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Influence of friction-lubrication characteristics varying with rolling speed on instability of chatter and slip in cold tandem rolling process

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Journal of Iron and Steel Research(International) 2024年第4期31卷 894-908页

作者： Yan-li Xin Zhi-ying Gao Bo Tian qing-dong Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the high-speed cold tandem rolling process of thin plate,chatter or slip instability gives rise to the deterioration of equipment and product *** instability behavior is closely related to interfacial friction-lubrication con-dition which is generally characterized by the friction ***,with higher and higher speed requirements,the commonly used model of friction coefficient is no longer applicable and accurate.A novel approach is suggested to calculate the speed-dependent friction coefficient,in which the viscosity-pressure-temperature effects of the lubricant,surface roughness states of work rolls and rolled piece are comprehensively involved and the mixed flm lubrication theory is ***,the influences of friction coefficient on the instability of slip and chatter are investigated for a five-stand cold tandem rolling *** one side,the critical friction coefficient for each stand is determined by calculating the corresponding slip factor;on the other hand,the friction coefficient varying with rolling speed is combined with the model of theoretical critical rolling speed presented under constant friction coefficient,so that the speed threshold is ***,the stable and unstable regions corresponding to the rear three stands are individually discussed,and the technical strategies are proposed to suppress both slip and chatter frequently occurring in the actual rolling process.

关键词： Cold tandem rolling:Oil film thickness Speed-dependent friction coefficient-Slip:Chatter

Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication

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World Journal of Gastroenterology 2024年第11期30卷 1609-1620页

作者： Jun-Tao Li Hong-Mei Zhang Wei Wang dong-qing Wei College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007Henan ProvinceChina College of Computer and Information Engineering Henan Normal UniversityXinxiang 453007Henan ProvinceChina State Key Laboratory of Microbial Metabolism and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

BACKGROUND Liver cancer is one of the deadliest malignant tumors *** has provided hope to patients with advanced liver cancer,but only a small fraction of patients benefit from this treatment due to individual *** immune-related gene signatures in liver cancer patients not only aids physicians in cancer diagnosis but also offers personalized treatment strategies,thereby improving patient survival *** several methods have been developed to predict the prognosis and immunotherapeutic efficacy in patients with liver cancer,the impact of cell-cell interactions in the tumor microenvir-onment has not been adequately *** To identify immune-related gene signals for predicting liver cancer prognosis and immunotherapy *** Cell grouping and cell-cell communication analysis were performed on single-cell RNA-sequencing data to identify highly active cell groups in immune-related *** active immune cells were identified by intersecting the highly active cell groups with B cells and T *** significantly differentially expressed genes between highly active immune cells and other cells were subsequently selected as features,and a least absolute shrinkage and selection operator(LASSO)regression model was constructed to screen for diagnostic-related *** genes that were selected more than 5 times in 10 LASSO regression experiments were included in a multivariable Cox regression ***,3 genes(stathmin 1,cofilin 1,and C-C chemokine ligand 5)significantly associated with survival were identified and used to construct an immune-related gene *** The immune-related gene signature composed of stathmin 1,cofilin 1,and C-C chemokine ligand 5 was identified through cell-cell *** effectiveness of the identified gene signature was validated based on experi-mental results of predictive immunotherapy response,tumor mutation burden analysis,immune cell infiltrat

关键词： Liver cancer Cell-cell communication Gene signature Prognosis Immunotherapy Single-cell RNA sequencing

Silicone oil as a corneal lubricant to reduce corneal edema and improve visualization during

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 92-96页

作者： Dan-Yang Che Zhu-Lin Chan Ji-Bo Zhou dong-qing Zhu Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Health Science and Technology Shanghai Jiao Tong University School of MedicineShanghai 200011China The PLA Navy Anqing Hospital Anqing 246004Anhui ProvinceChina

AIM:To evaluate the efficacy and safety of silicone oil(SO)as a corneal lubricant to improve visualization during ***:Patients who underwent vitreoretinal surgery were divided into two *** 1 was operated on with initial SO(Oxane 5700)as a corneal *** 2 was operated on with initial lactated ringer’s solution(LRS)and then replaced with SO as *** clarity was scored during the *** staining was performed to determine the damage to corneal ***:Totally 114 eyes of 114 patients were *** SO use maintained a clear cornea and provided excellent visualization of surgical *** group 1,the fundus clarity was grade 3 in 41/45 eyes and grade 2 in 4/45 *** group 2,corneal edema frequently occurred after initial LRS *** fundus clarity was grade 3 in 19/69 eyes,2 in 37/69 eyes and 1 in 13/69 eyes(P0.05).CONCLUSION:The use of SO as a corneal lubricant is effective and safe for preserving and improving corneal clarity and providing clear surgical field during vitrectomy.

