The Notch signaling pathway in retinal dysplasia and retina vascular homeostasis

作     者：Minhua Zheng Zifeng Zhang Xingcheng Zhao Yuqiang Ding Hua Han 

作者机构：Department of Medical Genetics and Developmental Biology Fourth Military Medical University Xi'an 710032 China Department of Ophthalmology Xifing Hospital Fourth Military Medical University Xi' an 710032 China Department of Anatomy and Neurobiology Tongji University School of Medicine Shanghai 200092 China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2010年第37卷第9期

页      面：573-582页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 080203[工学-机械设计及理论] 071006[理学-神经生物学] 0802[工学-机械工程] 

基　　金：supported by the grants from the Natural Science Foundation of China (Nos.30770693 and 30830067) the Ministry of Science and Technology of China (No. 2009CB521706) 

主　　题：Notch signaling retinal dysplasia vascular homeostasis neovascularization knockout mice 

摘      要：The retina is one of the most essential elements of vision pathway in vertebrate. The dysplasia of retina cause congenital blindness or vision disability in individuals, and the misbalance in adult retinal vascular homeostasis leads to neo adults, such as diabetic retinopathy or age-related macular degeneration. Many developmental signaling pathways are involved in the process of retinal development and vascular homeostasis. Among them, Notch signaling pathway has long been studied, and Notch signaling-interfered mouse models show both neural retina dysplasia and vascular abnormality. In this review, we discuss the roles of Notch signaling in the maintenance of retinal progenitor cells, specification of retinal neurons and glial cells, and the sustaining of retina vascular homeostasis, especially from the aspects of conditional knockout mouse models. The potential of Notch signal manipulation may provide a powerful cell fate- and neovascularization-controUing tool that could have important applications in treatment of retinal diseases.