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Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation

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Journal of Geriatric Cardiology 2020年第3期17卷 141-148,I0005-I0007页

作者： Gines Elvira-Ruiz Cesar Caro-Martinez Pedro JoseFlores-Blanco Juan JoseCerezo-Manchado Helena Albendin-Iglesias Alejandro Lova-Navarro Francisco Arregui-Montoya Francisca Maria Munoz-Franco Natalia Garcia-Iniesta Arcadio Garcia-Alberola JoseLuis Bailen-Lorenzo domingo Andres Pascual-Figal Sergio Manzano-Fernández Department of Cardiology University Hospital Virgen de la ArrixacaMurciaSpain Instituto Murciano de Investigación en Biomedicina(IMIB) MurciaSpain Department of Cardiology University Hospital Morales MeseguerMurciaSpain Department of Hematology University Hospital Virgen de la ArrixacaMurciaSpain Department of Internal Medicine University Hospital Virgen de la ArrixacaMurciaSpain School of Medicine University of MurciaMurciaSpain Department of Cardiology Hospital Vega BajaAlicanteSpain

Background The identification of modifiable bleeding risk factors may be of *** aim is to evaluate if aortic stenosis(AS)provides additional information to bleeding risk scores for predicting major bleeding(MB)in non-valvular atrial fibrillation(AF).Methods We designed a retrospective multi-center study including 2880 consecutive non-valvular AF patients initiating oral anticoagulation between January 2013 and December *** was defined as moderate or severe according to European echocardiography guidelines ***,ATRIA and ORBIT scores were used to evaluate the bleeding *** was defined according to the International Society on Thrombosis and Haemostasia criteria and registered at 18 months of *** 168(5.8%)patients had *** with AS had higher risk for MB compared to those without AS(HR=2.13,95%CI:1.40-3.23,P<0.001).Patients without AS and low-intermediate bleeding risk(0 points)showed the lowest MB rate,whereas the MB rate observed among patients with AS and high bleeding risk(2 points)was the highest *** and reclassification analyses showed that AS provided additional information to bleeding risk scores for predicting MB at 18 months of *** In this population,AS was associated with an increased risk for MB at midterm *** three scoring systems showed a moderate discriminatory ability for ***,the addition of AS was associated with a significant improvement in their predictive *** suggest that the presence of this valvulopathy should be taken into account for bleeding risk assessment.

关键词： Anticoagulants Aortic stenosis Atrial fibrillation Major bleeding Valvular disease

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Epigenetic regulation of stemness maintenance in the neurogenic niches

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World Journal of Stem Cells 2015年第4期7卷 700-710页

作者： Raquel Montalbán-Loro Ana domingo-Muelas Alexandra Bizy Sacri R Ferrón Departamento de Biología Celular Facultad de BiologíaUniversidad de Valencia

In the adult mouse brain, the subventricular zone lining the lateral ventricles and the subgranular zone in the dentate gyrus of the hippocampus are two zones that contain neural stem cells(NSCs) with the capacity to give rise to neurons and glia during the entire life of the animal. Spatial and temporal regulation of gene expression in the NSCs populationis established and maintained by the coordinated interaction between transcription factors and epigenetic regulators which control stem cell fate. Epigenetic mechanisms are heritable alterations in genome function that do not involve changes in DNA sequence itself but that modulate gene expression, acting as mediators between the environment and the genome. At the molecular level, those epigenetic mechanisms comprise chemical modifications of DNA such as methylation, hydroxymethylation and histone modifications needed for the maintenance of NSC identity. Genomic imprinting is another normal epigenetic process leading to parentalspecific expression of a gene, known to be implicated in the control of gene dosage in the neurogenic niches. The generation of induced pluripotent stem cells from NSCs by expression of defined transcription factors, provide key insights into fundamental principles of stem cell biology. Epigenetic modifications can also occur during reprogramming of NSCs to pluripotency and a better understanding of this process will help to elucidate the mechanisms required for stem cell maintenance. This review takes advantage of recent studies from the epigenetic field to report knowledge regarding the mechanisms of stemness maintenance of neural stem cells in the neurogenic niches.

