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不同文化传统的国家中饮酒模式与缺血性心脏病的关系：心肌梗死前瞻性流行病学研究（PRIME研究）

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英国医学杂志中文版 2011年第2期14卷 114-115页

作者： Jean-Bernard Ruidavets Pierre Ducimetiere Alun Evans Michele Montaye Bernadette Haas Annie Bingham John Yamell Philippe Amouyel dominique Arveiler Frank Kee Vanina Bongard Jean Ferrieres 齐文安(译) Department of Epidemiology INSERM U558 Toulouse University School of Medicine Toulouse France INSERM-Paris XI University Villejuif France UK Clinical Research Collaboration Centre of Excellence for Public Health Queen's University Belfast Belfast UK Department of Epidemiology and Public Health INSERM U744 Pasteur Institute of Lille Lille France Department of Epidemiology and Public Health EA 3430 Medical Faculty University of Stmsbourg Strasbourg France INSERM U970 Paul Brousse Hospital Villejuif France Department of Cardiology B and Depamnent of Epldemiology INSERM U558 Toulouse University Hospital Toulouse France 《中华病理学杂志》编辑部

目的探讨在两个生活方式不同的国家（北爱尔兰和法国）中，饮酒方式对缺血性心脏病发生的影响。

关键词：缺血性心脏病心肌梗死前流行病学饮酒模式文化传统北爱尔兰生活方式饮酒方式

Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1

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World Journal of Gastroenterology 2016年第12期22卷 3418-3431页

作者： Ira Jacobson Stefan Zeuzem Robert Flisiak Brygida Knysz Stefan Lueth Dorota Zarebska-Michaluk Ewa Janczewska Peter Ferenci Moises Diago Anna Linda Zignego Rifaat Safadi Yaacov Baruch Dzhamal Abdurakhmanov Stephen Shafran dominique Thabut Rafael Bruck Adrian Gadano Alexander James Thompson Justin Kopit Fiona Mc Phee Tracy Michener Eric A Hughes Philip D Yin Stephanie Noviello Weill Cornell Medical College New YorkNY 10029United States Icahn School of Medicine at Mount Sinai New YorkNY 10029United States JW Goethe University Hospital 60323 FrankfurtGermany Uniwersytet Medyczny w Bialymstoku 15-089 BialystokPoland EMC and Medical University 50-220 WroclawPoland Universitatsklinikum Hamburg-Eppendorf 20246 HamburgGermany Wojewodzki Szpital Zespolony w Kielcach 25-736 KielcePoland ID Clinic 41-400 MyslowicePoland Medizinische Universitat Wien 1090 ViennaAustria Clinica Quiron 46010 ValenciaSpain Universita degli Studi di Firenze 50121 FlorenceItaly Holy Family Hospital Nazareth 6004Israel Rambam Medical Center Haifa 31096Israel 1st Moscow State Medical University N.A.I.M.Sechenov 119991 MoscowRussia University of Alberta Hospital EdmontonAlberta T6G 2B7Canada Groupe Hospitalier Pitie-Salpetriere 75013 ParisFrance Tel Aviv Sourasky Medical Center and Tel Aviv University Tel Aviv 64239Israel Hospital Italiano de Buenos Aires Buenos Aires C1181ACHArgentina St.Vincents Hospital and the University of Melbourne Melbourne 3065Australia Fiona McPhee Bristol-Myers Squibb Research and DevelopmentWallingfordCT 06492United States Bristol-Myers Squibb Research and Development PrincetonNJ 08450United States

