检索结果-南通市图书馆

Mesenchymal stem cell-derived exosome:The likely game-changer in stem cell research

BIOCELL 2022年第5期46卷 1169-1172页

作者： dickson kofi wiredu ocansey XINWEI XU LU ZHANG FEI MAO Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province School of MedicineJiangsu UniversityZhenjiangChina Directorate of University Health Services University of Cape CoastCape CoastGhana

Stem cell research is a promising area of transplantation and regenerative medicine with tremendous potential for improving the clinical treatment and diagnostic options across a variety of conditions and enhancing understanding of human *** the past few decades,mesenchymal stem cell(MSCs)studies have exponentially increased with a promising ***,regardless of the huge investment and the research attention given to stem cell research,FDA approval for clinical use is still *** the challenges confronting stem cell research as a cellbased product,there appears to be evidence of superior effect and heightened potential success in its expressed vesicles,exosomes,as cell-free *** addition to their highly desirable intrinsic biologically unique structural,compositional,and morphological characteristics,as well as predominant physiochemical stability and biocompatibility properties,exosomes can also be altered to enhance their therapeutic capability or diagnostic imaging potential via physical,chemical,and biological modification *** importantly,the powerful therapeutic potential and superior biological functions of exosomes,particularly,regarding engineered exosomes as cell-free products,and their utilization in a new generation of nanomedicine treatment,vaccination,and diagnosis platforms,brings hope of a change in the near *** viewpoint discusses the trend of stem cell research and why stem cell-derived exosomes could be the game-changer.

关键词： Mesenchymal stem cell Exosome Cell-free therapy Regenerative medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging role of protein modification in inflammatory bowel disease

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第3期23卷 173-188页

作者： Gaoying WANG Jintao YUAN Ji LUO dickson kofi wiredu ocansey Xu ZHANG Hui QIAN Wenrong XU Fei MAO Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province School of MedicineJiangsu UniversityZhenjiang212013China Clinical Laboratory Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical UniversityWuxi214002China Clinical Laboratory the People’s Hospital of DanyangAffiliated Danyang Hospital of Nantong UniversityZhenjiang212300China Directorate of University Health Services University of Cape CoastCape Coast02630Ghana

The onset of inflammatory bowel disease(IBD)involves many factors,including environmental parameters,microorganisms,and the immune *** research on IBD continues to expand,the specific pathogenesis mechanism is still *** modification refers to chemical modification after protein biosynthesis,also known as post-translational modification(PTM),which causes changes in the properties and functions of *** proteins can be modified in different ways,such as acetylation,methylation,and phosphorylation,the functions of proteins in different modified states will also be *** between different states of protein or changes in modification sites can regulate protein properties and *** modifications like neddylation,sumoylation,glycosylation,and acetylation can activate or inhibit various signaling pathways(e.g.,nuclear factor-κB(NF-κB),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT))by changing the intestinal flora,regulating immune cells,modulating the release of cytokines such as interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ),and ultimately leading to the maintenance of the stability of the intestinal epithelial *** this review,we focus on the current understanding of PTM and describe its regulatory role in the pathogenesis of IBD.

关键词： Inflammatory bowel disease(IBD) Protein modification Neddylation Sumoylation Glycosylation Acetylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第5期23卷 423-431页

作者： Yuting XU Li ZHANG dickson kofi wiredu ocansey Bo WANG Yilin HOU Rong MEI Yongmin YAN Xu ZHANG Zhaoyang ZHANG Fei MAO Key Laboratory of Medical Science and Laboratory Medicine ofJiangsu Province School of MedicineJiangsu UniversityZhenjiang 212013China Nanjing Lishui People's Hospital Zhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200China Directorate of University Health Services University of Cape CoastCape CoastGhana Department of Gastroenterology the Second People's Hospital of ZhenjiangZhenjiang 212000China Clinical Lab Taicang Hospital of Traditional Chinese MedicineSuzhou 215400China

As a group of nonspecific inflammatory diseases affecting the intestine,inflammatory bowel disease(IBD)exhibits the characteristics of chronic recurring inflammation,and was proven to be increasing in incidence(Kaplan,2015).IBD induced by genetic background,environmental changes,immune functions,microbial composition,and toxin exposures(Sasson et al.,2021)primarily includes ulcerative colitis(UC)and Crohn's disease(CD)with complicated clinical symptoms featured by abdominal pain,diarrhea,and even blood in stools(Fan et al.,2021;Huang et al.,2021).

关键词： inflammatory intestine diarrhea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：