关键词： Neurogenesis Neural stem cell Epigenetics Gene expression regulation Chromatin modifications DNA methylation

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Evaluation of the Nutritional Supplement VIUSID Vet Powder on the Productive Behaviour of Sows and Boars

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Journal of Environmental Science and Engineering(B) 2016年第9期5卷 432-439页

作者： Juan Carlos Rodriguez-Femhndez Vicente Mendez-Garcia Ibrain Calero-Herrera Kolima Pefia-Calzada domingo Martos-Tejera Bulent Kukurtcu Department of Veterinary Medicine and Animal Husbandry University of Sancti Spiritus Sancti Spiritus 60100 Cuba Department of Production Swine Farm of Venega Yaguajay 64180 Cuba Scientific Department CATALYSIS S.L. Madrid28016 Spain

The objective of this research was to evaluate the effect of administering VIUSID vet powder on the productive behaviour of sows and the quality of semen of boars. Two experiments were conducted on farms in the province of Sancti Spiritus, in the central region of Cuba. One was with sows, starting 21 days before parturition until weaning, and another was with boars in directed mounting. Each sow received 10 grams of VIUSID vet powder everyday, mixed with food, from 21 days before the probable date of farrowing and until weaning （33-day lactation period）. In the boars, the treatment consisted of administering 10 grams of VIUSID vet powder with feed, once a day for 6 weeks （week 1 to 6）; from week 7 onwards, the supplement was suspended. Results showed that, supplying VIUSID vet powder significantly improved the principal post-partum productivity indicators and significantly reduced diarrhoea and administration to boars in production for 6 weeks, which has improved spermatic motility and does not affect the other variables representative of the quality of the semen.

关键词： VIUSID sows boars Glycyrrhizaglabra.

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Study of the Wear and Corrosion Performance of Hard Coatings Applied by Different Processes on Low Carbon Steel

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Materials Sciences and Applications 2016年第7期7卷 358-370页

作者： Carlos Roberto Camello Lima Rodolfo Libardi Flávio Camargo Miguel Angel Reyes Mojena Hipólito domingo Carvajal Fals Valtair Antonio Ferraresi Methodist University of Piracicaba Santa Bárbara d’Oeste Sao Paulo Brazil Ogramac Surface Engineering Santo Antonio de Posse Sao Paulo Brazil Oriente University Santiago de Cuba Cuba Federal University of Uberlandia Uberlandia Minas Gerais Brazil

Most of materials used in applications that require high wear resistance also undergo corrosive action of the service environment. The damage caused by the combination of both processes on the materials leads to huge economic losses in industry. Hard coatings are widely used as engineering solution to increase the lifetime of components operating in conditions of wear combined with corrosion. Nowadays, the most versatile techniques for applying such coatings are welding and thermal spraying. This work evaluates and compares the properties of coatings obtained by thermal spraying and welding using selected feeding materials. The performance of the coatings in corrosion and erosive wear tests is discussed. From the erosion tests performed for impact angle of 90°, a similar performance for the thermally sprayed tungsten carbide coatings and the welded stainless steel coatings with higher input energy was observed. Welded samples presented the best performance in corrosion test.

关键词： Hard Coatings HVOF Welding Erosive Wear Corrosion

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也许爱是……

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疯狂英语（阅读版） 2008年第2期 38-39页

作者：约翰·丹佛 Placido domingo 薇雨

关键词：丹佛金唱片记忆爱情约翰传奇牛仔美国装束理想

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Albumin-bound paclitaxel as new treatment for metastatic cholangiocarcinoma: A case report

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World Journal of Clinical Oncology 2020年第10期11卷 844-853页

作者： Roberto Martin Huertas Raquel Fuentes-Mateos Juan Jose Serrano domingo Elena Corral de la Fuente Mercedes Rodríguez-Garrote Medical Oncology Department Hospital Universitario Ramon y CajalMadrid 28034Spain

BACKGROUND Cholangiocarcinomas are rare and very aggressive *** patients have advanced-stage or unresectable disease at presentation,and the systemic therapies have limited ***-bound paclitaxel(nab-paclitaxel)is a solvent-free taxane that has been approved for the treatment of some cancers such as breast,non-small cell lung and pancreatic cancer,however it has not been applied to treat *** have both preclinical and clinical evidence of the efficacy of nab-paclitaxel in cholangiocarcinoma,yet no phase 3 trials have been *** SUMMARY A 63-year-old man was diagnosed in December 2016 with stage III B intrahepatic *** was performed,followed by adjuvant chemotherapy treatment with capecitabine and gemcitabine;although,the gemcitabine was suspended due to allergic reaction after two *** April 2019,metastatic cholangiocarcinoma relapse was diagnosed,and a first-line treatment with FOLFOX scheme was *** cycles were administered,producing an initial clinical improvement and decrease in blood tumor marker *** and serological progression was noted in September *** a second-line treatment,FOLFIRI was not recommended due to risk of worsening the patient’s tumor-related diarrhea.A combination therapy with gemcitabine was not feasible,as the patient had previously suffered from an allergic reaction to this *** decided to use nab-paclitaxel as a second-line treatment,and four cycles were *** clinical and serological responses were observed,and a radiological mixed response was also *** Advanced cholangiocarcinoma could be treated with nab-paclitaxel monotherapy,which should be studied in combination with other types of treatment(chemotherapy,fibroblast growth factor receptor inhibitors).