AIM: To evaluate daclatasvir vs telaprevir, each combined with peginterferon alfa-2a/ribavirin(peg IFN/RBV), in treatment-naive hepatitis C virus(HCV) genotype(GT) 1-infected ***: In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned(2:1) to daclatasvir vs telaprevir, stratified by IL28 B rs12979860 host genotype(CC vs non-CC), cirrhosis status(compensated cirrhosis vs no cirrhosis), and HCV GT1 subtype(GT1a vs GT1b). Patients were selected by study inclusion criteria from a total of 793 enrolled patients. Patients received daclatasvir 60 mg once daily or telaprevir 750 mg 3 times daily plus peg IFN/RBV. Daclatasvir recipients received 24 wk of daclatasvir plus peg IFN/RBV; those without an extended rapid virologic response(e RVR; undetectable HCV-RNA at weeks 4 and 12) received an additional 24 wk of peg IFN/RBV. Telaprevir-treated patients received 12 wk of telaprevir plus peg IFN/RBV followed by 12(with e RVR) or 36(no e RVR) wk of peg IFN/RBV. The primary objective was to compare for noninferiority of sustained virologic response rates at posttreatment week 12(SVR12) in GT1b-infected patients. Key secondary objectives were to demonstrate that the rates of anemia(hemoglobin < 10 g/d L) and rashrelated events, through week 12, were lower with daclatasvir + peg IFN/RBV than with telaprevir + peg IFN/RBV among GT1b-infected patients. Resistance testing was performed using population-based sequencing of the NS5 A region for all patients at baseline, and for patients with virologic failure or relapse and HCV-RNA ≥ 1000 IU/m L, to investigate any link between NS5 A polymorphisms associated with daclatasvir resistance and virologic outcome. RESULTS: Patient demographics and disease characteristics were generally balanced across treatment arms; however, there was a higher proportion of black/African Americans in the daclatasvir groups(6.0% and 8.2% in the GT1 b and GT1 a groups, respectively) than in the telaprevi

关键词： Direct-acting antiviral Chronic hepatitis C Daclatasvir Genotype 1b NS5A inhibitor Liver disease

中国与OECD成员国对化学农药原药登记中毒理数据和试验指南要求的比较

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中国与OECD成员国对化学农药原药登记中毒理数据和试验指南要求的...

Oxidized palm oil impairs reproductive functions and architectures in female rats

中国毒理学会第十次全国毒理学大会

作者： Nan Zhang dominique Renault-Billault Alessa Ignarski Lirong Chen Birgit Neumann Jing Ma Zi Liu Vickie Shang Katrin Bender Li Zhang Jens Peter Lampe Venoe 拜耳作物科学(中国)有限公司

2017年11月1日起,农业部开始实施2569号公告《农药登记资料要求》,其中对化学农药原药登记的毒理学数据(包括试验种类和试验物种)都进行了清晰的要求,相对应试验指南的国家标准《农药登记毒理学试验方法》也于2018年2月1日起开始实施。... 详细信息

2017年11月1日起,农业部开始实施2569号公告《农药登记资料要求》,其中对化学农药原药登记的毒理学数据(包括试验种类和试验物种)都进行了清晰的要求,相对应试验指南的国家标准《农药登记毒理学试验方法》也于2018年2月1日起开始实施。为了保证人体健康安全和环境安全,实现中国与OECD成员国数据互认(MAD)并将中国创新化学农药原药推向全球市场,本研究对中国与OECD成员国的毒理数据和试验指南要求进行了全面系统的比较。在毒理学数据要求方面,中国与OECD监管框架的要求基本一致,其中包括急性毒性、遗传毒性、慢性毒性和致癌性(大鼠和小鼠)、生殖毒性(大鼠和兔子)、致畸性和迟发性神经毒性等。某些毒理终点和毒理方法存在差异,例如中国要求进行亚急性吸入试验,并由此得到吸入途径的可接受操作暴露水平(AOEL)进行施药人员健康风险评估,而OECD成员国通常不要求此试验(除非有可预见的吸入毒性);OECD成员国要求在亚慢性试验中使用大鼠、小鼠和狗三个物种,以确定最敏感物种,而中国针对此试验并未进行物种要求;OECD成员国对代谢物毒性的试验基于QSAR/分组/交叉参照,且对无预测结论的代谢物要求急性、亚急性(28天)和遗传毒性试验,而中国尚无指南,当前也一般要求亚慢性(90天)试验;其他差别也可以见于急性神经毒性、代谢和毒物动力学试验或内分泌干扰作用评价方法等。在毒理学试验指南中方面,中国试验指南的起草在很大程度上参照OECD试验指南,但具体的试验方法和观察指标也有差异,比如基于更为保守的毒性分类标准,中国急性毒性的试验指南一般要求更高的限量剂量和每组动物数量;吸入试验的试验指南参考旧版OECD试验指南,因此测试物的颗粒物理化学和观察指标均存在较大差别;其他差别也可以见于致癌性、生殖毒性、代谢和毒动试验或内分泌干扰作用等。尽管中国与OECD成员国对化学农药原药登记在毒理方面的要求仍存在差异,但通过全面系统的比较,在对毒理数据和试验指南方面均可以认为其功能性是相当的,均涵盖了相似的评估方法指标及健全的评估能力。当然,为了中国与OECD成员国MAD问题的解决,目前的评估仍需要扩展,包括环境方面数据及实验指南的要求等。此外,具体的数据质量仍然要基于各个实验室对试验指南的理解和执行水平。

