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Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: Down-regulation in ulcerative colitis

World Journal of Gastroenterology 2013年第9期19卷 1416-1423页

作者： Ekaterini Chatzaki Peter A Anton Mulugeta Million Maria Lambropoulou Theodoros Constantinidis George Kolios Yvette Taché dimitri E Grigoriadis Neurocrine Biosciences Inc. San Diego CA 92121 United States Laboratory of Pharmacology Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece Center for HIV Prevention Research Division of Digestive Diseases University of California at Los Angeles and VA Greater Los Angeles Healthcare System Los Angeles CA 90073 United States Digestive Diseases Research Center and Center for Neurobiology of Stress Division of Digestive Diseases University of California at Los Angeles and VA Greater Los Angeles Healthcare System Los Angeles CA 90073 United States Laboratory of Histology-Embryology Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece Laboratory of Hygiene and Environmental Protection Faculty of Medicine Democritus University of Thrace 68100 Alexandroupolis Greece

AIM: To assess corticotropin-releasing factor receptor 2 (CRF 2 ) expression in the colon of healthy subjects and patients with ulcerative colitis (UC). METHODS: We examined CRF2 gene and protein expression in the distal/sigmoid colonic mucosal biopsies from healthy subjects and patients with UC (active or disease in remission), human immunodeficiency virus (HIV) and functional bowel disease (FBD) by reverse transcriptionpolymerase chain reaction and immunofluorescence. RESULTS: Gene expression of CRF2 was demonstrated in the normal human colonic biopsies, but not in the human colorectal adenocarcinoma cell line Caco2. Receptor protein localization showed immunoreactive CRF 2 receptors in the lamina propria and in the epithelial cells of the distal/sigmoid biopsy samples. Interestingly, CRF 2 immunoreactivity was no longer observed in epithelial cells of patients with mild-moderately active UC and disease in remission, while receptor protein expression did not change in the lamina propria. No differences in CRF 2 expression profile were observed in distal/sigmoid intestinal biopsies from HIV infection and FBD patients, showing no signs of inflammation. CONCLUSION: The down-regulation of the CRF2 receptor in the distal/sigmoid biopsies of UC patients is indicative of change in CRF 2 signalling associated with the process of inflammation.

关键词： Colonic mucosa Corticotropin-releasing factor Corticotropin-releasing factor receptor Human immunodeficiency virus Ulcerative colitis Urocortin

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Improving photosynthetic efficiency toward food security:Strategies,advances,and perspectives

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Molecular Plant 2023年第10期16卷 1547-1563页

作者： Edward N.Smith Marvin van Aalst Tiina Tosens Ülo Niinemets Benjamin Stich Tomas Morosinotto Alessandro Alboresi Tobias J.Erb Paul AGómez-Coronado dimitri Tolleter Giovanni Finazzi Gilles Curien Matthias Heinemann Oliver Ebenhöh Julian M.Hibberd Urte Schlüter Tianshu Sun Andreas P.M.Weber Faculty of Science and Engineering Molecular Systems Biology–Groningen Biomolecular Sciences and BiotechnologyNijenborgh 49747 AG Groningenthe Netherlands Institute of Quantitative and Theoretical Biology Cluster of Excellence on Plant Science(CEPLAS)Heinrich Heine UniversityUniversitätsstrasse 140225 DüsseldorfGermany Institute of Agricultural and Environmental Sciences Estonian University of Life Sciences51006 TartuEstonia Institute of Quantitative Genetics and Genomics of Plants Cluster of Excellence on Plant Science(CEPLAS)Heinrich Heine UniversityUniversitätsstrasse 140225 DüsseldorfGermany Department of Biology University of Padova35131 PadovaItaly Max Planck Institute for Terrestrial Microbiology Department of Biochemistry&Synthetic Metabolism35043 MarburgGermany Interdisciplinary Research Institute of Grenoble IRIG-LPCVGrenoble Alpes UniversityCNRSCEAINRAE38000 GrenobleFrance Molecular Physiology Department of Plant SciencesUniversity of CambridgeCambridge CB23EAUK Institute for Plant Biochemistry Cluster of Excellence on Plant Science(CEPLAS)Heinrich Heine UniversityUniversitätsstrasse 140225 DüsseldorfGermany Institute for Breeding Research on Agricultural Crops Federal Research Center for Cultivated Plants18190 SanitzGermany

Photosynthesis in crops and natural vegetation allows light energy to be converted into chemical energy and thus forms the foundation for almost all terrestrial trophic networks on *** efficiency of photosynthetic energy conversion plays a crucial role in determining the portion of incident solar radiation that can be used to generate plant biomass throughout a growth ***,alongside the factors such as resource availability,crop management,crop selection,maintenance costs,and intrinsic yield potential,photosynthetic energy use efficiency significantly influences crop *** efficiency is relevant to sustainability and food security because it affects water use efficiency,nutrient use efficiency,and land use *** review focuses specifically on the potential for improvements in photosynthetic efficiency to drive a sustainable increase in crop *** discuss bypassing photorespiration,enhancing light use efficiency,harnessing natural variation in photosynthetic parameters for breeding purposes,and adopting new-to-nature approaches that show promise for achieving unprecedented gains in photosynthetic efficiency.

