3) nanorods in the arrays with identical nanotopographic parameters(rod diameter,length and inter-rod spacing)by substitution of Na^(+) using hydrothermal treatment.The obtained arrays are denoted as STSr2,STSr4,and STSr7,where the arabic numbers indicate the incorporating amounts of Sr in Na_(2)TiO_(3).The modulation effects of the Sr-doped nanorods arrays on macrophage polarization and osteogenetic functions of osteoblasts are investigated,together with the array without Sr(ST).Moreover,osseointegration of these arrays are also assayed in rat femoral condyles.Sr-doped nanorods arrays accelerate M1(pro-inflammatory phenotype)-to-M2(anti-inflammatory phenotype)transformation of the adhered macrophages,enhancing secretion of pro-osteogenetic cytokines and growth factors(TGF-β1 and BMP2),moreover,the Sr doped arrays directly enhance osteogenetic functions of osteoblasts.The enhancement of paracrine of M2 macrophages and osteogenetic function of osteoblasts is promoted with the increase of Sr incorporating amounts.Consequently,Sr doped arrays show significantly enhanced osseointegration in vivo compared to ST,and STSr7 exhibits the best performance.Our work sheds a new light on the design of surface chemical components and structures for orthopedic implants to enhance their osseointegration.

关键词： Nanorods-patterned array Sr incorporation Macrophage polarization Osteogenetic function of osteoblast Osseointegration

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Consumption of Milk and Dairy Products Among Junior High and Senior High School Students — China, 2016–2017

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China CDC weekly 2022年第3期4卷 47-51页

作者： Xiaoli Xu Xue Cheng Liyun Zhao Hongyun Fang Qiya Guo Lahong Ju Shujuan Li Shuya Cai Wei Piao dongmei yu National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Chinese dietary guidelines recommend an intake of milk and dairy products to be closely related to human health.Although the production capacity of dairy in China is strong,the per capita consumption of dairy products is not high.What is added by this report?This report showed that the consumption rate of milk and dairy products of junior high and senior high school students in China was 82.5%from 2016 to 2017.Only 44.1%of them consumed milk and dairy products every day.Only 20.4%of these students reached intake levels recommended by the Dietary guidelines for Chinese residents(2016).What are the implications for public health practice?Milk and dairy products are a key food group in a healthy dietary pattern.To cultivate a healthy eating habit of including dairy for children and adolescents,the government,suppliers,schools,and parents need to cooperate together.

关键词： Junior Dairy senior

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Trends of Underweight Malnutrition Among Chinese Residents Aged 60 Years and Above—China,1992−2015

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China CDC weekly 2021年第11期3卷 232-236页

作者： Pengkun Song Qingqing Man yuqian Li Shanshan Jia dongmei yu Zhen Liu Jian Zhang National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention.BeijingChinaKey Laboratory of Trace Element NutritionNational Health Commission of the People’s Republic of ChinaBeijingChina.

Summary What is already known about this topic?The prevalence of underweight malnutrition largely decreased in Chinese adults in recent thirty years while obesity became increasingly concerning.However,underweight malnutrition still affected elderly populations and increased risk of anemia,infection diseases,some non-communicable chronic diseases and disability.

关键词： diseases anemia weight

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Sr-Nd-Pb Isotopic Compositions of the Neogene Eolian Deposits in the Xining Basin and Implications for Their Dust Sources

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Journal of Earth Science 2015年第5期26卷 669-676页

作者： Fangming Zeng Meiyan Liang Shuzhen Peng dongmei yu Shuyuan Xiang Key Laboratory of Salt Lake Resources and Chemistry Qinghai Institute of Salt LakesChinese Academy of Sciences School of Public Administration China University of Geosciences School of Tourism Resources and Environment Taishan University School of Earth Sciences China University of Geosciences

