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Etanercept-synthesizing adipose-derived stem cell secretome:A promising therapeutic option for inflammatory bowel disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 882-892页

作者： Say-June Kim Ok-Hee Kim Ha-Eun Hong Ji Hyeon Ju do sang lee Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract,with tumor necrosis factor(TNF)-αplaying a key role in its ***,a decoy receptor for TNF,is used to treat inflammatory *** secretome derived from adipose-derived stem cells(ASCs)has anti-inflammatory effects,making it a promising therapeutic option for *** To investigate the anti-inflammatory effects of the secretome obtained from ASCs synthesizing etanercept on colon cells and in a dextran sulfate sodium(DSS)-induced IBD mouse *** ASCs were transfected with etanercept-encoding mini-circle plasmids to create etanercept-producing *** secretory material from these cells was then tested for anti-inflammatory effects both in vitro and in a DSS-induced IBD mouse *** This study revealed promising results indicating that the group treated with the secretome derived from etanercept-synthesizing ASCs[Etanercept-Secretome(Et-Sec)group]had significantly lower expression levels of inflammatory mediators,such as interleukin-6,Monocyte Chemoattractant Protein-1,and TNF-α,when compared to the control secretome(Ct-Sec).Moreover,the Et-Sec group exhibited a marked therapeutic effect in terms of preserving the architecture of intestinal tissue compared to the *** These results suggest that the secretome derived from ASCs that synthesize etanercept has potential as a therapeutic agent for the treatment of IBD,potentially enhancing treatment efficacy by merging the anti-inflam-matory qualities of the ASC secretome with etanercept's targeted approach to better address the multifaceted pathophysiology of IBD.

关键词： Adipose-derived stem cells Etanercept Inflammatory bowel disease Secretome Tumor necrosis factor-α

Adaptive Controller Design for Dynamic Maneuvers of High Speed Underwater Vehicles

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China Ocean Engineering 2022年第2期36卷 311-321页

作者： Bui Duc Hong PHUC Sam-sang YOU Phuc Thinh doAN sang-do lee Department of Mechanical Engineering The University of TulsaTulsaOK 74104USA Division of Mechanical Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Institute of Interdisciplinary Social Sciences Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam Division of Navigation and Information System Mokpo National Maritime UniversityMokpoJeollanam-do 58628Republic of Korea

The control synthesis of the high-speed underwater vehicle faces many technical challenges due to its inherent structure and surrounding operational *** this paper,the dynamical behavior is firstly described through a bifurcation analysis to give some insights for robust control *** a novel adaptive fractional-order sliding mode controller(AFOSMC)is realized to effectively manipulate the supercavitating vehicle against payload changes,nonlinear planing force,and external *** fractional order(FO)calculus can offer more flexibility and more freedom for tuning active control synthesis than the integer-order *** addition,the adaptation law has been presented to directly handle the payload change *** stability of the controlled vehicle system is proven via Lyapunov stability ***,the dynamic performance of the proposed controller is verified through extensive simulation results,which demonstrate the control accuracy with faster responses compared with existing integer-order ***,the proposed fractional order controllers can provide higher performance than their integer order counterparts with control algorithms.

关键词： fractional order calculus supercavitating underwater vehicles planing force payload change adaptive sliding mode control

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Dynamics modeling and motion control for high-speed underwater vehicles using H-infinity synthesis with anti-windup compensator

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Journal of Ocean Engineering and Science 2022年第1期7卷 84-91页

作者： Phuc Duc Hong Bui Sam-sang You Hwan-Seong Kim sang-do lee Department of Mechanical Engineering The University of TulsaTulsaOK 74104United States Division of Mechanical Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Division of Logistics Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Division of Navigation and Information System Mokpo National Maritime UniversityMokpoJeollanam-do 58628Republic of Korea

The control synthesis of a high-speed supercavitating vehicle(HSSV)faces many difficulties such as the stability,control,and maneuvering with dynamical uncertainties due to parameter perturbations,exter-nal disturbances,unmodeled dynamics,measurement noises,and actuator *** by the HSSV dynamical analysis,this paper proposes the H∞(i.e."H-infinity")robust control synthesis to gen-erate a robust low-order controller,which is intended for real implementations to ensure active control ***,the presented control scheme includes a feedback component and an anti-windup *** anti-windup synthesis is to provide system stability under actuator ***-tensive simulations show that the designed controller provides good performances with high robustness for vertical plane manoeuver while effectively eliminating planning forces,exogenous disturbances and noises as well as overcoming cavitator saturations.