关键词： Cholangiocarcinoma Chemotherapy Albumin-bound paclitaxel Case report Metastatic Clinical trial

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Defining a Standard Methodology to Obtain Optimum WRF Configuration for Operational Forecast: Application over the Port of Huelva (Southern Spain)

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Atmospheric and Climate Sciences 2016年第2期6卷 329-350页

作者： Raúl Arasa Ignasi Porras Anna domingo-Dalmau Miquel Picanyol Bernat Codina Mª Ángeles González Jésica Piñón Technical Department Meteosim S.L. Barcelona Spain Department of Astronomy and Meteorology University of Barcelona Barcelona Spain

In this contribution, we calibrate the meteorological model weather and research forecasting (WRF) for operational forecasting in the Port of Huelva managed by the Authority Port of Huelva. Meteorological forecasting will allow reducing the impact of the meteorological phenomena over weather sensitive activities in the region. Concretely, the meteorological modeling developed will be used to analyze meteorological hazard impacts and to improve the management of the local air quality. To achieve these goals, numerous sensitive analyses corresponding to different model options have been developed. These analyses consider different physical and dynamical options, the coupling of very high resolution physiographic database (topography and land uses), and data assimilation. Comparing experiments, results with observational measures provide us by the Spanish National Meteorology Agency (AEMET). During a representative period, the optimum WRF configuration for the region is obtained. Calibration has been focused on wind due to this is the main risk factor in the region. When the model is satisfactorily calibrated, WRF is evaluated using whole modeling years 2012 and 2013, working with very high horizontal resolution, up to 0.333 km of horizontal grid resolution. Results obtained from the evaluation indicate that the numerical weather prediction system developed has a confidence level of 70% for the temperature, 81% and 66% for the wind speed and wind direction respectively, and 90% for the relative humidity. Methodology designed defines the quality control assurance of high-accuracy forecasting services of Meteosim S.L.

关键词： WRF Sensitive Analysis Meteorological Modelling Physical Options LES High Resolution

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Assessment of Climate Change in Nicaragua: Analysis of Precipitation and Temperature by Dynamical Downscaling over a 30-Year Horizon

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Atmospheric and Climate Sciences 2016年第3期6卷 445-474页

作者： Josep Maria Solé Raúl Arasa Miquel Picanyol Mª Ángeles González Anna domingo-Dalmau Marta Masdeu Ignasi Porras Bernat Codina Technical Department Meteosim S.L. Barcelona Spain Department of Astronomy and Meteorology University of Barcelona Barcelona Spain

The present study has generated and analyzed Climate Change projections in Nicaragua for the period 2010-2040. The obtained results are to be used for evaluating and planning more resilient transport infrastructures in the next decades. This study has focused its efforts to pay attention into the effect of Climate Change on precipitation and temperature from a mean and extreme event perspective. Dynamical Downscaling approach on a 4 km resolution grid has been chosen as the most appropriate methodology for the estimation of the projected climate, being able to account for local-scale factors like complex topography or local land uses properly. We selected MPI-ESM-MR as the global climate model with the best skill scores in terms of precipitation and temperature in Nicaragua. MPI-ESM-MR was coupled to a mesoscale model. We chose WRF mesoescale model as the most appropriate regional model and we optimized their physical and dynamical options in order to minimize the model uncertainty in Nicaragua. For this, model output against the available in-situ measurements from the national meteorological station network and satellite data were compared. Climate change signal was estimated by comparing the different climate statistics calculated from a model run over an historical period, 1980-2009, with a model run over a projected period, 2010-2040. The obtained results from the projected climate show an increase of the mean temperature between 0.6°C and 0.8°C and an increase of the number of days per year with maximum daily temperatures higher than 35°C. Regarding precipitation, annual projected amounts do not change remarkably with respect to the historical period. However, significant changes in the distribution of the precipitation within the wet period (May-October) were observed. Moreover, an increment between 5% and 10% of the number of days without precipitation is expected. Finally, Intensity-Duration-Frequency (IDF) projected curves show an increment of the rainfall