The Neogene eolian deposits in the Xining Basin are valuable archive for studying the evolution of the Asian monsoon system and geomorphic processes of Northwest China. The Neogene eolian deposits that paleomagnetically dated at about 14 Ma probably were sourced from the middle and west Qinghai-Tibetan Plateau（QTP） as indicated by elemental compositions and magnetic properties. This study provides the Sr-Nd-Pb isotopic ratios of different sediments（gravels from the river terraces, Neogene eolian deposits and Quaternary loess） in the Xining Basin. The results show that：（1） Sr-Nd isotopic compositions of terrace gravels are different from those of the Neogene and Quaternary eolian deposits, although the Nd isotope ratios of gravel on the 10 th terrace（T10） and eolian deposits are similar.（2） Pb isotopic compositions of river gravels are obviously different from the eolian deposits in the Xining Basin. However, Pb isotopic compositions of eolian deposits in the basin are similar to those of eolian deposits in the central Chinese Loess Plateau.（3） Sr-Nd-Pb isotope results indicate that the Neogene eolian deposits in the Xining Basin were probably sourced from remote areas outside of the basin by long-distance transportation. The Qaidam Basin is probably an important source area for the eolian deposits in the Xining Basin.

关键词： eolian deposits,Qinghai-Tibetan Plateau,Sr-Nd-Pb isotope,source area

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Weight Status and Self-Perception of Weight Among Women of Childbearing Age—China,2015

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China CDC weekly 2021年第9期3卷 185-188页

作者： Hongyun Fang Qiya Guo Lahong Ju Shujuan Li Xiaoli Xu Wei Piao dongmei yu Liyun Zhao National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina.

Summary What is already known about this topic?Both lean and obese women carry a risk for adverse pregnancy outcomes.Correct self-perception of body weight status is necessary for optimal weight control.What is added by this report?Data from the Nutrition and Chronic Disease Surveillance of Chinese Residents in 2015 were used in this study.The weight status and self-perception of weight among women of childbearing age in China were analyzed to provide basic data for improving the nutritional health of women of childbearing age.

关键词： weight carry women

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Therapeutic effect of ketogenic diet treatment on type 2 diabetes

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Journal of Future Foods 2022年第2期2卷 177-183页

作者： Fang Li Yang Shen Qun Chen Xingyu Li Hongnan Yang Canyang Zhang Jinjun Lin Zhicheng Du Chenyao Jiang Chengming Yang dongmei yu Peiwu Qin Institute of Bio-pharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518101China Department of Endocrinology Baoan Central Hospital of Shenzhenthe Fifth Affiliated Hospital of Shenzhen UniversityShenzhen 518055China Department of Automation Hangzhou Dianzi UniversityHangzhou 310016China Southern University of Science and Technology Hospital Shenzhen 518055China Department of Electromechanical and Information Engineering Shandong UniversityWeihai 264209China

Diet plays an important role in diabetes development.The effect of ketogenic diet on type 2 diabetes remains elusive.In this study,we collect diabetes related physiological parameters and abdominal MRI images to evaluate the effect of ketogenic diet after 3-months of consecutive treatment.Ketogenic diet mitigates the diabetes symptom inferring from the statistically significant reduction of key diabetic physiological parameters such as Hemoglobin A1c(HbA1c)concentration,Triglyceride(TG),Fasting blood glucose(FBG),Body Mass Index(BMI),and adipose tissue volume.Moreover,we propose a new parameter to quantify the treating effect of ketogenic diet since Slope and Offset of Oral Glucose Tolerance Test(SOOGTT)incorporate more sampling points by fitting OGTT(Oral Glucose Tolerance Test)curve.SOOGTT shows statistically significant(P<0.001)treating effect of ketogenic diet on type 2 diabetes.We use artificial intelligence to segment adipose tissue for treatment evaluation,which shows that ketogenic diet reduces the amount of adipose tissue.