关键词：毒理 OECD MAD 试验指南化学农药原药登记要求

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Asian pacific Journal of Reproduction 2023年第4期12卷 182-193页

作者： Wankeu-Nya Modeste Kengne Inès T Ateba Benjamin S Bend Fortune E Djeumeni Ornela N Hathodominique T Ngadjui E Moundipa Paul F Massoma DieudonnéL Dongmo Alain B Watcho Pierre Department of Animal Organisms Biology Faculty of ScienceUniversity of DoualaDoualaCameroon Department of Animal Production Faculty of Agronomy and Agricultural SciencesUniversity of DschangDschangCameroon Department of Biochemistry Faculty of ScienceUniversity of YaoundéIYaoundéCameroon Department of Animal Biology Faculty of ScienceUniversity of DschangDschangCameroon

Objective:To evaluate the effects of three oxidized palm oil diets(OPD)on female rat reproductive ***:Forty-four female Wistar rats presenting five consecutive and regular estrous cycles were divided into 4 *** rats were fed with:a standard diet,70%of standard diet+30%oxidized palm oil diet(OPD1),OPD1+5 g of boiled yolk egg(OPD2)and OPD1+10%sucrose(OPD3)for 125 days,*** the feeding period,morphometric,estrous cycle,sexual behavior,gestation,biochemical and histomorphometric parameters were ***:All OPDs significantly increased abdominal circumference,body mass index and Lee index coupled to an irregularity and lengthening of the estrous *** significantly decreased appetite and consumption behaviours,quantic pregnancy index,fertility rate,implantation sites and index,serum progesterone and high-density lipoprotein levels,increased pre-implantation losses,anti-implantation activities,serum estradiol,triglycerides,total and low-density lipoprotein-cholesterol levels,and impaired brain and ovaries oxidative *** examinations revealed increases in the number of atresic and primary follicles and decreases in secondary,tertiary,Degraaf,total and corpus luteum follicles in ovaries coupled to a neurodegeneration of hypothalamic anteroventral periventricular neurons in the OPD groups compared to the standard diet ***:The three OPDs induce obesity and impair the female reproductive function,especially OPD2 and *** findings contribute to a better understanding of the adverse effects of palm oil bleaching on the reproductive function in female rats,which could be useful in the management of women with obesity-related sexual dysfunction.

关键词： Bleached palm oil Reproductive function Anteroventral periventricular nucleus Ovary Estrogen Progesterone Female rat

局灶性皮质发育不良和神经发育肿瘤的癫痫发作模式与手术预后和神经病理亚型的联系

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癫痫杂志 2017年第2期3卷 158-166页

作者： Stanislas Lagarde Francesca Bonini Aileen McGonigal Patrick Chauvel Martine Gavaret Didier Scavarda Romain Carron Jean Regis Sandrine Aubert Nathalie Villeneuve Bernard Giusiano dominique Figarella-Branger Agnes Trebuchon Fabrice Bartolomei 张颖颖慕洁

