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Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation(Part Ⅱ:Treatment)

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World Journal of Gastroenterology 2012年第14期18卷 4994-5013页

作者： Antonio Bove Massimo Bellini Edda Battaglia Renato Bocchini Dario Gambaccini Vincenzo Bove Filippo Pucciani donato francesco altomare Giuseppe Dodi Guido Sciaudone Ezio Falletto Vittorio Piloni Gastroenterology and Endoscopy Unit Department of GastroenterologyAORN "A.Cardarelli"80131 NaplesItaly Gastrointestinal Unit Department of GastroenterologyUniversity of Pisa56100 PisaItaly Gastroenterology and Endoscopy Unit Cardinal Massaja Hospital14100 AstiItaly Gastroenterology Unit M.Bufalini Hospital47023 CesenaItaly Department of Medical and Surgical Critical Care University of Florence50141 FlorenceItaly Department of Emergency and Organ Transplantation University of Bari70124 BariItaly Department of Oncological and Surgical Sciences University of Padua35126 PaduaItaly Division of General and Geriatric Surgery Second University of Naples80131 NaplesItaly Sixth Division of University Surgery Department of General SurgerySan Giovanni Battista Hospital10126 TurinItaly Diagnostic Imaging Centre "N.Aliotta" Villa Silvia-SenigalliaI-60100 AnconaItaly

The second part of the Consensus Statement of the Italian Association of Hospital Gastroenterologists and Italian Society of Colo-Rectal Surgery reports on the treatment of chronic constipation and obstructed defecation. There is no evidence that increasing fluid intake and physical activity can relieve the symptoms of chronic constipation. Patients with normal-transit constipation should increase their fibre intake through their diet or with commercial fibre. Osmotic laxatives may be effective in patients who do not respond to fibre supplements. Stimulant laxatives should be re- served for patients who do not respond to osmotic laxatives. Controlled trials have shown that serotonin- ergic enterokinetic agents, such as prucalopride, and prosecretory agents, such as lubiprostone, are effec- tive in the treatment of patients with chronic constipa- tion. Surgery is sometimes necessary. Total colectomy with ileorectostomy may be considered in patients with slow-transit constipation and inertia coil who are resistant to medical therapy and who do not have defecatory disorders, generalised motility disorders or psychological disorders. Randomised controlled trials have established the efficacy of rehabilitative treat- ment in dys-synergic defecation. Many surgical proce- dures may be used to treat obstructed defecation in patients with acquired anatomical defects, but none is considered to be the gold standard. Surgery should be reserved for selected patients with an impaired quality of life. Obstructed defecation is often associated with pelvic organ prolapse. Surgery with the placement of prostheses is replacing fascial surgery in the treatment of pelvic organ prolapse, but the efficacy and safety of such procedures have not yet been established.

关键词： Laxatives Prokinetics Biofeedback Pelvicfloor rehabilitation Outlet obstruction Stapled trans-anal rectal resection Delorme operation Colectomy Pelvic organ prolapse Mesh

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Strangulated ileal trans-coloanal-anastomotic hernia:A complication of Altemeier's procedure previously never reported

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World Journal of Gastroenterology 2013年第5期19卷 776-777页

作者： Maria Di Lena Emanuele Angarano Ivana Giannini Altomarino Guglielmi donato francesco altomare Department of Emergency and Organ Transplantation University"Aldo Moro"of Bari70124 BariItaly

A postoperative complication after Altemeier operation, so far never reported,is described in a 42 years old mentally disabled patient with external full thickness rectal prolapse who usually had prolonged straining at *** 6 d from perineal rectosigmoidectomy, the patient,was discharged free of *** days later he was readmitted in emergency for stran-gulated perineal trans-anastomotic ileal hernia that occurred at home during efforts to *** clinical feature required an emergency operation for repositioning the ileal loops into the abdomen,resection of the necrotic ileum,and end *** outcome of the second operation was free of complication and the patient was discharged on the 6th postoperative *** conclusion,after Altemeier operation prolonged straining at defecation should be carefully

关键词： Rectal prolapsed Perineal rectosigmoidectomy Altemeier’s procedure Complication Hernia

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Durability of AZ31 magnesium biodegradable alloys polydopamine aided:Part 1

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Journal of Magnesium and Alloys 2017年第4期5卷 412-422页

