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Promoted intramolecular photoinduced-electron transfer for multi-mode imaging-guided cancer photothermal therapy

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Rare Metals 2022年第1期41卷 56-66页

作者： Xin-Yu Qu Ying Hong Han Cai Xu Sun Qing Shen dong-liang yang Xiao-Chen dong Ai-Hong Jiao Peng Chen Jin-Jun Shao Key Laboratory of Flexible Electronics and Institute of Advanced Materials Nanjing Tech UniversityNanjing 211800China Nanjing University of Information Science and Technology Nanjing 210044China Yuhuangding Hospital of Qingdao University Yantai 264000China School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore

To develop smart and efficient near-infrared(NIR)organic dyes for photothermal cancer therapy is of great ***,a pH-sensitive NIR dye BTN with donor–acceptor–donor scaffold has been *** periphery electron-donating dimethylamine groups in BTN can not only promote the intramolecular photoinduced electron transfer(PET),but also bind protons to transform into electron-deficient ammonium cation for enhanced intramolecular charge transfer(ICT)under acidic *** enveloping with amphiphilic polymeric 1,2-distearoyl-ras-glycerol-3-phosphatidyl ethanolamine-N-polyethyleneglycol-2000(DSPE-mPEG2000),BTN nanoparticles(NPs)were fabricated with robust NIR absorption covering 600–900 nm,excellent photothermal conversion efficiency(43.2%),and good ***,BTN NPs can selectively target *** tailing intravenous injection into tumor-bearing nude mice,BTN NPs demonstrate outstanding photoacoustic/photothermal/fluorescence imaging-guided photothermal therapy for tumor ablation.

关键词： Photothermal Phototherapy Near-infrared dye Photoinduced-electron transfer Intramolecular charge transfer

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang dong liang Lei yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Phase transitions in bismuth under rapid compression

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Chinese Physics B 2019年第3期28卷 300-303页

作者： dong-liang yang Jing Liu Chuan-Long Lin Qiu-Min Jing Yi Zhang Yu Gong Yan-Chun Li Xiao-dong Li Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of Science Center for High Pressure Science and Technology Advanced Research National Key Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChinese Academy of Engineering Physics

The structural phase transitions of bismuth under rapid compression has been investigated in a dynamic diamond anvil cell using time-resolved synchrotron x-ray diffraction. As the pressure increases, the transformations from phase I,to phase II, to phase III, and then to phase V have been observed under different compression rates at 300 K. Compared with static compression results, no new phase transition sequence appears under rapid compression at compression rate from 0.20 GPa/s to 183.8 GPa/s. However, during the process across the transition from phase III to phase V, the volume fraction of product phase as a function of pressure can be well fitted by a compression-rate-dependent sigmoidal *** resulting parameters indicate that the activation energy related to this phase transition, as well as the onset transition pressure, shows a compression-rate-dependent performance. A strong dependence of over-pressurization on compression rate occurs under rapid compression. A formula for over-pressure has been proposed, which can be used to quantify the over-pressurization.

关键词： bismuth high pressure rapid compression over-pressurization

Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/My D88 signaling in THP-1 cells

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World Journal of Gastroenterology 2016年第17期22卷 4354-4361页

作者： Cheng Peng Hua Wang Wen-Jing Zhang Sheng-Hua Jie Qiao-Xia Tong Meng-Ji Lu dong-liang yang Department of Infectious Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology Institute of Virology University Hospital of Essen University of Duisburg-Essen