关键词： photosynthesis photorespiration photorespiratory bypass natural variation synthetic biology plant metabolic engineering

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Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

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Protein & Cell 2020年第10期11卷 723-739页

作者： Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus ***,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against ***,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted *** results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out *** work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not.

关键词： de novo pyrimidine biosynthesis DHODH inhibitors SARS-CoV-2 influenza viruses virus replication immuno-regulation

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Petrogenetic Characterization of the Geological Formations of the Localities of Goumere-Iguela in the South West of the Bui Belt (North-East of Cote d’Ivoire)

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Open Journal of Geology 2022年第11期12卷 947-972页

作者： Fossou Jean-Luc Hervé Kouadio Tokpa Kakeu Lionel-dimitri Boya N’Guessan Nestor Houssou Roger Nicaise Kanga Alain Nicasie Kouamelan Laboratoire de Géologie Ressources Minérales et Energétiques Université Félix Houphou&#235 t-Boigny Abidjan-Cocody C&#244 te d’Ivoire

Located in the north-east of Côte d’Ivoire, the Gouméré-Iguéla sectors were the subject of a geological mapping. These geological formations are located southwest of the Bui trench. In order to improve the petrogenetic knowledge of the study area, a multidisciplinary methodology integrating microscopic observations and geochemical analyses of major and trace elements was carried out on 15 samples considered as representative of the studied outcrops. The macroscopic and microscopic petrographic study allowed to highlight three major lithological units: 1) a volcano-plutonic unit, formed by gabbros and amphibole-pyroxenite, basalt and rhyodacite;2) a volcano-sedimentary unit containing pyroclastites (of basaltic and andesitic composition);3) a sedimentary unit (meta-sedimentary). These rocks are affected by a general metamorphism of green schist facies and a hydrothermal alteration with pervasive and vein alteration marked by the presence of quartz, calcite, epidote, chlorite and sericite. From a geochemical point of view, the results obtained indicate that the plutonites are gabbros while the volcanites and volcanosedimentary rocks have compositions of basalts, basaltic andesites, rhyolites and dacites. They have mainly a tholeitic character related to subduction zones with crustal contamination. The metasediments are arenites emplaced in an active continental margin environment.

关键词： Petrography Geochemistry Petrogenetics Gouméré-Iguéla Côte d’Ivoire

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Acute Priapism: A Revealing Inaugural Mode of Chronic Myeloid Leukemia. A Case Report and Review of the Literature

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Open Journal of Urology 2022年第5期12卷 237-241页

作者： dimitri Mbethe Adrien Mougougou Steevy Ndang Ngou Milama Said Mohamed Moudouni Izoudine Bissiriou Giscard Smith Olagui Jean Massandé Mouyendi Urology Department of the University Hospital of Libreville Libreville Gabon Urology Department of the Mohamed 6 University Hospital of Marrakech Marrakesh Morocco Urological and Visceral Surgery Department Omar Bongo Ondimba Armed Forces Instruction Hospital Libreville Gabon

Priapism is a painful and prolonged erection occurring without any sexual stimulation and not resulting in ejaculation. It most often occurs in patients with sickle cell disease. We report here the case of acute recurrent priapism revealing inaugural mode of CML in a 22-year-old patient with no particular pathological history. The study of the onco-hematological karyotype revealed a karyotype with 46 chromosomes with a clonal chromosomal anomaly: The t (9;22) “Philadelphia chromosome”. The evolution was favorable under imatinib.

关键词： Priapism Chronic Myeloid Leukaemia Philadelphia Chromosome

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Sexual Functional Prognosis of Penile Emergencies at the University Hospital of Libreville

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Open Journal of Urology 2022年第10期12卷 527-538页

作者： Adrien Mougougou Steevy Ndang Ngou Milama Smith Giscard Olagui dimitri Mbethe Grace Cherile Ongouta Alice Armande Boutsomba Moukinda Jean Massandé Mouyendi Urology Department UHC of Libreville Libreville Gabon Department of Surgery and Surgical Specialties University of Health Sciences Owendo Gabon Department of General and Urological Surgery Omar Bongo Ondimba Army Training Hospital Libreville Gabon

Introduction: Penile emergencies are multiple and varied, and they can jeopardize the sexual functional prognosis of the patient. The objective of our study was to evaluate the sexual functional prognosis of patients admitted for penile emergencies. Patients and Methods: We conducted a cross-sectional study from January 1 to 31, 2021, in the urology department of the University Hospital. Variables included sociodemographic, diagnostic, and evolutionary data of sexually active patients admitted for a penile emergency. Results: During this period, 68 patients were admitted for penile emergencies. We included 45 sexually active patients, with a mean age ranging from 34.5 ± 14.1 years with extremes of 16 and 90 years. The most frequent penile emergencies were priapism (62.2%) and penile fracture (22.2%), with a mean time for treatment of 21.4 ± 52.5 hours. The sexual functional prognosis was very satisfactory (normal erection) in 71.1% (n = 32) of patients. Loss of erectile function was observed in 4.4% (n = 2) of cases. Conclusion: Penile emergencies are relatively frequent, dominated by priapism and penile fracture in our context. The sexual functional prognosis is good.

