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Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto's thyroiditis

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 789-791页

作者： Saul Levy-Blitchtein Stefany Plasencia-Rebata domingo Morales Luna Juana del Valle Mendoza School of Medicine Faculty of Health Sciences Universidad Peruana de Ciencias Aplicadas (UPC) Research Center and Innovation of the Health Sciences Faculty Universidad Peruana de Ciencias Aplicadas (UPC) Pathologist Service Hospital Nacional Edgardo Rebagliati Martins (HNERM)

Papillary thyroid cancer(PTC)represents 80%-85%of thyroid cancer and its prevalence has been rising in the last *** thyroid lymphoma(PTL)accounts for 3%of extranodal lymphomas and about 5%of thyroid malignancies,having a prevalence of one or two cases per million ***-Associated Lymphoid Tissue lymphoma represents approximately30%of *** entities have an indolent course and a very good *** is made by ultrasound and fine needle aspiration(FNA)or surgery specimen *** have also been associated with Hashimoto’s thyroiditis(HT),but pathogenesis and its links remains to be *** remains controversial and surgery is generally accepted in cases of disease limited to thyroid,as the *** with thyroid nodules should be observed and *** there is an enlargement by ultrasound or clinical symptoms,FNA should be performed *** with HT deserve additional surveillance,since this condition is associated with both PTC and *** this case,the management with surgery and radioactive iodine ablation therapy was effective for both *** with thyroid nodules should be properly evaluated with ultrasound and thyroid function *** there is an enlargement of the neck,reported by symptoms or ultrasound,it requires further *** is associated to both PTC and PTL so if the enlargement of the nodules is on this context additional tests such as FNA should be *** this case,the patient was managed with surgery and radioactive iodine ablation therapy and it was effective for both entities.

关键词： Thyroid cancer-clinical Hashimoto’s thyroiditis Pathology-thyroid Thyroid diseases

Small Hydropower in Southeast Asia

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Small Hydro Power News 2004年第77期21卷 15-16页

作者： NathanielC.domingo FidelpioV.Ferraris Prof.RowaldoR.delMundo University of the Philippines Solar Laboratory Diliman Quezon City Philippines

SHP has been applied in Southeast Asia (SEA) for three decades now. There is a number of existing SHP installations, both of mini and micro scale. However, comparing the current installed capacity to the potential cap... 详细信息

关键词：东南亚地区小水电水力资源水电建设水电规划发电量

Environmental pollution with psychiatric drugs

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World Journal of Psychiatry 2021年第10期11卷 791-804页

作者： Julene Argaluza Saioa domingo-Echaburu Gorka Orive Juan Medrano Rafael Hernandez Unax Lertxundi Department of Epidemiology and Public Health Bioaraba Health Research InstituteVitoria-Gasteiz 01002Spain Department of Pharmacy Alto Deba Integrated Health Care OrganizationArrasate 20500Spain NanoBioCel Group Laboratory of PharmaceuticsSchool of PharmacyUniversity of the Basque Country UPV/EHUPaseo de la Universidad 7Vitoria-Gasteiz 01006Spain Biomedical Research Networking Centre in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Vitoria-Gasteiz 01006Spain Bioaraba NanoBioCel Research GroupVitoria-Gasteiz 01006Spain Singapore Eye Research Institute Discovery TowerSingapore 168751Singapore Department of Psychiatry Biocruces Bizkaia Health Research InstituteMental Health Network Research GroupOsakidetzaPortugalete 48920Spain Department of Internal Medicine Araba Mental Health NetworkVitoria-Gasteiz 01006Spain Bioaraba Health Research Institute/Osakidetza Basque Health Service Araba Mental Health NetworkAraba Psychiatric HospitalPharmacy ServiceVitoria-Gasteiz 01006AlavaSpain

Among all contaminants of emerging interest,drugs are the ones that give rise to the greatest *** of the multiple stages of the drug's life cycle(production,consumption and waste management)is a possible entry point to the different environmental *** drugs have received special attention because of two ***,their use is ***,many of them act on phylogenetically highly conserved neuroendocrine systems,so they have the potential to affect many non-target ***,wastewater is considered the most important source of drugs to the ***,the currently available wastewater treatment plants are not specifically prepared to remove drugs,so they reach practically all environmental matrices,even tap *** drugs are designed to produce pharmacological effects at low concentrations,they are capable of producing ecotoxicological effects on microorganisms,flora and fauna,even on human *** has also been observed that certain antidepressants and antipsychotics can bioaccumulate along the food *** pollution is a complicated and diffuse problem characterized by scientific uncertainties,a large number of stakeholders with different values and interests,and enormous *** solutions consist on acting at source,using medicines more rationally,eco-prescribing or prescribing greener drugs,designing pharmaceuticals that are more readily biodegraded,educating both health professionals and citizens,and improving coordination and collaboration between environmental and healthcare ***,end of pipe measures like improving or developing new purification systems(biological,physical,chemical,combination)that eliminate these residues efficiently and at a sustainable cost should be a ***,we describe and discuss the main aspects of drug pollution,highlighting the specific issues of psychiatric drugs.