关键词： Vehicle dynamics Planing force Vertical maneuver H-infinity control Anti-windup Actuator saturation

Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes

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Acta Pharmacologica Sinica 2007年第4期28卷 503-510页

作者： Cuk-seong KIM Nam lee Sook-jin SON Kyu-seung lee Hyo-shin KIM Yong-geun KWAK Soo-wan CHAE sang-do lee Byeong-hwa JEON Jin-bong PARK Department of Physiology College of MedicineChungnam National UniversityDaejeon 301131Korea Department of Pharmacology Chonbuk National UniversityMedical SchoolChonju 561-180Korea

Aim:To characterize the effects of papaverine on HERG channels expressed inXenopus oocytes as well as cardiac action potential in rabbit ventricular ***:Conventional microelectrodes were used to record action potential inrabbit ventricular *** currents were recorded by 2-electrode voltageclamp technique in Xenopus oocytes injected with HERG ***:Papa-verine increased the cardiac action potential duration in rabbit ventricular *** blocked heterologously-expressed HERG currents in a concentration-depen-dent manner (IC5071.03±4.75 μmol/L,NH 0.80,n=6),whereas another phosphodi-esterase inhibitor,theophylline （500 μmol/L）,did *** blockade of papaverineon HERG currents was not *** slope conductance measuredas a slope of the fully activated HERG current-voltage curves decreased from78.03±4.25 μS of the control to 56.84±5.33,36.06±6.53,and 27.09±5.50 μS （n=4） by30,100,and 300 μmol/L of papaverine,*** （100 μmol/L）caused a 9 mV hyperpolarizing shift in the voltage-dependence of steady-stateinactivation,but there were no changes in the voltage-dependence of HERG cur-rent *** blocked HERG channels in the closed,open,andinactivated ***:These results showed that papaverine blockedHERG channels in a voltage-and state-independent manner,which may mostlikely be the major mechanism of papaverine-induced cardiac arrhythmia reportedin humans.

关键词： papaverine HERG cardiac action potential

Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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中医杂志:英文版 2023年第4期43卷 686-694页

作者： dong-Wook Kang Jae-Gyun Choi Hee Ju Song Jaehyuk Kim Miae lee Taehee Kim Suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo Jin Sun lee Jin Bong Park sang do lee Hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

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Establishment of a chicken intestinal organoid culture system to assess deoxynivalenol‑induced damage of the intestinal barrier function

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1119-1130页

作者： Tae Hong Kang sang In lee Department of Animal Science and Biotechnology Kyungpook National UniversitySangjuGyeong‑Sangbuk‑Do 37224Republic of Korea Research Institute for Innovative Animal Science Kyungpook National University37224SangjuGyeong‑Sangbuk‑DoRepublic of Korea

Background Deoxynivalenol(doN)is a mycotoxin that has received recognition worldwide because of its ability to cause growth delay,nutrient malabsorption,weight loss,emesis,and a reduction of feed intake in *** doN-contaminated feedstuff is absorbed in the gastrointestinal tract,we used chicken organoids to assess the doN-induced dysfunction of the small *** We established a culture system using chicken organoids and characterized the organoids at passages 1 and *** confirmed the mRNA expression levels of various cell markers in the organoids,such as KI67,leucine-rich repeat containing G protein-coupled receptor 5(Lgr5),mucin 2(MUC2),chromogranin A(CHGA),cytokeratin 19(CK19),lysozyme(LYZ),and microtubule-associated doublecortin-like kinase 1(DCLK1),and compared the results to those of the small *** results showed that the organoids displayed functional similarities in permeability compared to the small *** damaged the tight junctions of the organoids,which resulted in increased *** Our organoid culture displayed topological,genetic,and functional similarities with the small intes-tine *** on these similarities,we confirmed that doN causes small intestine *** organoids offer a practical model for the research of harmful substances.

