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Over-starvation aggravates intestinal injury and promotes bacterial and endotoxin translocation under high-altitude hypoxic environment

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World Journal of Gastroenterology 2011年第12期17卷 1584-1593页

作者： Qi-Quan zhou ding-zhou yang Yong-Jun Luo Su-Zhi Li Fu-Yu Liu Guan-Song Wang Department of High Altitude Disease College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine Ministry of EducationThird Military Medical universityChongqing 400038China Research Center of Mountain Sickness General Hospital of Tibetan Military Area CommandLhasa 850007Tibet Autonomous RegionChina Institute of Respiratory Diseases Xinqiao HospitalThird Military Medical UniversityChongqing 400037China

AIM:To study whether over-starvation aggravates intestinal mucosal injury and promotes bacterial and endotoxin translocation in a high-altitude hypoxic ***:Sprague-Dawley rats were exposed to hy-pobaric hypoxia at a simulated altitude of 7000 m for 72 *** nitrate was used as a tracer to detect intestinal *** apoptosis was observed with terminal deoxynucleotidyl transferase dUTP nick end labeling *** levels of diamino oxidase(DAO),malondialdehyde(MDA),glutamine(Gln),superoxide dismutase(SOD) and endotoxin were measured in intestinal *** translocation was detected in blood culture and intestinal *** addition,rats were given Gln intragastrically to observe its protective effect on intestinal ***:Apoptotic epithelial cells,exfoliated villi and inflammatory cells in intestine were increased with edema in the lamina propria accompanying effusion of red blood *** particles were found in the intercellular space and intracellular *** translocation to mesenteric lymph nodes(MLN) and spleen was *** serum endotoxin,DAO and MDA levels were significantly higher while the serum SOD,DAO and Gln levels were lower in intestine(P< 0.05).The bacterial translocation number was lower in the high altitude hypoxic group than in the high altitude starvation group(0.47±0.83 vs 2.38±1.45,P<0.05).The bacterial translocation was found in each organ,especially in MLN and spleen but not in peripheral *** bacterial and endotoxin translocations were both markedly improved in rats after treatment with ***:High-altitude hypoxia and starvation cause severe intestinal mucosal injury and increase bacterial and endotoxin translocation,which can be treated with Gln.

关键词： High altitude Hypoxia Starvation Intestinal mucosal injury Bacterial translocation Endotoxin Glutamine

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The City of Nanjing

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China City Planning Review 1988年第4期 61-71页

作者： zhou ding yang Rongliang Ye Maozhen

Ⅰ.Natural and Geographicalconditions of Nanjing and Its Re-sourcesThe City of Nanjing is situated in thesouthwest part of Jiangsu Province at the

关键词： The City of Nanjing

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing zhou Qihang ding Zixun Geng Chencheng Hu Long yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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基于行业分类的工业用地演变研究--以北京市为例

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中国土地科学 2017年第11期31卷 32-39页

作者：文雯周丁扬苏珊田盈盈北京师范大学地理科学学部资源学院土地资源与区域发展研究中心北京100875 河南省土地整理中心河南郑州450016

研究目的:分析市场和发展"双转型期"北京市工业行业用地演变特征。研究方法:基于2007—2015年北京市工业用地出让数据,运用核密度分析、重心转移分析等方法,从时间、空间和行业三个维度探讨了北京市工业用地演变特征。研究结果:北京市... 详细信息

研究目的:分析市场和发展"双转型期"北京市工业行业用地演变特征。研究方法:基于2007—2015年北京市工业用地出让数据,运用核密度分析、重心转移分析等方法,从时间、空间和行业三个维度探讨了北京市工业用地演变特征。研究结果:北京市工业用地出让总面积及各行业受让面积均呈下降趋势,出让行业以"现代制造业"为主,但出现由"现代制造业"向"高新技术工业"转变的趋势;出让工业用地集中分布于距市中心20—40 km的近郊区,具有明显的工业园区指向性和近郊区环状集聚态势,不同行业的空间集聚特征存在明显差异;工业用地出让重心经历了由东北向西南方向转移的过程。研究结论:北京市工业用地出让已展现出良好的发展态势,未来应加大高新技术工业集聚范围和集聚程度,并引导工业配套科教文卫福利服务业向西南方集聚转移。

关键词：土地管理转型期工业用地出让时空分异行业分布北京市

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei zhou Wei Chen Aidong Wen Minna Liu Yi ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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西北干旱区作物灌溉技术效率及影响因素

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自然资源学报 2019年第4期34卷 853-866页

作者：李贵芳周丁扬石敏俊中国人民大学经济学院北京100872 北京师范大学地理科学学部自然资源学院北京100875 浙江大学公共管理学院杭州310058

水资源短缺是制约西北干旱区可持续发展的硬约束,提高作物灌溉技术效率、压缩农业灌溉用水是缓解水资源供需矛盾的可能途径之一。基于2014年张掖市农户调研数据,采用DEA-Tobit模型,分析了黑河流域中段不同类型灌区作物灌溉技术效率及其... 详细信息

