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5-Fluorouracil loaded guar gum microspheres for colon delivery： preparation, characterization and in vitro release

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药学学报 2009年第11期44卷 1278-1284页

作者： KAUSHIK Dinesh SARDANA Satish MISHRA dn Department of Pharmaceutics Hindu College of Pharmacy Sonepat-131001 India Department of Pharmaceutical Sciences Guru Jambheswar University of Science and Technology Hisar (Haryana) India

The present investigation is aimed to develop a new formulation containing chemically crosslinked guar gum microspheres loaded with 5-fluorouracil for targeting colorectal cancer. The emulsification polymerization method involving the dispersion of aqueous phase of guar gum in castor oil was used to prepare spherical microspheres. Various processing parameters were studied in order to optimize the formulation. Particle size and surface morphology of the microspheres were determined using optical microscopy and scanning electron microscopy. The in vitro drug release studies performed in simulated gastric fluid (SGF) for 2 h followed by intestinal fluid for 3 h, revealed the retention of the drug inside the microspheres from which only (15.27 ± 0.56) % of the drug was released in 5 h. In vitro release rate studies were also carried out in simulated colonic fluid (SCF) in the presence of rat caecal contents, which showed improved drug release. The drug release from the formulation was found to be (41.6 ± 3.5) % with 2% (w/v) caecal matter in 24 h as compared to control study where (25.2 ± 3.5) % of drug was released. The drug release from the formulation with 2% and 4% rat caecal contents medium after 2 days of enzyme induction was found to be (56.3 ± 4.1) % and (78.9 ± 2.8) % in 24 h respectively. Similarly, (61.3 ± 5.4) % and (90.2 ± 2.9) % drug was released respectively with 2% and 4% rat caecal matter after 4 days of enzyme induction and (72.1 ± 2.9) % and (90.2 ± 3.2) % after 6 days of enzyme induction. In this way, 5-fluorouracil loaded guar gum microspheres have shown promising results in the management of colorectal cancer, warranting thorough in vivo study for scale up technology.

关键词：制剂学药学氟尿嘧啶临床

Effect of ciprofloxacin and chloramphenicol on humoral immune response elicited by bovine albumin encapsulated in niosomes

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药学学报 2007年第8期42卷 905-909,910页

作者： MADAN Jitender KAUSHIK Dinesh SARDANA Satish MISHRA dn Department of Pharmaceutics Hindu College of Pharmacy Faculty of Pharmacy Guru Jambheshwar University of Science and Technology

The aim is to evaluate the effect of ciprofloxacin and chloramphenicol on anti-BSA antibody production triggered by bovine albumin encapsulated in non-ionic surfactant vesicle,*** phase evaporation method was adopted to entrap the antigen in colloidal carrier composed of Span 80 and Span 85 followed by simultaneous characterization for particle size,entrapment efficiency and in vitro *** protein content was determined by Bradford method using UV Visible Spectrophotometer at 595 *** immune response was measured in terms of systemic IgG antibody titre by ELISA *** data indicated that 7∶3 molar ratio of Span 80 and cholesterol based niosomal formulation possessed maximum(39.8±2.9)% of soluble *** markedly(P0.05).It is necessary to explore the effect of a vaccine antigen when a candidate is medicated with a therapeutic agent,which might help in programming a new drug management and vaccination programme.

关键词：环丙沙星氯霉素体液免疫 IgG抗体牛蛋白胶囊免疫应答泡囊

Lingual hematoma causing upper airway obstruction:an unusual manifestation of dengue fever

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 412-413页

作者： Jaydeep Sarkar Charu Mohan dn Misra Atul Goel Department of Internal Medicine Lady Hardinge Medical CollegePGIMERDrRML Hospital

The spectrum of dengue infection varies from dengue fever to more severe forms such as dengue hemorrhagic fever(DHF) and dengue shock syndrome(DSS).In DHF bleeding may be overt (external) or *** time bleeding can occur at unusual *** report one such case of DHF in which bleeding occurred within the tongue manifesting as an intra-lingual hematoma, causing significant upper airway obstruction.

关键词： Hematoma Tongue Dengue Platelet

SGLT-2抑制剂对2型糖尿病肾病患者的心血管保护作用

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心血管康复医学杂志 2024年第4期33卷 449-455页

作者：桑亚菲袁静雅赵倩王佳琳马瑜瑾王宏运河南科技大学第一附属医院内分泌科河南洛阳471003

目的:探究钠-葡萄糖共转运蛋白2抑制剂(SGLT-2i)治疗2型糖尿病肾病患者的临床疗效及心血管保护作用。方法:选择2018年1月到2021年12月于我院内分泌科、心血管内科住院的2型糖尿病肾病患者376例,按治疗方案的不同分为对照组(177例,采用... 详细信息