关键词： Barrier function Deoxynivalenol Organoids

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YOLO-Based Damage Detection with StyleGAN3 Data Augmentation for Parcel Information-Recognition System

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Computers, Materials & Continua 2024年第7期80卷 195-215页

作者： Seolhee Kim sang-Duck lee Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Republic of Korea Logistics System Research Division Korea Railroad Research InstituteUiwang16105Republic of Korea

Damage to parcels reduces customer satisfactionwith delivery services and increases return-logistics *** can be prevented by detecting and addressing the damage before the parcels reach the ***,various studies have been conducted on deep learning techniques related to the detection of parcel *** study proposes a deep learning-based damage detectionmethod for various types of *** is intended to be part of a parcel information-recognition systemthat identifies the volume and shipping information of parcels,and determines whether they are damaged;this method is intended for use in the actual parcel-transportation *** this purpose,1)the study acquired image data in an environment simulating the actual parcel-transportation process,and 2)the training dataset was expanded based on StyleGAN3 with adaptive discriminator ***,3)a preliminary distinction was made between the appearance of parcels and their damage status to enhance the performance of the parcel damage detection model and analyze the causes of parcel ***,using the dataset constructed based on the proposed method,a damage type detection model was trained,and its mean average precision was *** model can improve customer satisfaction and reduce return costs for parcel delivery companies.

关键词： Parcel delivery service damage detection damage classification data augmentation generative adversarial network

Weighted Forwarding in Graph Convolution Networks for Recommendation Information Systems

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Computers, Materials & Continua 2024年第2期78卷 1897-1914页

作者： sang-min lee Namgi Kim Department of Computer Science Kyonggi UniversitySuwonKorea

Recommendation Information Systems(RIS)are pivotal in helping users in swiftly locating desired content from the vast amount of information available on the *** Convolution Network(GCN)algorithms have been employed to implement the RIS ***,the GCN algorithm faces limitations in terms of performance enhancement owing to the due to the embedding value-vanishing problem that occurs during the learning *** address this issue,we propose a Weighted Forwarding method using the GCN(WF-GCN)*** proposed method involves multiplying the embedding results with different weights for each hop layer during graph *** applying the WF-GCN algorithm,which adjusts weights for each hop layer before forwarding to the next,nodes with many neighbors achieve higher embedding *** approach facilitates the learning of more hop layers within the GCN *** efficacy of the WF-GCN was demonstrated through its application to various *** the MovieLens dataset,the implementation of WF-GCN in LightGCN resulted in significant performance improvements,with recall and NDCG increasing by up to+163.64%and+132.04%,***,in the *** dataset,LightGCN using WF-GCN enhanced with WF-GCN showed substantial improvements,with the recall and NDCG metrics rising by up to+174.40%and+169.95%,***,the application of WF-GCN to Self-supervised Graph Learning(SGL)and Simple Graph Contrastive Learning(SimGCL)also demonstrated notable enhancements in both recall and NDCG across these datasets.

关键词： Deep learning graph neural network graph convolution network graph convolution network model learning method recommender information systems

Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第6期20卷 569-580页

作者： Eun Joo lee Miyoung Choi sang Bong Ahn Jeong-Ju Yoo Seong Hee Kang Yuri Cho do Seon Song Hong Koh Dae Won Jeon Hye Won lee Department of Pediatrics Yonsei University College of MedicineSeoulKorea Clinical Evidence Research National Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea Department of Internal Medicine Nowon Eulji Medical CenterEulji University College of MedicineSeoulKorea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheonKorea Department of Internal Medicine Sangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangKorea Department of Internal Medicine College of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea Department of Internal Medicine Hanyang University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver disease(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MEDLINE,Korean Medical Database(KMBASE),Embase,Global Health,and Cochrane Library databases were searched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the increasing rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.

关键词： Meta-analysis Nonalcoholic fatty liver disease Pediatric Prevalence