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Extracellular vesicles in Alzheimer’s disease:from pathology to therapeutic approaches

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Neural Regeneration Research 2023年第1期18卷 18-22页

作者： marta Garcia-Contreras Avnesh S.Thakor Interventional Regenerative Medicine and Imaging Laboratory Department of RadiologyStanford UniversityPalo AltoCAUSA

Alzheimer’s disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive *** novel biomarkers for Alzheimer’s disease has the potential for patient risk stratification,early diagnosis,and disease monitoring in response to therapy.A novel class of biomarkers is extracellular vesicles given their sensitivity and specificity to specific *** addition,extracellular vesicles can be used as novel biological therapeutics given their ability to efficiently and functionally deliver therapeutic *** is critical given the huge unmet need for novel treatment strategies for Alzheimer’s *** review summarizes and discusses the most recent findings in this field.

关键词： Alzheimer’s disease brain diagnostic extracellular vesicles isolation methods microglia neurodegenerative diseases neuroinflammation neurons therapy

Effect of acceptor ions concentration in lead phosphate glasses co-doped with Tb3+-Ln3+（Ln=Eu,Sm）for LED applications

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Journal of Rare Earths 2019年第11期37卷 1145-1151页

作者： Agata Gorny marta Soltys Joanna Pisarska Wojciech A.Pisarski Institute of Chemistry University of Silesia

In this work,lead phosphate glasses doubly doped with Tb^3+and Ln^3+(Ln=Eu,Sm)ions were *** excitation and emission spectra of lanthanides ions were *** luminescent properties of lead phosphate glasses containing various concentrations of acceptor ions were *** is observed that luminescence bands corresponding to characteristic transitions of rare earth ions are present on emission spectra measured under direct excitation of Tb^3+.From the emission spectra,the Commission Internationale de I’Eclairage(CIE)chromaticity coordinates(x,y)were calculated in relation to potential application studied systems for white *** lifetimes were also determined based on decay measurements and discussed in *** general,the luminescence spectra and luminescence lifetimes depend on the relative concentrations of the optically active dopants.

关键词： Lead phosphate glasses Rare earth ions LED applications

Analysis and Efficient Solution of Stationary Schrodinger Equation Governing Electronic States of Quantum Dots and Rings in Magnetic Field

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Communications in Computational Physics 2012年第5期11卷 1591-1617页

作者： marta M.Betcke Heinrich Voss Department of Computer Science University College LondonGower StreetLondon WC1E 6BTUK Institute of Numerical Simulation Hamburg University of TechnologyD-21071 HamburgGermany

In this work the one-band effective Hamiltonian governing the electronic states of a quantum dot/ring in a homogenous magnetic field is used to derive a pair/quadruple of nonlinear eigenvalue problems corresponding to different spin orientations and in case of rotational symmetry additionally to quantum number±ℓ.We show,that each of those pair/quadruple of nonlinear problems allows for the minmax characterization of its eigenvalues under certain conditions,which are satisfied for our examples and the common InAs/GaAs *** the minmax property we devise efficient iterative projection methods simultaneously handling the pair/quadruple of nonlinear problems and thereby saving up to 40%of the computational time as compared to the nonlinear Arnoldi method applied to each of the problems separately.

关键词： Quantum dot quantum ring nonlinear eigenvalue problem minmax characterization iterative projection method electronic state spin orbit interaction magnetic field

Classification of low-density EEG for epileptic seizures by energy and fractal features based on EMD

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The Journal of Biomedical Research 2020年第3期34卷 180-190页

作者： Luis Alfredo Moctezuma marta Molinas Department of Engineering Cybernetics Norwegian University of Science and TechnologyTrondheim 7434Norway

We are here to present a new method for the classification of epileptic seizures from electroencephalogram(EEG) *** consists of applying empirical mode decomposition(EMD) to extract the most relevant intrinsic mode functions(IMFs) and subsequent computation of the Teager and instantaneous energy,Higuchi and Petrosian fractal dimension,and detrended fluctuation analysis(DFA) for each *** validated the method using a public dataset of 24 subjects with EEG signals from 22 channels and showed that it is possible to classify the epileptic seizures,even with segments of six seconds and a smaller number of channels(e.g.,an accuracy of0.93 using five channels).We were able to create a general machine-learning-based model to detect epileptic seizures of new subjects using epileptic-seizure data from various subjects,after reducing the number of instances,based on the k-means algorithm.