关键词： WRF Climate Change Global Warming Dynamical Downscaling Precipitation Projections IDF

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Open Journal of Respiratory Diseases 2012年第2期2卷 17-24页

作者： Manuel Lopez-Meseguer Río Aguilar Carles Bravo Víctor Monforte Laura Dos Carmen P. Simeon Enric domingo Antonio Roman Cardiology Department Hospital Universitari de Bellvitge Hospitalet de Llobregat Spain Cardiology Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain Department of Physiology Universitat Autonòma de Barcelona Barcelona Spain Internal Medicine Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain Respiratory Department Hospital Universitari Vall d’Hebron Institut de Recerca del Hospital Universitari Vall d’Hebron Universitat Autònoma de Barcelona Barcelona Spain

Background: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are serious diseases with similar pathophysiologic aspects. The prognosis of patients with these conditions is highly uncertain, particularly incident cases. Methods: A Cox proportional hazards model was applied to a group of 85 patients (81% women, mean age 52 (18 - 82) years) with PAH (80%) and non-surgical CTEPH (20%) to evaluate risk factors for mortality. The following variables were included in the model: age, etiology, baseline 6-minute walk test (6 mWT), cardiac index, and improvement in the 6 mWT following initiation of first medical treatment. Results: In the multivariate analysis, the response to treatment, assessed by an improvement on the 6 mWT, was the most relevant prognostic factor in these patients (RR, 4.832 (95% CI, 1.888 - 12.364);p = 0.001). The remaining variables studied in this model had less influence on the prognosis: age > 50 years (RR, 0.744 (95% CI, 0.26 - 2.133);p = 0.582);etiology of connective tissue disease-associated PAH (RR, 3.145 (95% CI, 0.995-9.946);p = 0.051) or CTEPH (RR, 0.654 (95% CI, 0.179 - 2.387);p = 0.521) with respect to idiopathic PAH;baseline 6 mWT (RR, 1.173 (95% CI, 0.599 - 4.895);p = 0.315);or cardiac index (RR, 2.295 (95% CI, 0.793 - 6.642);p = 0.125). Conclusions: There is a high degree of uncer-tainty regarding the prognosis of PAH and CTEPH at the start of appropriate treatment. Our results support the idea that the initial treatment response is of paramount importance as prognostic factor in these patients.

关键词： Pulmonary Arterial Hypertension Chronic Thromboembolic Pulmonary Hypertension Survival Risk Factors

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Geriatric epidemiology of trauma in a hospital in Southern Colombia

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Journal of Acute Disease 2017年第1期6卷 33-35页

作者： Yolercy Vsquez Jos Daniel Charry Juan Daniel Ochoa Ana Mara Gmez Karen Herrera Jorman Harvey Tejada Jose domingo Alarcn Department of Family Medicine Faculty of Health SciencesSurcolombiana UniversityNeivaColombia Grupo de Investigación Desarrollo Social Salud Pública y Derechos HumanosSurcolombiana UniversityNeivaColombia Department of Medicine Faculty of Health SciencesFundación Universitaria Navarra-UNINAVARRANeivaColombia. Department of Medicine Faculty of Health SciencesSurcolombiana UniversityNeivaColombia Neuroanesthesiologist Medical Coordinator of Postgraduate Program in Anesthesiology and ReanimationFaculty of Health Sciences-Surcolombiana UniversityNeivaColombia

Objective: To describe the clinical and sociodemographic characteristics of geriatric patients who were treated at a university hospital in southern Colombia. Methods: A database of trauma patients over 65 admitted between June 2014 and December 2015 was constructed. Univariate analysis was performed. Measures of central tendency and dispersion for continuous variables were calculated. Results: A total of 760 patients were analyzed, the median age was 74 years (65–98). The median injury severity score was 9 (4–25) the 71.97% were men, and overall mortality was 25.39%. The 92.10% was blunt trauma, and the main mechanism of injury was falls. Conclusions: Trauma in the elderly is a common condition with high risk of mortality. It is important to know the frequency of these injuries to provide the best possible handling. In our hospital we found that geriatric trauma is a common disease, the main cause is falls without embargos traffic accidents are common in this population.

关键词： Trauma Geriatrics Epidemiology

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