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Philippine retinoblastoma initiative multi-eye center study 2010-2020

International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept mari S.Poblete Charmaine Grace m.Cabebe Adriel Vincent R.Te melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria m.Castro mara Augustine S.Galang Aldous dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo michael maniwan Andrei P.martin Calvin Y.martinez John Alfred H.Lim Rena Ivy Bascuna Rachel m.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz m.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIm:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pm the Visayas(Pma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

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Optimized Image multiplication with Approximate Counter Based Compressor

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Computers, materials & Continua 2022年第8期72卷 3815-3834页

作者： m.maria dominic Savio T.Deepa1,N.Bharathiraja Anudeep Bonasu SRmIST Chennai603203India Vel Tech multi Tech Dr.Rangarajan Dr.Sakunthala Engineering College Chennai601206India Intel Corportation California93657USA

The processor is greatly hampered by the large dataset of picture or multimedia *** logic of approximation hardware is moving in the direction of multimedia processing with a given amount of acceptable *** study proposes various higher-order approximate counter-based compressor(CBC)using input shuffled 6:3 *** the Wallace multiplier using a CBC is a significant factor in partial product *** the design of 10-4,11-4,12-4,13-4 and 14-4 CBC are proposed in this paper using an input shuffled 6:3 compressor to attain two stage *** input shuffling aims to reduce the output combination of the 6:3 compressor from 64 to *** of 15-4,10-4,9-4,and 7-3 CBCs are performed using the proposed 6:3 compressor and the results obtained are compared with the existing *** existing models are constructed using multiplexers and 5-3 *** compared to input shuffled 5-3 the proposed 6:3 compressor shows better results in terms of area,power and *** approximation is performed on the 6:3 compressor to further reduce the computational energy of the system which is optimal for multimedia *** major contribution of this work is the development of two stage multiplier using various proposed *** designs of the approximate compressor(AC)and true compressor(TC)are analysed with 8 ×8 and 16 × 16 *** proposed multipliers also provide adequate levels of accuracy,according to the mATLAB simulations,in addition to greater hardware *** the result approximate circuits over image processing shows the stunning performance in many deep learning network in the current research which is only oriented to multimedia.

关键词： multiplier PSNR image processing approximate compressor NED

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modified correlation for minimum fluidization velocity of low-density particles in inverse liquid-solid fluidized beds

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Particuology 2022年第12期71卷 56-62页

作者： michael Nelson Saleh Srabet Tian Nan dominic Pjontek Jesse Zhu Collaborative Innovation Center of Chemical Science and Engineering School of Chemical Engineering and TechnologyTianjin UniversityChina Particle Technology Research Centre Department of Chemical and Biochemical EngineeringWestern UniversityCanada

The minimum fluidization velocity(U_(mf))is a key parameter for the scale-up of inverse liquid-solid flu-idized *** predictions using common correlations were compared against experimental minimum fluidization velocity measurements of low density(28-638 kg/m^(3)),0.80-1.13 mm Styrofoam particles in a fluidized bed with a height of 4.5 m and 0.2 m *** average absolute relative deviation for the predicted minimum fluidization velocity for particles below 300 kg/m^(3) was above 40%using the studied common correlations.A modified Wen and Yu correlation was thus proposed based on novel and past measurements with low-density and small-diameter particles,expanding the range for predicting U_(mf).The new correlation predicted U_(mf) with deviations below 15%for ST028,ST122 and *** modified correlation also improved U_(mf) predictions for comparable particles from a previous study,demonstrating its validity for a larger range of low-density particles.

关键词： Liquid-solid fluidization Inverse fluidization minimum fluidization velocity Low-density particles

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Synchrotron Characterisation of Ultra-Fine Grain TiB_(2)/Al-Cu Composite Fabricated by Laser Powder Bed Fusion

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Acta metallurgica Sinica(English Letters) 2022年第1期35卷 78-92页

作者： Sheng Li Biao Cai Ranxi Duan Lei Tang Zihan Song dominic White Oxana V.magdysyuk moataz m.Attallah School of metallurgy and materials University of BirminghamEdgbastonBirminghamB152TTUK Department of materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China ZEISS House Building 1030Cambourne Business ParkCambourneCambridgeCB236DWUK Diamond Light Source Ltd Harwell Science and Innovation CampusDidcotOX110DEOxfordshireUK

Isotropy in microstructure and mechanical properties remains a challenge for laser powder bed fusion(LPBF)processed materials due to the epitaxial growth and rapid cooling in *** this study,a high-strength TiB_(2)/Al-Cu composite with random texture was successfully fabricated by laser powder bed fusion(LPBF)using pre-doped TiB_(2)/Al-Cu composite powder.A series of advanced characterisation techniques,including synchrotron X-ray tomography,correlative focussed ion beam-scanning electron microscopy(FIB-SEm),scanning transmission electron microscopy(STEm),and synchrotron in situ X-ray diffraction,were applied to investigate the defects and microstructure of the as-fabricated TiB_(2)/Al-Cu composite across multiple length *** study showed ultra-fine grains with an average grain size of about 0.86μm,and a random texture was formed in the as-fabricated condition due to rapid solidification and the TiB_(2)particles promoting heterogeneous *** yield strength and total elongation of the as-fabricated composite were 317 mPa and 10%,*** contributions of fine grains,solid solutions,dislocations,particles,and Guinier-Preston(GP)zones were *** was found to be initiated from the largest lack-of-fusion pore,as revealed by in situ synchrotron tomography during tensile *** situ synchrotron diffraction was used to characterise the lattice strain evolution during tensile loading,providing important data for the development of crystal-plasticity models.

