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The neurosphere assay:an effective in vitro technique to study neural stem cells

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Neural Regeneration Research 2021年第11期16卷 2229-2231页

作者： Rita Soares Filipa F.Ribeiro diogo M.Lourenço Rui S.rodrigues João B.Moreira Ana M.Sebastião Vanessa A.Morais Sara Xapelli Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Instituto de Farmacologia e Neurociências Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Instituto de Biologia Molecular Faculdade de MedicinaUniversidade de LisboaLisboaPortugal

Neural stem cells(NSCs)are known to be present in the adult mammalian brain where they constitutively differentiate into the neuronal,astroglial,and oligodendroglial lineages,in defined processes termed neurogenesis,ast rogl iogenesis and oligodendrogenesis,respectively(reviewed in Braun and Jessberger,2014).During brain development,NSCs are present throughout the brain,becoming progressively restricted to defined brain *** the adult brain,NSCs are mainly present in areas classically known as neurogenic niches,*** subventricular zone(SVZ),along the lateral walls of the lateral ventricles,and the subgranular zone,located in the dentate gyrus(DG)of the hippocampus.

关键词： walls neural becoming

Modeling and Numerical Simulation of Ammonia Synthesis Reactors Using Compositional Approach

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Advances in Chemical Engineering and Science 2018年第3期8卷 124-143页

作者： diogo Silva Sanches Jorqueira Antonio Marinho Barbosa Neto Maria Teresa Moreira rodrigues department of Chemical Systems Engineering Campinas University Campinas Brazil Simworx Engineering Research & Development Campinas Brazil

Ammonia synthesis reactors operate in conditions of high pressure and high temperature. Consequently, the flow inside these reactors always presents interaction between components in the feed mixture. A modeling accounts these interactions with pressure, temperature and the molar fraction is essential to converter simulation more realistic. The compositional approach based on cubic equations of state provides the influences of the component of a gas mixture using mixing rules and binary interaction parameters. This multicomponent description makes the model more robust and reliable for properties mixture prediction. In this work, two models of ammonia synthesis reactors were simulated: adiabatic and autothermal. The fitted expression of Singh and Saraf was used. The adiabatic reactor model presented a maximum relative error of 1.6% in temperature and 11.4% in conversion while the autothermal reactor model presents a maximum error of 2.7% in temperature, when compared to plant data. Furthermore, a sensitivity analysis in input variables of both converter models was performed to predict operational limits and performance of the Models for Ammonia Reactor Simulation (MARS).

关键词： Cubic Equation of State Adiabatic Converter Autothermal Converter Temkin-Pyzhev Expression

First-year experience of a new skin bank in Brazil

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Plastic and Aesthetic Research 2015年第1期2卷 326-331页

作者： Alysson Rogerio Matioski Clóvis Rodrigo Guimarães Braz Pereira da Silva diogo rodrigues da Silva-Cunha Luiz Henrique Auerswald Calomeno Flávia Thaiana Bonato Marcelus Vinícios Araujo Nigro department of Burn and Plastic Surgery Evangelical University Hospital of CuritibaCuritibaParaná80730150Brazil

Aim:To report the 1st year experience of the skin bank opened at the Evangelical University Hospital of Curitiba(HUEC),Brazil in June ***:A retrospective statistical and epidemiological study was conducted from data obtained from the activities of the HUEC skin bank from June 2013 to August ***:The HUEC skin bank harvested tissue from 45 cadaveric donors(46.6%female and 53.3%male),with an average age of *** white skin-colored donors represented 91%of *** causes of death were of neurological origin(55.6%).Eighty-one batches were *** bank processed 31,314.63 cm^(2)of skin for transplantation(41 batches),and 38 batches were *** distributed allografts totaled 28,940.82 cm^(2),with tissue from a single donor benefitting up to 5 patients.A total of 52 transplant procedures were performed(66.6%of recipients were male and 33.3%female),burn victims represented 83.3%of the ***:The HUEC skin bank provides skin primarily for victims with severe third-degree burns,mostly men,and who are treated and transplanted in the HUEC as a result of high *** successful outcomes highlight the potential use for other clinical indications.

关键词： Allograft Brazil burns donation Evangelical University Hospital of Curitiba skin skin bank

Mechanical Circulatory Support in Patients with Sepsis： A Case Series

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Journal of Pharmacy and Pharmacology 2018年第5期6卷 541-546页

作者： Helmgton Jose Brito de Souza Henrique Louzan Machado Thiago do Amaral Cavalcante Leonardo Jadyr Santos rodrigues Alves diogo Assis Souza Rafael Ramos Amaral Felipe Bruno Santos da Cunha Marcus Vinicius Nasimento dos Santos Glauco Kalil da Silva Pina Isaac Azevedo Silva Ricardo Borros Corso The department of Medicine University Center of Brasilia Brasilia 70790-075 Brazil

MCS （mechanical circulatory support） has shown great efficacy in treatment of respiratory mid cardiovascular diseases when conventional therapy is insufficient. The use of ECMO （extracolporeal membrane oxygenation） for the treatment of cardiogenic shock secondary to sepsis is still controversial. Studies have shown that ECMO should be considered as a valuable therapeutic option in cases of refractory cardiovascular dysfunction in severe septic patients, although more studies ale needed to consolidate its efficacy. We report the case of two patients, without previous history of cardiopathy, subjected to temporary MCS, with use of ECMO for the treatment of refractory cardiogenic shock secondary to sepsis.

关键词： ECMO MCS sepsis cardiogenic shock.

Healthcare Application:An Analysis of Reception Studies in Interactive Digital Television

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Journalism and Mass Communication 2019年第5期9卷 235-242页

作者： Alexandre Kieling Amanda Caroline rodrigues élida Borges Jhéssika Almeida Watson Odilon áulus Diniz diogo Caetano Kênia Freitas Catholic University BrasíliaBrazil Brasilia University BrasíliaBrazil Communication Paulista State University Julio Mesquita BauruBrazil

This paper presents a healthcare application for Brazilian digital television,its main purposes and its reception tests with end *** is an applied research for testing the scope of the Global ITV project funded by the Brazilian National Council for Scientific and Technological development(CNPq)and the European community which has developed a hybrid broadband and broadcasting platform.

关键词： interactive digital television TV application healthcare Ginga ecosystem Global ITV project