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MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

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Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharma Melissa MTorres Sheryl rodriguez Laxman Gangwani Subodh Kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

Efficiently searching extreme mechanical properties via boundless objective-free exploration and minimal first-principles calculations

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npj Computational Materials 2022年第1期8卷 1336-1347页

作者： Joshua Ojih Mohammed Al-Fahdi Alejandro David rodriguez Kamal Choudhary Ming Hu Department of Mechanical Engineering University of South CarolinaColumbiaSC29208USA Materials Science and Engineering Division National Institute of Standards and TechnologyGaithersburgMD20899USA

Despite the machine learning(ML)methods have been largely used recently,the predicted materials properties usually cannot exceed the range of original training *** deployed a boundless objective-free exploration approach to combine traditional ML and density functional theory(DFT)in searching extreme material *** combination not only improves the efficiency for screening large-scale materials with minimal DFT inquiry,but also yields properties beyond original training *** use Stein novelty to recommend outliers and then verify using *** data are then added into the training dataset for next round *** test the loop of training-recommendation-validation in mechanical property *** screening 85,707 crystal structures,we identify 21 ultrahigh hardness structures and 11 negative Poisson’s ratio *** algorithm is very promising for future materials discovery that can push materials properties to the limit with minimal DFT calculations on only~1%of the structures in the screening pool.

关键词： extreme properties minimal

A Survey on Model Predictive Control of DFIGs in Wind Energy Conversion Systems

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1085-1104页

作者： Shuo Yan Junyu Chen Minghao Wang Yongheng Yang Jose M.rodriguez STEM College RMIT UniversityMelbourneAustralia Hong Kong Polytechnic University Hong KongChina State Key Laboratory of Internet of Things for Smart City(UM) Department of Electrical and Computer EngineeringUniversity of MacaoMacaoChina College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Universidad San Sebastin Campus BellavistaSantiago de ChileCLSantiago de Chile 000000Chile IEEE

This paper presents a comprehensive study on the model predictive control(MPC)of doubly fed induction generators(DFIG)in wind energy conversion systems(WECS);in particular the MPC of the rotor side *** general principle of prevalent MPC strategies is discussed to introduce the theoretical framework in the first ***,mainstream and high-performance MPC methods of DFIGs have been identified as model predictive current control(MPCC),model predictive torque control(MPTC),and model predictive power control(MPPC).Starting from analyzing dynamic models,these MPC strategies are investigated in terms of operating principles and technical *** paper further investigates implementation of MPC strategies in unbalanced *** on the quantitative and qualitative analysis of several case studies,performance of various MPC schemes is compared and their special features are *** for designing MPC strategies of DFIGs in WECS are provided.

关键词： Doubly fed induction generator(DFIG) model predictive control(MPC) wind energy

The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates

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Cellular & Molecular Immunology 2018年第5期15卷 421-427页

作者： Eslam Mohamed Amir A.Al-Khami Paulo C.rodriguez lee moffitt cancer center and research institute 12902 magnolia dr.mrc-annex 2ndtampafl 33612usa stanley s.scott cancer center louisiana state university health sciences centernew orleansla 70112usa

Malignant cells upregulate distinct energy metabolism programs that support their proliferation,migration,and adaptation to the stressful tumor microenvironment(TME).Additionally,this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring infiltrating immune cells,thereby impairing antitumor *** recent years,there has been great interest in the field to understand the tumor-induced energy metabolism signals that regulate the function of immune cells in individuals with ***,it is now well accepted that uncovering the mechanisms that instruct the metabolic behavior of cancer cells and tumor-associated immune cells is an indispensable strategy for the development of new approaches to overcome immune suppression in ***,in this minireview,we briefly discuss the interaction between particular metabolic signaling pathways and immunosuppressive activity in different subsets of myeloid cells within the ***,we illustrate potential central mechanisms controlling the metabolic reprogramming of myeloid cells in response to tumor-derived factors.

关键词： Tumor microenvironment metabolic reprogramming immune suppression myeloid cells

Robust Predictive Current Control of Induction Motors Based on Linear Extended State Observer

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Chinese Journal of Electrical Engineering 2021年第1期7卷 94-105页

作者： Yongchang Zhang Xing Wang Haitao Yang Boyue Zhang Jose rodriguez Inverter Technologies Engineering Research Center of Beijing North China University of TechnologyBeijing 100144China School of Electrical and Electroric Engineering North China Electric Power UniversityBeijing 102206China College of Engineering Universidad Andres BelloSantiago 8370146Chile

Model predictive current control can achieve fast dynamic response and satisfactory steady-state performance for induction motor(IM)***,many motor parameters are required to implement the control ***,if the motor parameters used in the controller are not accurate,the performance may *** this paper,a new robust predictive current control is proposed to improve robustness against parameter *** proposed method employs an ultra-local model to replace the mathematical model of the ***,to improve the control performance,a linear extended state observer is developed for disturbance *** tests confirm that satisfactory tracking performance can still be obtained although the motor parameters may not be accurately set in the controller.