关键词： Aluminium metal matrix composite Laser powder bed fusion Heterogeneous nucleation Synchrotron characterisation

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The effect of volume change and stack pressure on solid-state battery cathodes

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Susmat 2023年第5期3卷 721-728页

作者： Boyang Liu Shengda DPu Christopher Doerrer dominic Spencer Jolly Robert A.House dominic L.R.melvin Paul Adamson Patrick S.Grant Xiangwen Gao Peter G.Bruce Department of materials University of OxfordOxfordUK The Faraday Institution DidcotUK The Henry Royce Institute University of OxfordOxfordUK Future Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghaiChina Department of Chemistry University of OxfordOxfordUK

Solid-state lithium batteries may provide increased energy density and improved safety compared with Li-ion ***,in a solid-state composite cathode,mechanical degradation due to repeated cathode volume changes during cycling may occur,whichmay be partially mitigated by applying a significant,but often impractical,uniaxial stack ***,we compare the behavior of composite electrodes based on Li4Ti5O12(LTO)(negligible volume change)and Nb2O5(+4%expansion)cycled at different stack *** initial LTO capacity and retention are not affected by pressure but for Nb2O5,they are significantly lower when a stack pressure ofmPa is applied,due to inter-particle cracking and solid-solid contact loss because of cyclic volume *** confirms the importance of cathode mechanical stability and the stack pressures for long-term cyclability for solid-state *** suggests that low volumechange cathode materials or a proper buffer layer are required for solid-state batteries,especially at low stack pressures.

关键词： cathode interface mechanical degradation stack pressure solid-state battery

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Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate

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International Journal of Oral Science 2023年第4期15卷 701-717页

作者： maria B.Asparuhova Xiaoqing Song dominic Riedwyl Geert van Geest Dieter D.Bosshardt Anton Sculean Laboratory of Oral Cell Biology School of Dental MedicineUniversity of BernBernSwitzerland Department of Periodontology School of Dental MedicineUniversity of BernBernSwitzerland Interfaculty Bioinformatics Unit University of BernBernSwitzerland Robert K.Schenk Laboratory of Oral Histology School of Dental MedicineUniversity of BernBernSwitzerland

The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human ***-four CTGs belonging to anterior deep(AD),anterior superficial(AS),posterior deep(PD),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed *** correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was ***,endothelial,and monocytic cell migration was strongly(Pmotif chemokine ligands as well as significantly(Pmmunomodulatory phenotype for AD-and *** growth factor gene expression and significantly activated(Pm A-CTGs implied their involvement in cell survival,proliferation,and *** collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(Pmad1/5/8 signaling characterized HPFs originating from *** present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than *** findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.

关键词： selecting characterizing showing

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Novel endoscopic management of buried bumper syndrome in percutaneous endoscopic gastrostomy: The Olympus Hook Knife

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World Journal of Gastroenterology 2017年第35期23卷 6546-6548页

作者： Laura E Wolpert dominic m.sum.ers Andrew Tsang Department of General Surgery Peterborough City HospitalEdith Cavell Campus

Buried bumper syndrome(BBS) is an uncommon but serious complication of percutaneous endoscopic gastrostomy. It involves the internal fixation device, or "bumper", migrating into the gastric wall and subsequent mucosal overgrowth. We described a case series of four patients with BBS treated with a novel endoscopic technique using a Hook Knife between June 2016 and February 2017. The Hook Knife is a rotating L-shaped cutting wire designed for hooking tissue and pulling it away from the gastric wall towards the lumen. The technique was successful in all four cases with no complications. Each patient was discharged on the day of treatment. The Hook Knife is a manoeuvrable, safe and effective device for endoscopic removal of buried bumpers and could avoid surgery in a high risk group of patients. To our knowledge this technique has not been described previously. We suggest that this technique should be added to the treatment algorithms for managing BBS.

