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A Multiple Exponential Smoothing Scheme For Quality Control

数理统计与管理 1993年第6期 46-54页

作者： C D lai,dong QIAN wang Department of Statistics Massey University Department of Statistics Massey University Palmerston North New Zealand Palmerston North New Zealand

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DIVERSITY OF PETROLEUM HYDROCARBON-DEGRADING BACTERIA IN OPEN SEA

DIVERSITY OF PETROLEUM HYDROCARBON-DEGRADING BACTERIA IN OPE...

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第二届全国微生物资源学术暨国家微生物资源平台运行服务研讨会

作者： Zongze Shao,Chunming dong,Qiliang lai,Liping wang and Wanpeng wang(Third Institute of Oceanography,State Oceanic Administration,Xiamen 361005,China)

The diversity of hydrocarbon-degrading bacteria in open sea has been less exploited. Hydrocarbons are ubiquitous in marine environments. Both aliphatic and aromatic hydrocarbons can be generated by vent activity in de...

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A method of percutaneous vertebroplasty under the guidance of two C-arm fluoroscopes

A method of percutaneous vertebroplasty under the guidance o...

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2015年浙江省骨科学学术年会

作者： Ren-Jie Xu Yong-Qing Yan Guang-Xiang Chen Tian-Ming Zou Xiao-Qiang Cai dong-lai wang

Objective:To compare the clinical application in the percutaneous vertebroplasty under the guidance of one or two C-arm ***:One hundred forty three elderly patients with Osteoporotic vertebral compression fractures(OVCFs)underwent percutaneous vertebroplasty under the guidance of one or two C-arm *** number of pulsed imagings,the time of operation and the incidence of cement leakage were ***:The average number of pulsed imagings was 16.00±1.58 vs 13.07±2.00 per patient under the guidance of one vs two C-arm *** average time of operation was 48.42±5.00 minutes vs 39.70±7.42 minutes per patient under the guidance of one vs two C-arm *** incidence of cement leakage was 20%vs 15.7%of the patients under the guidance of one vs two C-arm *** differences in the number of pulsed imagings and the time of operation were statistically *** difference in incidence of cement leakage was not statistically ***:The two-fluoroscopic technique reduce the labor cost,the radiation,the time of operation and the operation risk.

关键词： Osteoporotic vertebral compression fractures Percutaneous vertebroplasty Two C-arm fluoroscopes

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A method of percutaneous vertebroplasty under the guidance of two C-arm fluoroscopes

A method of percutaneous vertebroplasty under the guidance o...

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2016年浙江省骨科学学术年会

作者： Ren-Jie Xu Yong-Qing Yan Guang-Xiang Chen Tian-Ming Zou Xiao-Qiang Cai dong-lai wang

Objective:To compare the clinical application in the percutaneous vertebroplasty under the guidance ofone or two C-arm ***:One hundred forty three elderly patients with Osteoporotic vertebral compression fractures(OVCFs) underwent percutaneous vertebroplasty under the guidance of one or two C-arm *** number of pulsed imagings,the time of operation and the incidence of cement leakage were ***:The average number of pulsed imagings was 16.00±1.58 vs 13.07±2.00 per patient under theguidance of one vs two C-arm *** average time of operation was 48.42±5.00 minutes vs39.70±7.42 minutes per patient under the guidance of one vs two C-arm *** incidenceof cement leakage was 20%vs 15.7%of the patients under the guidance of one vs two C-arm *** differences in the number of pulsed imagings and the time of operation were statistically *** difference in incidence of cement leakage was not statistically ***:The two-fluoroscopic technique reduce the labor cost,the radiation,the time of operationand the operation risk.

关键词： Osteoporotic vertebral compression fractures Percutaneous vertebroplasty Two C-arm fluoroscopes

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An Artificial Intelligence-Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： dong, Yan An, Wenzheng wang, Zihu Zhang, dongzhi China Univ Petr East China Coll Control Sci & Engn Qingdao 266580 Peoples R China

The sandwich-structured flexible mechanoluminescent sensor (SFLC) film shows great application potential as wireless wearable strain sensor and encryption ***-level integration of SFLC film with deep learning-based artificial intelligence enables fast and accurate interpretation of color data to strain values with automatic correction of errors caused by varying color *** smart glove wearable sensor based on the SFLC film combined with deep learning neural network enables fast and accurate hand gesture recognition. The complex wiring, bulky data collection devices, and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable devices. To tackle these challenges, this work develops an artificial intelligence-assisted, wireless, flexible, and wearable mechanoluminescent strain sensor system (AIFWMLS) by integration of deep learning neural network-based color data processing system (CDPS) with a sandwich-structured flexible mechanoluminescent sensor (SFLC) film. The SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy fabrication. The CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature, which significantly improves the accuracy of the predicted strain. A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture recognition. Moreover, the versatile SFLC film can also serve as a encryption device. The integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the "color to strain value" bottleneck that hinders the practical application of flexible colorimetric strain sensors, which could promote the development of wearable and flexible strain sensors from laboratory research to

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue wang Shijie Su Weicheng Feng Yaona lai Kongli Huang Dandan Cao Qi wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng wang Guo-Cui Mao Hui-Lin Jiang Bao-Xia dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi wang Mengke Zhao dong Fu Meina wang Chao Han Zhongyue Lv Liang wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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露天矿边坡残煤自燃温度场及燃深研究

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安全与环境学报 2016年第6期16卷 50-54页

作者：崔铁军马云东王来贵辽宁工程技术大学安全科学与工程学院辽宁阜新123000 大连交通大学辽宁省隧道与地下结构工程技术研究中心辽宁大连116028 辽宁工程技术大学力学与工程学院辽宁阜新123000

为确定露天矿边坡内残煤发生自燃时内部温度分布及燃空区深度,以PFC3D作为模拟平台,借助其热力耦合模型,模拟了氧在裂隙中运动并与煤层反应且相互促进发展的过程,从而得到了边坡内温度场及燃空区发展深度;使用极小颗粒模拟氧气的流动及... 详细信息

为确定露天矿边坡内残煤发生自燃时内部温度分布及燃空区深度,以PFC3D作为模拟平台,借助其热力耦合模型,模拟了氧在裂隙中运动并与煤层反应且相互促进发展的过程,从而得到了边坡内温度场及燃空区发展深度;使用极小颗粒模拟氧气的流动及其与煤的反应,并通过FISH实现该过程。使用该模型模拟的结果表明,氧流通道的形成与煤层自燃是相互促进的,但燃空区的发展应该有一个最大深度。燃空区发展过中边坡内温场分布区域的变化可划分为3个阶段,分别是燃空区深度为60~70 m、70~120 m、120~170 m。海州露天矿边坡的残煤自燃的燃空区深度为165 m,与物探确定的150~200 m的距离相吻合。研究能估计燃空区的深度,从而为判断有残煤自燃情况下的边坡稳定性提供依据。

关键词：安全工程矿业工程露天矿边坡残煤自燃温场分布 PFC3D模拟

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