目的:探究钠-葡萄糖共转运蛋白2抑制剂(SGLT-2i)治疗2型糖尿病肾病患者的临床疗效及心血管保护作用。方法:选择2018年1月到2021年12月于我院内分泌科、心血管内科住院的2型糖尿病肾病患者376例,按治疗方案的不同分为对照组(177例,采用常规治疗方案)和SGLT-2i组(199例,在常规治疗方案的基础上联合使用SGLT-2i),且两组患者持续治疗1年。对比两组患者治疗12个月后血糖、血压、血脂、尿酸、人体质量指数、肾功能相关指标及主要不良心血管事件的发生情况,并记录药物的不良反应。结果:治疗12个月后,与对照组比较,SGLT-2i组的血压、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、尿微量白蛋白/肌酐(UACR)、肌酐(Cr)、尿素氮(BUN)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)水平均显著降低,估算的肾小球滤过率(eGFR)、高密度脂蛋白胆固醇(HDL-C)、白蛋白(Alb)、丙氨酸氨基转移酶(ALT)水平均显著升高(P<0.05或<0.01)。SGLT-2i组的急性心肌梗死(1.51%比6.21%)、因心力衰竭住院的发生率(2.51%比6.78%)均显著低于对照组,泌尿系感染的发生率(8.54%比1.69%)显著高于对照组(P均<0.05)。结论:SGLT-2i不仅能有效控制血糖,而且还有减轻体重、降低血压、改善血脂、降低尿酸、改善肾脏高滤过、减少尿蛋白的作用以及特有的心血管获益优势,但需注意泌尿系统感染风险。

关键词：糖尿病肾病钠-葡萄糖转运体2 心血管系统

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挤奶机检测专家系统

农业工程学报 1994年第A9期10卷 27-33页

作者：安居白 Kerr,dn

成套挤奶设备的检测是设备检测人员的日常工作，内容包括设备故障的检测，这些故障经常导致乳头杯离开乳牛的乳头，乳头的损坏，乳房炎发病率的增加等，在研制过程中采用了逐步提练技术来获取专家知识；系统中主要使用演绎推理技术，个... 详细信息

成套挤奶设备的检测是设备检测人员的日常工作，内容包括设备故障的检测，这些故障经常导致乳头杯离开乳牛的乳头，乳头的损坏，乳房炎发病率的增加等，在研制过程中采用了逐步提练技术来获取专家知识；系统中主要使用演绎推理技术，个别问题用模糊推理技术处理，该系统能使没有经验的设备检测人员的不咨询专家的情况下完成检测的各项内容，从而减少了专家进行重复性咨询的时间，并能更那地，有效地消除事故隐患，提高设备效率。

关键词：挤奶机检测专家系统

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城市化的动态：替代假设的实证

经济译文 1990年第5期 41-44页

作者：饶,dn 费洪平

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小儿烧伤治疗

国外医学（创伤与外科基本问题分册） 1993年第4期14卷 212-214页

作者： Dobke MK Herndon dn 葛绳德

小儿烧伤占烧伤总数的30％～40％,平均年龄2岁8个月。男孩占67％。烧伤原因:火焰占13％,热水或液85％,电和化学2％。致伤情况:16％不属意外,其中一半属虐待所致。早期复苏补液婴儿烧伤面积≥10％,儿童≥15％,就应给予补液。按450ml/m^2... 详细信息

小儿烧伤占烧伤总数的30％～40％,平均年龄2岁8个月。男孩占67％。烧伤原因:火焰占13％,热水或液85％,电和化学2％。致伤情况:16％不属意外,其中一半属虐待所致。早期复苏补液婴儿烧伤面积≥10％,儿童≥15％,就应给予补液。按450ml/m^2体表面积掌握,维持尿量在1ml/kg/h。故需按标准图中小儿体表比例来估计烧伤面积。补液公式要求5000ml/m^2烧伤面积,维持量200ml/m^2。第一个8小时给半量,用等渗电解质溶液乳酸林格液。

关键词：烧伤儿童

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石材抛光表面的质量检测

机械工程师 2000年第2期 1-4页

作者： Wrih.,dn 羊松灿

介绍了两种用于对石材抛光表面质量进行检测的方法。

关键词：石材抛光测试仪光泽度粗糙度表面质量

Polyurethane-degrading fungi from soils contaminated with rocket propellant and their ability to decompose alkyne terminated polybutadiene with urethane

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Studies in Fungi 2021年第1期6卷 224-239页

作者： Ren GC Pang AM Gao Y Wu SX Ge ZQ Zhang TF Wanasinghe dn Khan S Mortimer PE Xu JC Gui H Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Guiyang Nursing Vocational College Guiyang 550081GuizhouChina Honghe Center for Mountain Futures Kunming Institute of BotanyChinese Academy of SciencesHonghe County 654400YunnanChina School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang441003HubeiChina

A large amount of propellant materials are produced every year,and storage and disposal of these propellant materials seriously contributes to environmental *** terminated polybutadiene with urethane segments(PUPB)is the macromolecule backbone of these propellant materials,and degradation of PUPB is central to the eco-friendly treatment of propellant *** this study,we isolated a polyurethane(PU)-and PUPB-degrading fungus from soils contaminated with rocket propellant,and the fungus H14 was identified as Fusarium solani(Mart.)*** on macro-and micro-morphology as well as phylogenetic *** ability of *** H14 to degrade PU film and PUPB patches was evaluated via mass loss,scanning electron microscopy(SEM)and enzyme production *** loss analyses revealed a 25.8%reduction in mass of PU and 1.3%reduction in mass of PUPB after *** H14 was incubated with PU and PUPB for 90 days,*** found that *** H14 mycelia significantly colonized both PU and *** images showed that the surface of PU films and PUPB patches formed holes,underwent folding and experienced damage as well as irregular fissuring from the erosion of fungal ***,two possible degradative enzymes,lipase and esterase,were produced by *** study opens a new avenue of research for eco-friendly treatments of explosive materials and *** paper represents the first article on the degradation of PUPB patches.

关键词： enzyme Fusarium solani mass loss PU PUPB