关键词： Buried bumper syndrome Percutaneous endoscopic gastrostomy Hook Knife

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Performance of a data-driven technique applied to changes in wave height and its effect on beach response

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Water Science and Engineering 2016年第1期9卷 42-51页

作者： José m.Horrillo-Caraballo Harshinie Karunarathna Shun-qi Pan dominic Reeve Energy&Environment Research Group Zienkiewicz Centre for Computational EngineeringSwansea UniversityBay CampusSwansea SA1 8ENUK Hydro-environmental Research Centre School of EngineeringCardiff UniversityCardiff CF24 3AAUK

In this study the medium-term response of beach profiles was investigated at two sites： a gently sloping sandy beach and a steeper mixed sand and gravel beach. The former is the Duck site in North Carolina, on the east coast of the USA, which is exposed to Atlantic Ocean swells and storm waves, and the latter is the milford-on-Sea site at Christchurch Bay, on the south coast of England, which is partially sheltered from Atlantic swells but has a directionally bimodal wave exposure. The data sets comprise detailed bathymetric surveys of beach profiles covering a period of more than 25 years for the Duck site and over 18 years for the milford-on-Sea site. The structure of the data sets and the data-driven methods are described. Canonical correlation analysis （CCA） was used to find linkages between the wave characteristics and beach profiles. The sensitivity of the linkages was investigated by deploying a wave height threshold to filter out the smaller waves incrementally. The results of the analysis indicate that, for the gently sloping sandy beach, waves of all heights are important to the morphological response. For the mixed sand and gravel beach, filtering the smaller waves improves the statistical fit and it suggests that low-height waves do not play a primary role in the medium-term morohological resoonse, which is primarily driven by the intermittent larger storm waves.

关键词： Beach profile Canonical correlation analysis Data-driven technique Empirical orthogonal function Forecast Statistical model Wave height threshold

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A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling

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Bioactive materials 2023年第1期19卷 167-178页

作者： Alexander Stahl Dake Hao Janos Barrera dominic Henn Sien Lin Seyedsina moeinzadeh Sungwoo Kim William maloney Geoffrey Gurtner Aijun Wang Yunzhi Peter Yang Department of Orthopaedic Surgery Stanford University240 Pasteur DriveStanfordCA94304USA Department of Chemistry Stanford University121 Mudd BuildingStanfordCA94305USA Department of Surgery School of MedicineUniversity of California DavisSacramentoCA95817USA Institute for Pediatric Regenerative medicine Shriners Hospitals for ChildrenSacramentoCA95817USA Department of Surgery Stanford University300 Pasteur DriveStanfordCA94305USA Department of Biomedical Engineering University of California DavisDavisCA95616USA Department of materials Science and Engineering Stanford University496 Lomita MallStanfordCA94305USA Department of Bioengineering Stanford University443 Via OrtegaStanfordCA4305USA

Conventional synthetic vascular grafts are associated with significant failure rates due to their mismatched mechanical properties with the native vessel and poor regenerative *** different tissue engineering approaches have been used to improve the biocompatibility of synthetic vascular grafts,it is still crucial to develop a new generation of synthetic grafts that can match the dynamics of native vessel and direct the host response to achieve robust vascular *** size of pores within implanted biomaterials has shown significant effects on macrophage polarization,which has been further confirmed as necessary for efficient vascular formation and ***,we developed biodegradable,autoclavable synthetic vascular grafts from a new polyurethane elastomer and tailored the grafts’interconnected pore sizes to promote macrophage populations with a pro-regenerative phenotype and improve vascular regeneration and patency *** synthetic vascular grafts showed similar mechanical properties to native blood vessels,encouraged macrophage populations with varying m2 to m1 phenotypic expression,and maintained patency and vascular regeneration in a one-month rat carotid interposition model and in a four-month rat aortic interposition *** innovative bioactive synthetic vascular graft holds promise to treat clinical vascular diseases.

关键词： Vascular graft Vascular compliance Pore size macrophage polarization Vascular remodeling

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Effects of liquid feed rate and impeller rotation speed on heat transfer in a mechanically fluidized reactor

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Particuology 2018年第4期16卷 25-32页

作者： Dhiraj Kankariya Cedric Briens dominic Pjontek Stefano Tacchino Department of Chemical and Biochemical Engineering University of Western Ontario London Ontario N6A 5B9 Canada

A mechanically fluidized reactor （mFR） is a novel and compact reactor used for biomass pyrolysis. Endothermic biomass pyrolysis requires heat provided from the wall of the mFR. meanwhile, mixing with a vertical stirrer helps achieve effective heat transfer from the wall to the bed. Here, the heat trans- fer characteristics between the wall of a 1.0-L mFR and its bed of mechanically fluidized sand particles were studied. An induction heating system was used to heat the wall, while a vertical blade stirrer was used for mixing. Heat transfer measurements were carried out using silica sand particles, having three average Sauter mean diameters： 190, 300, and 600 p.m. The overall wall-to-bed heat transfer coeffi- cients were estimated using temperature measurements taken during continuous injection of water onto the fluidized bed. The overall heat transfer coefficient for bed temperatures of 500-700℃ increased as particle size increased or superficial velocity of the vaporized liquid increased. Effect of impeller rotation speed also was investigated. Typically, the overall heat transfer coefficient increased as rotation speed increased. The wall-to-bed heat transfer coefficients obtained in this study are comparable to estimates from traditional bubbling fluidized beds, even at vapor velocities below the minimum fluidization veloccity.

关键词： mechanical fluidization Induction heating Impeller rotation Heat transfer Particle size

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