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Clinical significance of surgical resection for hepatocellular carcinoma with portal vein invasion:a nationwide cohort study

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 814-823,I0006-I0008页

作者： Hye-Sung Jo Pyoung-Jae Park Young-dong Yu Yoo Jin Choi Se Hyeon Yu dong-sik kim Korean Liver Cancer Association Division of HBP Surgery and Liver Transplantation Department of SurgeryKorea University College of MedicineSeoulRepublic of Korea Division of Transplantation and Vascular Surgery Department of SurgeryKorea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea

Background:Hepatocellular carcinoma(HCC)with portal vein invasion(PVI)is considered an advanced stage with a poor *** current guidelines recommend systemic treatment for HCC with PVI,surgical resection could produce acceptable outcomes in selected *** study aimed to identify the clinical significance of surgical resection for HCC with PVI patients using a large-scale nationwide ***:This retrospective,multicenter,observational cohort analyzed data from the Korean Primary Liver Cancer Registry.A total of 16,781 patients who were newly diagnosed with HCC between 2008 and 2018 were enrolled in this *** with worse Child-Turcotte-Pugh scores(≥7)or performance status(≥2)were *** them,998 patients who received treatment for HCC with PVI were included in the analysis and were divided into two groups:resection group of 151(15.1%)and palliative group of 847(84.9%)who received transarterial and systemic therapy according to the treatment *** matching the number and size of the tumors and model for end-stage liver disease(MELD)score between the groups,the final study cohort for analysis comprised 151(26.6%)patients in the resection group and 417(73.4%)in the palliative *** primary endpoints were overall survival(OS)and cancer-specific survival(CSS).Results:The number and maximum size of HCC did not differ between the resection and palliative groups after matching[1(range,1-5)vs.1(range,1-6),P=0.11 and 5.5(range,1.2-20.6)vs.6.0(range,1.0-20.5)cm,P=0.24,respectively].Tumor markers,including alpha-fetoprotein(AFP)and protein induced by vitamin K absence or antagonist-II(PIVKA-II),also did not differ between the groups(P=0.29 and P=0.36,respectively).The 5-year OS and CSS rates of the resection and palliative groups were 44.8%and 17.4%(P<0.001)and 47.7%and 18.6%(P<0.001),*** analysis showed that palliative treatment intent was the most significant risk factor for OS and CSS[odds ratio(OR

关键词： Hepatocellular carcinoma(HCC) portal vein invasion(PVI) overall survival(OS) cancer-specific survival(CSS) surgical resection

Intraductal papillary bile duct adenocarcinoma and gastrointestinal stromal tumor in a case of neurofibromatosis type 1

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World Journal of Gastroenterology 2018年第4期24卷 537-542页

作者： Jung Min Lee Jae Min Lee Jong Jin Hyun Hyuk Soon Choi Eun Sun kim Bora Keum Yoon Tae Jeen Hoon Jai Chun Hong sik Lee Chang Duck kim dong sik kim Joo Young kim Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointestinal Medical Instrument Research Korea University College of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University Anam Hospital Division of HBP Surgery and Liver Trans- plantation Department of Surgery Korea University College of Medicine Department of Pathology Korea University College of Medicine

We report our experience with a synchronous case of gastrointestinal stromal tumor(GIST) and intraductal papillary neoplasm of the bile duct(IPNB) in anelderly woman with neurofibromatosis type 1(NF-1). A 72-year-old woman presented with a 2-mo history of right upper abdominal pain unrelated to diet and indigestion. Fourteen years earlier, she had been diagnosed with NF-1, which manifested as café au lait spots and multiple nodules on the skin. Computed tomography(CT) revealed a multilocular low-density mass with septation, and mural nodules in the right hepatic lobe, as well as a 1.7-cm-sized well-demarcated enhancing mass in the third portion of the duodenum. The patient subsequently underwent right hepatectomy and duodenal wedge resection. We present here the first report of a case involving a synchronous IPNB and GIST in a patient with NF-1. Our findings demonstrate the possibility of various tumors in NF-1 patients and the importance of diagnosis at an early

关键词： Neurofibromatosis type 1 Intraductal papillary neoplasm of the bile duct Gastrointestinal stromal tumor Synchronous

Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma:A multicenter study

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1340-1353页

作者： Jongman kim dong-Jin Joo Shin Hwang Jeong-Moo Lee Je-Ho Ryu Yang-Won Nah dong-sik kim Doo-Jin kim Young-Kyoung You Hee-Chul Yu Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Surgery Yonsei University College of MedicineSeoul 03722South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Pusan National University College of MedicineBusan 50612South Korea Department of Surgery Ulsan University HospitalUniversity of Ulsan College of MedicineUlsan 44033South Korea Department of Surgery Korea University College of MedicineSeoul 02841South Korea Department of Surgery Gachon University Gil Medical CenterGachon University College of MedicineIncheon 21565South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Patients with combined hepatocellular carcinoma and cholangiocarcinoma(cHCC-CC)are not traditionally considered eligible for liver transplantation(LT)AIM To compare outcomes between living donor LT(LDLT)patients with hepatocellular carcinoma(HCC)and LT patients with cHCC-CC and to identify risk factors for tumor recurrence and death after LT in cHCC-CC *** Data for pathologically diagnosed cHCC-CC patients(n=111)who underwent LT from 2000 to 2018 were collected for a nine-center retrospective ***(n=141)who received LDLT for HCC at Samsung Medical Center from January 2013 to March 2017 were selected as the control *** patients in two groups,respectively,were selected by 1:1 *** Cumulative disease-free survival(DFS)and overall survival(OS)in the cHCC-CC group were significantly worse than in the HCC group both before and after *** recurrence incidence in the cHCC-CC group was higher than that in the HCC group(75.5%vs 33.3%,P3,tumor size>3 cm,and lymph node metastasis were predisposing factors for tumor recurrence in multivariate *** a maximum tumor size>3 cm was a predisposing factor for *** The poor prognosis of patients diagnosed with cHCC-CC after LT can be predicted based on the explanted *** regular surveillance for cHCC-CC patients should be required for early detection of tumor recurrence.

关键词： Liver transplantation Outcomes Intrahepatic cholangiocarcinoma Hepatocellular carcinoma Recurrence

The beneficial impacts of splanchnic vasoactive agents on hepatic functional recovery in massive hepatectomy porcine model

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 325-336页

作者： Hye-Sung Jo Jae Hyun Han Yoon Young Choi Jin-I Seok Young-In Yoon dong-sik kim Division of HBP Surgery and Liver Transplantation Department of SurgeryKorea University College of MedicineSeoulRepublic of Korea Department of Surgery St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Biomedical Science Korea University College of Medicine Graduate SchoolSeoulRepublic of Korea Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

Background:Excessive portal pressure after massive hepatectomy can cause hepatic sinusoidal injury and have deleterious impacts on hepatic functional recovery,contributing to developing post-hepatectomy liver *** study aimed to assess the effects of splanchnic vasoactive agents on hepatic functional recovery and regeneration while clarifying the underlying mechanism,using a 70%hepatectomy porcine ***:Eighteen pigs undergoing 70%hepatectomy were involved in this study and divided into three groups:control(n=6),terlipressin(n=6),and octreotide(n=6).Terlipressin(0.5 mg)and octreotide(0.2 mg)were administered 3 times a day for each group with the first dose starting just before surgery until the 7th postoperative day,at which time the surviving pigs were *** the period,portal pressure,liver weight,biochemical analysis,histological injury score,and molecular markers were evaluated and compared between ***:The 7-day survival rates in the octreotide,terlipressin,and control groups were 100%,83.3%,and 66.7%,*** portal pressures decreased in both terlipressin and octreotide groups than the control group at 30 minutes,1 hour and 6 hours after *** amount of regeneration measured by liver weight to body weight ratio at the time of sacrifice in the terlipressin group was smaller than that in the control group(117%vs.129%,P=0.03).Serum aspartate aminotransferase(AST)and total bilirubin levels at 1 and 6 hours after hepatectomy and prothrombin time/international normalized ratio(PT/INR)at 6 hours after hepatectomy were significantly improved in the terlipressin and octreotide groups compared to the control *** endothelin-1(ET-1)was significantly lower in the terlipressin group than that in the control group 6 hours after hepatectomy(P<0.01).The histological injury score in the control group was significantly higher than that in the terlipressin group on the 7th postoperative day(P<0.01).Conclusions:Splanc