作者： Tullio Monetta Annalisa Acquesta Anna Carangelo Nicola donato francesco Bellucci Department of Chemical Engineering Materials and Industrial ProductionUniversity of Napoli Federico IIPiazzale Tecchio 8080125 NapoliItaly FCA Italy–Avvocato Giovanni Agnelli Plant Via San Paolo 67/7110095 Grugliasco(TO)Italy

The use of magnesium alloys,as a biodegradable medical device,is an interesting challenge for the biomaterials *** rapid degradation and the release of hydrogen,when exposed to biological fluids,are the main drawbacks for clinical *** this work,a coating made of polydopamine(PDOPA),is used as an intermediate layer to decrease the degradation rate of AZ31 magnesium alloy/polymeric coating system,when exposed to Hank’s *** results highlighted:(i)the formation of a thin PDOPA layer,(ii)an increased adhesion in the organic coating/metallic substrate system,(iii)a decrease of two orders of magnitude of the corrosion rate when the PDOPA film is used together with an external organic coating,(iv)the efficacy in the use of PDODA due to the synergistic effect of both,physical and chemical,interactions between the PDOPA layer and the organic coating.

关键词： AZ31 Polydopamine Biodegradable alloy Roughness Electrochemical characterization Medical device

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EMPLOYMENT OF COMPREHENSIVE TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY IN COMBINATION WITH MASS SPECTROMETRY FOR THE ANALYSIS OF COMPLEX SAMPLES

EMPLOYMENT OF COMPREHENSIVE TWO-DIMENSIONAL LIQUID CHROMATOG...

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第十四届北京分析测试学术报告会暨展览会(BCEIA 2011)

作者： Paola DUGO Paola donato francesco CACCIOLA Luigi MONDELLO Dipartimento Farmaco-chimico University of Messina University Campus Bio-Medico Chromaleont s.r.l. a Spin-off of the University of Messina

Nowadays comprehensive two-dimensional liquid chromatography(LCx LC)undoubtedly represents a definite trend in the chromatographic *** dealing with complex samples,in order to achieve the desired level of accuracy and...

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The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts

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Science China(Technological Sciences) 2018年第5期61卷 643-652页

作者： AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE donato Cinzia DE SANTIS Cristian FOLLEGA francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Perugia Perugia 06123 Italy Uninettuno University Rome 00186 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Roma Tor Vergata Rome 00133 Italy Istituto Nazionale di Fisica Nucleare (INFN) TIFPA Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Trento Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Roma Tor Vergata Rome 00133 Italy IFAC-CNR Sesto Fiorentino (FI) 50019 Italy Dipartimento di Fisica e Astronomia Universita di Bologna Bologna 40127 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Bologna Bologna 40127 Italy Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Napoli Naples 80126 Italy Istituto Nazionale di Fisica Nucleare (INFN) LNE Frascati (RM) 00044 Italy Agenzia Spaziale Italiana (ASI) SSDC Rome 00133 Italy

CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China).

关键词： earthquake seismic-precursors particle detector Van Allen belts magnetosphere ionosphere space weather cosmic rays

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Imaging of the small bowel in Crohn's disease: A review of old and new techniques

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World Journal of Gastroenterology 2007年第24期13卷 3279-3287页

作者： Simone Saibeni Emanuele Rondonotti Andrea Iozzelli Luisa Spina Gian Eugenio Tontini Flaminia Cavallaro Camilla Ciscato Roberto de Franchis francesco Sardanelli Maurizio Vecchi Gastroenterology and Gastrointestinal Endoscopy Service IRCCS Fondazione Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Milan Italy Gastroenterology and Gastrointestinal Endoscopy Unit IRCCS Policlinico San Donato University of Milan School of Medicine Milan Italy Radiology Unit IRCCS Policlinico San Donato San Donato Milanese University of Milan School of Medicine Milan Italy Departments of Medical and Surgical Sciences University of Milan School of Medicine Milan Italy Gastroenterology and Gastrointestinal Endoscopy Unit University of Milan School of Medicine Milan Italy Gastroenterology and Gastrointestinal Endoscopy Unit IRCCS Policlinico San Donato University of Milan School of Medicine Milan Italy