关键词： epileptic seizure electroencephalograms empirical mode decomposition detrended fluctuation analysis energy distribution fractal dimension

Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas

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World Journal of Gastroenterology 2014年第3期20卷 684-698页

作者： marta-Isabel Pereira José Augusto Medeiros Clinical Hematology Department Coimbra University Hospital Center Institute of Physiology Faculty of MedicineUniversity of CoimbraAzinhaga de Santa Comba

Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent extranodal marginal zone B-cell lymphoma, originating in acquired MALT that is induced in mucosal barriers as part of a normal adaptive immune response to a chronic immunoinflammatory stimulus, most notably chronic infection by Helicobacter pylori (H. pylori). This antigenic stimulation initially leads to lymphoid hyperplasia; the acquisition of additional genetic aberrations culminates in the activation of intracellular survival pathways, with disease progression due to proliferation and resistance to apoptosis, and the emergence of a malignant clone. There are descriptions of MALT lymphomas affecting practically every organ and system, with a marked geographic variability partially attributable to the epidemiology of the underlying risk factors; nevertheless, the digestive system (and predominantly the stomach) is the most frequently involved location, reflecting the gastrointestinal tract’s unique characteristics of contact with foreign antigens, high mucosal permeability, large extension and intrinsic lymphoid system. While early-stage gastric MALT lymphoma can frequently regress after the therapeutic reversal of the chronic immune stimulus through antibiotic eradication of H. pylori infection, the presence of immortalizing genetic abnormalities, of advanced disease or of eradication-refractoriness requires a more aggressive approach which is, presently, not consensual. The fact that MALT lymphomas are rare neoplasms, with a worldwide incidence of 1-1.5 cases per 105 population, per year, limits the ease of accrual of representative series of patients for robust clinical trials that could sustain informed evidence-based therapeutic decisions to optimize the quality of patient care.

关键词： Mucosa-associated lymphoid tissue lymphoma Marginal zone lymphoma Helicobacter pylori Gastric lymphoma Eradication therapy Nuclear factor-kappa B pathway

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大象会用姓名呼唤彼此

环球科学 2024年第17期 12-14页

作者：玛尔塔·扎拉斯卡林清(翻译) 不详

人类为大象取名的历史由来已久。我们熟知的就有迪士尼电影《小飞象》(Dumbo)、19世纪美国一个马戏团的当家明星詹伯(Jumbo),以及美国亚利桑那州凤凰动物园(PhoenixZoo)著名的大象画家鲁比(Ruby)。一项新的研究表明,野生非洲象群体中可... 详细信息

人类为大象取名的历史由来已久。我们熟知的就有迪士尼电影《小飞象》(Dumbo)、19世纪美国一个马戏团的当家明星詹伯(Jumbo),以及美国亚利桑那州凤凰动物园(PhoenixZoo)著名的大象画家鲁比(Ruby)。一项新的研究表明,野生非洲象群体中可能已经发明了名字。

关键词：非洲象大象小飞象动物园

Coarse woody debris and wood-colonizing fungi differences between a reserve stand and a managed forest in the Taborz region of Poland

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Journal of Forestry Research 2019年第3期30卷 1081-1091页

作者： Slwomir Pieeka Agata Sotnik marta Damszel Zbigniew Sierota Department of Forestry and Forest Ecology Warmia and Mazury University in OlsztynPl.Lodzki 210-727 Olsztyn Poland Milomlyn Forest District Nadlesna 914-140 Milomlyn Poland Department of Entomology Phytopathology and Molecular DiagnosticsWarmia and Mazury University in Olsztyn Prawochen′skiego 1710-721 OlsztynPoland