关键词： Hepatectomy portal pressure terlipressin somatostatin

Al^(3+) doped CeO_(2) for proton conducting fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2253-2262页

作者： Sarfraz Shahzad Rasool Muhammad Khalid MAKYousaf Shah Bin Zhu Jung-sik kim Muhammad Imran Asghar Nabeela Akbar Wenjing dong Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology/Energy Storage joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096China School of Microelectronics Hubei UniversityWuhan 430062China Sino-French Engineer School/School of General Engineering Beihang UniversityBeijing 100191China Renewable Energy Technologies Group Faculty of Engineering and Natural SciencesTampere UniversityFI-33014Finland

Developing high ionic conducting electrolytes is crucial for applying proton-conducting fuel cell(PCFCs)*** cur-rent study investigates the effect of alumina on the structural,morphological,electrical,and electrochemical properties of CeO_(2).Lattice oxygen vacancies are induced in CeO_(2) by a general doping concept that enables fast ionic conduction at low-temperature ranges(300-500℃)for *** refinement of the X-ray diffraction(XRD)patterns established the pure cubic fluorite structure of Al-doped CeO_(2)(ADC)samples and confirmed Al ions’fruitful integration in the CeO_(2) *** electronic structure of the alumina-doped ceria of the materials(10ADC,20ADC,and 30ADC)has been *** a result,it was found that the best composition of 30ADC-based electrolytes induced maximum lattice oxygen *** corresponding PCFC exhibited a maximum power output of 923 mW/cm^(2)at 500℃.Moreover,the investigation proves the proton-conducting ability of alumina-doped ceria-based fuel cells by using an oxide ion-blocking layer.

关键词： proton ceramic fuel cells oxygen vacancies higher fuel cell performance doping fast ions transportation

Modeling asymmetric fracture mechanics of Mg alloy wire in drawing process

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Journal of Magnesium and Alloys 2024年第5期12卷 2057-2069页

作者： Sunghoon Choi Jongwon Shin Joung sik Suh dongchoul kim Department of Mechanical Engineering Sogang UniversitySeoul04107Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study,a numerical analysis was conducted on the ductile fracture of a 2-mm diameter Mg-1Zn-0.5Mn-0.5Sr-0.1Ca alloy wire during *** hexagonally close-packed crystal structure of Mg alloys causes asymmetric fracture behavior,especially in the compression *** aim of this study is to develop a comprehensive damage model for Mg alloy wire that accurately predicts ductile fracture,with a focus on the compression region.A novel experimental method was introduced to measure the ductile fracture of Mg alloy wires under different stress *** wire drawing process was simulated using the Generalized Incremental Stress-State dependent damage(GISSMO)Model and the Semi-Analytical Model for Polymers(SAMP)*** damage model's prediction and the experimental results were found to be in excellent agreement,especially in determining crack *** analysis established a safe zone diagram for die angle and reduction ratio,and experimental validation confirmed the feasibility of this *** proposed damage model can provide a practical and reliable analysis for optimizing the drawing process of Mg alloy wire.

关键词： Mg alloy Wire drawing Finite element method Damage model Safe zone diagram

Dragonfly Interaction Algorithm for Optimization of Queuing Delay in Industrial Wireless Networks

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Journal of Bionic Engineering 2024年第1期21卷 447-485页

作者： Sanjay Bhardwaj Da-Hye kim dong-Seong kim Department of IT Convergence Engineering ICT Convergence Research CenterKumoh National Institute of TechnologyGumiSouth Korea

