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Predicting hepatocellular carcinoma: A new non-invasive model based on shear wave elastography

World Journal of Gastroenterology 2024年第25期30卷 3166-3178页

作者： dong Jiang Yi Qian Yi-Jun Gu Ru Wang Hua yu Hui dong dong-yu chen Yan chen Hao-Zheng Jiang Bi-Bo Tan Min Peng Yi-Ran Li Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalThird Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of College of Art and Science Case Western Reserve UniversityClevelandOH 44106United States Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China

BACKGROUND Integrating conventional ultrasound features with 2D shear wave elastography(2D-SWE)can potentially enhance preoperative hepatocellular carcinoma(HCC)*** To develop a 2D-SWE-based predictive model for preoperative identification of *** A retrospective analysis of 884 patients who underwent liver resection and pathology evaluation from February 2021 to August 2023 was conducted at the Oriental Hepatobiliary Surgery *** patients were divided into the modeling group(n=720)and the control group(n=164).The study included conventional ultrasound,2D-SWE,and preoperative laboratory *** logistic regression was used to identify independent predictive factors for RESULTS In the modeling group analysis,maximal elasticity(Emax)of tumors and their peripheries,platelet count,cirrhosis,and blood flow were independent risk indicators for *** factors yielded an area under the curve of 0.77(95%confidence interval:0.73-0.81)with 84%sensitivity and 61%*** model demonstrated good calibration in both the construction and validation cohorts,as shown by the calibration graph and Hosmer-Lemeshow test(P=0.683 and P=0.658,respectively).Additionally,the mean elasticity(Emean)of the tumor periphery was identified as a risk factor for microvascular invasion(MVI)in malignant liver tumors(P=0.003).Patients receiving antiviral treatment differed significantly in platelet count(P=0.002),Emax of tumors(P=0.033),Emean of tumors(P=0.042),Emax at tumor periphery(P<0.001),and Emean at tumor periphery(P=0.003).CONCLUSION 2D-SWE’s hardness value serves as a valuable marker for enhancing the preoperative diagnosis of malignant liver lesions,correlating significantly with MVI and antiviral treatment efficacy.

关键词： Shear wave elastography Predicting model Microvascular invasion Antiviral treatment Hepatocellular carcinoma

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结合最近邻图模型的稀疏ISAR成像方法

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电子学报 2024年第1期52卷 170-180页

作者：胡长雨陈春风易文忆董宇宸李晖汪玲无锡学院电子信息工程学院江苏无锡214000 南京航空航天大学雷达成像与微波光子教育部重点实验室江苏南京210016 无锡学院自动化学院江苏无锡214000

逆合成孔径雷达(Inverse Synthetic Aperture Radar,ISAR)稀疏成像方法可提供图像对比度高、旁瓣干扰少的成像结果 .稀疏成像以场景或目标散射率分布具有稀疏性为前提,待成像目标场景的稀疏特性决定了最终成像质量. ISAR目标场景的自然... 详细信息

逆合成孔径雷达(Inverse Synthetic Aperture Radar,ISAR)稀疏成像方法可提供图像对比度高、旁瓣干扰少的成像结果 .稀疏成像以场景或目标散射率分布具有稀疏性为前提,待成像目标场景的稀疏特性决定了最终成像质量. ISAR目标场景的自然稀疏特性着重刻画点状特征,变换域稀疏表示可增强目标图像的纹理等通用特征.通过学习获得的稀疏变换字典,可自适应于待成像的ISAR目标场景,找到面向ISAR目标图像块的特有稀疏表示.但是,图像块的特有稀疏表示中忽略了待成像目标场景中目标的几何特征信息.最近邻图模型可建立给定数据的几何特征描述算子,刻画出给定数据的几何特征信息.本文利用最近邻图模型来刻画待成像目标场景中目标的几何特征信息,并映射到待成像目标场景的特有稀疏表示中;提出结合最近邻图模型的ISAR稀疏成像方法,用于不同类别实测ISAR数据成像.相比已有的ISAR稀疏成像方法,所提成像方法可获得目标轮廓更清晰的成像结果,成像所需时间平均减少10.4%.

关键词：逆合成孔径雷达稀疏成像最近邻图模型稀疏表示字典学习

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生物炭改良盐碱地研究与应用进展

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环境科学 2024年第2期45卷 940-951页

作者：魏盈焦乐张鹏刘福德肖辉董昱辰孙红文天津理工大学环境科学与安全工程学院天津300384 农业农村部环境保护科研监测所天津300191 南开大学环境科学与工程学院天津300350 天津市农业科学院天津300384 天津亚派绿肥生物科技发展有限公司天津301600

盐碱地作为21世纪严重威胁粮食产量的农田问题土壤之一,分布广泛,具有极大的开发潜力.生物炭作为高效的新型土壤改良剂,在缓解土壤酸碱障碍、土壤污染治理、碳封存和肥料缓释等方面发挥了重要作用,有力地推动了盐碱地农业的可持续发展.... 详细信息