颅内脑电图对癫痫发作模式的研究对癫痫灶的精确定位和指导成功切除有重要作用。它也引出了癫痫发生机制相关的重要病理生理问题。目前,植入硬膜下和深部电极等记录方式已经描述了几种癫痫发作模式(主要是颞叶癫痫和伴有异质新皮层病变... 详细信息

颅内脑电图对癫痫发作模式的研究对癫痫灶的精确定位和指导成功切除有重要作用。它也引出了癫痫发生机制相关的重要病理生理问题。目前,植入硬膜下和深部电极等记录方式已经描述了几种癫痫发作模式(主要是颞叶癫痫和伴有异质新皮层病变的癫痫)。研究分析了53例患者的连续性队列资料,所有患者均行立体定向脑电图(SEEG)监测,且病理证实为皮质发育畸形(Malformation of cortical development,MCD)——局灶性皮质发育不良(Focal cortical dysplasia,FCD)和神经发育肿瘤(Neurodevelopmental tumors,NDTs)。通过对视觉和时间-频率的分析,证实了存在6种癫痫发作模式:低压快波活动(Low-voltage fast activity,LVFA);发作前棘波继之LVFA;爆发性多棘波继之LVFA;慢波/直流电漂移继之LVFA;θ或α尖波;节律性棘波/棘波。结果表明包含LVFA的模式(83%)普遍性较高,但是LVFA并不是癫痫发作的一个固定特征。癫痫发作模式和组织学类型具有相关性(P=0.01)。更加普遍的模式如下:(1)FCDⅠ型:LVFA占23.1%,慢波/基线漂移继之LVFA占15.4%;(2)FCDⅡ型:爆发性多棘波继之LVFA占31%,LVFA占27.6%;发作前棘波继之LVFA占27.6%;(3)NDTs:LVFA占54.5%。发现包含LVFA的癫痫发作模式与较好的手术预后具有相关性,但癫痫灶切除的完整性是一个独立预测因子;FCD和NDTs有6种不同的癫痫发作模式;包含LVFA的癫痫发作模式的患者手术预后更好。

关键词：癫痫局灶性皮质发育不良神经发育肿瘤皮质发育畸形立体定向脑电图癫痫发作癫痫手术癫痫灶

WHV/myc转基因小鼠肝癌发生过程中的基因异常

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南京医科大学学报(自然科学版) 2000年第5期20卷 394-394页

作者：刘平,赵志泉,dominique Bernuau,Gerard Feldmann 南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科南京医科大学第一附属医院消化科

目的　探测WHV/myc转基因小鼠肝癌发生过程中有关基因在肝脏中的异常表达。方法　用原位杂交方法检测WHV/myc转基因小鼠肝肿瘤形成的不同阶段 ,c myc转染基因、胰岛素样生长因子Ⅱ (IGF Ⅱ )基因c jun、c fos和c H ras等基因的表达。结... 详细信息

目的　探测WHV/myc转基因小鼠肝癌发生过程中有关基因在肝脏中的异常表达。方法　用原位杂交方法检测WHV/myc转基因小鼠肝肿瘤形成的不同阶段 ,c myc转染基因、胰岛素样生长因子Ⅱ (IGF Ⅱ )基因c jun、c fos和c H ras等基因的表达。结果　c myc转染基因IGF Ⅱ基因在转基因小鼠出生后早期的肝脏中异常表达 ,随后表达水平即降低至不能测出。上述两基因的表达在肝肿瘤形成期重新出现。c jun、c fos和c H ras基因在转基因小鼠肝癌发生前肝脏中的表达强度明显高于正常小鼠。结论　c myc转染基因和IGF Ⅱ基因在小鼠出生后早期和肿瘤形成期的异常表达对肝肿瘤的发生和瘤细胞转化表型的维持可能具有重要意义 ;在c myc转染基因表达的“沉默”期 ,一些癌基因在肝脏中的异常表达对日后肝脏肿瘤的形成可能也具有一定作用。