In industrial wireless networks,data transmitted from source to destination are highly *** often leads to the queuing of the data,and poor management of the queued data results in excessive delays,increased energy consumption,and packet ***,a nature-inspired-based Dragonfly Interaction Optimization Algorithm(DMOA)is proposed for optimization of the queue delay in industrial wireless *** term“interaction”herein used is the characterization of the“flying movement”of the dragonfly towards damselflies(female dragonflies)for *** a result,interaction is represented as the flow of transmitted data packets,or traffic,from the source to the base *** includes each and every feature of dragonfly movement as well as awareness of the rival dragonflies,predators,and damselflies for the desired optimization of the queue *** features are juxtaposed as noise and interference,which are further used in the calculation of industrial wireless metrics:latency,error rate(reliability),throughput,energy efficiency,and fairness for the optimization of the queue *** analysis,convergence analysis,the Wilcoxon test,the Friedman test,and the classical as well as the 2014 IEEE Congress of Evolutionary Computation(CEC)on the benchmark functions are also used for the evaluation of DMOA in terms of its robustness and *** results demonstrate the robustness of the proposed algorithm for both classical and benchmarking functions of the IEEE CEC ***,the accuracy and efficacy of DMOA were demonstrated by means of the convergence rate,Wilcoxon testing,and ***,fairness using Jain’s index in queue delay optimization in terms of throughput and latency,along with computational complexity,is also evaluated and compared with other *** results show that DMOA exceeds other bio-inspired optimization algorithms in terms of fairness in queue delay management and average packet *** proposed a

关键词： Dragonfly Damselfly Interaction Queuing delay Optimization Industrial wireless networks

New-onset diabetes after adult liver transplantation in the Korean Organ Transplantation Registry (KOTRY) study

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 425-439页

作者： Jong Man kim Shin Hwang Kwang-Woong Lee Jae-Geun Lee Je Ho Ryu Bong-Wan kim dong Lak Choi Young Kyoung You dong-sik kim Yang Won Nah Koo Jeong Kang Jai Young Cho Geun Hong In Seok Choi Hee Chul Yu dongho Choi Myoung Soo kim 无 Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea Department of Surgery Asan Medical CenterCollege of Medicine University of UlsanSouth Korea Department of Surgery Seoul National University College of MedicineSeoulSouth Korea Department of Surgery Yonsei University College of MedicineSeoulSouth Korea Department of Surgery Pusan National University College of MedicineBusanSouth Korea Department of Liver Transplantation and Hepatobiliary Surgery Ajou University School of MedicineSuwonSouth Korea Department of Surgery Catholic University of Daegu College of MedicineDaeguSouth Korea Department of Surgery College of MedicineCatholic University of KoreaSeoulSouth Korea Division of HBP Surgery and Liver Transplantation Department of SurgeryKorea University College of MedicineSeoulSouth Korea Department of Surgery Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea Department of Surgery Keimyung University School of MedicineDaeguSouth Korea Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSungnamSouth Korea Department of Surgery Ewha Woman’s University School of MedicineSeoulSouth Korea Department of Surgery Konyang University HospitalDaejonSouth Korea Department of Surgery Chonbuk National University School of MedicineJeonjuSouth Korea Department of Surgery Hanyang University College of MedicineSeoulSouth Korea The Korean Organ Transplantation Registry Study Group

Background:New-onset diabetes after transplantation(NODAT)is a serious complication following liver transplantation(LT).The present study aimed to investigate the incidence of and risk factors for NODAT using the Korean Organ Transplantation Registry(KOTRY)***:Patients with history of pediatric transplantation(age≤18 years),re-transplantation,multi-organ transplantation,or pre-existing diabetes mellitus were excluded.A total of 1,919 non-diabetic adult patients who underwent a primary LT between May 2014 and December 2017 were *** factors were identified using Cox regression ***:NODAT occurred in 19.7%(n=377)of adult liver transplant *** analysis showed steroid use,increased age,and high body mass index(BMI)in recipients,and implantation of a left-side liver graft was closely associated with NODAT in adult *** living donor liver transplant(LDLT)patients(n=1,473),open donor hepatectomy in the living donors,steroid use,small for size liver graft(graft to recipient weight ratio≤0.8),increased age,and high BMI in the recipient were predictive factors for *** use of antimetabolite and basiliximab induction reduced the incidence of NODAT in adult LT and in adult ***:Basiliximab induction,early steroid withdrawal,and antimetabolite therapy may prevent NODAT after adult *** BMI or advanced age in liver recipients,open donor hepatectomy in living donors,and small size liver graft can predict the occurrence of NODAT after adult LT or LDLT.

关键词： Diabetes living donors immunosuppression Asia

Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： K JAMES Jintu kim Heuy dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT Korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation