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燃气透平叶栅端壁冷却研究进展

动力工程学报 2024年第9期44卷 1340-1352页

作者：丰镇平刘钊陆熠璇张韦馨谢晔航丁玉强宋宇西安交通大学能源与动力工程学院西安710049

燃气透平叶栅端壁区域的流动呈现高度复杂的强三维特性,端壁冷却设计不仅需要考虑端壁强烈的二次流对冷却特性的影响,也需要考虑冷却布局对近端壁流动与换热特性的影响。针对燃气透平叶栅端壁冷却需求,结合数值模拟和试验测试方法,系统... 详细信息

燃气透平叶栅端壁区域的流动呈现高度复杂的强三维特性,端壁冷却设计不仅需要考虑端壁强烈的二次流对冷却特性的影响,也需要考虑冷却布局对近端壁流动与换热特性的影响。针对燃气透平叶栅端壁冷却需求,结合数值模拟和试验测试方法,系统研究了不同冷气质量流量比条件下,离散气膜孔、泄漏流、端壁改型等措施对端壁表面气膜冷却、换热、流动及叶栅气动特性的影响。结果表明:采用合适的气膜孔射流角和布局、泄漏流冷却单元几何结构和端壁表面微尺度肋等方式可以有效提高端壁表面的气膜冷却有效度;上游槽缝及轮缘密封泄漏流可以对端壁上游及前半部分近吸力面区域提供较好的冷却保护,而叶片装配间隙泄漏流对于端壁下半部分靠近叶片吸力面区域的冷却更加有利;扇形气膜孔布置及曲线型装配间隙不仅能提高气膜冷却有效度,还可以有效控制气动损失。

关键词：燃气透平叶栅端壁气膜冷却泄漏流端壁改型

The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis

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Journal of Genetics and Genomics 2010年第9期37卷 573-582页

作者： Minhua Zheng Zifeng Zhang Xingcheng Zhao yuqiang ding Hua Han Department of Medical Genetics and Developmental Biology Fourth Military Medical University Xi'an 710032 China Department of Ophthalmology Xifing Hospital Fourth Military Medical University Xi' an 710032 China Department of Anatomy and Neurobiology Tongji University School of Medicine Shanghai 200092 China

The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neo adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controUing tool that could have important applications in treatment of retinal diseases.

关键词： Notch signaling retinal dysplasia vascular homeostasis neovascularization knockout mice

Waveguide-based augmented reality displays:perspectives and challenges

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eLight 2023年第1期3卷 1-34页

作者： yuqiang ding Qian Yang Yannanqi Li Zhiyong Yang Zhengyang Wang Haowen Liang Shin‑Tson Wu College of Optics and Photonics University of Central FloridaOrlandoFL 32816USA State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-Sen UniversityGuangzhou 510275China

Augmented reality(AR)displays,as the next generation platform for spatial computing and digital twins,enable users to view digital images superimposed on real-world environment,fostering a deeper level of human-digital ***,as a critical element in an AR system,optical combiners face unprecedented challenges to match the exceptional performance requirements of human vision system while keeping the headset ultracompact and *** decades of extensive device and material research efforts,and heavy investment in manufacturing technologies,several promising waveguide combiners have been *** this review paper,we focus on the perspectives and challenges of optical waveguide combiners for AR *** will begin by introducing the basic device structures and operation principles of different AR architectures,and then delve into different waveguide combiners,including geometric and diffractive waveguide *** commonly used in-couplers and out-couplers,such as prisms,mirrors,surface relief gratings,volume holographic gratings,polarization volume gratings,and metasurface-based couplers,will be discussed,and their properties analyzed in ***,we will explore recent advances in waveguide combiner design and modeling,such as exit pupil expansion,wide field of view,geometric architectures of waveguide couplers,full-color propagation,and brightness and color uniformity ***,we will discuss the bottlenecks and future development trends in waveguide combiner *** objective of this review is to provide a comprehensive overview of the current state of waveguide combiner technologies,analyze their pros and cons,and then present the future challenges of AR displays.

关键词： Augmented reality Waveguide display Surface relief gratings Volume holographic grating Polarization volume gratings Metasurface devices

Antiparkinsonian treatment for depression in Parkinson's disease: Are selective serotonin reuptake inhibitors recommended?

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Translational Neuroscience and Clinics 2016年第2期2卷 138-149页

作者： Philippe De Deurwaerdère yuqiang ding Institut des Maladies Neurodégénératives Centre National de la Recherche Scientifique Key Laboratory of Arrhythmias Ministry of Education East Hospital Tongji University School of Medicine Department of Anatomy and Neurobiology Collaborative Innovation Center for Brain Science Tongji University School of Medicine

Depression is a frequent comorbid syndrome in Parkinson's disease. It is a difficult symptom to manage, as patients continuously receive antiparkinsonian medication and may also have to be treated for the amelioration of the side-effects of antiparkinsonian therapy. The first-line treatment for depression in Parkinson's disease is the use of selective serotonin reuptake inhibitors(SSRIs). The clinical efficacy of these medications in patients with Parkinson's disease is questionable. In fact, based on their mechanism of action, which requires at least a functional serotonergic system, it is predicted that SSRIs will have lower efficacy in patients with Parkinson's disease. Here, we consider the mechanism of action of SSRIs in the context of Parkinson's disease by investigating the fall in the levels of serotonergic markers and the inhibitory outcomes of antiparkinsonian treatment on serotonergic nerve activity. Because certain classes of antidepressant drugs are widely available, it is necessary to perform translational research to address different strategies used to manage depression in Parkinson's disease.

关键词： antidepressant drugs animal behavior high-frequency stimulation of the subthalamic nucleus L-DOPA monoamine neurochemistry

Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder:a voxelbased morphometry study

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Neuroscience Bulletin 2015年第1期31卷 4-12页

作者： Yi Cai Jun Liu Li Zhang Mei Liao Yan Zhang Lifeng Wang Hongjun Peng Zhong He Zexuan Li Weihui Li Shaojia Lu yuqiang ding Lingjiang Li Mental Health Institute of the Second Xiangya Hospital National Technology Institute of Psychiatry Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceCentral South University Department of Mental Health and Psychiatry Brain Hospital of Hunan Province Hunan University of Chinese Medicine Clinical Medical College Department of Radiology the Second Xiangya Hospital of Central South University Guangzhou Psychiatric Hospital Affiliated Hospital of Guangzhou Medical College Key Laboratory of Arrhythmias Ministry of EducationEast HospitalTongji University School of Medicine Shenzhen Kangning Hospital of Guangdong Province

Bipolar disorder and unipolar depressive disorder（UD） may be different in brain structure. In the present study,we performed voxel-based morphometry（VBM） to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder（BP1） and 23 patients with UD,and 23 age-,gender-,and educationmatched healthy controls（HCs） using magnetic resonance imaging. We found that compared with the HC and UD groups,the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus,while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition,correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together,the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD,and decreasedgrey matter volume in the right middle cingulate gyrus may be specifi c to BP1.

关键词： bipolar depressive disorder unipolar depressive disorder prefrontal cortex cingulate gyrus voxel-based morphometry

Coupled Surface Process and Orographic Precipitation Model for the Landscape Evolution of the Himalayas

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Journal of Earth Science 2024年第3期35卷 1063-1068页

作者： yuqiang Li Xiaoping Yuan Hubei Key Laboratory of Critical Zone Evolution School of Earth SciencesChina University of GeosciencesWuhan 430074China

0 INTRODUCTION The landscape evolution of mountain belts links rock uplift caused by tectonic deformation in the lithosphere to fluvial erosion and deposition driven by climatic precipitation in the *** Himalayas,one of the most typical mountain belts in the world,are undergoing the strong collision of the Indian and Eurasian plates and the strong South Asian monsoon precipitation(Figure 1a).It is a natural laboratory to research the evolution mechanisms of orogenic growth involving tectonic and climatic *** addition,it is a good prototype to advance and verify many research methods in multiple *** Indian-Eurasian collision initiated since the Early Paleogene(ca.50 Ma)based on geological,stratigraphic,and palaeomagnetic records(ding et al.,2022;van Hinsbergen et al.,2012),causing an early slow topographic change in the Himalayas until the Neogene(ca.23 Ma)(ding et al.,2022).

关键词： Eurasian climatic tectonic

The Synthesis of A New Cyclodextrin-Crown Ether Chiral Stationary Phase and Application in Gas Chromatography

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Wuhan University Journal of Natural Sciences 1998年第3期3卷 83-86页

作者： Liu Min Zeng Zhaorui ding yuqiang Liu Suhuai Wuhan University College of Chemisty Wuhan China (GRID:grid.49470.3e) (ISNI:***) Experiment Center of Nan-Yang College of Science and Technolegy Nanyang China (GRID:grid.49470.3e)

A new compound of mono 6 (1' benzo aza 15 crown 5) 2,3,6 permethyl β cyclodextrin (BA 15C5 PM CD) was synthesized. The structure was determined to be coincide with our anticipation by spectroscopy. As a stationary phase for capillary gas chromatography, excellent separation for enantiomers and positional isomers was achieved.

关键词： cyclodextrin crown ether gas chromatography chiral stationary phase

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量子相干在量子热力学中演化规律的研究

中国激光 2021年第12期48卷 363-370页

作者：丁峰丁玉强韩森胡雪元山东大学信息科学与工程学院山东青岛266237

在量子热力学的研究中,量子相干扮演着重要的角色。基于本课题组的研究结果,分别从热力学操作与增强热力学操作间的相干鸿沟猜想及关联催化相干放大猜想两个角度,讨论了能级之间的量子相干在热力学中的奇特行为。首先,通过研究单模热力... 详细信息

在量子热力学的研究中,量子相干扮演着重要的角色。基于本课题组的研究结果,分别从热力学操作与增强热力学操作间的相干鸿沟猜想及关联催化相干放大猜想两个角度,讨论了能级之间的量子相干在热力学中的奇特行为。首先,通过研究单模热力学操作,进一步发掘了相干转化在划分量子热力学操作中的作用。其次,通过研究关联催化协变操作,发现关联催化在含有相干的量子热力学中存在尚未发掘的作用。研究结果对进一步完善量子热力学第二定律具有重要意义。

关键词：量子光学量子信息理论量子热力学能级之间的量子相干热力学操作非对称性催化

The E3 ligase RNF220 is required for vertebrate central noradrenergic neuron development

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The E3 ligase RNF220 is required for vertebrate central nora...