盐碱地作为21世纪严重威胁粮食产量的农田问题土壤之一,分布广泛,具有极大的开发潜力.生物炭作为高效的新型土壤改良剂,在缓解土壤酸碱障碍、土壤污染治理、碳封存和肥料缓释等方面发挥了重要作用,有力地推动了盐碱地农业的可持续发展.近年来,关于生物炭改良盐碱地的研究和应用备受关注.但由于生物炭来源、结构和组分的复杂性和非均质性,其对盐碱地的改良效果存在极大的不确定,也缺乏关键机制的系统总结和深度探讨,这限制了生物炭技术在盐碱地改良中的进一步推广和应用.通过综合分析生物炭对盐碱地土壤理化性质、养分有效性和生物特征的影响,归纳总结生物炭和改性生物炭对盐碱地的改良效果及其提质增效作用,阐明生物炭在盐碱地改良中存在的可能机制,并对未来研究方向进行了展望,可为进一步研发绿色高效精准的盐碱地生物炭改良技术及其推广应用提供参考.

关键词：盐碱地生物炭改性理化性质养分

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A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis:Applied COVID-19 aggregated datasets

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Computational Visual Media 2024年第1期10卷 161-186页

作者： yu dong Christy Jie Liang Yi chen Jie Hua School of Computer Science University of Technology SydneySydneyNSW2007Australia Beijing Key Laboratory of Big Data Technology for Food Safety Beijing Technology and Business UniversityBeijing100048China

The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological ***,most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation,resulting in a lack of quantitative and qualitative *** address this issue,we developed a portrait-based visual modeling method called+*** method considers the spatiotemporal features of virus transmission patterns and multidimensional features of objective risk factors in communities,enabling portrait-based exploration and comparison in epidemiological *** applied+msRNAer to aggregate COVID-19-related datasets in New South Wales,Australia,combining COVID-19 case number trends,geo-information,intervention events,and expert-supervised risk factors extracted from local government area-based *** perfected the+msRNAer workflow with collaborative views and evaluated its feasibility,effectiveness,and usefulness through one user study and three subject-driven case *** feedback from experts indicates that+msRNAer provides a general understanding for analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical,timeline,and other factor *** adopting interactions,experts discovered functional and practical implications for potential patterns of long-standing community factors regarding the vulnerability faced by the *** confirmed that+msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.

关键词： visual modeling epidemiological analysis spatiotemporal multidimensional COVID-19

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Microscopic nonlinear optical activities and ultrafast carrier dynamics in layered AgInP_(2)S_(6)

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Photonics Research 2024年第4期12卷 691-700页

作者： ZIXIN WANG NINGNING dong yu MAO chenDUAN chen XIN chen CHANG XU ZHOUyuAN YAN JUN WANG Aerospace Laser Technology and Systems Department CAS Key Laboratory of Materials for High-Power LaserShanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Ultra-intense Laser Science(CEULS) State Key Laboratory of High Field Laser PhysicsShanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China

Since the emergence of graphene, transition metal dichalcogenides, and black phosphorus, two-dimensional materials have attracted significant attention and have driven the development of fundamental physics and optoelectronic devices. Metal phosphorus trichalcogenides(MPX3), due to their large bandgap of 1.3–3.5 eV, enable the extension of optoelectronic applications to visible and ultraviolet(UV) wavelengths.

关键词： nonlinear ultraviolet phosphorus

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Proposal for valleytronic materials:Ferrovalley metal and valley gapless semiconductor

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Frontiers of physics 2024年第2期19卷 131-139页

作者： San-dong Guo yu-Ling Tao Guangzhao Wang Shaobo chen dong Huang Yee Sin Ang School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information EngineeringYangtze Normal UniversityChongqing 408100China College of Electronic and Information Engineering Anshun UniversityAnshun 561000China Science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore

Valleytronic materials can provide new degrees of freedom to future electronic *** this work,the concepts of the ferrovalley metal(FVM)and valley gapless semiconductor(VGS)are proposed,which can be achieved in valleytronic bilayer systems by electric field *** valleytronic bilayer systems,the interaction between out-of-plane ferroelectricity and A-type antiferromagnetism can induce layer-polarized anomalous valley Hall(LP-AVH)*** K and−K valleys of FVM are both metallic,and electron and hole carriers simultaneously *** the extreme case,the FVM can become VGS by analogizing spin gapless semiconductor(SGS).Moreover,it is proposed that the valley splitting enhancement and valley polarization reversal can be achieved by electric field engineering in valleytronic bilayer *** the bilayer RuBr_(2)as an example,our proposal is confirmed by the first-principle *** FVM and VGS can be achieved in bilayer RuBr_(2)by applying electric *** appropriate electric field range,increasing electric field can enhance valley splitting,and the valley polarization can be reversed by flipping electric field *** effectively tune valley properties by electric field in bilayer systems,the parent monolayer should possess out-of-plane magnetization,and have large valley *** results shed light on the possible role of electric field in tuning valleytronic bilayer systems,and provide a way to design the ferrovalley-related material by electric field.