水资源短缺是制约西北干旱区可持续发展的硬约束,提高作物灌溉技术效率、压缩农业灌溉用水是缓解水资源供需矛盾的可能途径之一。基于2014年张掖市农户调研数据,采用DEA-Tobit模型,分析了黑河流域中段不同类型灌区作物灌溉技术效率及其影响因素。结果表明:(1)典型灌区主要作物灌溉技术效率均存在改进空间,节水潜力较大。在其他投入保持不变的情况下,如果典型灌区主要作物灌溉技术效率达到目前的最高水平,平原灌区生产同样产量的制种玉米和大田玉米,灌溉用水可分别减少34.47%和38.15%;北部荒漠灌区生产同样产量的棉花、制种西瓜和玉米套小麦,灌溉用水可分别减少48.42%、34.82%和22.99%;沿山灌区生产同样产量的小麦、马铃薯、大麦和大田玉米,灌溉用水可分别减少14.48%、30.75%、25.50%和35.96%。(2)不同灌区之间作物灌溉技术效率的变异系数与作物种植面积占比呈负向关系,同一灌区内部种植相同作物的农户生产管理水平存在明显差异。(3)农地细碎化程度和农户耕地面积扩大会降低作物灌溉技术效率,改善耕地质量能提高北部荒漠灌区作物灌溉技术效率,增加井水灌溉会提高平原灌区大田玉米和沿山灌区作物灌溉技术效率,灌溉次数与多数作物灌溉技术效率呈"倒U型"关系,而农户耕作需求及其对风险态度的影响需结合具体情况进行判断。合理确定种植规模、加快农地空间优化,因地制宜地改善耕地质量,完善水利设施、合理使用井灌、增强河水灌溉放水的灵活性,是提升黑河流域作物灌溉技术效率的主要途径。

关键词：张掖市黑河流域典型灌区作物灌溉技术效率 DEA-Tobit模型

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单面针茎中生物碱类成分研究

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中药材 2011年第4期34卷 551-553页

作者：肖灿袁园丁扬洲靳铁飞裴刚湖南中医药大学药学院湖南长沙410208

目的：对单面针茎中的生物碱成分进行研究。方法：将0.5%盐酸渗滤得到酸水用氨水调pH值至11,以此提取单面针茎中总生物碱,采用氧化铝、硅胶柱层析法进行分离,并根据理化性质及光谱数据对单体化合物进行结构鉴定。结果：分离得到4个化合... 详细信息

目的：对单面针茎中的生物碱成分进行研究。方法：将0.5%盐酸渗滤得到酸水用氨水调pH值至11,以此提取单面针茎中总生物碱,采用氧化铝、硅胶柱层析法进行分离,并根据理化性质及光谱数据对单体化合物进行结构鉴定。结果：分离得到4个化合物,经鉴定分别为：两面针碱（Ⅰ）、血根碱（Ⅱ）、花椒棚碱（Ⅲ）、白鲜碱（Ⅳ）。结论：其中,化合物Ⅰ~Ⅲ为首次从单面针茎中分离得到。

关键词：单面针生物碱

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang zhou Feng ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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基于PRA方法的农户对干旱区草原生态保护政策的认知分析

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干旱区地理 2018年第1期41卷 152-159页

作者：苏珊周丁扬李晓李贵芳北京师范大学地理科学学部资源学院北京100875 环境保护部环境与经济政策研究中心北京100029 中国人民大学经济学院北京100872

自2000年以来,中国草原牧区实施的一系列草原建设和保护工程引起了草地利用方式和农牧民传统生产模式的改变。农牧户作为生产经营活动的直接参与者和草原生态保护政策的实施主体,其认知态度与行为选择将直接影响政策实施效果,对草原生... 详细信息

自2000年以来,中国草原牧区实施的一系列草原建设和保护工程引起了草地利用方式和农牧民传统生产模式的改变。农牧户作为生产经营活动的直接参与者和草原生态保护政策的实施主体,其认知态度与行为选择将直接影响政策实施效果,对草原生态环境有着直接影响。以黑河上游肃南县干旱区草原为例,选取了自由放牧区、半农半牧区和舍饲养殖区三个不同类型牧区,采用参与式农户评估方法(PRA),分析了农牧民对草原生态保护政策的认知情况和实施效果及其在当前政策背景下倾向性的草原放牧措施。结果表明:(1)相对宽松的草地资源约束使自由放牧区内农牧民的草原保护政策认知水平较高,58.1%的农牧户对季节性休牧和补贴数额有较高的认同度,但存在超载放牧现象。(2)半农半牧区和舍饲养殖区农牧民对草原保护政策的认知水平偏低,同时,舍饲养殖导致的生产成本上升使该趋势进一步加剧,71.7%的农牧户响应禁牧政策的积极性不高且认为禁牧补贴数额不合理。建议从增加非农就业机会、完善农村金融服务体系、细化草原补奖标准和调整草地资源约束的角度因地制宜采取配套措施,实现保护生态和农牧民增收双目标。

关键词：草原生态参与式农户评估认知行为选择黑河上游

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang zhou Yuan-Yan Huang ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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