关键词： Antipsychotics Pharmaceuticals in the environment Drug pollution Antidepressants Wastewater Ecotoxicity

Determination of One Unknown Thermal Coefficient through the One-Phase Fractional Lamé-Clapeyron-Stefan Problem

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Applied Mathematics 2015年第13期6卷 2182-2191页

作者： domingo Alberto Tarzia CONICET and Department of Mathematics FCE Universidad Austral Rosario Argentina

We obtain explicit expressions for one unknown thermal coefficient (among the conductivity, mass density, specific heat and latent heat of fusion) of a semi-infinite material through the one-phase fractional Lamé-Clapeyron-Stefan problem with an over-specified boundary condition on the fixed face . The partial differential equation and one of the conditions on the free boundary include a time Caputo’s fractional derivative of order . Moreover, we obtain the necessary and sufficient conditions on data in order to have a unique solution by using recent results obtained for the fractional diffusion equation exploiting the properties of the Wright and Mainardi functions, given in: 1) Roscani-Santillan Marcus, Fract. Calc. Appl. Anal., 16 (2013), 802 - 815;2) Roscani-Tarzia, Adv. Math. Sci. Appl., 24 (2014), 237 - 249 and 3) Voller, Int. J. Heat Mass Transfer, 74 (2014), 269 - 277. This work generalizes the method developed for the determination of unknown thermal coefficients for the classical Lamé-Clapeyron-Stefan problem given in Tarzia, Adv. Appl. Math., 3 (1982), 74 - 82, which is recovered by taking the limit when the order .

关键词： Free Boundary Problems Fractional Diffusion Lamé-Clapeyron-Stefan Problem Unknown Thermal Coefficients Explicit Solution Over-Specified Boundary Condition

Nanostructured biohybrid material with wide-ranging antiviral action

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Nano Research 2023年第8期16卷 11455-11463页

作者： Noelia Losada-Garcia Angela Vazquez-Calvo David Ortega-Alarcon Olga Abian Adrian Velazquez-Campoy Pilar domingo-Calap Antonio Alcami Jose M.Palomo Instituto de Catálisis y Petroleoquímica(ICP) CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI) Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón) Zaragoza 50009Spain CIBERehd Madrid 28029Spain Instituto de Biología Integrativa de Sistemas I2SyBioUniversitat de València-CSICValència E-46071Spain

Respiratory pathogens kill more people than any other infectious agent each year *** of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major ***,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous *** evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was *** characterization revealed the formation of Cu species in the protein *** best biomaterial synthesized using a lipase called BioCuNPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACE)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of *** these in vitro results into account,an efficacy analysis against human coronavirus 229E(HCoV-E229)coronavirus was performed.A virus reduction of 99%was obtained in 5 ***,SARS-CoV-2 virus was tested to demonstrate high efficiency,with>99%inhibition in 15 min using 500 microgram of *** determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 ***,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).

关键词： antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses

A Practical Solution to the Small Sample Size Bias and Uncertainty Problems of Model Selection Criteria in Two-Input Process Multiple Response Surface Methodology Datasets

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Open Journal of Statistics 2019年第1期9卷 109-142页

作者： domingo Pavolo Delson Chikobvu The University of the Free State Bloemfontein South Africa

Multiple response surface methodology (MRSM) most often involves the analysis of small sample size datasets which have associated inherent statistical modeling problems. Firstly, classical model selection criteria in use are very inefficient with small sample size datasets. Secondly, classical model selection criteria have an acknowledged selection uncertainty problem. Finally, there is a credibility problem associated with modeling small sample sizes of the order of most MRSM datasets. This work focuses on determination of a solution to these identified problems. The small sample model selection uncertainty problem is analysed using sixteen model selection criteria and a typical two-input MRSM dataset. Selection of candidate models, for the responses in consideration, is done based on response surface conformity to expectation to deliberately avoid selection of models using the problematic classical model selection criteria. A set of permutations of combinations of response models with conforming response surfaces is determined. Each combination is optimised and results are obtained using overlaying of data matrices. The permutation of results is then averaged to obtain credible results. Thus, a transparent multiple model approach is used to obtain the solution which gives some credibility to the small sample size results of the typical MRSM dataset. The conclusion is that, for a two-input process MRSM problem, conformity of response surfaces can be effectively used to select candidate models and thus the use of the problematic model selection criteria is avoidable.