关键词： silicone oil corneal lubricant corneal edema vitrectomy

Computed tomography radiomic features and clinical factors predicting the response to first transarterial chemoembolization in intermediate-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 361-369页

作者： Zhong-Xing Shi Chang-Fu Li Li-Feng Zhao Zhong-Qi Sun Li-Ming Cui Yan-Jie Xin dong-qing Wang Tan-Rong Kang Hui-Jie Jiang Department of Interventional Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Digestive Medicine Daqing Longnan HospitalDaqing 163453China Department of Radiology Daqing Longnan HospitalDaqing 163453China Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Background:According to clinical practice guidelines,transarterial chemoembolization(TACE)is the standard treatment modality for patients with intermediate-stage hepatocellular carcinoma(HCC).Early prediction of treatment response can help patients choose a reasonable treatment *** study aimed to investigate the value of the radiomic-clinical model in predicting the efficacy of the first TACE treatment for HCC to prolong patient ***:A total of 164 patients with HCC who underwent the first TACE from January 2017 to September 2021 were *** tumor response was assessed by modified response evaluation criteria in solid tumors(mRECIST),and the response of the first TACE to each session and its correlation with overall survival were *** radiomic signatures associated with the treatment response were identified by the least absolute shrinkage and selection operator(LASSO),and four machine learning models were built with different types of regions of interest(ROIs)(tumor and corresponding tissues)and the model with the best performance was *** predictive performance was assessed with receiver operating characteristic(ROC)curves and calibration ***:Of all the models,the random forest(RF)model with peritumor(+10 mm)radiomic signatures had the best performance[area under ROC curve(AUC)=0.964 in the training cohort,AUC=0.949 in the validation cohort].The RF model was used to calculate the radiomic score(Rad-score),and the optimal cutoff value(0.34)was calculated according to the Youden’s *** were then divided into a high-risk group(Rad-score>0.34)and a low-risk group(Rad-score≤0.34),and a nomogram model was successfully established to predict treatment *** predicted treatment response also allowed for significant discrimination of Kaplan-Meier *** Cox regression identified six independent prognostic factors for overall survival,including male[hazard ratio(HR)=0.500,95%confidence interva

关键词： Hepatocellular carcinoma Transarterial chemoembolization Radiomics Treatment response Prediction

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马克思的文字之思与汉字美学

江苏行政学院学报 2024年第2期 35-41页

作者：骆冬青南京师范大学文学院南京210097

马克思晚年关注人类文字起源,思考“象形文字”相关问题,是“回到事情本身”的本原之思。汉字初文与图象思维和马克思实践观下的图象实践--“原初书写”有着密切关系。汉字之“意义”,尤其是深层之“本义”,正由“初文”之“图象”显示... 详细信息

马克思晚年关注人类文字起源,思考“象形文字”相关问题,是“回到事情本身”的本原之思。汉字初文与图象思维和马克思实践观下的图象实践--“原初书写”有着密切关系。汉字之“意义”,尤其是深层之“本义”,正由“初文”之“图象”显示。汉字的“形、音、义”结构中,“形”、“义”直接发生关系。汉字“初文”直接捕捉“象”,以及此“象”直接指向“事物”。马克思对于人类交往实践的重视,启发了维特根斯坦的后期语言哲学。马克思对原初文字的关注,与早期人类交往中的手势语言密不可分。手势语言,以手“指”事、“言”事,乃指事之先声。汉字指事,使“事”这一无形可象的对象,能够用“指”这一带有强烈意向性的行为来图画,突出汉字美学中元图象可自指本身的美学核心。汉字迻译马克思文本,“勞動”二字所蕴含的汉字图象,相当程度上阐释了马克思劳动概念的内核,印证了马克思的文字之思。

关键词：马克思原初文字汉字图象初文本义

Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning Li Yong Wang Chun Li Xu Chen Xue-Feng Zhang Nan Nan Tan Yi-Qin Hong Ming-Yan Shao Bing-Hua Tang dong-qing Guo School of Life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

甘肃省土地利用碳排放时空演变特征及影响因素

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环境科学 2024年

作者：李梓赫周冬梅江晶马静朱小燕石鹏张军 dong qing-han FlemishInstituteforTechnologicalResearch(VITO) 甘肃农业大学管理学院甘肃省节水农业工程技术研究中心甘肃农业大学资源与环境学院

