Natural heme oxygenase-1 inducers in hepatobiliary function

作     者：Giovanni Li Volti David Sacerdoti Claudia Di Giacomo Maria Luisa Barcellona Antonio Scacco Paolo Murabito Antonio Biondi Francesco Basile Diego Gazzolo Raul Abella Alessandro Frigiola Fabio Galvano 

作者机构：Department of Biological ChemistryMedical Chemistry and Molecular BiologyUniversity of Catania Department of Clinical and Experimental MedicineUniversity of Padova Department of Surgerysection of AnesthesiologyUniversity of Catania Department of SurgerySection of General and Oncological SurgeryUniversity of Catania Neonatal Intensive Care Unit "Cesare Arrigo" Children Hospital Department of PediatricsG.Gaslini Children's University Hospital Perinatal Research Laboratory IRCSS San Donato Milanese 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第40期

页      面：6122-6132页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Grants (ex 60%) from MURST (Ministero dell’ Università e della Ricerca Scientifica e Tecnologica) Rome Italy 

主　　题：Heme oxygenase Hepatobiliary function Natural inducers Carbon monoxide Oxidative stress 

摘      要：Many physiological effects of natural antioxidants, their extracts or their major active components, have been reported in recent decades. Most of these compounds are characterized by a phenolic structure, similar to that of o-tocopherol, and present antioxidant properties that have been demonstrated both in vitro and in vivo. Polyphenors may increase the capacity of endogenous antioxidant defences and modulate the cellular redox state. Changes in the cellular redox state may have wide-ranging consequences for cellular growth and differentiation. The majority of in vitro and in vivo studies conducted so far have attributed the protective effect of bioactive polyphenols to their chemical reactivity toward free radicals and their capacity to prevent the oxidation of important intracellular components. However, in recent years a possible novel aspect inthe mode of action of these compounds has been suggested; that is, the ultimate stimulation of the heme oxygenase-1 （HO-1） pathway is likely to account for the established and powerful antioxidant/anti-inflammatory properties of these polyphenols. The products of the HO-catalyzed reaction, particularly carbon mon- oxide （CO） and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli. In this context, it is interesting to note that induction of HO-1 expression by means of natural compounds contributes to protection against liver damage in various experimental models. The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against various stressors in several pathological conditions.