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differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate

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International Journal of Oral Science 2023年第4期15卷 701-717页

作者： Maria B.Asparuhova Xiaoqing Song dominic Riedwyl Geert van Geest dieter d.bosshardt Anton Sculean Laboratory of Oral Cell Biology School of Dental MedicineUniversity of BernBernSwitzerland department of Periodontology School of Dental MedicineUniversity of BernBernSwitzerland Interfaculty Bioinformatics Unit University of BernBernSwitzerland Robert K.Schenk Laboratory of Oral Histology School of Dental MedicineUniversity of BernBernSwitzerland

The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human ***-four CTGs belonging to anterior deep(Ad),anterior superficial(AS),posterior deep(Pd),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed *** correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was ***,endothelial,and monocytic cell migration was strongly(Pd by Ad-and ***,significantly increased expression of genes encoding C-C and C-X-C motif chemokine ligands as well as significantly(Pd p38 signaling suggested immunomodulatory phenotype for Ad-and *** growth factor gene expression and significantly activated(Pd Akt signaling in HPFs originating from A-CTGs implied their involvement in cell survival,proliferation,and *** collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(Pd1/5/8 signaling characterized HPFs originating from *** present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than *** findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.

关键词： selecting characterizing showing

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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dental and periodontal phenotype in sclerostin knockout mice

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International Journal of Oral Science 2014年第2期6卷 70-76页

作者： Ulrike Kuchler Uwe Y Schwarze Toni dobsak Patrick Heimel dieter d.bosshardt Michaela Kneissel Reinhard Gruber department of Oral Surgery Medical University of Vienna Vienna Austria Austrian Cluster for Tissue Regeneration Vienna Austria department of Oral Surgery and Stomatology School of Dental Medicine University of Berne Berne Switzerland Karl donath Laboratory for Hard Tissue and Biomaterial Research University Clinic of Dentistry Medical University of Vienna Vienna Austria Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA Research Center Vienna Austria Robert K. Schenk Laboratory of Oral Histology School of Dental Medicine University of Berne Berne Switzerland Musculoskeletal disease Area Novartis Institutes for BioMedical Research Basel Switzerland Laboratory of Oral Cell Biology School of Dental Medicine University of Berne Berne Switzerland

Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear. Here, we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography （μCT） imaging, μCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls, pCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice. No significant differences were observed for the tooth and pulp chamber volume. descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width. Taken together, these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin.

关键词： alveolar bone micro-computed tomography mouse periodontium sclerostin tooth

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Hybrid system-a promising way solving future energy problems

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航空动力学报 2007年第4期22卷 565-576页

作者： dieter Bohn Institute of Steam and Gas Turbines RWTH Aachen University

With the increasing demand for electricity,an efficiency improvement and thereby reduced CO2 emissions of the power plants are expected in order to reach the goals set in the Kyoto *** comparison to conventional systems,the hybrid-systems with the use of synergetic effects offer the possibility to provide a substantial contribution to spare our natural resources and protect our *** Cycle Power Plants belongs innately hybrid system in the centralized energy *** can provide large amounts of power and have a quick start-up *** MGT/FC hybrid system is quite promising in the decentralized energy *** is widely used in stand-alone ***,the combination of fossil and renewable power plant technologies contains a large synergy potential to increase the efficiency of processes for power *** materials,innovative cooling technology,new combustion concepts and optimized production methods are needed to make the potential of these new technologies accessible for a quantum leap in the *** this it needs considerable research work and good coordinated research projects between the state,industry,research laboratories and universities.

关键词：航空推进系统混合燃料涡轮机能源

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designing a power plant with highest efficiency:results from SFB 561

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航空动力学报 2009年第4期24卷 717-728页

作者： dieter Bohn Institute of Steam and Gas Turbines RWTH Aachen University

The goal of Collaborative Research Centre(SFB) 561 "thermally highly loaded,porous and cooled multi-layer systems for combined cycle power plants" is to expand the current technological and scientific knowledge on power plants in order to achieve total efficiencies of 65% in a combined cycle power plant in the year ***,the aero-thermomechanical,structural-mechanical,materials' scientific and production fundamentals for the development of steam and gas turbine components that are able to withstand highest thermal loads are being worked out within this *** means for the gas turbine that combustion chamber outlet temperatures of 1520℃ at 1.7MPa are to be *** order to control these high temperatures,it is not only required to develop new materials' solutions,including thermal barrier coatings,but also to apply improved cooling techniques,as for example effusion *** novel cooling concept is to be realised through open-porous *** structures can consist of drilled open-porous multi-layer systems or open-porous metallic *** development of graded multi-layer systems is also extremely important,as the grading will enable the use of coolant in dependence of the *** live steam parameters in the high pressure turbine are expected to be increased up to approximately 700℃ with pressure of *** elevated steam parameters can be encountered with Ni-base alloys,but this is a costly alternative,associated with many manufacturing ***,the SFB proposes cooling the highly loaded turbines instead,as this would necessitate the application of far less Ni-base *** protect the thermally highly loaded casing,a sandwich material consisting of two thin face sheets with a core of a woven wire mesh is used to cover the walls of the steam turbine *** current state of the research shows that by utilising innovative cooling technologies a total efficiency of 65% can be reached without exceeding the m

关键词： gas turbine steam turbine cooling novel materials process calculation

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Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

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An Assessment Tool for Land Reuse with Artificial Intelligence Method

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International Journal of Automation and computing 2010年第1期7卷 1-8页

作者： dieter d. Genske dongbin Huang Ariane Ruff Institute of Architecture and Planning University of Liechtenstein Fiirst-Franz-Josefstrasse Vaduz LI 9490 Liechtenstein Institute for Environmental decisions ETH Zurich Universitaetstrasse 22 Zurich CH 8092 Switzerland Fachhochschule Nordhausen Weinberghof 4 Nordhausen D-99734 Germany

This paper focuses on land resource consumption due to urban sprawl. Special attention is given to shrinking regions, characterized by economic decline, demographic change, and high unemployment rates. In these regions, vast terrain is abandoned and falls derelict. A geographic information system （GIS） based multi-criteria decision tool is introduced to determine the reuse potential of derelict terrain, to investigate the possible reuse options （housing, business and trade, industry, services, tourism and leisure, and re-greening）, and to visualize the best reuse options for groups of sites on a regional scale. Achievement functions for attribute data are presented to assess the best reuse options based on a multi-attribute technique. The assessment tool developed is applied to a model region in Germany. The application of the assessment tool enables communities to become aware of their resources of derelict land and their reuse potential.

关键词： decision support system land assessment geographic information system (GIS) sustainable development artificial intelligence.

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