关键词： Penile Emergency Diagnosis Sexual Functional Prognosis Libreville

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汽油机GPF碳载量模型和再生策略的试验研究

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内燃机与动力装置 2018年第6期35卷 1-10,25页

作者：范明哲张宾 Sterzer Alexander Sokolov dimitri 博世(中国)投资有限公司博世工程技术事业部上海200335 BoschEngineeringGmbH heilbronn74003

针对某V型六缸GDI机械增压汽油机,搭建基于Matlab Simulink平台的颗粒捕集器(gasoline particulate filter,GPF)碳载量模型,通过试验数据对模型中的相关脉谱进行仿真标定;并对样机的GPF主动及被动再生策略进行研究,评价分析策略表现。... 详细信息

针对某V型六缸GDI机械增压汽油机,搭建基于Matlab Simulink平台的颗粒捕集器(gasoline particulate filter,GPF)碳载量模型,通过试验数据对模型中的相关脉谱进行仿真标定;并对样机的GPF主动及被动再生策略进行研究,评价分析策略表现。模型试验验证结果表明,累碳模型的偏差值为+5.8%;主动再生模型的偏差值为+9%;被动再生(断油)模型的偏差值为+6%;综合碳载量模型的偏差值为+3%,模型精度良好。

关键词：汽油机 GPF 碳载量模型再生策略

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荷兰:利益主体参与的地方水管理

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中国水利 2005年第20期 62-64页

作者： Rafael Lazaroms dimitri Poos Rob Uijterlinde 洪林荷兰水利董事会

几个世纪以来,荷兰的水利董事会在水管理中起着关键作用。这些水利董事会的基本任务是防洪和排水。最近几十年里,水利董事会增加了水质管理和污水处理的职能。荷兰的水利董事会是政府机构,是省级权力机构下属的一般政府职能部门。水利... 详细信息

几个世纪以来,荷兰的水利董事会在水管理中起着关键作用。这些水利董事会的基本任务是防洪和排水。最近几十年里,水利董事会增加了水质管理和污水处理的职能。荷兰的水利董事会是政府机构,是省级权力机构下属的一般政府职能部门。水利董事会具有法定权力和自己的税收制度。水利董事会的基本原则是在水利服务中谁受益(称为利益主体)谁付费,而且水利董事会成员是这些利益主体通过大会选举的代表。在过去50年里,水利董事会经过了多次大的合并过程,使得全国水利董事会的数目从2500个锐减到27个。在合并的过程中,水利董事会的规模扩大了,而且专业水平也有了很大提高。但是,利益主体和管理机构之间的距离加大了,使得利益主体参与水利管理活动的机会少了。本文主要研究荷兰水利董事会的模式和进展情况,使得利益主体与水利董事会更密切地联系起来。

关键词：荷兰水管理水利董事会利益主体主体参与水利服务政府机构董事会职能部门污水处理

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电线绞制和成缆的三种SZ方法的比较

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电线电缆 1993年第5期 42-45页

作者： Rainer Duewelheuke dimitri R.Stein 徐龙

SZ扭绞是一种正反旋转相间的绞制方法。其优点是可以制造大长度电缆,能与护层挤出机串联生产,占地小而不需基础,以及电缆制造成本低。在SZ绞制和成缆设备中,双扭绞机和管式储线机适用于绞制单线根数多而规格较小的裸线或绝缘线,夹紧履... 详细信息

SZ扭绞是一种正反旋转相间的绞制方法。其优点是可以制造大长度电缆,能与护层挤出机串联生产,占地小而不需基础,以及电缆制造成本低。在SZ绞制和成缆设备中,双扭绞机和管式储线机适用于绞制单线根数多而规格较小的裸线或绝缘线,夹紧履带牵引成缆机适用于截面较大的电力电缆。介绍了这三种SZ绞线及成缆的原理和方法。

关键词： SZ绞合机绞线电线电缆

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一种新的减小电机噪声的被动方法：模态分析中一些参数的影响

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国外大电机 2012年第1期 50-56页

作者： [法]dimitri Torregrossa 刘晶石[译] 关玉薇[校]

本文介绍了一种3D有限元模态分析，用来减小无刷永磁同步电机产生的噪声并避免任何共振现象。此方法可以分析一些设计参数对所有共振频率的影响并达到减小总声能的目的，还可以对它们的选择提供一些指导。不用任何声学计算，在仿真中分... 详细信息

本文介绍了一种3D有限元模态分析，用来减小无刷永磁同步电机产生的噪声并避免任何共振现象。此方法可以分析一些设计参数对所有共振频率的影响并达到减小总声能的目的，还可以对它们的选择提供一些指导。不用任何声学计算，在仿真中分析并建立了一个低噪声模型，并通过试验结果进行验证。

关键词：有限元方法振动噪声被动减小斜槽定子结构分析

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