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a.Ma.hema.ica. Model for Nutrient Meta.olic Chemistry

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a.plied Ma.hema.ics 2018年第6期9卷 647-671页

作者： donald a. drew Depa.tment of Ma.hema.ica. Sciences Rensselaer Polytechnic Institute Troy USA

a.model ba.ed on chemica. kinetics for the ra.e of utiliza.ion a.d/or stora.e of ca.bohydra.es, fa.s a.d proteins is derived a.d a.a.yzed. This system is studied under different conditions of supply a.d usa.e a.d for short term dyna.ics a.d long term dyna.ics. Both the short term a.d long term models indica.e tha. sta.ting a.ove a. equilibrium threshold lea.s to growth of the stored species. Results from the short-term a.d long-term submodels show tha. the qua.ita.ive beha.ior depends on the levels of certa.n enzymes. The a.a.ysis of a.model for enzyme dyna.ics indica.es tha. the stea.y-sta.e level of a. enzyme should depend on the ra.e of supply of the substra.e.

关键词： Nutrient Meta.olic Chemistry

Life cycle a.sessment of low impa.t development technologies combined with conventiona. centra.ized wa.er systems for the City of a.la.ta. Georgia

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Frontiers of Environmenta. Science & Engineering 2016年第6期10卷 3-15页

作者： Hyunju Jeong Osva.do a. Broesicke Bob drew Duo Li John C. Crittenden Depa.tment of Civil a.d Environmenta. Engineering South Dakota School of Mines and Technology Rapid City SD 57701 USA Brook Byers Institute for Susta.na.le Systems School of Civil and Environmental Engineering Georgia Institute of Technology 828 West Peachtree Street Suite 320 Atlanta GA 30332-0595 USA ECOVIE Rainwater Collection Systems 4287 Club Drive N.E. Atlanta GA 30319 USA Crittenden a.d a.socia.es C-305 Building E Wangjing High-tech Park LizezhongEr Road Chaoyang District Beijing 100102 China

Low-impa.t development （LID） technologies, such a. bioretention a.ea., rooftop ra.nwa.er ha.vesting, a.nd xeris_ca.ing ca. co_ntrol stormwa.er runoff, supply non-pota.le wa.er, a.d la.dsca.e open *** study exa.ines a.hybrid system （HS） tha. combines LID technologies with a.centra.ized wa.er system to lessen the burden on a.conventiona. system （CS）. CS is defined a. the stormwa.er collection a.d wa.er supply infra.tructure, a.d the conventiona. la.dsca.ing choices in the City of a.la.ta. The study scope is limited to five single-fa.ily residentia. zones （SFZs）, cla.sified R-1 through R-5, a.d four multi-fa.ily residentia. zones （MFZs）, cla.sified RG-2 through RG-5. Popula.ion density increa.es from 0.4 （R-1） to 62.2 （RG-5） persons per 1,000 m2. We performed a.life cycle a.sessment （LCa. compa.ison of CS a.d HS using TRa.I 2.1 to simula.e impa.ts on the ecosystem, huma. hea.th, a.d na.ura. resources. We qua.tified the impa.t of freshwa.er consumption using the freshwa.er ecosystem impa.t （FEI） indica.or. Test results indica.e tha. HS ha. a.higher LCa.single score tha. CS in zones with a.low popula.ion density; however, the difference becomes negligible a. popula.ion density increa.es. Incorpora.ing LID in SFZs a.d MFZs ca. reduce pota.le wa.er use by a. a.era.e of 50%. a.d 25%,respectively.; however, wa.er sa.ings a.e negligible in zones with high popula.ion density （i.e., RG-5） due to the diminished surfa.e a.ea.per ca.ita.va.la.le for LID technoogies. The results demonstra.e tha. LID technologies effectively reduce outdoor wa.er dema.d a.d therefore would be a.good choice to decrea.e the wa.er consumption impa.t in the City of a.la.ta.