The investigation of small bowel morphology is often mandatory in many patients with Crohn's disease. Traditional radiological techniques (small bowel enteroclysis and small bowel follow-through) have long been the only suitable methods for this purpose. In recent years, several alternative imaging techniques have been proposed. To review the most recent advances in imaging studies of the small bowel, with particular reference to their possible application in Crohn's disease, we conducted a complete review of the most important studies in which traditional and newer imaging methods were performed and compared in patients with Crohn's disease. Several radiological and endoscopic techniques are now available for the study of the small bowel; each of them is characterized by a distinct profile of favourable and unfavourable features. In some cases, they may also be used as complementary rather than alternative techniques. In everyday practice, the choice of the technique to be used stands upon its availability and a careful evaluation of diagnostic accuracy, clinical usefulness, safety and cost. The recent development ofinnovative imaging techniques has opened a new and exciting area in the exploration of the small bowel in Crohn's disease patients.

关键词： Crohn's disease Small bowel Imaging techniques Ultrasonography Magnetic resonance Computed tomography Video-capsule endoscopy Double-balloon endoscopy

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Natural heme oxygenase-1 inducers in hepatobiliary function

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World Journal of Gastroenterology 2008年第40期14卷 6122-6132页

作者： Giovanni Li Volti David Sacerdoti Claudia Di Giacomo Maria Luisa Barcellona Antonio Scacco Paolo Murabito Antonio Biondi francesco Basile Diego Gazzolo Raul Abella Alessandro Frigiola Fabio Galvano Department of Biological Chemistry Medical Chemistry and Molecular BiologyUniversity of Catania Department of Clinical and Experimental Medicine University of Padova Department of Surgery section of AnesthesiologyUniversity of Catania Department of Surgery Section of General and Oncological SurgeryUniversity of Catania Neonatal Intensive Care Unit "Cesare Arrigo" Children Hospital Department of Pediatrics G.Gaslini Children's University Hospital Perinatal Research Laboratory IRCSS San donato Milanese

Many physiological effects of natural antioxidants, their extracts or their major active components, have been reported in recent decades. Most of these compounds are characterized by a phenolic structure, similar to that of o-tocopherol, and present antioxidant properties that have been demonstrated both in vitro and in vivo. Polyphenors may increase the capacity of endogenous antioxidant defences and modulate the cellular redox state. Changes in the cellular redox state may have wide-ranging consequences for cellular growth and differentiation. The majority of in vitro and in vivo studies conducted so far have attributed the protective effect of bioactive polyphenols to their chemical reactivity toward free radicals and their capacity to prevent the oxidation of important intracellular components. However, in recent years a possible novel aspect inthe mode of action of these compounds has been suggested; that is, the ultimate stimulation of the heme oxygenase-1 （HO-1） pathway is likely to account for the established and powerful antioxidant/anti-inflammatory properties of these polyphenols. The products of the HO-catalyzed reaction, particularly carbon mon- oxide （CO） and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli. In this context, it is interesting to note that induction of HO-1 expression by means of natural compounds contributes to protection against liver damage in various experimental models. The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against various stressors in several pathological conditions.

关键词： Heme oxygenase Hepatobiliary function Natural inducers Carbon monoxide Oxidative stress

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Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation

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World Journal of Gastroenterology 2015年第13期21卷 3912-3920页

作者： Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone Department of Medical and Surgical Sciences University of Bologna and Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’Orsola Malpighi40138 BolognaItaly Department of Gastroenterology Azienda Ospedaliero-Universitaria and University of Modena and Reggio Emilia41124 ModenaItaly Department of Hepatology and Gastroenterology Niguarda Hospital20162 MilanItaly Hepatobiliopancreatic and General Surgery Unit Regina Elena Institute00186 RomeItaly Department of General Surgery and Transplantation Niguarda Hospital20162 MilanItaly

AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic ***: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, "too sick to be treated" and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the "non-responders"(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence.

