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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao dong Fu Meina Wang chao Han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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磁性d波超导特性的研究

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淮阴师范学院学报（自然科学版） 2006年第1期5卷 37-40页

作者：董正超付浩淮阴师范学院物理与电子学系江苏淮安223001

通过外加Zeeman磁场在d波超导中,在平均场近似下,自洽求解d波超导能隙和Zeeman能量的方程,研究了Zeeman效应对d波超导序参数和热力学势的影响,阐述了磁性与超导共存条件.

关键词： Zeeman效应 d波超导热力学势

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Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang zheng Jiajia Yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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3种食源性致病菌的实时荧光PCR快速检测

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食品研究与开发 2016年第16期37卷 143-147页

作者：霍胜楠孟静杨振东郑世超张然山东省食品药品检验研究院山东济南250101 江南大学食品学院江苏无锡214122

DNA提取方法采用先钢珠机械破坏细菌细胞壁,再添加丙酮、蛋白酶K溶解去除杂质,大大提高了食源性致病菌基因组DNA的得率和纯度。继而针对金黄色葡萄球菌egc基因、沙门氏菌NA(not availabale)基因、志贺氏菌ipaH基因为靶基因设计特异性引... 详细信息

DNA提取方法采用先钢珠机械破坏细菌细胞壁,再添加丙酮、蛋白酶K溶解去除杂质,大大提高了食源性致病菌基因组DNA的得率和纯度。继而针对金黄色葡萄球菌egc基因、沙门氏菌NA(not availabale)基因、志贺氏菌ipaH基因为靶基因设计特异性引物对样品建立实时荧光定量PCR检测方法。结果试验设计的引物对3种细菌具有很强特异性,除目标细菌外,对单核细胞增生李斯特氏菌、副溶血性弧菌、蜡样芽孢杆菌3种对照菌均未检测到荧光信号。对金黄色葡萄球菌、沙门氏菌和志贺氏菌的检测灵敏度分别达到10^(-6)、10^(-6)、10^(-7) ng/μL。

关键词：食源性致病菌基因组DNA提取实时荧光定量PCR

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo zheng Yu-Tao zheng Yi-Wei dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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地方高校应用型人才培养协同创新模式

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南通大学学报（社会科学版） 2013年第6期29卷 123-128页

作者：董正超成鸣飞南通大学江苏南通226007

协同创新是推进地方高校内涵式发展的战略选择。协同创新的基本涵义奠基于协同学理论土壤,涵盖了主体与客体之间的协作以及在此过程中获得的新知识和新方法。当它延展至高等教育领域,则表现为基于多元主体协同互动的创新人才培养模式。... 详细信息

协同创新是推进地方高校内涵式发展的战略选择。协同创新的基本涵义奠基于协同学理论土壤,涵盖了主体与客体之间的协作以及在此过程中获得的新知识和新方法。当它延展至高等教育领域,则表现为基于多元主体协同互动的创新人才培养模式。协同创新模式是科学发展观在教育领域的具体体现,也是建设创新型国家、实现科学发展的必由之路。地方高校应用型人才培养的内部协同创新系统构建主要在于培养方案和课程体系的顶层设计,创新教师团队互补协同、师生互动协同、教学模式多元协同的高效课堂;外部协同创新系统的塑造则需要完善"校企合作"、"校研协作"、"校校联盟"等产学研合作机制。

关键词：地方高校协同创新应用型人才教学模式

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玉米HMG全长cDNA的克隆及其分析

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山东农业大学学报（自然科学版） 2002年第2期33卷 239-241页

作者：牛林海杨国栋郑成超山东农业大学生命科学院山东泰安271018

HMG蛋白质是染色质中一种高度丰富的非组蛋白，其分子量比较小。这类蛋白质往往与活性染色质结合在一起，而且能优先与单链DNA相结合，由于HMG蛋白质在细胞核内含量极为丰富，因而推测它们在染色质的结构与功能中可能起着重要的作用。HM... 详细信息

HMG蛋白质是染色质中一种高度丰富的非组蛋白，其分子量比较小。这类蛋白质往往与活性染色质结合在一起，而且能优先与单链DNA相结合，由于HMG蛋白质在细胞核内含量极为丰富，因而推测它们在染色质的结构与功能中可能起着重要的作用。HMG蛋白质结构分为3部分：N-末端、HMG-box中心片段和酸性C-末端。其中C-末端可与组蛋白相互作用，在调节染色体结构或调节HMG与DNA之间的亲合力方面起一定功能。有实验结果显示HMG1的HMG-box可以通过成环、浓缩及拓扑构象的改变来操纵DNA。而酸性末端可通过调节DNA结合特性来调节这些作用。体外钙与HMG蛋白质的酸性末端结合可以提高HMG与裸露DNA的亲和力。HMG中心片段在3个结构域最为重要，它含有DNA结合域（即HMG-box）。HMG中含有HMG-box序列的部分称为HMG结构域，不同动、植物HMG蛋白质中HMG结构域比较保守。目前在许多转录因子中已鉴定出HMG-box的存在，如hUBF（human upstream binding factor）及性别决定基因SRY等，表明含有HMG-box的转录因子与动物的生殖发育及性别决定关系密切。然而，在高等植物中，HMG蛋白是否也参与植物的生殖发育国内外均未见报道。我们在从裂叶牵牛中克隆并分析了HMG基因的基础上，又从重要作物玉米中分离出HMG基因，并初步研究了HMG基因的表达，为进一步探讨该基因在与玉米雌雄花发育中的作用奠定了基础。

关键词：玉米 HMG cDNA 克隆基因表达转录因子雌雄花发育杂交分析

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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应变作用下EuTiO_3材料磁性的格林函数理论研究

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原子与分子物理学报 2017年第6期34卷 1167-1174页

作者：王歆钰镇思琦李剑锋董正超仲崇贵南通大学理学院南通226019

基于自旋波和格林函数理论,研究了低温下二维应变诱导的EuTiO_3在铁电四方相下的磁性性质,主要讨论了在铁电四方相下Eu离子在铁磁性和反铁磁性有序时系统沿不同高对称性方向的自旋波散射和磁化.我们发现施加外加应变不仅可改变晶格结构... 详细信息

基于自旋波和格林函数理论,研究了低温下二维应变诱导的EuTiO_3在铁电四方相下的磁性性质,主要讨论了在铁电四方相下Eu离子在铁磁性和反铁磁性有序时系统沿不同高对称性方向的自旋波散射和磁化.我们发现施加外加应变不仅可改变晶格结构的对称性,还可以通过改变电子自旋之间的交换耦合作用,进而改变该材料的磁性散射和磁化等.

关键词：格林函数自旋波散射磁性性质

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Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

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