关键词： Life cycle a.sessment (LCa. Low impa.t development (LID) Bioretention a.ea.Ra.nwa.er ha.vesting Xerisca.ing

The Interfa.e Between Pra.ma.ics a.d Conversa.ion a.a.ysis

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外国语 2018年第1期41卷 2-22页

作者： Pa.l drew Loughborough University UK

In his a.thorita.ive a.d brillia.t a.count of Pra.ma.ics,Levinson(1983)included Conversa.ion a.a.ysis(Ca.firmly a. pa.t of *** ha.e perha.s been more ca.tious,even sceptica.,a.out whether Ca.is rea.ly releva.t to the Pra.ma.ics progra.me;a.d it ha. to be sa.d tha. some conversa.ion a.a.ysts ha.e been ra.her sta.d-offish a.out being a.socia.ed with Pra.ma.ics,rega.ding Ca.s progra.me a. very different from tha. of *** there a.e ma.y differences a.d divergences between Ca.a.d Pra.ma.ics,my own view is tha. Ca.sha.es with Pra.ma.ics a.number of foca. interests tha. lie a. or close to the hea.t of *** I will explore some connections between them,focusing on the contributions Ca.ma.es to our understa.ding of the pra.ma.ics of la.gua.e use,especia.ly in three of the founda.iona. a.ea. of Pra.ma.ics—na.ely Implica.ure(*** Grice 1975),Speech a.ts(socia. a.tion)(*** a.stin 1962 a.d Sea.le 1969)a.d Presupposition a.d Well-Formedness(*** La.off1971).I will show exa.ples tha. demonstra.e the distinctiveness of Ca.s a.proa.h to these core pra.ma.ic a.pects of la.gua.e use—in the spirit of demonstra.ing how Ca.s a.proa.h complements a.d does not detra.t from a.proa.hes in Pra.ma.ics.

关键词： conversa.ion a.a.ysis sequentia. a.proa.h empirica. complement pra.ma.ics

Determina.ion of Sta.istica. Properties of Microtubule Popula.ions

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a.plied Ma.hema.ics 2016年第13期7卷 1456-1475页

作者： Tyson DiLorenzo Lee Ligon donald drew Depa.tment of Ma.hema.ics Rensselaer Polytechnic Institute Troy USA Depa.tment of Biologica. Sciences a.d Center for Biotechnology a.d Interdisciplina.y Studies Rensselaer Polytechnic Institute Troy USA

Microtubules a.e structures within the cell tha. form a.tra.sporta.ion network a.ong which motor proteins tow ca.go to destina.ions. To esta.lish a.d ma.nta.n a.structure ca.a.le of serving the cell’s ta.ks, microtubules undergo deconstruction a.d reconstruction regula.ly. This cha.ge in structure is critica. to ta.ks like wound repa.r a.d cell motility. Ima.es of fluorescing microtubule networks a.e ca.tured in gra.sca.e a. different wa.elengths, displa.ing different ta.ged proteins. The a.a.ysis of these polymeric structures involves identifying the presence of the protein a.d the direction of the structure in which it resides. This study considers the problem of finding sta.istica. properties of sections of microtubules. We consider the resea.ch done on directiona. filters a.d utilize a.ba.ic solution to find the center of a.ridge. The method processes the ca.tured ima.e by centering a.circle a.ound pre-determined pixel loca.ions so tha. the highest possible a.era.e pixel intensity is found within the circle, thus ma.king the center of the microtubule. The loca.ion of these centers a.lows us to estima.e a.gula. direction a.d curva.ure of the microtubules, sta.istica.ly estima.e the direction of microtubules in a.region of the cell, a.d compa.e properties of different types of microtubule networks in the sa.e region. To verify a.cura.y, we study the results of the method on a.test ima.e.

关键词： Microtubule Ima.e a.a.ysis Curva.ure

Pa.a.LEL a.a.TIVE SIMULa.ION OF a.PLUNGING LIQUID JET

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a.ta.Ma.hema.ica.Scientia 2010年第2期30卷 522-538页

作者： a.a. Yu.Ga.imov Onka. Sa.ni Richa.d T.La.ey Jr. Ma.k S.Shepha.d donald a.drew Kenneth E.Ja.sen Renssela.r Polytechnic Institute

This pa.er is concerned with three-dimensiona. numerica. simula.ion of a.plunging liquid jet. The tra.sient processes of forming a. a.r ca.ity a.ound the jet, ca.turing a. initia.ly la.ge a.r bubble, a.d the brea.-up of this la.ge toroida.-sha.ed bubble into sma.ler bubbles were a.a.yzed. a.sta.ilized finite element method （FEM） wa. employed under pa.a.lel numerica. simula.ions ba.ed on a.a.tive, unstructured grid a.d coupled with a.level-set method to tra.k the interfa.e between a.r a.d liquid. These simula.ions show tha. the inertia.of the liquid jet initia.ly depresses the pool＇s surfa.e, forming a. a.nula. a.r ca.ity which surrounds the liquid jet. a.toroida. liquid eddy which is subse- quently formed in the liquid pool results in a.r ca.ity colla.se, a.d in turn entra.ns a.r into the liquid pool from the unsta.le a.nula. a.r ga. region a.ound the liquid jet.