AIM: To investigate the role of mi R-125 b in regulating monocyte immune responses induced by hepatitis C virus(HCV) core ***: Monocytic THP-1 cells were treated with various concentrations of recombinant HCV core protein, and cytokines and mi R-125 b expression in these cells were analyzed. The requirement of Tolllike receptor 2(TLR2) or My D88 gene for HCV core protein-induced immune responses was determined by the transfection of THP-1 cells with gene knockdown vectors expressing either TLR2 si RNA or My D88 si RNA. The effect of mi R-125 b overexpression on TLR2/My D88 signaling was examined by transfecting THP-1 cells with mi R-125 b mimic RNA ***: In response to HCV core protein stimulation, cytokine production was up-regulated and mi R-125 b expression was down-regulated in THP-1 cells. The modulatory effect of HCV core protein on cellular events was dose-dependent and required functional TLR2 or My D88 gene. Forced mi R-125 b expression abolished the HCV core protein-induced enhancement of tumor necrosis factor-α, interleukin(IL)-6, and IL-10 expression by 66%, 54%, and 66%, respectively(P < 0.001), by inhibiting My D88-mediated signaling, including phosphorylation of NF-k Bp65, ERK, and ***: The inverse correlation between mi R-125 b and cytokine expression after HCV core challenge suggests that mi R-125 b may negatively regulate HCVinduced immune responses by targeting TLR2/My D88 signaling in monocytes.

关键词： mi R-125b Hepatitis virus C Toll like receptor 2 Monocytes Innate immunity

Hepatitis C virus may infect extrahepatic tissues in patients with hepatitis C

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World Journal of Gastroenterology 2000年第6期6卷 805-811页

作者： Fu Ming Yan An Shen Chen Fei Hao Xi Ping Zhao Chang Hai Gu Li Bin Zhao dong liang yang Lian Jie Hao Department of Infectious Diseases the 161st Central Hospital of Chinese PLAWuhan 430010Hubei ProvinceChina Department of Infectious Diseases Southwest HospitalThird Military Medical UniversityChongqingChina Division of Clinical Immunology Tongji HospitalTongji Medical UniversityWuhanHubei ProvinceChina

AIM To explore the status of extrahepatichepatitis C virus(HCV)infection and replicationin hepatitis C patients,and its potentialimplication in HCV infection and *** By reverse-transcriptase poly-merase chain reaction(RT-PCR),in situhybridization(ISH)and immunohistochemistry,HCV RNA,HCV replicative intermediate(minus-strand of HCV RNA),and HCV antigens weredetected in 38 autopsy extrahepatic tissuespecimens(including 9 kidneys,9 hearts,9pancreas,5 intestines,2 adrenal glands,2spleens,1 lymph node,and 1 gallbladder)from 9hepatitis C patients,respectively;and thestatus of HCV replication in extrahepatic tissueswas *** By RT-PCR,all 9 patients werepositive for HCV RNA in kidney,heart,pancreas,and intestine,but only 6(66.7%)patients were positive for HCV *** RNA and HCV antigens weredetected in kidney,heart,pancreas,intestine,adrenal gland,lymph node,and gallbladder in 5(55.6%)and 6(66.7%)patients by ISH andimmunohistochemistry,*** RNA and HCV antigens were not detected in theseextrahepatic organs in 3(33.3%)patients,although their livers were positive for *** intermediate detected by RT-PCR wasconsistent with HCV RNA and HCV antigensdetected by ISH and immunohistochemistry(Kappa=0.42-0.75).HCV RNA and HCVantigens were detected in myocardial cells,epithelial cells of intestinal gladular,interstitialcells of kidney,epithelial cells of tubules andglomerulus,pancreas acinar cells and epithelialcells of pancreatic duct,epithelial cells ofmucous membrane sinus of gallbladder,cortexand medulla cells in adrenal gland,andmononuclear cells in lymph *** RNA wasalso detected in bile duct epithelial cells,sinusoidal cells,and mononuclear cells in livertissues by *** HCV can infect extrahepatictissues,and many various tissue cells maysupport HCV replication;extrahepatic HCVinfection and replication may be of'concomitantstate'in most of patients with hepatitis *** extrahepatic

关键词： hepatitis C virus hepatitis C antigens in situ hybridization immunohistochemistry RNA polymerase chain reaction antibodies monoclonal digoxigenin

Effect of Hepatitis C Virus Core Protein on Interferon-Induced Antiviral Genes Expression and Its Mechanisms

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中国病毒学 2007年第5期22卷 374-379页

作者： Yan-zi CHANG Yan-chang LEI Wen WU Shan-shan CHEN Han-ju HUANG dong-liang yang Meng-ji LU Department of Pathogen Biology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Division of Clinical Immunology Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 China.