关键词： Ketogenic diet Type 2 diabetes Diabetic physiological parameters MRI images Offset of Oral Glucose Tolerance Test(SOOGTT)

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用于高效去除水中孔雀石绿的三层结构磁性复合材料Fe_(3)O_(4)@聚丙烯酸@ZiF-8的制备

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无机化学学报 2024年第3期40卷 544-554页

作者：徐鹏王莎莎陈难难王澳于冬妹南京林业大学化学工程学院南京210037

设计并合成了一种以磁性纳米粒子为核,聚合物为中间层,金属有机骨架材料为外层的三层结构磁性复合材料(Fe_(3)O_(4)@PAA@ZIF-8)。首先利用溶剂热法制备Fe_(3)O_(4)纳米粒子,然后通过蒸馏沉淀聚合法在Fe_(3)O_(4)纳米粒子表面包覆聚丙烯... 详细信息

设计并合成了一种以磁性纳米粒子为核,聚合物为中间层,金属有机骨架材料为外层的三层结构磁性复合材料(Fe_(3)O_(4)@PAA@ZIF-8)。首先利用溶剂热法制备Fe_(3)O_(4)纳米粒子,然后通过蒸馏沉淀聚合法在Fe_(3)O_(4)纳米粒子表面包覆聚丙烯酸(PAA)层,最后通过原位沉积法在PAA外部包覆ZIF-8。在对Fe_(3)O_(4)@PAA@ZIF-8的组成和结构进行表征的基础上,深入研究其对孔雀石绿(MG)的吸附性能。透射电子显微镜(TEM)显示Fe_(3)O_(4)@PAA@ZIF-8具有明显的三层结构,Fe_(3)O_(4)的平均粒径为117nm,PAA层厚度约为17 nm,ZIF-8层的厚度约为14 nm。Fe_(3)O_(4)@PAA@ZIF-8对MG的吸附量随着p H的升高而增大,吸附过程符合准二阶动力学模型和Langmuir等温吸附模型。此外,Fe_(3)O_(4)@PAA@ZIF-8还表现出良好的重复利用性能,8次循环利用后对MG(500 mg·L^(-1))的最大吸附量仍可达982 mg·g^(-1)。

关键词： Fe_(3)O_(4) 沸石咪唑酯骨架材料吸附孔雀石绿

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CT血管成像对脑血管病变的临床应用价值

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中国医药指南 2024年第1期22卷 79-81页

作者：于冬梅沈阳医学院附属第二医院沈阳110035

目的分析CT血管成像(CTA)对脑血管病变的应用价值。方法选择我院2019年1月至2019年12月接诊的脑血管病变患者45例为研究对象,所有患者均进行CTA及CT检查,对比分析参与研究患者的诊断结果。结果CT检查结果显示12例颅内出血、21例蛛网膜... 详细信息

目的分析CT血管成像(CTA)对脑血管病变的应用价值。方法选择我院2019年1月至2019年12月接诊的脑血管病变患者45例为研究对象,所有患者均进行CTA及CT检查,对比分析参与研究患者的诊断结果。结果CT检查结果显示12例颅内出血、21例蛛网膜下腔出血、12例正常,CTA检查结果显示24例脑动脉瘤、9例动静脉畸形、6例动脉狭窄、2例动脉硬化、4例正常。以患者出院诊断为标准,CTA检查的准确率高于CT(95.56%vs.80.00%,P=0.024)。结论CTA检查对脑血管病变诊断效果佳,尤其是在动静脉畸形及脑动脉瘤方面的诊断中具有十分突出的优势,蛛网膜下腔出血问题的诊出率相对较好。

关键词： CT血管成像脑血管病变应用价值

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电视台演播室灯光与视频技术的配合研究

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电视技术 2024年第6期48卷 1-3页

作者：于冬梅武城县融媒体中心山东德州253300

电视演播室为电视节目的制作提供了一个良好的空间。保证演播室内环境整洁、光线充足,能够为电视台录制高质量视频奠定基础。电视演播室灯光与视频技术之间的配合,成为影响电视节目质量的一个重要因素。基于此,从电视台演播室对灯光与... 详细信息

电视演播室为电视节目的制作提供了一个良好的空间。保证演播室内环境整洁、光线充足,能够为电视台录制高质量视频奠定基础。电视演播室灯光与视频技术之间的配合,成为影响电视节目质量的一个重要因素。基于此,从电视台演播室对灯光与视频技术的要求入手,对电视台演播室灯光与视频技术之间的配合进行分析与研究。

关键词：电视台演播室灯光与视频技术

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