关键词： valleytronics electric field bilayer

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Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase

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Science China Chemistry 2024年第7期67卷 2382-2391页

作者： Ke-Wei chen Jia-Nan chen Jun Zhang Chao Wang Tian-yu Sun yun-dong Wu Key Laboratory of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicSchool of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Changping Laboratory Beijing 102200China

Fluoroacetate dehalogenases(FAcD),a homodimeric enzyme,catalyzes the conversion of fluoroacetic acid to glycolic acid(GoA).It has been proved that the enzyme has a half-of-the-site ***,its catalytic(C)subunit converts the first substrate to a covalent intermediate;then,the non-catalytic(NC)subunit binds a second substrate and promotes the conversion of the intermediate in the C subunit into the final *** the release of the product,the C subunit becomes the NC subunit,and the previous NC subunit becomes the C *** elucidate the detailed mechanism behind this cooperative catalysis,we have conducted microsecond-scale MD simulations along the reaction *** simulations indicate that the substrate in the NC subunit induces W185 and Y141 adopting an open conformation in the C *** opening of W185(C)facilitates the entry of catalytic water,enhancing the catalytic activity for product formation,while the opening of Y141(C)creates an unfavorable environment for product binding,promoting its *** interaction network analysis reveals that the substrate in the NC subunit can induce conformational changes through a conserved water chain at the interface.

关键词： enzyme catalysis molecular dynamics cooperative effect pre-reaction state

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A semi-analytical model for coupled flow in stress-sensitive multi-scale shale reservoirs with fractal characteristics

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Petroleum Science 2024年第1期21卷 327-342页

作者： Qian Zhang Wen-dong Wang yu-Liang Su Wei chen Zheng-dong Lei Lei Li Yong-Mao Hao Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Oil Development Branch Changqing Oilfield CompanyPetroChinaQingyang745708GansuChina PetroChina Research Institute of Petroleum Exploration&Development Beijing100083China

A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation.

关键词： Multi-scale coupled flow Stress sensitivity Shale oil Micro-scale effect Fractal theory

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Study on the interannual variability of the Kerama Gap transport and its relation to the Kuroshio/Ryukyu Current system

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Acta Oceanologica Sinica 2024年第3期43卷 1-14页

作者： Han Zhou Kai yu Jianhuang Qin Xuhua cheng Meixiang chen Changming dong Key Laboratory of Marine Hazards Forecasting Ministry of Natural ResourcesHohai UniversityNanjing 210003China College of Oceanography Hohai UniversityNanjing 210003China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 211800China

An analysis of a 68-year monthly hindcast output from an eddy-resolving ocean general circulation model reveals the relationship between the interannual variability of the Kerama Gap transport(KGT)and the Kuroshio/Ryukyu Current *** study found a significant difference in the interannual variability of the upstream and downstream transports of the East China Sea-(ECS-)Kuroshio and the Ryukyu *** interannual variability of the KGT was found to be of paramount importance in causing the differences between the upstream and downstream ***,it contributed approximately 37%to the variability of the Ryukyu *** interannual variability of the KGT was well described by a two-layer rotating hydraulic *** was dominated by its subsurface-intensified flow core,and the upper layer transport made a weaker negative contribution to the total *** subsurface flow core was found to be mainly driven by the subsurface pressure head across the Kerama Gap,and the pressure head was further dominated by the subsurface density anomalies on the Pacific *** density anomalies could be traced back to the eastern open ocean,and their propagation speed was estimated to be about 7.4 km/d,which is consistent with the speed of the local first-order baroclinic Rossby *** the negative(positive)density anomaly signal reached the southern region of the Kerama Gap,it triggered the increase(decrease)of the KGT towards the Pacific side and the formation of an anticyclonic(cyclonic)vortex by baroclinic ***,there is an increase(decrease)in the upstream transport of the entire Kuroshio/Ryukyu Current system and an offshore flow that decreases(increases)the downstream Ryukyu Current.

关键词： Kerama Gap Kuroshio Ryukyu Current OGCM for the Earth Simulator(OFES) hydraulic theory

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Drug delivery systems for colorectal cancer chemotherapy

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Chinese Chemical Letters 2024年第2期35卷 163-175页

作者： Wen chen Kun Shi Yan yu Peipei Yang Zhongwu Bei dong Mo Liping yuan Meng Pan yu chen Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Colorectal cancer causes the third most common type of malignant tumors with high morbidity and *** is currently one of the most effective and common treatments for colorectal ***,the poor water solubility of some chemotherapeutics,untargeted drug delivery,and the undesirable systemic side effects of conventional treatment remain the major issues for colorectal cancer ***,drug delivery systems(DDS)based on biomaterials have been widely investigated and found to be capable of resolving those issues with good ***,the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer *** not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics,including liposomes,micelles,and nanoparticles,but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus ***,locally administered systems based on hydrogels and microspheres,which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity,were also *** provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.

关键词： Colorectal cancer Chemotherapy Drug delivery systems Solubility Targeted Local administration

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