Emerging data indicated that HCV subverts the antiviral activity of interferon(IFN);however,whether HCV core protein contributes to the process remains *** the present study,we examined the effect of HCV core protein on interferon-induced antiviral gene expression and whether the effect is involved in the activation and negative regulation of the Jak/STAT signaling *** results showed that,following treatment with IFN-α,the transcription of PKR,MxA and 2'-5'OAS were down-regulated in HepG2 cells expressing the core *** the presence of HCV core protein,ISRE-dependent luciferase activity also *** study indicated that the core protein could inhibit the tyrosine phosphorylation of STAT1,whereas the level of STAT1 expression was ***,SOCS3,the negative regulator of the Jak/STAT pathway,was induced by HCV core *** results suggests that HCV core protein may interfere with the expression of some interferon-induced antiviral genes by inhibiting STAT1 phosphorylation and induction of SOCS3.

关键词：丙型肝炎病毒核心蛋白质 α-干扰素抗病毒基因表达作用机理

Expression of PTEN,PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues

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World Journal of Gastroenterology 2007年第34期13卷 4554-4559页

作者： Shu-Kun Wu Bao-Ju Wang Yan yang Xin-Hua Feng Xi-Ping Zhao dong-liang yang dong-liangyang Division of Clinical Immunology Tongji Hospitai-Tongji Medical College Huazhong University of Science andTechnology Wuhan 430030 Hubei Province China Center of Experimental MedicineResearch Tongji Hospital Tongji Medical College HuazhongUniversity of Science and Technology Wuhan 430030 HubeiProvince China Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 United States Department of infectious Disease Hubei ProvinceCorps Hospital The Chinese People's Armed Police ForcesWuhan 430061 Hubei Province China

AIM： To investigate the expressions of PTEN, PPMIA and P-Smad2 in hepatocellular carcinoma （HCC） and their significance.METHODS： The expressions of PTEN, PPMIA and P-Smad2 in 31 HCC tissues, 25 adjacent liver tissues and 13 non-tumor liver tissues were detected by using Envision immunohistochemical technique. RESULTS： The positive expression （64.52%） and staining intensity （4.19 ± 3.31） of PTEN in the cytoplasm of HCC were significantly lower and weaker than those in the adjacent or non-tumor liver tissues （97.37%, 7.88 ± 0.93; 100%, 7.77 ± 0.93, respectively）（P 〈 0.05）, and its staining intensity in the cytoplasm of HCC, which belongs to Edmondson pathologic grades Ⅱ-Ⅲ and above, was also lower than that of grade I and I-Ⅱ. Furthermore, its location in the nucleus or cytoplasm of liver cells was negatively correlated with the progression of liver disease （r = -0.339, P = 0.002）; most of PPMIA might be only expressed in the nucleus of adjacent liver tissues, non-HCC tissues or Edmondson grade I and I - Ⅱ HCC, but it was mainly expressed in the cytoplasm of HCC with Edmondson grade ≥ Ⅱ, weakly or negatively expressed in the nucleus （P 〈 0.05）, and its location was negatively correlated with the progression of liver disease （r = -0.45, P = 0.0000）. P-Smad2, which was mostly located in the nucleus and cytoplasm of grade I and I -Ⅱ HCC, surrounding or non-tumor liver tissues, was only in the nucleus of HCC with Edmondson grade Ⅱ and above （P 〈 0.001）, and its location was positively correlated with the disease progression （r = 0.224, P = 0.016）. Spearman correlation analysis revealed that P-Smad2 was significantly negatively correlated with PTEN and PPMIA （r = -0.748, P = 0.000; r = -0.366, P = 0.001, respectively）; and PTEN and PPMIA were positively correlated with HCC carcinogenesis （r = 0.428, P = 0.000）.CONCLUSION： The aberrant location of expression and staining intensity of PTEN, PPMIA and P-Smad2 in HCC and their relationship might have an impact on the p

关键词： Hepatocellular carcinoma PhosphorylatedSmad2 PTEN PPMIA

Ultrasound-responsive microbubbles in antibacterial therapy

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Biomedical Engineering Communications 2023年第2期2卷 1-3页

