HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway

作     者：Yuting XU Li ZHANG Dickson Kofi Wiredu OCANSEY Bo WANG Yilin HOU Rong MEI Yongmin YAN Xu ZHANG Zhaoyang ZHANG Fei MAO Yuting XU;Li ZHANG;Dickson Kofi Wiredu OCANSEY;Bo WANG;Yilin HOU;Rong MEI;Yongmin YAN;Xu ZHANG;Zhaoyang ZHANG;Fei MAO

作者机构：Key Laboratory of Medical Science and Laboratory Medicine ofJiangsu ProvinceSchool of MedicineJiangsu UniversityZhenjiang 212013China Nanjing Lishui People's HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200China Directorate of University Health ServicesUniversity of Cape CoastCape CoastGhana Department of Gastroenterologythe Second People's Hospital of ZhenjiangZhenjiang 212000China Clinical LabTaicang Hospital of Traditional Chinese MedicineSuzhou 215400China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2022年第23卷第5期

页      面：423-431页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Zhenjiang Key Research and Development Plan(Social Development)(No.SH2021066) the Clinical Medical Science and Technology Development Fund Project of Jiangsu University in 2018(No.JLY20180031) the Taicang Science and Technology Planning Project(No.TC2020JCYL17),China 

主　　题：inflammatory intestine diarrhea 

摘      要：As a group of nonspecific inflammatory diseases affecting the intestine,inflammatory bowel disease(IBD)exhibits the characteristics of chronic recurring inflammation,and was proven to be increasing in incidence(Kaplan,2015).IBD induced by genetic background,environmental changes,immune functions,microbial composition,and toxin exposures(Sasson et al.,2021)primarily includes ulcerative colitis(UC)and Crohn s disease(CD)with complicated clinical symptoms featured by abdominal pain,diarrhea,and even blood in stools(Fan et al.,2021;Huang et al.,2021).