关键词： Hepatitis C Liver transplantation Hepatitis C viru

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Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy:A review of literature

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World Journal of Clinical Cases 2021年第30期9卷 9077-9089页

作者： Durim Delishaj Ilaria Costanza Fumagalli Stefano Ursino Agostino Cristaudo francesco Colangelo Antonio Stefanelli Alessandro Alghisi Giuseppe De Nobili Romerai D’Amico Alessandra Cocchi Antonio Ardizzoia Carlo Pietro Soatti Department of Radiation Oncology Alessandro Manzoni HospitalLecco 23900Italy Department of Radiation Oncology San Donato HospitalMilan 20097Italy Department of Radiation Oncology Santa Chiara University HospitalPisa 56126Italy Royal Preston Hospital Lancashire Teaching Hospital-NHS TustPreston PR29HTUnited Kingdom Department of Radiation Oncology Azienda Ospedaliero-Universitaria di FerraraFerrara 44124Italy Department of Clinical Oncology Alessandro Manzoni HospitalLecco 23900Italy

BACKGROUND The standard treatment of locally advanced rectal cancers(LARC)consists on neoadjuvant chemoradiotherapy followed by total mesorectal *** data in literature showed a benefit on tumor downstaging and pathological complete response(pCR)rate using radiotherapy dose escalation,however there is shortage of studies regarding dose escalation using the innovative techniques for LARC(T3-4 or N1-2).AIM To analyze the role of neoadjuvant radiotherapy dose escalation for LARC using innovative radiotherapy *** In December 2020,we conducted a comprehensive literature search of the following electronic databases:PubMed,Web of Science,Scopus and Cochrane *** limit period of research included articles published from January 2009 to December *** by title and abstract was carried out to identify only studies using radiation doses equivalent dose 2 Gy fraction(EQD2)≥54 Gy and Volumetric Modulated Arc Therapy(VMAT),intensity-modulated radiotherapy or image-guided radiotherapy(IGRT)*** authors’searches generated a total of 2287 results and,according to PRISMA Group(2009)screening process,21 publications fulfil selection criteria and were included for the *** The main radiotherapy technique used consisted in VMAT and IGRT *** mainly dose prescription was 55 Gy to high risk volume and 45 Gy as prophylactic volume in 25 fractions given with simultaneous integrated boosts technique(42.85%).The mean pCR was 28.2%with no correlation between dose prescribed and response rates(P value≥0.5).The R0 margins and sphincter preservation rates were 98.88%and 76.03%,*** a mean follow-up of 35 months local control was 92.29%.G3 or higher toxicity was 11.06%with no correlation between dose prescription and *** receiving EQD2 dose>58.9 Gy and BED>70.7 Gy had higher surgical complications rates compared to other group(P value=0.047).CONCLUSION Dose escalation neoadjuvant radiotherapy usi

关键词： Rectal cancer Radiotherapy Volumetric Modulated Arc Therapy Imageguided radiotherapy Intensity-modulated radiotherapy Neoadjuvant radiotherapy

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Use of non-selective beta blockers in cirrhosis:The evidence we need before closing(or not) the window

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World Journal of Gastroenterology 2015年第8期21卷 2265-2268页

作者： Vincenzo La Mura Giulia Tosetti Massimo Primignani francesco Salerno U.O. Medicina Interna IRCCS-San Donato Dipartimento di Scienze Biomediche per la Salute Università degli studi di Milano U.O. Gastroenterologia-1 IRCCS-Ca’ Granda Ospedale Maggiore Policlinico

Non selective beta blockers(NSBBs)are used in primary and secondary prophylaxis of portal hypertensionrelated bleeding in patients with *** efficacy of NSBBs treatment is predicted by hemodynamic response in term of reduction of the hepatic venouspressure gradient(HVPG)below 12 mm Hg or at least20%of the basal *** a relevant number of patients who do not achieve this HVPG reduction during NSBBs therapy do not bleed during follow up;this evidence suggests an additional non-hemodynamic advantage of NSBBs treatment to modify the natural history of *** studies have questioned the efficacy and safety of NSBBs in patients with advanced stage of liver disease characterized by refractory ascites and/or spontaneous bacterial *** studies have suggested the existence of a defined and limited period to modify the natural history of cirrhosis by NSBBs:the"window hypothesis".According with this hypothesis,patients with cirrhosis benefit from the use of NSBBs from the appearance of varices up to the development of an advanced stage of ***,in patients with refractory ascites and/or spontaneous bacterial peritonitis the hemodynamic effects of NSBBs may expose to a high risk of further complications such as renal insufficiency and/or *** concerns and contrasting results counterbalance the evidence produced up to now on this issue and are the main topic of this editorial.

关键词： Bleeding prophylaxis End stage liver disease Non-s

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