关键词： Induction motor drives current control predictive control observers robustness

Homotypic Vacuole Fusion Requires VTI11 and Is Regulated by Phosphoinositides

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Molecular Plant 2014年第6期7卷 1026-1040页

作者： Sang Won Han Maria Fernanda rodriguez-Welsh Marcela Rojas-Pierce Department of Plant and Microbial Biology North Carolina State University Raleigh NC 27695 USA

Most plant cells contain a large central vacuole that is essential to maintain cellular turgor. We report a new mutant allele of VTI11 that implicates the SNARE protein VTI11 in homotypic fusion of protein storage and lytic vacuoles. Fusion of the multiple vacuoles present in vtill mutants could be induced by treatment with Wortmannin and LY294002, which are inhibitors of Phosphatidylinositol 3-Kinase （PI3K）. We provide evidence that Phosphatidylinositol 3-Phosphate （Ptdlns（3）P） regulates vacuole fusion in vtill mutants, and that fusion of these vacuoles requires intact microtubules and actin filaments. Finally, we show that Wortmannin also induced the fusion of guard cell vacuoles in fava beans, where vacuoles are naturally fragmented after ABA-induced stomata closure. These results suggest a ubiquitous role of phosphoinositides in vacuole fusion, both during the development of the large central vacuole and during the dynamic vacuole remodeling that occurs as part of stomata movements.

关键词： vacuole SNARE phosphoinositides membrane fusion Wortmannin.

Designing price-contingent vegetable rotation schedules using agent-based simulation

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Journal of Integrative Agriculture 2018年第2期17卷 461-472页

作者： LI Jing Daniel rodriguez WANG Hao-xiang WU Liu-san Faculty of Engineering Nanjing Agricultural University Queensland Alliance for Agriculture and Food Innovation (QAAFI) University of Queensland

Chinese vegetable production cooperatives supply their members, mostly smallholder farmers, with a rotation schedule for the year. Since vegetable prices are not stable throughout the year, designing a rotation schedule that maximizes expected profits, distributes farmers＇ profits more equitably, maintains the diversity of produce in the market, and reduces the risk of pests and diseases, requires adaptive, price-contingent rotation schedules（here, called ＂self-adaptive adjustment＂）. This study uses an agent-based simulation（ABS） to design self-adaptive rotation schedules that deliver these aims. The selfadaptive adjustment strategy was more profitable for farmers when faced with price volatility, and more equitable as well. This work provides a decision-support tool for managers of Chinese vegetable production cooperatives to provide farmers with more profitable and equitable rotation schedules.

关键词： operation research in agriculture self-adaptive algorithm cooperatives market fluctuation

Abscisic Acid, High-Light, and Oxidative Stress Down-Regulate a Photosynthetic Gene via a Promoter Motif Not Involved in Phytochrome- Mediated Transcriptional Regulation

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Molecular Plant 2008年第1期1卷 75-83页

作者： Roberto J. Staneloni Maria Jose rodriguez-Batiller Jorge J. Casal Fundacion Instituto Leloir and IIBBA-CONICET C1405BWE-Buenos Aires Argentina IFEVA Facultad de Agronomia Universidad de Buenos Aires and CONICET 1417 Buenos Aires Argentina

In etiolated seedlings, light perceived by phytochrome promotes the expression of light-harvesting chlorophyll a/b protein of photosystem Ⅱ （Lhcb） genes. However, excess of photosynthetically active radiation can reduce Lhcb expression. Here, we investigate the convergence and divergence of phytochrome, high-light stress and abscisic acid （ABA） signaling, which could connect these processes. Etiolated Arabidopsis thaliana seedlings bearing an Lhcb promoter fused to a reporter were exposed to continuous far-red light to activate phytochrome and not photosynthesis, and treated with ABA. We identified a cis-acting region of the promoter required for down-regulation by ABA. This region contains a CCAC sequence recently found to be necessary for ABI4-binding to an Lhcb promoter. However, we did not find a G-box-binding core motif often associated with the ABI4-binding site in genes promoted by light and repressed by ABI4. Mutations involving this motif also impaired the responses to reduced water potential, the response to high photosynthetic light and the response to methyl viologen but not the response to low temperature or to Norflurazon. We propose a model based on current and previous findings, in which hydrogen peroxide produced in the chloroplasts under high light conditions inter- acts with the ABA signaling network to regulate Lhcb expression. Since the mutation that affects high-light and methyl viologen responses does not affect phytochrome-mediated responses, the regulation by retrograde and phytochrome signaling can finally be separated at the target promoter level.

关键词： .cis-Acting Abscisic ABA signaling High-Light and Oxidative Lhcb expression high-light stress Lhcb promoter

OTB-morph:One-time Biometrics via Morphing

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Machine Intelligence Research 2023年第6期20卷 855-871页

作者： Mahdi Ghafourian Julian Fierrez Ruben Vera-rodriguez Aythami Morales Ignacio Serna Biometrics and Data Pattern Analytics Laboratory(BiDA Lab) Universidad Autonoma de MadridMadrid28049Spain

Cancelable biometrics are a group of techniques to transform the input biometric to an irreversible feature intentionally using a transformation function and usually a key in order to provide security and privacy in biometric recognition *** transformation is repeatable enabling subsequent biometric *** paper introduces a new idea to be exploited as a transformation function for cancelable biometrics aimed at protecting templates against iterative optimization *** proposed scheme is based on time-varying keys(random biometrics in our case)and morphing *** experimental implementation of the proposed scheme is given for face *** results confirm that the proposed approach is able to withstand leakage attacks while improving the recognition performance.

关键词： Biometrics face recognition template protection morphing security