陆地生态系统是世界上最大的碳汇，而土地利用变化是导致区域碳排放主要因素之一，通过对2000～2020年甘肃省土地利用碳排放时空演变特征和影响因素研究，为促进甘肃省土地低碳利用、低碳经济发展提供一定科学依据与参考。利用土地利用... 详细信息

陆地生态系统是世界上最大的碳汇，而土地利用变化是导致区域碳排放主要因素之一，通过对2000～2020年甘肃省土地利用碳排放时空演变特征和影响因素研究，为促进甘肃省土地低碳利用、低碳经济发展提供一定科学依据与参考。利用土地利用数据，结合温室气体排放系数法，研究甘肃省市域尺度土地利用碳排放增长趋势与省域尺度时空演变特征，并通过主成分分析研究其控制因素。结果表明：①2000～2020年甘肃省土地利用碳排放整体为增加趋势，由2428.93万t长至5773.96万t，其中2000～2014年第一阶段为显著增加阶段，2014～2020年第二阶段为稳定且略有降低阶段。建设用地为主要碳源，碳源强度仍呈增加态势。②空间上表现为“东高西低”的特征，河东碳排放量明显高于河西碳排放量。③根据排放特征将甘肃省划分为缓慢增长型、较慢增长型、中速增长型、较快增长型和迅猛增长型5类碳排放类型区。④经济发展水平、土地利用程度与能源消费是导致甘肃省土地利用碳排放不断增加的主要原因。

关键词：土地利用碳排放时空特征主成分分析甘肃省

治黄保运大局下的王家营减水坝及相关问题探析

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中国农史 2024年第2期43卷 120-130页

作者：董清刘光亮南京大学历史学院江苏南京210023 淮安市淮安区考古和文物保护中心江苏淮安223200

王营减水坝是康熙年间修建于黄河北岸堤防上的溢流坝,南临黄河,北通盐河,为黄河、淮河和运河交会处清口附近的一项大型工程。该工程充分利用独特的地理位置和地形条件,往北排水入盐河,可分减下泄黄河洪水,防止水流盛涨危害河堤安全的同... 详细信息

王营减水坝是康熙年间修建于黄河北岸堤防上的溢流坝,南临黄河,北通盐河,为黄河、淮河和运河交会处清口附近的一项大型工程。该工程充分利用独特的地理位置和地形条件,往北排水入盐河,可分减下泄黄河洪水,防止水流盛涨危害河堤安全的同时,能加大淮河清水畅出,并可接济盐河水源,用来运输盐、苇等。后因减坝启放年久,坝下冲刷成深塘,坝底桩石冲坏,原址施工困难,乾隆、嘉庆、道光年间曾多次重修、移建。经考古勘探证实,王营减水坝的移动,整体呈现出向西移的趋势。这是由于黄河东流,溢流坝向西靠近来水方向,更利于排泄洪水,有着治黄保漕、舍农的考量,以及尽量避免洪水淹没城市或人口稠密地区(官署就在城里),既实现了政治、经济利益的最大化,也契合了朝廷治河保漕的政治方向。

关键词：王营减水坝黄河盐河清口水利枢纽

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考虑时段划分的高风电渗透率系统储能配置

电力系统及其自动化学报 2024年第5期36卷 80-89页

作者：颜湘武卜劲勇王庆澳董梁悦董清贾焦心华北电力大学河北省分布式储能与微网重点实验室保定071003

随着风电渗透率不断升高,其波动性、随机性的特点使得电力系统出现严重的弃风及调峰困难问题。为此,提出一种考虑时段划分的高风电渗透率系统储能优化配置模型。首先,在净负荷的基础上计算峰谷隶属度,综合考虑风电消纳、峰谷差和用户满... 详细信息

随着风电渗透率不断升高,其波动性、随机性的特点使得电力系统出现严重的弃风及调峰困难问题。为此,提出一种考虑时段划分的高风电渗透率系统储能优化配置模型。首先,在净负荷的基础上计算峰谷隶属度,综合考虑风电消纳、峰谷差和用户满意度,采用量子粒子群算法寻优;其次,在最优时段的基础上综合考虑火电机组和储能的成本及收益,以净成本最小为目标函数优化出最优储能配置方案;最后,通过不同风电渗透率的算例分析验证所提优化模型的合理性和有效性。

关键词：时段划分储能配置风电消纳高风电渗透率储能调峰

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