关键词：小鼠肝癌肝脏 WHV/myc 转基因基因转移

FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

婴儿配方粉成分的全球标准:欧洲儿科胃肠病、肝病和营养学会牵头的国际专家组建议

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中国循证儿科杂志 2006年第4期1卷 307-319页

作者： Berthold Koletzko Susan Baker Geoff Cleghorn Ulysses Fagundes Neto Sarath Gopalan Olle Hernell Quak Seng Hock Pipop Jirapinyo Bo Lonnerdal Paul Pencharz Hildegard Pzyrembel Jaime Ramirez-Mayans Raanan Shamir dominique Turck Yuichiro Yamashiro 丁宗一(译) 无德国慕尼黑大学冯豪内儿童医院国际专家组美国纽约州布法罗大学儿科系澳大利亚布里斯班昆士兰大学儿科与儿童健康系巴西圣保罗联邦大学儿科系印度新德里营养支持系统研究中心瑞典Umea大学儿科系临床科学部新加坡国立大学儿科系泰国曼谷大学儿科系美国加州大学营养与内科系加拿大多伦多儿童医院胃肠病与营养系德国柏林联邦风险评估研究所墨西哥国家儿科研究所胃肠病与营养系以色列海法Meyer儿童医院儿科胃肠病与营养系法国里尔胃肠病肝病与营养系日本东京顺天堂大学儿科系中国北京市儿童医院欧洲儿科胃肠病肝病和营养学会牵头的国际专家组

联合国粮食及农业组织(FAO)和WHO的食品法典委员会提出的食品标准、指南和其他相关文件旨在保护消费者健康以及全球的公平贸易.

关键词：全球标准婴儿配方营养学会胃肠病专家组食品法典委员会儿科欧洲

迷走神经刺激治疗难治性癫痫:欧洲347例儿童24个月随访研究

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癫痫杂志 2016年第5期2卷 454-460页

作者： Iren Orosz David McCormic Nelia Zamponi Sophia Varadkar Martha Feucht dominique Parain Roger Griens Louis Vallee Paul Boon Christopher Rittey Amara K. Jayewardene Mark Bunker Alexis Arzimanoglou Lieven Lagae 刘文钰(译) 慕洁(审) 不详

为了进一步探究迷走神经刺激术(Vagus nerve stimulation,VNS)在儿童难治性癫痫中的作用,进行了连续随访达24个月,系迄今最大样本量的多中心回顾性研究.主要目标是评估VNS术后癫痫主要发作类型(定义为最易致残的发作类型)的频率变化,连... 详细信息

为了进一步探究迷走神经刺激术(Vagus nerve stimulation,VNS)在儿童难治性癫痫中的作用,进行了连续随访达24个月,系迄今最大样本量的多中心回顾性研究.主要目标是评估VNS术后癫痫主要发作类型(定义为最易致残的发作类型)的频率变化,连续收集从基线开始一直到植入术后6、12及24个月的患者数据.统计人群包括347例患者(年龄6个月~17.9岁).在植入后第6、12及24月,分别有32.5%、37.6%及43.8%的患者主要发作类型的发作与基线相比,有50%减少.亚组分析中,在试验期间没有更换抗癫痫药物(AEDs)的患者有更好的反应.较好的结果也存在于所有次要指标,包括癫痫发作持续时间、严重程度和发作后严重程度、生活质量、安全性等.多组分析表明VNS每天总放电量与反应效率有相关性.VNS治疗被认为是局灶性结构性癫痫患儿的附加治疗,指那些经过两种及以上AEDs治疗后仍不适合外科手术的患者.全面性发作,有遗传及结构异常的,如Dravet综合征和Lennox-Gastaut综合征的患者能从VNS治疗中获益.结果表明随访24个月后,难治性癫痫患儿通过附加的VNS治疗能够减少癫痫发作频率,安全性良好;多组分析表明VNS有剂量相关性.

关键词：临床试验癫痫儿童生活质量迷走神经刺激术