Extracellular vesicles in Alzheimer’s disease:from pathology to therapeutic approaches

作     者：Marta Garcia-Contreras Avnesh S.Thakor Marta Garcia-Contreras;Avnesh S.Thakor

作者机构：Interventional Regenerative Medicine and Imaging LaboratoryDepartment of RadiologyStanford UniversityPalo AltoCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第1期

页      面：18-22页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：This work was supported by the Radiology Research Fund for Alzheimer’s Disease at Stanford University(to AST) 

主　　题：Alzheimer’s disease brain diagnostic extracellular vesicles isolation methods microglia neurodegenerative diseases neuroinflammation neurons therapy 

摘      要：Alzheimer’s disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive *** novel biomarkers for Alzheimer’s disease has the potential for patient risk stratification,early diagnosis,and disease monitoring in response to therapy.A novel class of biomarkers is extracellular vesicles given their sensitivity and specificity to specific *** addition,extracellular vesicles can be used as novel biological therapeutics given their ability to efficiently and functionally deliver therapeutic *** is critical given the huge unmet need for novel treatment strategies for Alzheimer’s *** review summarizes and discusses the most recent findings in this field.