关键词： Multiple Response Surface Methodology All Possible Regressions Model Selection Criteria Data Matrices

Michael E. DeBakey and Denton A. Cooley— Mike, the Master Assembler;Denton, the Courageous Fighter: A Personal Overview Unforgettable Past Remembrances in the 1960s

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Open Journal of Thoracic Surgery 2012年第3期2卷 37-45页

作者： domingo S. Liotta domingo S. Liotta is the Dean of the School of Medicine the Secretary for Science and Technology and Emeritus Professor of Clinical Anatomy University of Morón Morón Buenos Aires Argentina

domingo S. Liotta discovered Assisted Circulation at the Department of Surgery of Baylor College of Medicine in Houston in 1961 and opened up a new medical therapy: Prolonged mechanical Cardiocirculatory Assistance (LVASs) for the treatment of Refractory and Irreversible Heart Failure. The American Society of Cardiology selected Liotta’s work for the “Young Investigator Award” granted in Denver in May 1962: ”This prolonged left ventricular bypass decompresses the left ventricle, reduces left ventricular work, decreases left ventricular wall tension and increases coronary circulation” (D. Liotta, D. A. Cooley, M. E. DeBakey et al. Prolonged assisted circulation during and after cardiac or aortic surgery: prolonged partial left ventricular bypass by means of intracorporeal circulation (Am J Cardiol 1963;12: 399-405). Indeed, there is a lucky occurrence in science;I had the good luck to start this research at a moment when initially unrelated developments were actively taking place in cardiac surgery, long before any rigor or fine statistics were produced. The first observation was to recognize an interaction between the overstretched myocardial fibers and the result of cardiac assistance causing their shortening within the normal values when the excess of blood volume retained in the heart chamber was unloaded, and the second one was that the oxygen consumption of the heart (a measurement of its energy use) decreases during Cardiac Assistance. With the collaboration of Michael E. DeBakey, Liotta started the clinical experience of Cardiocirculatory Assistance and on August 6 1966 they succeeded in the first survival of a patient in postcardiotomy cardiogenic shock. Today, after 50 years, LVASs are in force in the medical practice worldwide and contrarily to transplantation practices, they have an unlimited future;they are continuously fed back by the scientific advances of general technologies. On April 4 1969 Cooley and Liotta implanted the first clinical Total Artifi

关键词： Michael E. Debakey-Denton A. Cooley-Total Artificial Heart-Assisted Circulation

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(P<0.02)and those from the Visayas(P<0.003).Based on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

Appendiceal Colic in Children: Is It A True Surgical Entity?

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Surgical Science 2012年第8期3卷 399-402页

作者： Jason Marone domingo Alvear Department of Surgery Pinnacle Health Harrisburg PA

Background/Purpose: For decades children have been crowding the offices of Pediatricians’ and Pediatric Surgeons with a common complaint of unexplained recurrent right lower quadrant pain. For years the topic of appendiceal colic as a cause for this recurrent abdominal pain has remain controversial. This paper highlights the experience of a single surgeon over a 5 years period using an algorithmic approach to diagnose and treat children with appendiceal colic. Methods: This is a retrospective review of 31 consecutive cases of patients experiencing recurrent unexplained right lower quadrant abdominal pain for greater than three weeks. All patients were evaluated by a single surgeon at the same institution. The patients meeting the criteria for appendiceal colic had an elective open appendectomy. The data included was compiled by a retrospective chart review from Jan 1, 2006 to December 31, 2010. Results: Twelve percent or 31 of the 238 elective appendectomies done between Jan. 2006 to Dec. 2010 where done for appendiceal colic. Sixteen were females and 15 where males ranging in age from 5-17 years of age. Average duration of symptoms was 3 weeks to 5 years. All patients had previous work up most of which where inconclusive for an organic cause. All patients presented with colic and McBurney’s point tenderness. On pathological examination the presence of a fecalith, inspissated stool or fibrosis were the most common findings. A normal appendix was observed in 14% of the cases. 100% of the patients were symptom free with three months of operation. Conclusion: Appendiceal colic proves to be true in a small subset of patients presenting with unexplained right lower quadrant abdominal pain. A high index of suspicion coupled with a thorough history and physical exam is needed to identify these patients. Classically they will present with recurrent right lower abdominal pain at McBurney’s. In our experience an elective appendectomy has been curative.

关键词： Natural Asset Financial Value Neural Network