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A prospective study on radiofrequency ablation locally advanced pancreatic cancer

Hepatobiliary & Pancreatic Diseases International 2010年第3期9卷 306-311页

作者： Riccardo Casadei Claudio Ricci Raffaele Pezzilli Carla Serra Lucia Calculli Antonio Maria Morselli-Labate donatella santini Francesco Minni Department of Surgery S.Orsola-Malpighi Hospital University of Bologna Department of Internal Medicine and Gastroenterology S.Orsola-Malpighi Hospital University of Bologna Department of Radiology S.Orsola-Malpighi Hospital University of Bologna Department of Internal Medicine and Gastroenterology Department of Pathology S.Orsola-Malpighi Hospital University of Bologna

BACKGROUND:Radiofrequency ablation(RFA)has been suggested as a new treatment option for patients with locally advanced *** study aimed to prospectively evaluate the efficacy and safety of intraoperative RFA in patients with unresectable,locally advanced,non-metastatic carcinoma of the pancreatic ***:RFA was the first step of the surgical procedure and was carried out on the mobilized pancreatic head followed by biliary by-pass and ***-and post-operative morbidity and mortality,performance status, pain control,quality of life,and survival at 24 months were ***:Seven patients(3 men and 4 women;median age 66 years,range 47-80 years)were studied and 4 were eligible for *** RFA procedure was carried out in 3 of the 4 patients;in one patient it was not carried out because of the upstaging of the *** all 3 patients RFA achieved complete necrosis of the lesion.A biliary fistula developed 7 days after the procedure in one patient;all 3 patients developed ascites 8.6 days(range 7-9 days)on average after *** patients died respectively,at 3,4,and 5 months after the ***:In our experience,RFA is a feasible procedure, but it presents a very high rate of postoperative ***,pain control,life quality and survival rate are *** few data suggest no impact on survival.

关键词： pancreatic neoplasms radiofrequency ablation survival efficacy safety

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Cystic dystrophy of the duodenal wall is not always associated with chronic pancreatitis

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World Journal of Gastroenterology 2011年第39期17卷 4349-4364页

作者： Raffaele Pezzilli donatella santini Lucia Calculli Riccardo Casadei Antonio Maria Morselli-Labate Andrea Imbrogno Dario Fabbri Giovanni Taffurelli Claudio Ricci Roberto Corinaldesi Pancreas Unit Department of Digestive Diseases and Internal MedicineSant'Orsola-Malpighi Hospital Department of Pathology Sant'Orsola-Malpighi HospitalUniversity of Bologna Department of Radiology Sant'Orsola-Malpighi HospitalUniversity of Bologna Department of Surgery Sant'Orsola-Malpighi HospitalUniversity of Bologna

Cystic dystrophy of the duodenal wall is a rare form of the disease which was described in 1970 by French authors who reported the presence of focal pancreatic disease localized in an area comprising the C-loop of the duodenum and the head of the ***-man authors have defined this area as a"groove".We report our recent experience on cystic dystrophy of the paraduodenal space and systematically review the data in the literature regarding the alterations of this space.A MEDLINE search of papers published between 1966 and 2010 was carried out and 59 paperswere considered for the present study;there were 19 cohort studies and 40 case *** majority of patients having groove pancreatitis were middle *** age was significantly higher in patients having groove *** diagnosis of cystic dystrophy of the duodenal wall can now be assessed by multi-detector computer tomography,magnetic resonance imaging and endoscopic *** latter two techniques may also add more information on the involvement of the remaining pancreatic gland not involved by the duodenal malformation and they may help in differentiating"groove pancreatitis"from "groove adenocarcinoma".In conclusion,chronic pan-creatitis involving the entire pancreatic gland was present in half of the patients with cystic dystrophy of the duodenal wall and,in the majority of them,the pan-creatitis had calcifications.

关键词： Pancreatitis Cystic dystrophy of duodenal wall Therapy Outcome

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State of the art biological therapies in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 55-66页

作者： mariacristina di marco elisa grassi sandra durante silvia vecchiarelli andrea palloni marina macchini riccardo casadei claudio ricci riccardo panzacchi donatella santini guido biasco department of experimental diagnostic and specialty medicineuniversity of bolognasant’orsola-malpighi hospital40138 BolognaItaly department of medical and surgical sciences university of bolognasant’orsola-malpighi hospital40138 BolognaItaly pathology unit sant’orsola-malpighi hospital40138 BolognaItaly

Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal malignancies with a five-year survival rate of approximately 5%. Several target agents have been tested in PDAC, but almost all have failed to demonstrate efficacy in late phase clinical trials, despite the better understanding of PDAC molecular biology generated by large cancer sequencing initiatives in the past decade. Eroltinib(a small-molecule tyrosine-kinase inhibitor of epidermal growth factor receptor) plus gemcitabine is the only schedule with a biological agent approved for advanced pancreatic cancer, but it has resulted in a very modest survival benefit in unselected patients. In our work, we report a summary of the main clinical trials(closed and ongoing) that refer to biological therapy evaluation in pancreatic cancer treatment.

