Cubic multi-ions-doped Na_(2)TiO_(3) nanorod-like coatings:Structure-stable,highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition
作者机构：a State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an710049ShaanxiChina Department of OrthopaedicsTangdu HospitalFourth Military Medical UniversityXi’an710038ShaanxiChina
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第12期
页 面：72-90页
核心收录：
学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 10[医学]
主 题：Nanorod-like coating Ion doping Sodium titanate Immunomodulation Angiogenesis Osseointegration
摘 要：The dissolution-derived release of bioactive ions from ceramic coatings on metallic implants,despite improving osseointegration,renders a concern on the interfacial breakdown of the metal/coating/bone system during longterm ***,persistent efforts to seek alternative strategies instead of dissolution-derived activation are pressingly carrying *** by bone mineral containing ions as Ca2+,Mg2+,Sr2+and Zn2+,here we hydrothermally grew the quadruple ions co-doped Na2TiO3 nanorod-like *** co-doped ions partially substitute Na+in Na2TiO3,and can be efficiently released from cubic lattice via exchange with Na+in fluid rather than dissolution,endowing the coatings superior long-term stability of structure and bond *** by the coatings-conditioned extracellular ions,TLR4-NFκB signalling is enhanced to act primarily in macrophages(MΦs)at 6 h while CaSR-PI3K-Akt1 signalling is potentiated to act predominately since 24 h,triggering MΦs in a M1 response early and then in a M2 response to sequentially secrete diverse *** on endothelial and mesenchymal stem cells with the released ions and cytokines,the immunomodulatory coatings greatly promote Type-H(CD31hiEmcnhi)angiogenesis and osteogenesis in vitro and in vivo,providing new insights into orchestrating insoluble ceramics-coated implants for early vascularized osseointegration in combination with long-term fixation to bone.
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