作者： Xiao-Ye Li Wei-Jun Xiu dong-liang yang Heng dong Nanjing Stomatological Hospital Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Key Laboratory for Organic Electronics and Information Displays Jiangsu Key Laboratory for BiosensorsInstitute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210023China School of Physical and Mathematical Sciences Nanjing Tech University(NanjingTech)Nanjing 211800China

Microbubbles(MBs)are gas-filled micrometer-scale spheres that are commonly formed by the gas core encapsulated with stabilizing shells,including polymers,surfactants,proteins,or liposomes ***,MBs were originally used as contrast agents for enhanced ultrasound(US)imaging and ***,MBs were given expectations that they can be alternative platforms for drug delivery owing to their unique acoustic *** can respond to the US by cavitation effect which refers to a series of complex dynamic processes,such as oscillation,expansion,contraction,and implosion[1].Drug molecules or therapeutic agents can be associated with the MB shells by means of van-der-Waals forces,electrostatic or hydrophobic interactions,or merely by physical encapsulation[2].Therefore,strategies are emerging which take advantages of US-mediated MBs drug delivery systems,mainly focusing on sonothrombolysis,cancer therapy and central nervous system(CNS)pathologies[3].Nevertheless,several researchers have apperceived the promising potential of US-responsive MBs in antibacterial ***,we aimed to paint an overview of the latest published papers on MBs for antibacterial therapy,hoping to help understand the perspectives that the field may offer emerging generations of antibacterial agents.

关键词： properties. shells cavitation

Models for predicting hepatitis B e antigen seroconversion in response to interferon-α in chronic hepatitis B patients

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World Journal of Gastroenterology 2015年第18期21卷 5668-5676页

作者： Chang-Tai Wang Ya-Fei Zhang Bing-Hu Sun Yu Dai Hui-Lan Zhu Yuan-Hong Xu Meng-Ji Lu dong-liang yang Xu Li Zhen-Hua Zhang Department of Infectious Diseases the First Affiliated Hospital Anhui Medical University Department of Clinical Laboratory the First Affiliated Hospital Anhui Medical University Institute of Virology University Hospital of Essen University of Duisburg-Essen Department of Infectious Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology

AIM:To develop models to predict hepatitis B e antigen(HBe Ag)seroconversion in response to interferon(IFN)-αtreatment in chronic hepatitis B ***:We enrolled 147 treatment-nave HBe Agpositive chronic hepatitis B patients in China and analyzed variables after initiating IFN-α1b *** were tested for serum alanine aminotransferase(ALT),hepatitis B virus-DNA,hepatitis B surface antigen(HBs Ag),antibody to hepatitis B surface antigen,HBe Ag,antibody to hepatitis B e antigen(anti-HBe),and antibody to hepatitis B core antigen(anti-HBc)at baseline and 12 wk,24 wk,and 52 wk after initiating *** performed univariate analysis to identify response predictors among the *** models to predict treatment response were constructed at baseline,12 wk,and 24 ***:At baseline,the 3 factors correlating most with HBe Ag seroconversion were serum ALT level>4×the upper limit of normal(ULN),HBe Ag≤500 S/CO,and anti-HBc>11.4 S/*** 12 wk,the 3 factors most associated with HBe Ag seroconversion were HBe Ag level≤250 S/CO,decline in HBe Ag>1 log10 S/CO,and anti-HBc>11.8 S/*** 24 wk,the 3 factors most associated with HBe Ag seroconversion were HBe Ag level≤5 S/CO,anti-HBc>11.4 S/CO,and decline in HBe Ag>2 log10 S/*** variable was assigned a score of1,a score of 0 was given if patients did not have any of the 3 *** 3 factors most strongly correlating with HBe Ag seroconversion at each time point were used to build models to predict the outcome after IFN-α*** the score was 3,the response rates at the 3 time points were 57.7%,83.3%,and 84.0%,*** the score was 0,the response rates were 2.9%,0.0%,and 2.1%,***:Models with good negative and positive predictive values were developed to calculate the probability of response to IFN-αtherapy.

关键词： Chronic hepatitis B Interferon Hepatitis B e antigen Treatment Model