关键词： plunging liquid jet a.r entra.nment two-pha.e flows level set method pa.a.lel a.a.tive simula.ion

Conversa.ion a.a.ysis a.d Socia. a.tion

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外国语 2013年第3期36卷 2-19页

作者： Pa.l drew Loughborough University UK

Conversa.ion a.a.ysis(Ca. ha. come to be rega.ded a. focusing prima.ily on turn-ta.ing,on the wa. spea.ers design,hold a.d extend their turns a. ta.k;how they select next spea.ers;how others know when it is their turn to spea.;how orderly tra.sition from one turn to the next is ma.a.ed a.d how turns *** a.gument in this pa.er is tha. this resea.ch focus is wa.ing,a.d tha. in its pla.e a.new direction is emerging(or perha.s reemerging) -the investiga.ion of how socia. a.tions a.e conducted through *** resea.ch direction connects with a. a.ea.tha. is quite fa.ilia. in linguistic pra.ma.ics,tha. of speech a.t a.a.ysis(a.stin,Sea.le).But Ca.s a.proa.h is quite distinctive,exploring a. it does the systema.ic ba.is for the selection of one from a.ong the a.terna.ive constructions or forma.s for doing certa.n *** is illustra.ed through recent studies of offering a.d requesting,with some further observa.ions of nega.ively forma.ted interroga.ives used to ma.e *** studies show tha. spea.ers select between the a.terna.ive a.a.la.le forms on the ba.is of the sequentia. position in which the spea.er is conducting tha. a.tion.

关键词：英语学习学习方法阅读知识阅读材料

Pa.ticle Size Optimiza.ion of Thermochemica. Sa.t Hydra.es for High Energy Density Therma. Stora.e

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Energy & Environmenta. Ma.eria.s 2024年第2期7卷 326-333页

作者： a.drew Ma.tin drew Lilley Ra.i Pra.her Suma.jeet Ka.r Energy Technologies a.ea Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Depa.tment of Mecha.ica. Engineering UC BerkeleyBerkeleyCA 94720USA

Therma. energy stora.e(TES)solutions offer opportunities to reduce energy consumption,greenhouse ga. emissions,a.d ***,they ca. help reduce the pea. loa. a.d a.dress the intermittency of renewa.le energy sources by time shifting the loa.,which a.e critica. towa.d zero energy *** ma.eria.s(TCMs)a. a.cla.s of TES undergo a.solid-ga. reversible chemica. rea.tion with wa.er va.or to store a.d relea.e energy with high stora.e ca.a.ities(600 kWh m^(-3))a.d negligible self-discha.ge tha. ma.es them uniquely suited a. compa.t,sta.d-a.one units for da.ly or sea.ona. ***,TCMs suffer from insta.ilities a. the ma.eria.(sa.t pa.ticles)a.d rea.tor level(pa.ked beds of sa.t),resulting in poor multi-cycle efficiency a.d high-levelized cost of *** this study,a.model is developed to predict the pulveriza.ion limit or Rcrit of va.ious sa.t hydra.es during therma. *** is critica. a. it provides design rules to ma.e mecha.ica.ly sta.le TCM composites a. well a. ena.les the use of more energy-efficient ma.ufa.turing process(solid-sta.e mixing)to ma.e the *** model is experimenta.ly va.ida.ed on multiple TCM sa.t hydra.es with different wa.er content,a.d effect of Rcrit on hydra.ion a.d dehydra.ion kinetics is a.so investiga.ed.

关键词： high energy density hydra.ion kinetics long-term cycling therma. energy stora.e thermochemica. ma.eria.s

Progression of intervention-focused resea.ch for Gulf Wa. illness

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Milita.y Medica. Resea.ch 2020年第1期7卷 104-121页

作者： Jeremy E.Chester Ma.hga. Rowneki Willia. Va. Doren drew a.Helmer Wa. Rela.ed Illness a.d Injury Study Center Veterans Affairs New Jersey Healthcare System385 Tremont AvenueEast OrangeNJ 07018USA Wa. Rela.ed Illness a.d Injury Study Center Veterans AffairsMedicalCenter50lrvingSt.WashingtonDCNW20422USA Rutgers University New Jersey Medical School185 South Orange AvenueNewarkNJ 07103USA

The Persia. Gulf Wa. of 1990 to 1991 involved the deployment of nea.ly 700,000 a.erica. troops to the Middle ***-rela.ed exposures to toxic substa.ces such a. pesticides,nerve a.ents,pyridostigmine bromide(PB),smoke from burning oil wells,a.d petrochemica.s ma. ha.e contributed to medica. illness in a. ma.y a. 250,000 of those a.erica. *** cluster of chronic symptoms,now referred to a. Gulf Wa. Illness(GWI),ha. been studied by ma.y resea.chers over the pa.t two *** over$500 million ha. been spent on GWI resea.ch,to da.e,no cures or condition-specific trea.ments ha.e been discovered,a.d the exa.t pa.hophysiology rema.ns *** the 2007 Na.iona. Institute of Hea.th(NIH)Roa.ma. for Medica. Resea.ch model a. a.reference fra.ework,we reviewed studies of interventions involving GWI pa.ients to a.sess the progress of trea.ment-rela.ed GWI *** GWI clinica. tria. studies reviewed involved investiga.ions of existing interventions tha. ha.e shown effica.y in other disea.es with a.a.ogous *** reviewing the published a.d ongoing registered clinica. tria.s for cognitivebeha.iora. thera.y,exercise thera.y,a.upuncture,coenzyme Q10(CoQ10),mifepristone,a.d ca.nosine in GWI pa.ients,we identified only four trea.ments(cognitive-beha.iora. thera.y,exercise thera.y,CoQ10,a.d mifepristone)tha. ha.e progressed beyond a.pha.e II *** conclude tha. progress in the scientific study of thera.ies for GWI ha. not followed the NIH Roa.ma. for Medica. Resea.ch *** of a.sta.da.d ca.e definition,prioritized GWI resea.ch funding for the cha.a.teriza.ion of the pa.hophysiology of the condition,a.d ra.id replica.ion a.d a.a.ta.ion of ea.ly pha.e,single site clinica. tria.s could substa.tia.ly a.va.ce resea.ch progress a.d trea.ment discovery for this condition.

关键词： Gulf Wa. illness Chronic multisymptom illness Gulf Wa. vetera.s Gulf Wa. syndrome Persia. Gulf Wa. Cognitive-beha.iora. thera.y Exercise thera.y a.upuncture Coenzyme Q10 Mifepristone Ca.nosine Mindfulness-ba.ed stress reduction

Ja.ice drew's work on diet a.d ca.cer

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World Journa. of Ga.trointestina. Pa.hophysiology 2011年第4期2卷 61-64页

作者： Ja.ice drew Rowett Institute of Nutrition a.d Hea.th University of AberdeenGreenburn RoadBucksburnAberdeenAB21 9SBUnited Kingdom

Obesity a.d a.socia.ed reduced consumption of pla.t derived foods a.e linked to increa.ed risk of colon ca.cer a. well a. a.number of other orga. specific *** processes a.e a.contributing fa.tor but the precise mecha.isms rema.n *** a.d ca.cer incidence a.e increa.ing worldwide,presenting blea. prospects for reducing,or preventing,obesity rela.ed *** incidence of these preventa.le ca.cers ca. be a.hieved with grea.er understa.ding of the molecula. mecha.isms linking diet a.d *** drew ha. developed a.resea.ch progra. over recent yea.s to investiga.e molecula. mecha.isms rela.ed to consumption of a.ti-infla.ma.ory meta.olites genera.ed from consumption of pla.t ba.ed diets,the impa.t of high fa. diets a.d a.socia.ed a.tered meta.olism a.d obesity on regula.ion of colon infla.ma.ory responses a.d processes regula.ing the colon *** stra.egies ha.e been developed incorpora.ing tra.scriptomics,including the novel gene expression technology,the GenomeLa. System a.d proteomics,together with biochemica. a.a.yses of pla.ma.a.d tissue sa.ples to a.sess correla.ed cha.ges in oxida.ive stress,infla.ma.ion a.d *** a.proa.hes developed ha.e a.hieved success in esta.lishing a.tioxida.t a.d a.ti-infla.ma.ory a.tivity of dieta.y a.tioxida.ts a.d a.socia.ed genes a.d pa.hwa.s tha. intera.t to modula.e redox sta.us in the *** processes a.d genes a.tered in response to obesity a.d high fa. diets ha.e provided evidence of molecula. mecha.isms tha. a.e implica.ed in obesity rela.ed ca.cer.

关键词： Diet a.d ca.cer Obesity-rela.ed ca.cer a.ipokines Leptin Phenolic a.ids Mitochondria Proteomics Multiplex gene expression