The aim of this research was to evaluate the amount of woody debris (m3/ha) on the forest floor and the associated wood-colonizing fungi. The study was performed in the Taborz region, known for its Scots pine provenance experiments, against the background of a recently launched Polish legislation to protect the biodiversity on the forest floor in managed (harvested) stands. We investigated a managed stand (136-years-old) and the reserve stand ‘Sosna Taborska’(261-years-old). In the reserve stand, the mean volume of woody debris was six times higher than in the managed forests, i.e. 65 versus 11 m3/ha. In addition, in the reserve stand, the number of fungi taxa colonizing the dead wood was larger than in the managed stands, with a higher number of fruitbodies. Total fungal richness was higher in the reserve than in the managed stand, i.e. 28 versus 12 species. The dominant taxa at both sites were Fomitopsis pinicola and Fomes The aim of this research was to evaluate the amount of woody debris (m^3/ha) on the forest floor and the associated wood-colonizing fungi. The study was performed in the Taborz region, known for its Scots pine provenance experiments, against the background of a recently launched Polish legislation to protect the biodiversity on the forest floor in managed (harvested) stands. We investigated a managed stand (136-years-old) and the reserve stand ‘Sosna Taborska’(261-years-old). In the reserve stand, the mean volume of woody debris was six times higher than in the managed forests, i.e. 65 versus 11 m^3/ha. In addition, in the reserve stand, the number of fungi taxa colonizing the dead wood was larger than in the managed stands, with a higher number of fruitbodies. Total fungal richness was higher in the reserve than in the managed stand, i.e. 28 versus 12 species. The dominant taxa at both sites were Fomitopsis pinicola and Fomes fomentarius, although some taxa were only found in the reserve (e.g., Stereum hirsutum). The volume of woody debris as w

关键词： Coarse woody debris Fungi Managed (harvested) stands Reserve Sosna Taborska Reserve Forest Indices

Influence of mulching and tree shelters on 4-year survival and growth of zeen oak (Quercus canariensis) seedlings

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Journal of Forestry Research 2019年第1期30卷 129-141页

作者： Taher Mechergui marta Pardos Douglass F.Jacobs Facultédes Sciences de Bizerte Laboratoire des Ressources Sylvo-Pastorales (Institut Sylvo-Pastoral de Tabarka) Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA) Centro de Investigacion Forestal Department of Forestry and Natural Resources Hardwood Tree Improvement and Regeneration Center Purdue University

We assessed the effect of mulching and tree shelters on the establishment and early growth of zeen oak(Quercus canariensis Willd.) during the first 4 years after planting in Northwestern Tunisia. Five mulch types(Italian Stone Pine(Pinus pinea L.), Lentisk(Pistacia lentiscus L.),and a combination of Italian Stone Pine and Lentisk(organic mulches), gravel(inorganic mulch) and control), and three tree shelter types(non-vented and vented tree shelters, and control) were tested. An increase in the number of internodes occurred under the gravel mulch, while a reduction in survival was found for the lentisk mulch. Tree shelters had no effect on survival, but increased mean height growth and reduced mean diameter growth during the 4 years(excepting a non-significant effect for vented tree shelter at year four). Comparison of the annual shoots and growth units(GU) between sheltered and unsheltered plants according to year of formation revealed two growth phases. In first phase, shoots were totally or partially inside the shelters; mean length of annual shoots and GU were greater for sheltered plants. The second phase was characterized by shoots emerging from shelters; mean length of annual shoots and GU were similar for all plants, with or without tree shelters. Results suggest that the use of tree shelters, particularly vented shelters, could contribute to the improvement of the artificial regeneration of zeen *** use of mulching alone or in combination with tree shelters did not improve zeen oak performance in the field.

关键词： Zeen oak Mulching Tree shelters Plantation Survival rate Growth

The relationship between the black carbon and bisphenol A in sea and river sediments(Southern Baltic)

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Journal of Environmental Sciences 2016年第3期28卷 24-32页

作者： marta Staniszewska Iga Koniecko Lucyna Falkowska Dorota Burska Joanna Kielczewska Institute of Oceanography University of OdanskA1.Marszaika Pilsudskiego 4681-378 GdyniaPoland

This study was derived from field investigations to assess bisphenol A（BPA）concentrations in the sea and river sediments of the Gulf of *** carbon（BC）and total organic carbon（TOC）were identified as influencing factors on the *** a result of the transportation of BC with organic matter via rivers into the Gulf of Gdansk,the highest mean concentrations（11.26 ng BPA/（g dry weight（dw）））,were determined in the sediments of river *** in coastal stations were characterized by the lowest mean concentrations（5.73 ng BPA/（g dw））.TOC content below 0.1% determined the sorption of BPA on BC particles in sediments,and statistically significant correlation between the concentration of BPA and the BC/TOC ratio was found in these *** addition,dependency between the concentration of BPA and the content of BC was discovered in sediments where the BC/TOC ratio was 〉 0.33.

关键词： Bisphenol A Total organic carbon Black carbon Sediments Gulf of Gdansk