关键词： Pancreatic cancer Molecular characterization Targeted therapy Epidermal growth factor receptorinhibitors Embryonic pathway inhibitors Antiangiogenictherapies

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Enteric neuropathology of congenital intestinal obstruction:A case report

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World Journal of Gastroenterology 2006年第32期12卷 5229-5233页

作者： Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli donatella santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio Department of Pediatrics Pediatric Gastroenterology Unit University of Rome 'La Sapienza' Rome Italy Department of Internal Medicine and Gastroenterology and Centro di Ricerca Biomedica Applicata (CRBA) Rome Italy 不详 Department of Pathology and Department of Surgery and Transplantation University of Bologna Bologna Italy Department of Physiology and Cell Biology University of Nevada School of Medicine Reno Nevada United States

Experimental evidence indicates that chronic mechanical sub-occlusion of the intestine may damage the enteric nervous system （ENS）, although data in humans are lacking. We here describe the first case of enteric degenerative neuropathy related to a congenital obstruction of the gut. A 3-year and 9-mo old girl began to complain of vomiting, abdominal distension, constipation with air-fluid levels at plane abdominal radiology. Her subsequent medical history was characterized by 3 operations： the first showed dilated duodeno-jejunal loops in the absence of occlusive lesions; the second （2 years later） was performed to obtain full-thickness biopsies of the dilated intestinal loops and revealed hyperganglionosis at histopathology; the third （9 years after the hyperganglionosis was identified） disclosed a Ladd＇s band which was removed and the associated gut malrotation was corrected. Repeated intraoperative full-thickness biopsies showed enteric degenerative neuropathy along with reduced interstitial cells of Cajal network in dilated loops above the obstruction and a normal neuromuscular layer below the Ladd＇s band. One year after the latest surgery the patient tolerated oral feeding and did well, suggesting that congenital （partial） mechanical obstruction of the small bowel in humans can evoke progressive adaptive changes of the ENS which are similar to those found in animal models of intestinal mechanical occlusion. Such ENS changes mimic neuronal abnormalities observed in intestinal pseudoobstruction.

关键词： Enteric neuropathy Chronic intestinal pseudo-obstruction Congenital intestinal obstruction Ladd's band Enteric nervous system

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Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report

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World Journal of Gastrointestinal Oncology 2020年第12期12卷 1456-1463页

作者： Mariacristina Di Marco Riccardo Carloni Stefania De Lorenzo Cristina Mosconi Andrea Palloni Elisa Grassi Daria Maria Filippini Angela Dalia Ricci Alessandro Rizzo Alessandro Di Federico donatella santini Daniela Turchetti Claudio Ricci Carlo Ingaldi Laura Alberici Francesco Minni Rita Golfieri Giovanni Brandi Riccardo Casadei Department of Experimental Diagnosticand Specialty Medicine-DIMESSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Division of Oncology Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Radiology Unit Department of Diagnostic Medicine and PreventionSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Medical Oncology Ospedale Degli InfermiFaenza 48018Italy Pathology Unit Sant'Orsola-Malpighi HospitalBologna 40138Italy Unit of Medical Genetics Sant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Division of Pancreatic Surgery Azienda Ospedaliero-Universitaria Di BolognaBologna 40138Italy Department of Internal Medicine and Surgery Alma Mater StudiorumUniversity of BolognaBologna 40138Italy

BACKGROUND Pancreatic mucinous cystadenocarcinoma(MCAC)is a rare malignancy with a poor prognosis when it presents metastases at *** to its very low incidence,there are no clear recommendations for the treatment of advanced ***(an oral PARP inhibitor)has been approved for the maintenance treatment of patients with metastatic pancreatic adenocarcinoma harbouring germline BRCA1/2 ***,we report the first case of a germline BRCA1 mutated unresectable MCAC which was effectively treated with *** SUMMARY A 41-year-old woman,without personal or family history of cancer,was diagnosed with ovarian and peritoneal metastases of *** underwent 12 cycles of gemcitabine plus oxaliplatin(GEMOX)obtaining a partial response and allowing radical *** year later,local recurrence was documented,and other 12 cycles of GEMOX were administered obtaining a complete *** years later,another local recurrence,not amenable to surgical resection,was *** started FOLFIRINOX(oxaliplatin,irinotecan,leucovorin and fluorouracil),obtaining a partial response after 8 *** the excellent response to platinum-based chemotherapy,BRCA testing was performed,and a BRCA1 germline mutation was *** was switched to maintenance olaparib due to chemotherapy-related toxicities and achieved an almost complete metabolic response,with a reduction in the diameter of the lesion,after three months of *** The current case suggests the beneficial effect of olaparib in BRCA mutated ***,further studies are required.

关键词： Mucinous cystadenocarcinoma Pancreatic cancer BRCA1 gene Olaparib Case report

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Gynecological malignancies and hormonal therapies: Clinical management and recommendations

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World Journal of Obstetrics and Gynecology 2014年第4期3卷 162-170页

作者： Anna Myriam Perrone Federica Pozzati donatella santini Martina Rossi Martina Procaccini Lucia Casalini Erica Santi Marco Tesei Claudio Zamagni Pierandrea De Iaco Oncologic Gynecology Unit Sant’Orsola-Malpighi Hospital40138 BolognaItaly Pathology Unit Sant’Orsola-Malpighi University Hospital40138 BolognaItaly Medical Oncology Unit Sant’Orsola-Malpighi University Hospital40138 BolognaItaly

Every year in the world a large number of women receive a diagnosis of gynecological cancer and undergo a therapy such as surgery, chemotherapy and radiotherapy to the pelvic region. A large portion of these patients are already in menopause, but for younger patients therapies are responsible of early menopause. The physical and psychological symptoms due to iatrogenic menopause significantly reduce the quality of life; however hormone replacement therapy(HRT) has a high efficacy in reducing menopausal symptoms. The prescription of HRT in patients with story of gynecological cancer is debated because its safety has not been completely proven. The main criticism is based on the theory that the hormone replacement could stimulate growth of residual cancer cells increasing the risk of recurrence.

关键词： Iatrogenic menopause Gynecological cancer Hormone replacement therapy Risk of recurrence Climateric symptoms Cardiovascular benefits Clinical practice

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